Role of calcineurin and ionotropic glutamate receptors in Alzheimer's disease: A systematic review by Awgichew Behaile Teklemariam, Edgeit Abebe Zewde, Melaku Mekonnen Agidew, Sisay Ayalkibet Siyamrew, Lemlemu Maru, Zelalem Tilahun Muche

“…Therapeutic approaches targeting the CaN-iGluR axis, including CaN inhibitors and iGluR modulators, have the potential to mitigate the progression of AD and improve cognitive functions associated with the disease.This systematic review aims to consolidate current knowledge on the molecular mechanisms underlying CaN and iGluR dysregulation in AD and discuss their potential as therapeutic targets. …”
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Theoretical Analyses of Different Nonlinear Compensation Methods Based on Perturbation Theories in the Unrepeatered System With Raman Amplification by You Wang, Wei Li, Muyang Mei, Zhongshuai Feng, Hao Zheng, YaoBing Chen

“…Firstly, the numerical error functions of pre-NLC and original NLC are derived, revealing that the numerical error of pre-NLC is more severe due to the error accumulation. …”
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Effects of selenium-enriched yeast dietary supplementation on egg quality, gut morphology and caecal microflora of laying hens by Ruili Li, Jiewei Liu, Minxiao Liu, Mingzhi Liang, Zengguang Wang, Yufen Sha, Huiwen Ma, Yafeng Lin, Baohua Li, Jinming You, Lei Zhang, Ming Qin

“…Selenium (Se) is an essential micronutrient for humans and animals and is a powerful antioxidant that can promote reproductive and immune functions. The purpose of this study was to evaluate the effects of supplemental dietary selenium-enriched yeast (SeY) on egg quality, gut morphology and microflora in laying hens. …”
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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology by Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers

“…We conclude that genetic risk of AD functionally translates into different microglia pathway responses to Aβ pathology, placing AD genetic risk downstream of the amyloid pathway but upstream of TAU pathology.…”
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New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…However, their physiological functions in bacterial and host physiologies are still controversial and not clear. …”
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PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment by Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei

“…ABSTRACT The PI3K/AKT/mTOR signaling axis is a pivotal regulator of key cellular functions, including proliferation, metabolism, survival, and immune modulation. …”
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Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-β/ERK/p90RSK Signalling by Fei Li, Zhenzeng Ma, Heng Liu, Qidi Zhang, Xiaobo Cai, Ying Qu, Mingyi Xu, Lungen Lu

“…This study aims to explore the functions of YB-1 in hepatic progenitor cells (HPCs). …”
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Chaperone-mediated autophagy dysfunction in imiquimod-induced psoriasiform dermatitis by Wei Zhao, Kainan Liao, Wei Song, Jing Wang, Chunlin Cai, Fusheng Zhou, Dandan Zang, Deping Xu, Haisheng Zhou

“…Autophagy plays a critical role in regulating the functions of immune cells, endothelial cells, and especially keratinocytes, contributing to the pathogenesis of psoriasis. …”
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Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress by Jurica Novak, Olga B. Tseilikman, Vladislav A. Shatilov, Maxim S. Zhukov, Vadim A. Shevyrin, Zuhra R. Khismatullina, Albina M. Fedorova, Georgiy N. Patrikyan, Timur L. Khaibullin, Vadim E. Tseilikman

“…<b>Conclusions</b>: The primary outcomes of the study include the identification of the role of hepatic MAO-A in the development of anxiety-like behavior, as well as the determination of resveratrol dose ranges at which it functions as an allosteric modulator of MAO-A activity.…”
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The action of Poria cocos polysaccharides against non-alcoholic fatty liver disease: A preliminary study by Rui Zhou, Qinting Chen, Jie Mo, Meizhen Liu, Ka Wu, Chao Guo

“…Based on these bioinformatics data, 31 intersecting genes in PCP (483 target genes), NAFLD (1445 target genes), and pyroptosis (905 target genes) were identified via network pharmacology analysis, and a total of 16 key genes in PCP against NAFLD through the modulation of pyroptosis were determined. Further enrichment analysis revealed the detailed anti-NAFLD functions and molecular mechanisms of PCP. …”
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The role of atropine in myopia control: insights into choroidal and scleral mechanisms by Longxiang Huang, Longxiang Huang, Longxiang Huang, Longxiang Huang, Jingjin Zhang, Jingjin Zhang, Jingjin Zhang, Jingjin Zhang, Youfang Luo

“…In this study, we investigate the inhibitory effects of atropine on the progression of experimental myopia by targeting the functions of the choroid and sclera and exploring its potential therapeutic mechanisms. …”
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Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 by Yu Zhang, Xuefei Zhao, Shuqi Li, Yanchun Xu, Suying Bai, Wei Zhang

“…The retinoic acid-related orphan receptor alpha, a nuclear receptor with extensive involvement in the regulation of cellular physiological states, exerts its functions predominantly through the modulation of downstream target gene transcription. …”
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Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

“…Future directions include CRISPR-based gene editing to understand TLR functions, development of specific TLR modulators for targeted therapy, and machine learning applications to predict drug responses and identify novel ligands. …”
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ER-mitochondria tethering and its signaling: A novel therapeutic target in breast cancer by Chamanthi Paidi, Yerusha Nuthalapati, Anuveda Sree Samudrala, Priyamvada Bhamidipati, Charanteja Mangam, Danny R. Welch, Ganji Purnachandra Nagaraju, RamaRao Malla

“…Abnormal MAM structures and altered ER-mitochondrial tethering impair mitochondrial functions and thereby drive BC progression. Altered mitochondrial dynamics, often characterized by dysregulated dynamin-related protein 1 (Drp1) and mitofusin-2 (Mfn2) activity, enhances BC cell survival. …”
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PIEZO1 activity promotes stemness in mesenchymal stem cells under shear stress and enhances protection of leukemia cells by Amit Sharma, Jina Bhattacharyya, Piruthivi Sukumar, Bithiah Grace Jaganathan

“…Mechanosensor proteins regulate the interaction of the cells with the microenvironment and control several cellular functions. Here, we determined the cellular effects of PIEZO1, a mechanically activated ion channel protein on proliferation, differentiation, migration, and leukemia support of human bone marrow-derived MSCs (BM-MSCs). …”
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Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer by Jing Li, Mimi Chen, Dingwen Huang, Ziyin Li, Yu Chen, Jinhua Huang, Yuanqun Chen, Zhili Zhou, Zhiying Yu

“…Here, we comprehensively analyzed SELENOI expression patterns, functions, and clinical implications across various malignancies through the integration of bulk transcriptomics, cancer databases, and in vitro and in vivo experiments. …”
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Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer by Natalya Maluchenko, Alexandra Saulina, Olga Geraskina, Elena Kotova, Anna Korovina, Grigoriy Armeev, Mikhail Kirpichnikov, Alexey Feofanov, Vasily Studitsky

“…Auto(poly-ADP-ribosylation) activity of PARP2 is enhanced by Mg2+ ions and modulated by Zn2+ ions: suppressed or enhanced depending on the occupancy of two functionally different zinc binding sites. …”
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Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity by Laura Antonucci, Cristiana Porcu, Eleonora Timperi, Silvano Junior Santini, Gino Iannucci, Clara Balsano

“…Neutrophils or PolyMorphonuclear Neutrophils (PMNs) are key effector cells of the innate immune system and thanks to their remarkable plasticity, establish a cross talk with T cells modulating their survival and effector functions. During Nonalcoholic Steatohepatitis (NASH), the advanced form of hepatic steatosis or NAFL, PMNs infiltrate liver tissue, becoming a histological feature of NASH. …”
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Recent Preclinical Evidence on Phytocannabinoids in Neurodegenerative Disorders: A Focus on Parkinson’s and Alzheimer’s Disease by Nicoleta-Mirela Blebea, Ciprian Pușcașu, Gabriel Hancu, Alina Mihaela Stăniguț, Cornel Chiriță

“…The endocannabinoid system (ECS) is a vital biological network essential for maintaining homeostasis and supporting various physiological functions. It comprises cannabinoid receptors, endogenous lipid-based ligands, known as endocannabinoids, as well as metabolic enzymes and associated proteins responsible for regulating their levels within tissues. …”
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Enhanced selectivity of carbon quantum dots for metal ion detection through surface modification by heteroatom doping: A study on optical properties and theoretical approach by María Belén Cánchig, Floralba López, Zaillmar Morales-Navarro, Alexis Debut, Karla Vizuete, Thibault Terencio, Manuel Caetano, Juan Pablo Saucedo-Vázquez

“…The study also demonstrated that functionalization with sulfur could modulate emission frequencies, enhancing the detection capabilities for specific ions. …”
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