Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review by Hossein Shirvani, Maryam Naghibzadeh, Seyed Ebrahim Hashemi

“…Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. …”
Get full text

In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems by Chenyu Zong, Fei Wang, Wenguo Cui

“…Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. …”
Get full text

Hybrid DNA Origami – Graphene Platform for Electrically‐Gated Nanoscale Motion by João D. G. Azevedo, Tiago Queirós, Filipe Camarneiro, Maria João Lopes, João Freitas, Agnes Purwidyantri, Praneetha Sundar Prakash, Soumya Chandrasekhar, Thorsten‐Lars Schmidt, Pedro Alpuim, Jana B. Nieder

“…Abstract A proof‐of‐principle device for axial high‐resolution operation that combines a deoxyribonucleic acid (DNA) origami with a functionalized graphene layer is presented, analyzed by nanoscopy. …”
Get full text

Targeting T cell exhaustion: emerging strategies in non-small cell lung cancer by Xianqiang Liu, Xianqiang Liu, Xiaowei Xi, Shengshan Xu, Hongyu Chu, Penghui Hu, Dong Li, Bin Zhang, Bin Zhang, Hejie Liu, Tianxiao Jiang, Zhuming Lu

“…Recent advances in immunotherapy have introduced promising treatments targeting T cell functionality. Central to the efficacy of these therapies is the role of T cells, which are often rendered dysfunctional due to continuous antigenic stimulation in the tumor microenvironment–a condition referred to as T cell exhaustion. …”
Get full text

The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value by Shao-Ze Zhang, Shao-Ze Zhang, Shao-Ze Zhang, Shao-Yan Liu, Meng-Die Cheng, Yin-Feng Zhang, Jia-Wei Tian

“…As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splicing, transport, and degradation of both mRNAs and noncoding RNAs. …”
Get full text

A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy by Yizheng Zu, Yizheng Zu, Min Li, Min Li, Ruyue Li, Ruyue Li, Shaohan Ma, Shaohan Ma, Yu’e Yang, Yu’e Yang, Shun Zhang, Yuan Ma, Yuan Ma, Tiantian Wu, Chunfang Ha, Chunfang Ha

“…EXOs derived from ginger were purified, loaded with the natural bioactive compound curcumin (Cur) with high encapsulation efficiency, and functionalized with a tumor-targeting aptamer. Upon intravenous administration, the resulting multifaceted microenvironment nanoregulator, termed AGE@Cur, effectively accumulates at the tumor site and exerts a tumor-suppressive effect through remodeling the tumor microenvironment. …”
Get full text

The Structural Regulation and Properties of Energetic Materials: A Review by Jin Yu, Siyu Xu, Weiqiang Pang, Hanyu Jiang, Zihao Zhang

“…Future directions emphasize computational simulations and novel fabrication methods to guide the rational design and precise preparation of next-generation EMs with specific functions.…”
Get full text

Alternative splicing of KLF4 in myeloid cells: implications for cellular plasticity and trained immunity in cancer and inflammatory disease by Amanda Rosewell Shaw, Amanda Rosewell Shaw, Amanda Rosewell Shaw, Attoria Bennett, Daping Fan, Walden Ai, Walden Ai

“…A novel and underexplored dimension of KLF4 biology lies in its alternative splicing (AS), which generates distinct isoforms that may drive the transcription factor’s functions, depending on specific cellular environments, disease states, or signaling programs. …”
Get full text

Decomposition-Aware Framework for Probabilistic and Flexible Time Series Forecasting in Aerospace Electronic Systems by Yuanhong Mao, Xin Hu, Yulang Xu, Yilin Zhang, Yunan Li, Zixiang Lu, Qiguang Miao

“…Additionally, the framework incorporates probabilistic distribution forecasting using likelihood functions, addressing the dynamic variations and uncertainty in time series data. …”
Get full text

A High-Sensitivity Graphene Metasurface and Four-Frequency Switch Application Based on Plasmon-Induced Transparency Effects by Aijun Zhu, Mengyi Zhang, Weigang Hou, Lei Cheng, Cong Hu, Chuanpei Xu

“…In this paper, we propose the use of a monolayer graphene metasurface to achieve various excellent functions, such as sensing, slow light, and optical switching through the phenomenon of plasmon-induced transparency (PIT). …”
Get full text

ApoBDs: a paradigm shift from cellular debris to therapeutic vehicles by Zixuan Xiong, Zixuan Xiong, Fen Xiao, Yuanyuan Sun, Yuanyuan Sun, Hankun Su, Hankun Su, Di Liu, Di Liu, Boya Tang, Boya Tang, Wenyan Jian, Tianli Yang, Tianli Yang, Jing Zhao, Jing Zhao, Yanping Li, Yanping Li, Hui Li, Hui Li

“…This review focus on the origins, formation mechanisms, and dual functions of ApoBDs across various diseases, highlighting their paradoxical nature as both disease promoters and therapeutic allies. …”
Get full text

Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence by Enze Fu, Kai Pan, Benjamin Hinnant, Shang Chen, Zhibo Han, Zhikun Guo, Zhong-chao Han, Qiong Li, Zongjin Li

“…We developed selectin binding peptide (SBP)-engineered extracellular vesicles (EVs) with targeted functions, which are loaded with LINE1 antisense oligonucleotide (ASO). …”
Get full text

Cyclophilin A: promising target in cancer therapy by Shujuan Jin, Mengjiao Zhang, Xiaoting Qiao

“…Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exerts critical functions within the cell via its peptidyl-prolyl cis-trans isomerase (PPIase) activity, which is crucial for processes, such as protein folding, trafficking, assembly, modulation of immune responses, and cell signaling. …”
Get full text

circFOXP1: a potential diagnostic and therapeutic target in human diseases by Qiang Yi, Xinting Ouyang, Kui Zhong, Zheng Chen, Weijian Zhu, Gangfeng Zhu, Jinghua Zhong

“…Mechanistically, circFOXP1 functions through miRNA sponging, protein interactions, and modulation of key signaling pathways such as Wnt and PI3K/AKT. …”
Get full text

Dendritic cells immunotargeted therapy for atherosclerosis by Zhaohui Li, Yanyan Yang, Jinbao Zong, Bei Zhang, Xiaolu Li, Hongzhao Qi, Tao Yu, Yongxin Li

“…In this review, we delineate the essential functions and underlying mechanisms of dendritic cells and their subsets in the modulation of atherosclerotic inflammation and immune responses. …”
Get full text

Unconscious processing of happy faces correlates with prosocial tendency but not extraversion by Qian Xu, Qian Xu

“…These findings shed new light on the adaptive functions of unconscious emotional face processing, and highlight the importance of future investigations into the unconscious processing of extrafoveal happy expression.…”
Get full text

Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus by Wei Zheng, Xin Ji, Qiao qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu

“…In this review, we summarize the current understanding of the role of exosomes derived from immune and nonimmune cells in modulating immune responses in T2DM by regulating immune cell functions and cytokine production. …”
Get full text

Polarization-controlled chiral transport by Hang Zhu, Jian Wang, Andrea Alù, Lin Chen

“…This limits both device functionality reconfiguration and information transmission capacity. …”
Get full text

Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke by Ozal Beylerli, Ilgiz Gareev, Huaizhang Shi, Tatiana Ilyasova

“…Recent studies have shed light on the remarkable potential of MSC-derived exosomes to not only suppress the inflammatory responses of microglia and astrocytes, but also enhance their neuroprotective functions. Moreover, these exosomes have demonstrated a remarkable ability to modulate various immune cells and inflammatory mediators, thereby exerting profound mitigating effects on neuroinflammation. …”
Get full text

Coumarin: A natural solution for alleviating inflammatory disorders by Farnoosh Saadati, Amir Modarresi Chahardehi, Negar Jamshidi, Nazanin Jamshidi, Darioush Ghasemi

“…The review focuses on elucidating the mechanisms through which coumarin exerts its anti-inflammatory effects, including its antioxidant activity, inhibiting pro-inflammatory cytokine production, and modulation of immune cell functions. Additionally, the paper addresses potential limitations of using coumarin, such as concerns about toxicity at high doses or with prolonged use. …”
Get full text