Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein by Xin Yan, Robert B. Denman

“…Altogether, our data continue to support a model in which BC1 RNA functions independently of FMRP.…”
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The developmental transcriptome dynamics of current-year shoot utilized as scion in Camellia chekiangoleosa by Yu Sheng, Haili Gao, Chunlian Yu, Guangyuan Huang, Kunxi Wang, Kailiang Wang, Leyan Lv, Wei Long

“…We further analyzed a unique module showing a negative correlation between the module and traits (cell wall composition, i.e., lignin, cellulose, and hemicellulose content). …”
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Small non-coding RNA profiling in patients with non-muscle invasive bladder cancer by Jiajia Cai, Zeqin Yan, Yadi Zhong, Yuqing Li, Jianxu Huang, Huijuan Hu, Yingrui Li, Hu Fang, Song Wu

“…Abstract The intricate regulatory roles of small non-coding RNAs (sncRNAs), including PIWI-interacting RNAs (piRNAs) and microRNAs (miRNAs), have been increasingly recognized in the modulation of cellular functions and are associated with the pathogenesis of various diseases, notably cancer. …”
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Atypical oscillatory and aperiodic signatures of visual sampling in developmental dyslexia by Alessia Santoni, Giuseppe Di Dona, David Melcher, Laura Franchin, Luca Ronconi

“…Despite reading being primarily supported by visual functions, experimental evidence supporting these theories remains scarce. …”
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Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor by Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai, Hongkui Deng

“…In addition to neutralizing PDL1 and CD155, this chimeric receptor is engineered with the transmembrane region and intracellular domain of CD28, thereby effectively enhancing T cell survival and tumor-targeting functions. Notably, under simultaneous stimulation of PDL1 and CD155, CISR-CAR T cells demonstrate superior performance in terms of cell survival, proliferation, cytokine release, and cytotoxicity in vitro, compared with conventional CAR T cells. …”
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Modular Neural Network Model for Biometric Authentication of Personnel in Critical Infrastructure Facilities Based on Facial Images by Oleksandr Korchenko, Ihor Tereikovskyi, Ruslana Ziubina, Liudmyla Tereikovska, Oleksandr Korystin, Oleh Tereikovskyi, Volodymyr Karpinskyi

“…When developing the model, an approach was used in which the functionality of each module was defined in such a way as to correspond to a task traditionally solved by a separate neural network model. …”
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β-Arrestin 2 as a Prognostic Indicator and Immunomodulatory Factor in Multiple Myeloma by Parker Mathews, Xiaobei Wang, Jian Wu, Shaima Jabbar, Kimberly Burcher, Lindsay Rein, Yubin Kang

“…Our study provides new evidence that ARRB2 may have non-canonical functions independent of GPCRs with relevance to the understanding of MM pathobiology as well as immunotherapy and checkpoint inhibitor escape/resistance more broadly.…”
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Slow-Paced Breathing Intervention in Healthcare Workers Affected by Long COVID: Effects on Systemic and Dysfunctional Breathing Symptoms, Manual Dexterity and HRV by Marcella Mauro, Elisa Zulian, Nicoletta Bestiaco, Maurizio Polano, Francesca Larese Filon

“…The aim of the present study was to evaluate physical, cognitive, emotional symptoms, executive functions and autonomic cardiac modulation after one month of at-home slow breathing intervention. …”
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Fine-Grained Aircraft Recognition Based on Dynamic Feature Synthesis and Contrastive Learning by Huiyao Wan, Pazlat Nurmamat, Jie Chen, Yice Cao, Shuai Wang, Yan Zhang, Zhixiang Huang

“…However, methods based on deep learning are confronted with several challenges: (1) the inherent limitations of activation functions and downsampling operations in convolutional networks lead to frequency deviations and loss of local detail information, affecting fine-grained object recognition; (2) class imbalance and long-tail distributions further degrade the performance of minority categories; (3) large intra-class variations and small inter-class differences make it difficult for traditional deep learning methods to effectively extract fine-grained discriminative features. …”
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Dual roles of innate immune cells and cytokines in shaping the breast cancer microenvironment by Chen Zhang, Chen Zhang, Wei Liu, Ping Yang, Ping Yang, Rubing Lin, Lulan Pu, Hongying Zhang

“…Innate immune effectors, including tumor-associated macrophages (TAMs) and natural killer (NK) cells, exert dual functions by either initiating robust antitumor responses or facilitating immune evasion, metastatic dissemination, and therapeutic resistance. …”
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ggClusterNet 2: An R package for microbial co‐occurrence networks and associated indicator correlation patterns by Tao Wen, Yong‐Xin Liu, Lanlan Liu, Guoqing Niu, Zhexu Ding, Xinyang Teng, Jie Ma, Ying Liu, Shengdie Yang, Penghao Xie, Tianjiao Zhang, Lei Wang, Zhanyuan Lu, Qirong Shen, Jun Yuan

“…To address emerging challenges, including multi‐factor experimental designs, multi‐treatment conditions, and multi‐omics data, we present a comprehensive upgrade with four key components: (1) A microbial co‐occurrence network pipeline integrating network computation (Pearson/Spearman/SparCC correlations), visualization, topological characterization of network and node properties, multi‐network comparison with statistical testing, network stability (robustness) analysis, and module identification and analysis; (2) Network mining functions for multi‐factor, multi‐treatment, and spatiotemporal‐scale analysis, including Facet.Network() and module.compare.m.ts(); (3) Transkingdom network construction using microbiota, multi‐omics, and other relevant data, with diverse visualization layouts such as MatCorPlot2() and cor_link3(); and (4) Transkingdom and multi‐omics network analysis, including corBionetwork.st() and visualization algorithms tailored for complex network exploration, including model_maptree2(), model_Gephi.3(), and cir.squ(). …”
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Production of <i>Aloe vera</i> Phytoplacenta Extract and Potential Applications in Skincare by Seung Min Jung, Hye-In Kim, Soo-Yun Kim, Sung Joo Jang, Hyo Hyun Seo, Jeong Hun Lee, Ju-Duck Kim, Won Kyong Cho, Sang Hyun Moh

“…In addition, gene expression data indicated subtle changes in epidermal differentiation genes, modulation of inflammatory markers, and alterations in genes related to cell signaling and skin-specific functions. …”
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Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process by Jun-Xi He, Bing-Dong Sui, Yan Jin, Chen-Xi Zheng, Fang Jin

“…Crucially, these biophysical processes are functionally coupled with metabolic reprogramming events, where cytoskeletal strain modulates glycolytic flux and nuclear mechanotransduction pathways to inform differentiation decisions, forging a feedback loop between tissue mechanics and cellular fate specification. …”
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The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the KRASG12D/+ Trp53−/− murine model of sarcoma by Karys M. Hildebrand, Kurt N. Hildebrand, Carolina Salazar Arcila, Kayla Marritt, Jahanara Rajwani, Golpira Elmi Assadzadeh, Antoine Dufour, Frank R. Jirik, Michael J. Monument

“…Using STING deficient mice, and CRISPR/Cas9 gene editing, we demonstrated that STS clearance following STING therapy was dependent on host STING and not tumor-intrinsic STING pathway functionality. E7766 represents a promising candidate able to remodel the TME of murine STS tumors toward an inflamed phenotype independent of tumor-intrinsic STING functionality, and should be considered for potential translation in STS treatment.…”
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Mixed photonic/electronic neural network based on microLED arrays by M Müller, R Kraneis, N Kälin, N von Malm, A Waag, C Werner

“…The system is fully analog, with the synaptic fan-out and weighting implemented in free-space optics, while the fan-in and nonlinear activation functions are realized by optoelectronic components. …”
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KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells by Bishu Zhang, Tuoya Qi, Jiewei Lin, Shuyu Zhai, Xuelong Wang, Leqi Zhou, Xiaxing Deng

“…Abstract Histone lysine succinylation, an emerging epigenetic marker, has been implicated in diverse cellular functions, yet its role in cancer drug resistance is not well understood. …”
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A novel plasmid-encoded transposon-derived small RNA reveals the mechanism of sRNA-regulated bacterial persistence by Shu-Ling Lin, Qi-Chang Nie, Carmen Oi-Kwan Law, Hoa-Quynh Pham, Ho-Fai Chau, Terrence Chi-Kong Lau

“…ABSTRACT Small regulatory RNAs (sRNAs) in bacteria are crucial for controlling various cellular functions and provide immediate response to the environmental stresses. …”
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Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma by Min Zhou, Bing Wang, Richu Liang, Xinping Luan

“…Corresponding pathways and functions were analyzed between different groups. The difference of immune environment was compared. …”
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Real-Time Electro-Optical Tunable Hyperlens Under Subwavelength Scale by Dan Su, Xiao-Yang Zhang, Yuan-Liang Ma, Feng Shan, Jing-Yuan Wu, Xing-Chang Fu, Li-Jiang Zhang, Ke-Qiang Yuan, Tong Zhang

“…Hyperlens consisted by period plasmonic metamaterials is an interesting technology for the optical imaging of arbitrary objects beyond the diffraction limit in the far field, which has great potential applications in nanophotonics. However, the functionality of previously presented hyperlens is limited to image two-dimensional (2-D) objects and work at a certain wavelength due to the dispersion of metal, dramatically impose restrictions on its practical application. …”
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Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling by Yan Ding, Xiaoli Xu, Biying Meng, Li Wang, Biao Zhu, Bei Guo, Jiajia Zhang, Lin Xiang, Jing Dong, Min Liu, Guangda Xiang

“…Abstract Whether bone marrow modulates systemic metabolism remains unknown. Our recent study suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. …”
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