Liquid-liquid phase separation in cell physiology and cancer biology: recent advances and therapeutic implications by Ziyuan Huang, Ziyuan Huang, Zimeng Liu, Lieqian Chen, Yanlin Liu, Gaofei Yan, Yizheng Ni, Qiuxia Yan, Wenqian He, Junhong Liu, Shufang Luo, Jindong Xie

“…LLPS drives the formation of biomolecular condensates, which are crucial for various cellular functions. Increasing evidences link alterations in LLPS to the onset and progression of various diseases, particularly cancer. …”
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Comparison of Protective Immune Responses to Apicomplexan Parasites by Sonja Frölich, Rolf Entzeroth, Michael Wallach

“…Finally, the evolutionary relationships of these parasites and their hosts, as well as the modulation of immune functions that are critical in determining the outcome of the infection by these pathogenic organisms, are discussed.…”
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ESP32-CAM-based Smart Surveillance: Real-time Transmission and Alerts Via Telegram by Fernando Esparza-Segundo, Shany-Lizbeth Enríquez-Arcadio, Juan Carlos Gonzalez-Islas, Alberto Suarez-Navarrete, Ma. de Jesus Gutiérrez-Sanchez

“…In addition, integration with other messaging platforms and incorporation of a module developed with App Inventor 2 is planned. The results of the proof-of-concept demonstrate the efficiency and functionality of the video surveillance system, offering users an agile and adaptable solution to diverse technological needs, with an affordable cost and free access. …”
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Transcriptional regulatory network analysis of microglia in multiple sclerosis by CAI Qiangwei, SUN Feng, WU Wenyu, SHAO Fuming, GAO Zhengliang, JIN Shengkai

“…The results of GO and KEGG pathway analysis showed that in gray matter microglia, functions such as endocytosis, ion homeostasis, and lipid localization were downregulated during disease progression, while in white matter microglia, functions such as protein folding, cytoplasmic translation, and response to thermal stimuli were upregulated. …”
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Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination by Weimin Xu, Zhebin Hua, Yaosheng Wang, Wenbo Tang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Yubei Gu, Chen‐Ying Liu, Peng Du

“…In this study, it is found that AMBRA1 functions as a pro‐oxidative factor that increases oxidative stress in intestinal epithelial cells (IECs) in vitro and in vivo. …”
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Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations by Noémie Petit, Yu-yin Joanne Chang, Franz Acker Lobianco, Tom Hodgkinson, Shane Browne

“…These modifications enable precise control over stiffness, swelling, degradation, and advanced functionalities such as shear-thinning, self-healing, and injectability. …”
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Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway by Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

“…This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro‐ and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. …”
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<i>HOXA10</i> and <i>HOXA11</i> in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction by Lorin-Manuel Pîrlog, Andrada-Adelaida Pătrășcanu, Mara-Diana Ona, Andreea Cătană, Ioana Cristina Rotar

“…<i>HOX</i> genes, a family of conserved transcription factors, are critical for reproductive tract development and endometrial functionality. This review highlights the molecular underpinnings of <i>HOXA10/HOXA11</i> in reproductive health and their dysregulation in benign pathologies associated with infertility, such as endometriosis, adenomyosis, and endometrial polyps. …”
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Inverse design of compact nonvolatile reconfigurable silicon photonic devices with phase-change materials by Wei Maoliang, Lin Xiaobin, Xu Kai, Wu Yingchun, Wang Chi, Wang Zijia, Lei Kunhao, Bao Kangjian, Li Junying, Li Lan, Li Erping, Lin Hongtao

“…In the development of silicon photonics, the continued downsizing of photonic integrated circuits will further increase the integration density, which augments the functionality of photonic chips. Compared with the traditional design method, inverse design presents a novel approach for achieving compact photonic devices. …”
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A Fluorescent Probe for Imaging and Treating S-Nitrosation Stress in OGD/R Cells by Hui Ye, Chen Zhang, Lerong Li, Cunrui Li, Jiayue Yu, Duorui Ji, Zhuangzhuang Liang, Jianbing Wu, Zhangjian Huang

“…Protein S-nitrosation, a redox post-translational modification elicited by nitric oxide (NO), is essential for modulating diverse protein functions and signaling pathways. …”
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Immunoregulation in Fungal Infections: A Review and Update on the Critical Role of Myeloid-Derived Suppressor Cells by Valéria de Lima Kaminski, Ana Luiza Oliveira Menezes, Kauan Gonçalves de Lima, Stephani Leonelo de Almeida, Diego Vinícius Alves da Silva, Filipe Nogueira Franco, Nycolas Willian Preite, Flávio Vieira Loures

“…Once activated, MDSCs suppress T-cell and natural killer cell functions through immunosuppressive cytokines like IL-10 and TGF-β, as well as enzymes such as arginase-1 and indoleamine 2,3-dioxygenase 1 (IDO-1). …”
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Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis by Alycia Williams, Daniel J. Hossack, Nia Thompson, Yul Eum Sim, Cristina Wilson, Viviane Schuch, Tiffany Hailstorks, Rana Chakraborty, Erica L. Johnson, Erica L. Johnson, Erica L. Johnson

“…These results highlight the inflammatory roles of elevated PRL at the maternal-fetal interface, underscoring the need for further mechanistic studies to elucidate its functions in pregnancy.…”
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Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia by Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei Li

“…These cells demonstrated expression of microglia-enriched genes and showed typical microglial functions such as LPS-induced responses and phagocytosis. …”
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Osteoinductive activity of photobiomodulation in an organotypic bone model by Guilherme Silva Furtado, Victor Martin, Rita Araújo, Pedro Sousa Gomes, Andréa Dias Neves Lago

“…Notwithstanding, the impact of PBM on bone functionality remains largely undisclosed, particularly in the absence of influencing factors such as pathologies or regenerative therapies. …”
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SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish by Alicia Martínez-López, Alicia Martínez-López, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Constantino Abenza-Olmos, Juan M. Lozano-Gil, Juan M. Lozano-Gil, Juan M. Lozano-Gil, Sergio Candel, Sergio Candel, Sergio Candel, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…It has also been suggested that SAMHD1 negatively regulates interferon (IFN) and the inflammatory responses to viral infections; however, the functions and mechanisms of SAMHD1 in modulating innate immunity are still under study.MethodsIn our laboratory, we have generated Samhd1-deficient zebrafish larvae using CRISPR-Cas9 and studied its role in the activation of nuclear factor kappa B (NF-κB) and the induction of type I IFN (IFN-I).ResultsIt was shown that Samhd1 deficiency results in the overactivation of the IFN-I response, assayed as the increased transcript levels of the Interferon Stimulated Genes (ISGs), but only if the larvae were stimulated with suboptimal doses of IFN-I. …”
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Effect of diurnal solar radiation regime and tree density on sap flow of Norway spruce (Picea abies [L.] Karst.) in fragmented stand by Singh Vivek Vikram, Zabihi Khodabakhsh, Trubin Aleksei, Cudlín Pavel, Korolyova Nataliya, Jakuš Rastislav, Blaženec Miroslav

“…Our findings emphasize the critical role of stand density in modulating forest functioning and underscore the importance of maintaining specific canopy densities as part of effective silvicultural practices in the face of ongoing climate change.…”
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Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis by Sadique Hussain, Gaurav Gupta, Moyad Shahwan, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Kumud Pant, Haider Ali, Sachin Kumar Singh, Venkata Sita Rama Raju Allam, Keshav Raj Paudel, Kamal Dua, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Specifically, we delve into the functions of miRNAs, lncRNAs, and circRNAs in regulating GPX4 expression and impacting cellular susceptibility to ferroptosis. …”
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LncRNA PVT1 promotes malignant progression by regulating the miR-7-5p/CDKL1 axis in oral squamous cell carcinoma by Jun Li, Shuxin Ding, Min Li, Bo Zou, Miaomiao Chu, Guohao Gu, Cheng Chen, Yu-jiao Liu, Ke Zheng, Zhen Meng

“…We found that PVT1 enhanced cell proliferation, migration, and invasion by targeting CDKL1. In addition, PVT1 functions as a sponge to modulate miR-7-5p, thereby influencing the expression of CDKL1 and the progression of OSCC. …”
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Genome-wide analysis of the BoBZR1 family genes and transcriptome analysis in Brassica oleracea by Muhammad Asad Ullah, Muhammad Hamza, Rozia Gull, Muhammad Shafiq, Abdul Wahid, Shahab Ahmad, Tayebeh Ahmadi, Mehdi Rahimi

“…Despite this, the BZR1 functioning in B. oleracea is not elucidated. A complete genome-wide analysis identified 12 BZR1 genes in B. oleracea, categorized into three groups based on their gene motif and structural features. …”
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Regulation of Vascular Injury and Repair by P21-Activated Kinase 1 and P21-Activated Kinase 2: Therapeutic Potential and Challenges by Chuting Han, Mengying Zhu, Yiting Liu, Yan Yang, Jun Cheng, Pengyun Li

“…The PAK (p21-activated kinases) family is a class of intracellular signal transduction protein kinases that regulate various cellular functions, mainly through their interactions with small GTP enzymes. …”
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