Assessment of quality of life as an element of monitoring health status in children and adolescents with type 1 diabetes mellitus by Nina Viktorovna Bolotova, Olga Viktorovna Kompaniets, Natalya Yur'evna Filina, Natalya Valer'evna Nikolaeva

“…The psycho-social activity of most patients in all age groups was ratherhigh in contrast to suppressed physical functions due to complications of DM1 ten or more years in duration (51,4?…”
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Understanding the Brassinosteroid-Dependent Environmental Adaption in Brassicaceae Plants by Zhenni Lu, Changrui Ma, Yuzhen Xie, Yuqing Zeng, Jiashi Peng, Dinggang Zhou, Jinfeng Wu

“…In this review, we introduce BR metabolism, signaling transduction and discuss their functions in regulating growth and development processes under adverse environment in Brassicaceae plants. …”
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Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing by Na-Young Park, Giuseppe Valacchi, Yunsook Lim

“…We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. …”
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Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex by Tatiane Marcusso Orsini, Natalia Yoshie Kawakami, Carolina Panis, Ana Paula Fortes dos Santos Thomazelli, Fernanda Tomiotto-Pellissier, Allan Henrique Depieri Cataneo, Danielle Kian, Lucy Megumi Yamauchi, Florêncio S. Gouveia Júnior, Luiz Gonzaga de França Lopes, Rubens Cecchini, Idessânia Nazareth Costa, Jean Jerley Nogueira da Silva, Ivete Conchon-Costa, Wander Rogério Pavanelli

“…Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of the major antileishmanial substance nitric oxide (NO), favoring then its replication and successful infection. …”
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APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs by Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang

“…In summary, APC functions as a positive regulator of MT-destabilizer and a negative regulator of MT-stabilizer to orchestrate MT dynamics.…”
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Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment by Nadi Rostami Ravari, Farzad Sadri, Farzad Sadri, Mohammad Ali Mahdiabadi, Yaser Mohammadi, Zahra Ourang, Zohreh Rezaei, Zohreh Rezaei

“…By understanding the dual functions of ncRNAs in both activating and inhibiting ferroptosis, we aim to uncover new therapeutic targets and strategies for LC. …”
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Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging by Dongfeng Lan, Dan Zhang, Xiaofang Dai, Ji Cai, He Zhou, Tao Song, Xianyao Wang, Qinghong Kong, Zhengzhen Tang, Jun Tan, Jidong Zhang

“…Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating evidence from extensive research underscores the remarkable anti-aging potential of both MSCs and their Exos. …”
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Harnessing the Rhizosphere Microbiome for Selenium Biofortification in Plants: Mechanisms, Applications and Future Perspectives by Ruixin Fu, Mengyuan Zhu, Yanrong Zhang, Junmin Li, Haichao Feng

“…In this review, systematic collection and analysis of research on selenobacteria, including both Se-oxidizing and Se-reducing bacteria, are therefore essential to elucidate their functions in enhancing crop growth and health. These insights can (i) deepen our mechanistic understanding of microbially mediated Se cycling and stress resilience and (ii) offer a novel framework for nanomicrobiome engineering aimed at promoting sustainable food production.…”
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Insect Detection Using mm-Waves: Integrated Communication and Biodiversity Sensing Based on Micro-Doppler Effects by Linta Antony, Nicola Marchetti, Ian Donohue, Adam Narbudowicz

“…Due to the simplicity of this proposed method, the technique can be integrated into the mm-Wave telecommunication system to monitor flying insects to bring about a step-change in our understanding of the dynamics of insect communities and the critical roles they play in ecosystem functioning and biodiversity.…”
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A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery by Mujibur Khan, Jannatul Ferdaus, Khaleda Akter, Hossain Ahmed, Mahrima Parvin, Sawaiz Kashif, Ali S. Arbab

“…Moreover, nanoparticles can be functionalized with molecular targeting agents, such as peptides, and combined with imaging dyes to improve the precision and monitoring of in-vivo treatments. …”
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A structural atlas of druggable sites on Nav channels by Zhangqiang Li, Qiurong Wu, Nieng Yan

“…In addition, a large number of natural toxins, both small molecules and peptides, can bind to Nav channels and modulate their functions. Technological breakthrough in cryo-electron microscopy (cryo-EM) has enabled the determination of high-resolution structures of eukaryotic and eventually human Nav channels, alone or in complex with auxiliary subunits, toxins, and drugs. …”
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High-performance photon-driven DC motor system by Dingyi Lin, Fujin Deng, Wei Hua, Ming Cheng, Zhe Chen, Zhiming Wang

“…The operation principle and power modulation-based speed control are also presented for the proposed photon-driven DC motor system. …”
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Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions by Yang Xiao, Longyi Zhu, Songyuan Du, Xinyi Ge, Lequn Ma, Shengyuan Deng, Kewei Ren

“…Although genetically encoded protein based optogenetic technique is developed to regulate such interactions, it still suffers from shortcomings including complicated operation and potential interference to organelle functions. Here, we present a fast, simple, biocompatible and programmable platform via activable DNA regulators to achieve spatiotemporal regulation of mitochondria-lysosome interactions in living cells. …”
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CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation by Siqi Chen, Yingyu Wang, Jessica Dang, Nuozi Song, Xiaoxin Chen, Jinhui Wang, Guo N. Huang, Christine E. Brown, Jianhua Yu, Irving L. Weissman, Steven T. Rosen, Mingye Feng

“…We also validate the functionality of the eSPR system in human primary macrophages.…”
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Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment by Taoxing Peng, Yiqi Wan, Yuxuan Sun, Yuexiang Ren, Fuli Shi, Yangfeng Lv, Xiangqiong Wen, Qiongfeng Chen, Xianhe Yang, Shan Xu, Jianming Li

“…Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. …”
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Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature by F. J. Valenzuela, J. Vera, C. Venegas, S. Muñoz, S. Oyarce, K. Muñoz, C. Lagunas

“…The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. …”
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Machine learning uncovers the transcriptional regulatory network for the production host Streptomyces albidoflavus by Mathias Jönsson, Renata Sigrist, Tetiana Gren, Mykhaylo Semenov Petrov, Nils Emil Junge Marcussen, Anna Svetlova, Pep Charusanti, Peter Gockel, Bernhard O. Palsson, Lei Yang, Emre Özdemir

“…We identify 78 independently modulated sets of genes (iModulons) that quantitatively describe the TRN across diverse conditions. …”
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Spatial Patterns and Drivers of Nonperennial Flow Regimes in the Contiguous United States by John C. Hammond, Margaret Zimmer, Margaret Shanafield, Kendra Kaiser, Sarah E. Godsey, Meryl C. Mims, Samuel C. Zipper, Ryan M. Burrows, Stephanie K. Kampf, Walter Dodds, C. Nathan Jones, Corey A. Krabbenhoft, Kate S. Boersma, Thibault Datry, Julian D. Olden, George H. Allen, Adam N. Price, Katie Costigan, Rebecca Hale, Adam S. Ward, Daniel C. Allen

“…Abstract Over half of global rivers and streams lack perennial flow, and understanding the distribution and drivers of their flow regimes is critical for understanding their hydrologic, biogeochemical, and ecological functions. We analyzed nonperennial flow regimes using 540 U.S. …”
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The Polyphenols – Valuable Bioactive Compounds by Andrea-Maria Malanca, Eniko Miheleș, Magdalena Roșu, Patricia Cristina Tarkanyi, Monica Dragomirescu

“…The structural characteristics of polyphenols make them to interact with free radicals, proteins, but also with enzymes, highly selective protein biocatalysts, essential in the functioning of living organisms. The polyphenol content and the antioxidant activity can be assayed, in the laboratory, by spectrophotometric methods.…”
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Discoidin Domain Receptors in Tumor Biology and Immunology: Progression and Challenge by Heng Zhang, Wenlong Chen, Haitao Zhu, Hsiang-i Tsai

“…This review begins with an overview of the discovery, structural features, and canonical and non-canonical functions of DDRs. It then focuses on the reciprocal regulation between DDRs and collagen in the tumor microenvironment, highlighting how this interplay contributes to cancer progression. …”
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