Long Noncoding RNA SAMMSON Promotes Melanoma Progression by Inhibiting FOXA2 Expression by Lijuan Yang, Meiling Zhou, Shulei Wang, Xiaojia Yi, Guohang Xiong, Jing Cheng, Buqing Sai, Qiao Zhang, Zhe Yang, Yingmin Kuang, Yuechun Zhu

“…Long noncoding RNAs (lncRNAs) play crucial roles in melanoma initiation and development, serving as potential therapeutic targets and prognostic markers for melanoma. lncRNA survival-associated mitochondrial melanoma-specific oncogenic noncoding RNA (SAMMSON) is upregulated in many types of human cancers. However, the functions of SAMMSON in melanoma have not been fully elucidated. …”
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Influence of Peptide Conjugation Sites on Lunatin–Alumina Nanoparticles: Implications for Membrane Interaction and Antimicrobial Activity by Carolina Silva Ferreira, Lívia Mara Fontes Costa, Lúcio Otávio Nunes, Kelton Rodrigues de Souza, Giovanna Paula Araújo, Evgeniy S. Salnikov, Kelly Cristina Kato, Helen Rodrigues Martins, Adriano Monteiro de Castro Pimenta, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…This study aimed to develop and evaluate a novel nanobiostructure combining alumina nanoparticles (NPs) with the antimicrobial peptide lunatin-1 (Lun-1), forming peptide-functionalized nanofilaments. The main objective was to investigate how the site of peptide functionalization (C-terminal vs. …”
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The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature by Julia Marcinkowska, Mateusz Szymon Muras, Tomasz Lorenc, Maciej Michalik, Krzysztof Marcinkowski, Jakub Mikszta, Natalia Mikszta

“…This review article examines the impact of chronic AAS administration on the functionality of selected human organs and physiological systems. …”
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GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis by Elisa Calvo-Jiménez, Kirsten Stam, Angélique Jossi, Yves Jossin

“…This study reveals that Reelin promotes de novo translation of Golgi Re-Assembly Stacking Proteins (GRASPs), which are essential for the functions of Reelin on cortical neurons. Downregulation of GRASPs in migrating excitatory neurons of the embryonic neocortex leads to disoriented cells during the multipolar phase of migration and an aberrant leading process length during locomotion. …”
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Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling by Sofie Burgmer, Fenja L. Meyer zu Altenschildesche, Akos Gyenis, Hyun Ju Lee, David Vilchez, Patrick Giavalisco, Arnaud Fichant, Mirka Uhlirova, Gilles Storelli

“…We show that, in Drosophila, the PRRs PGRP-LC and PGRP-LE act independently of canonical NF-κB signaling to repress essential metabolic functions in the gut, such as digestion and central carbon metabolism. …”
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Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer by Changjian Wang, Zhikun Zheng, Chuangyan Wu, Dan Zhang, Yangchenxi Wang, Sheng Zhang, Geng Wang, Rui Zhou

“…These nanoscale vesicles carry microRNAs, proteins, and lipids that influence tumor cell proliferation, migration, metastasis, and immune modulation. The dual functions of ADEs – both in promoting and suppressing tumorigenesis – are largely dependent on their cellular origin, molecular cargo, and the characteristics of the tumor microenvironment. …”
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Fine-tuning immunity: ubiquitin-dependent regulation of interleukin-17A expression by Th17 cells by Desh Raj, Desh Raj, Desh Raj, Amit K. Verma, Amit K. Verma, Amit K. Verma, Risha Mathur, Risha Mathur, Risha Mathur, Jenna Woody, Jenna Woody, Jenna Woody, Mahesh Kathania, Mahesh Kathania, Mahesh Kathania, K. Venuprasad, K. Venuprasad, K. Venuprasad

“…Here, we summarize the intricate relationship between IL-17A and ubiquitination, exploring how ubiquitin-mediated processes influence IL-17A production, receptor signaling, and downstream effector functions. We provide insights into the potential therapeutic implications of targeting IL-17A and its ubiquitination pathways in inflammatory diseases and autoimmune disorders. …”
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The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response by Xuanyu Guo, Jiajun Song, Miao Liu, Xinyi Ou, Yongcan Guo

“…Extracellular vesicles (EVs) are small particles released by all cell types and often reflect the state of their parental cells and modulate other cells’ functions through the various cargo they transport. …”
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Formulation and Validation of Turmeric and Black Pepper Flavored Probiotics by Ranjith Arimboor, Zavier Thaliakuzhy, Nagamani Chintalarevi

“…<p class="Abstract">The beneficial or harmless microorganisms naturally found in the digestive tract have major roles in modulating the physiological functions of the host. …”
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The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment by Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang

“…The human microbiota affect host metabolism and immune functions, with disruptions in microbiota homeostasis leading to metabolic alterations and immune dysfunction in various diseases. …”
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Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence by Weijing Wen, Simeng Gu, Fanjia Guo, Zhijian Chen, Sujun Yan, Zhe Mo

“…This review aims to provide an overview of the epigenetic mechanisms involved in obesity, with an emphasis on their molecular functions and regulatory networks. Integrating findings from relevant studies, we discuss how these modifications influence obesity-related outcomes through regulating key processes such as adipocyte differentiation and energy metabolism. …”
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Three‐Channel Wavefront Shaping Using Non‐Interleaved Spin‐Multiplexed Plasmonic Metasurfaces by Xingling Pan, Yadong Deng, Ziru Cai, Zhiming Chen, Yingtao Ding, Ziwei Zheng, Fei Ding

“…This plasmonic metasurface platform paves the way for customizable, multi‐channel functionalities, advancing the development of integrated photonic devices with enhanced versatility.…”
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Interplay of light and nitrogen for plant growth and development by Chenlong Guan, Dong Zhang, Chengcai Chu

“…Nitrogen, as the most crucial mineral nutrient for plants, is a component of numerous biomolecules. It also functions as a signaling molecule, regulating plant growth and development. …”
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Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology by Yifei Ge, Lixue Jiang, Chengru Yang, Qingfu Dong, Chengwu Tang, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Xiangyu Zhong

“…These strategies encompass reprogramming TAMs, inhibiting their recruitment, and selectively eliminating them to enhance anti-tumor functions, alongside modulating RCD pathways to amplify immune responses. …”
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A Combinatory Therapy of Metformin and Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrodes by Bruno Rodríguez-Meana, Jaume del Valle, Xavier Navarro

“…This process involves protein adsorption, immune cell recruitment, cytokine release, and fibroblast activation, leading to a fibrous capsule formation and a decrease in electrode functionality. Anti-inflammatory and antifibrotic strategies have the potential to diminish the impact of the foreign body response. …”
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Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation by Chengyuan Lv, Ziyi Wang, Ziyi Wang, Ziyi Wang, Zehui Li, Xialing Shi, Mingming Xiao, Yan Xu

“…This mini-review summarizes recent scientific progress on the formation, structural dynamics, and ecological functions of oral biofilms. It also highlights emerging strategies for modulating biofilm composition and activity, the regulatory systems governing these interactions, and potential directions for microbiome-based therapies in future research.…”
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GIS based monitoring and warning system for residual pollution of soil inputs in irrigation areas by MA Haixia, GUO Quanen, ZHAN Zongbing, LIU Qiangde, BAI Yulong, YANG Cheng

“…The system combined a VOC-PF1 sensor, an STM32 master chip, and a GSM communication module to achieve efficient data collection and communication functions. …”
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Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders by Hailin Wang, Ying Yang, Ziwei Ni, Xiaoting Qiao, Yaqian Guo, Xiaomin Wang, Duo Cao, Yayun Wang, Cailian Ruan

“…This review aims to elucidate the structure and molecular functions of the BCL11 gene family, discuss its impact on the development of the central nervous system, and explore its association with neurodevelopmental disorders.…”
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Insights into the molecular and genetic role of obesity in breast cancer pathogenesis by Sandeep Mallya, Varsha Gangadhar, Sophia Evangeline Aldrin, Meghana Acharya, Shama Prasada Kabekkodu, Kiran Kumar Kolathur, Sanjiban Chakrabarty

“…Inflammation and hormone dysregulation play an important role in promoting a protumorigenic environment through adipose tissue, which is involved in energy storage and functions as an endocrine organ. As a result, various cytokines, primarily proinflammatory in nature, are released, resulting in low-grade inflammation promoting tumor growth. …”
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The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies by Rui Zhao, Jiaju Tian, Jing Peng, Ruiting Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…Contemporary studies reveal widespread dysregulation of ncRNA expression profiles in thyroid malignancies, where differentially expressed ncRNAs exert either tumor-suppressive or oncogenic functions by modulating epithelial-mesenchymal transition (EMT) mechanisms. …”
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