Effects of PPARγ Ligands on Leukemia by Yoko Tabe, Marina Konopleva, Michael Andreeff, Akimichi Ohsaka

“…Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions. PPARs form heterodimers retinoid X receptor (RXR), an obligate heterodimeric partner for other nuclear receptors. …”
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The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma by Zhiyong Pan, Yuyi Liu, Hui Li, Huisi Qiu, Pingmei Zhang, Zhiying Li, Xinyu Wang, Yuxiao Tian, Zhengfu Feng, Song Zhu, Xin Wang

“…Key enzymes such as hexokinase 2, lactate dehydrogenase A, phosphofructokinase 1, and pyruvate kinase M2 are discussed for their regulatory functions in NPC glycolysis through signaling pathways like PI3K/Akt and mTOR. …”
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A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling by Anders Dalby, Mathias Kaas, Lars Meinertz Byg, Signe Bundgaard Christiansen, Christian M. Longworth, Simon Bøggild Hansen, Per Qvist, Jens R. Nyengaard, Peder Madsen, Simon Mølgaard, Simon Glerup

“…Here we report that the SorCS2 intracellular domain (ICD) contains a triple serine motif that potentially functions as a signaling switch to induce intracellular signaling in hippocampal neurons. …”
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Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies by Xiaoyu Xuan, Jilin Fan, Jingyi Zhang, Ming Ren, Limin Feng, Limin Feng

“…Multiple immune cells are present in the reperfusion area, executing specific functions and engaging in crosstalk during diverse stages, constituting a complex immune microenvironment involved in tissue repair and regeneration after MIRI. …”
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Ultrafast signatures of merocyanine overcoming steric impedance in crystalline spiropyran by Khalid M. Siddiqui, Simon F. Bittmann, Stuart A. Hayes, Kamil M. Krawczyk, Antoine Sarracini, Gastón Corthey, Raison Dsouza, R. J. Dwayne Miller

“…Abstract Isomerisation through stereochemical changes and modulation in bond order conjugation are processes that occur ubiquitously in diverse chemical systems and for photochromic spirocompounds, it imparts them their functionality as phototransformable molecules. …”
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Signal Management: Updated Requirements of the EAEU Good Pharmacovigilance Practice by A. V. Matveev, A. E. Krasheninnikov, A. Yu. Zelinskaya

“…The key changes include a detailed consideration of terminology issues, signal validation and prioritisation processes, notifying competent authorities of signal evaluation results, managing emerging safety issues, and functions of new automated systems: an integrated database of adverse drug reactions and a system for tracking safety issues.…”
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Role of microbiota in pain: From bench to bedside by Huiguang Ren, Bo Cao, Qixuan Xu, Ruiyang Zhao, Hanghang Li, Bo Wei

“…Efforts to decipher the mechanisms of microbiota functions will help to promote achievements in pain management from bench to bedside.…”
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The BES1/BZR1 family transcription factor as critical regulator of plant stress resilience by Long Li, Tingting Mu, Rongrong Zhang, Guobin Zhang, Jian Lyu, Zeci Liu, Shilei Luo, Jihua Yu

“…The insights will serve as valuable references for further exploration of the multifaceted functions of BZR.…”
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Preclinical insights into gamma-tACS: foundations for clinical translation in neurodegenerative diseases by Guillermo Sánchez-Garrido Campos, Ángela M. Zafra, Marta Estévez-Rodríguez, Isabel Cordones, Giulio Ruffini, Javier Márquez-Ruiz

“…Early clinical studies indicate that gamma-tACS may improve cognitive functions and network connectivity, underscoring its ability to restore disrupted oscillatory patterns central to cognitive performance. …”
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Recent Approaches for Broadening the Spectral Bandwidth in Resonant Cavity Optoelectronic Devices by Gun Wu Ju, Byung Hoon Na, Yong-Hwa Park, Young Min Song, Yong Tak Lee

“…Recently, in order to overcome such drawbacks and/or to accomplish multiple functionalities, several approaches for broadening the spectral bandwidth in resonant cavity optoelectronic devices have been extensively studied. …”
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Speed Control of BLDC Motor using PWM and Arduino Uno by Sai Prasad Reddy M., Pranav K., Rahman Wasiqur, Vijay Kumar B., Jain Alok, A B Gurulakshmi

“…The system employs a microprocessor-based control mechanism to enhance functionality and precision, implemented with an Arduino bash, a brushless DC (BLDC) motor, and an electronic speed controller (ESC), which permits very fine control of motor speed by employing pulse width modulation (PWM). …”
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Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseases by Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald

“…SAA-/- mice carrying a deletion of the Saa1, Saa2, Saa3, and Saa4 serum amyloid A genes have better survival rates in sterile sepsis but are more prone to bacterial sepsis than their SAA+/+ counterparts, emphasizing their dual functionality in immune regulation. Overexpression of Saa1, Saa2, Saa3, and Saa4 in macrophages enhances NF-κB-mediated pro-inflammatory cytokine production and bacterial clearance during infection. …”
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Decoding glycosylation in cardiovascular diseases: mechanisms, biomarkers, and therapeutic opportunities by Gang Li, Kaidi Ren, Yage Jin, Yang Yang, Yi Luan

“…Protein glycosylation, particularly O-GlcNAcylation, is a critical post-translational modification (PTM) that regulates cardiac and vascular functions by modulating protein stability, localization, and interactions. …”
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Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning by Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet‐Trin Dinh, David Holcman, Pascale Gilardi‐Hebenstreit, Patrick Charnay

“…Abstract Although feedback loops are essential in development, their molecular implementation and precise functions remain elusive. Using enhancer knockout in mice, we demonstrate that a direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation. …”
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Optimizing selectivity via steering dominant reaction mechanisms in steam reforming of methanol for hydrogen production by Mengyuan Zhang, Zhi Liu, Yong Yan, Diru Liu, Guangyan Xu, Yingsheng An, Yingtong Zou, Yunbo Yu, Joseph S. Francisco, Hong He

“…Simultaneously, the CO desorption energy barrier on PdCu alloys is elevated, thereby hindering CH2O* decomposition. This dual functionality enhances both the selectivity and activity of the methanol steam reforming reaction. …”
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External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient’s health by Frederico P. Costa, Jack Tuszynski, Antonio F. Iemma, Willian A. Trevizan, Bertram Wiedenmann, Eckehard Schöll

“…All cells in the human body, including cancer cells, possess specific electrical properties crucial for their functions. These properties are notably different between normal and cancerous cells. …”
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Tailoring CAR surface density and dynamics to improve CAR-T cell therapy by Michael Hudecek, Francisco Martin, Pedro Justicia-Lirio, Ana Hinckley-Boned, Carmen Barbero-Jiménez, Maria Tristán-Manzano, Noelia Maldonado-Perez

“…The dynamics of CAR downmodulation remain underexplored; however, recent data point to its modification as a useful tool for improving functionality. Notably, transcriptional control of CAR expression and the incorporation of specific elements into the CAR design have emerged as interesting strategies to tailor CAR expression profiles. …”
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Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications by Mehrdad Hashemi, Asal Abolghasemi Fard, Bita Pakshad, Pezhman Shafiei Asheghabadi, Amineh Hosseinkhani, Atena Sadat Hosseini, Parham Moradi, Mohammadreza Mohammadbeygi Niye, Ghazal Najafi, Mohadeseh Farahzadi, Saloomeh Khoushab, Afshin Taheriazam, Najma Farahani, Mahya Mohammadi, Salman Daneshi, Noushin Nabavi, Maliheh Entezari

“…As a result, we investigated the expression and role of PI3K/AKT-related ncRNAs in clinical characteristics of lung cancer, as well as their functions as potential biomarkers in lung cancer diagnosis, prognosis, and treatment.…”
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Induction of the pro-myelocytic leukaemia gene by type I and type II interferons by M. Heuser, H. van der Kuip, B. Falini, C. Peschel, C. Huber, T. Fischer

“…The physiological role of the pro-myelocytic leukaemia (PML) gene product is poorly defined. Among other functions, PML is involved in haem atopoietic differentiation and in control of cell growth and tumorigenesis. …”
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Engineering flexible dopamine biosensors: blended EGylated conjugated and radical polymers in organic electrochemical transistors by Dinh Cung Tien Nguyen, Quyen Vu Thi, Quynh H. Nguyen, Jaehyoung Ko, Hoyeon Lee, Bryan Boudouris, Seung-Yeol Jeon, Yongho Joo

“…Abstract We demonstrate an enhancement in the figure of merit (μC*) of a flexible organic electrochemical transistor (OECT) and its dopamine (DA) biosensor by blending various open-shell, non-conjugated radical polymers featuring nitroxide radical active sites as pendant groups with closed-shell, ethylene glycol (EG)-functionalized conjugated polymers as a macromolecular active layer system. …”
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