A FAN1 point mutation associated with accelerated Huntington’s disease progression alters its PCNA-mediated assembly on DNA by Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F. Vogt, Julien Boudet, Brinda C. Prasad

“…FAN1 has previously been implicated in modulating triplet repeat expansion in a PCNA dependent manner. …”
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Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies by Dandan Guo, Songhua Cai, Lvdan Deng, Wangting Xu, Sentao Fu, Yaling Lin, Tong Jiang, Qing Li, Zhijun Shen, Jian Zhang, Peng Luo, Bufu Tang, Ling Wang

“…Conversely, ferroptosis can reciprocally alter the metabolic environment, leading to the activation or inhibition of immune cell functions, thereby modulating immune responses. This paper reviews the molecular mechanism of ferroptosis and describes the tumor immune microenvironment, discusses the connection between ferroptosis and the tumor microenvironment in lung cancer and pulmonary diseases, and discusses the development prospect of their interaction in the treatment of lung cancer and pulmonary diseases.…”
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Dissecting the dual role of OTU family proteins in tumor progression and immune escape by Xiaolong Tang, Yadan Li, Yongshuo Liu

“…As a core mechanism regulating intracellular protein homeostasis, the dynamic equilibrium between ubiquitination and deubiquitination profoundly impacts the functionality and fate of target proteins. The Ovarian tumor domain (OTU) family, a vital subclass of deubiquitinating enzymes, comprises 16 members that mediate ubiquitin binding and hydrolysis through their characteristic OTU domain. …”
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Terahertz photons promote neuron growth and synapse formation through cAMP signaling pathway by Yuan Zhong, Yun Yu, Yangmei Li, Junkai Yin, Yuankun Sun, Rundong Jiang, Chao Chang

“…Abstract Neurite outgrowth and synapse formation constitute the cellular basis for the establishment and plasticity of neural networks, crucially involved in cognitive functions. However, the techniques currently available to effectively and specifically modulate these processes remain limited. …”
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The central role of microglia in major depressive disorder and its potential as a therapeutic target by Xue Xia, Kaiqing Li, Wei Zou, Long Wang

“…In MDD, microglia shift from a surveillant resting state to either an overactivated or functionally inhibited phenotype, exacerbating pathology via aberrant cytokine release, dysregulated synaptic pruning and impaired myelin support. …”
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Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration by Yue-Qi Zhang, Rong Nie, Zi-Yuan Feng, Ming-Hui Fan, Zhi-Xue Shen, Xiu-Zhen Zhang, Qing-Yi Zhang, Chen-Yu Zou, Ji-Ye Zhang, Kai Huang, Li-Ping Mou, Hui-Qi Xie

“…The manuscript is structured to first establish a fundamental understanding of efferocytosis, encompassing its core concepts, molecular mechanisms, and physiological functions within tissue repair. Subsequently, it provides an in-depth analysis of the regulatory role of efferocytosis in inflammatory response modulation during tissue repair cascades. …”
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Gut Microbiota in Chronic Inflammatory Diseases - Literature Review by Joanna Zygadło, Kamila Jałocha, Piotr Bakuła

“… Introduction The gut microbiota, a complex community of microorganisms residing in the human gastrointestinal tract, is integral to various bodily functions. Understanding the role of gut microbiota is essential due to its significant influence on human health and disease. …”
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The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers by Eun Jung Choi, Yoon Young Jang, Eun Joo Choi, Chang Joo Oh

“…Particular emphasis is placed on the dichotomous effects of endogenous versus exogenous lactate, with the former supporting glycolytic effector functions and the latter reprogramming immune cells toward regulatory phenotypes via redox shifts and epigenetic remodeling. …”
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Identification of lipid metabolism-related genes in myocardial infarction: implications for diagnosis and therapy by Qiang Wang, Xian Wu, Bo Yu

“…They influence inflammatory responses and modulate leukocyte, vascular cell and cardiac cell functions, affecting the vasculature and heart. …”
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Research progress of deubiquitinating enzymes in cerebral ischemia-reperfusion injury by XiaoHong Qin, JiangRui Zhu, HaoRan Lu, MaoRui Yi, ZiLong Zhao, WenFei Zhang, Jing Cheng

“…We further reveal that CIRI disrupts DUBs functionality through a tripartite mechanism—transcriptional dysregulation, catalytic inactivation, and subcellular mislocalization—transforming DUBs from guardians of homeostasis into mediators of injury. …”
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Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis by Dipasree Hajra, Raju S Rajmani, Ayushi Devendrasingh Chaudhary, Shashi Kumar Gupta, Dipshikha Chakravortty

“…Alongside, governing immunological functions by modulating p65 NF-κB acetylation, SIRT1, and SIRT3 also skew Salmonella-induced host metabolic switch by regulating the acetylation status of HIF-1α and PDHA1. …”
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Design and implementation of NB-IoT based environmental temperature and humidity monitoring system by Minmin MAO, Jiaqi JU, Yuling OUYANG, Yan JIN

“…In view of the disadvantages of the traditional environmental monitoring system, such as high power consumption, high maintenance cost and no real-time monitoring, an environmental temperature and humidity monitoring system based on narrow band Internet of things (NB-IoT) technology was developed, which is mainly controlled by singlechip microcomputer.The work flow of the main controller and the working mode of the communication module were optimized to reduce the power consumption of the system.NB-IoT communication technology was utilized for data transmission to the cloud platform through the base station and core network.China Mobile IoT open platform (OneNET platform) was adopted to achieve the connection between the terminal device and the application, and expanded functions provided by the platform was used to design a mobile phone application to achieve the remote real-time monitoring of environmental parameters and improve the user’s convenience.…”
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Suppression of Nonlinear XPM Phenomenon by Selection of Appropriate Transmit Power Levels in the DWDM System by Tomáš Ivaniga, Petr Ivaniga

“…In optical transfer data systems a system is functioning if the measured BER parameter is not bigger than 10−12.…”
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Creating a Quasi-Resonant Induction Cooktop Integrating Zero-Voltage Switching (ZVS) and Load Management by Ahmet Aksöz

“…Subsequently, rigorous testing was conducted to evaluate the functionality and applicability of the device in real-world scenarios.…”
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The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress. by Chaitali Dutta, Nicholas Rhind

“…We test the relative contributions to replication-stress resistance of transcriptional regulation and the two other major checkpoint functions: cell-cycle arrest and fork stabilization. …”
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Nonassociative Algebras: A Framework for Differential Geometry by Lucian M. Ionescu

“…Conditions on torsion algebras allowing to construct an algebra of functions, whose algebra of derivations is the initial Lie algebra, are considered. …”
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Cuckoo by Lena Galanopoulou

“…In this context, repetition simultaneously serves two seemingly opposing functions: it creates patterns of return to previous encounters while also opening potential lines of flight away from established norms. …”
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Metabolism by Suhr F

“…These cleavage fragments in turn exert defined biological functions, such as angiogenesis modulation, nitric oxide generation or muscle regulation. …”
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Nanocluster-mediated signaling crosstalk between FcγR and TLR4 in macrophage inflammatory responses by Seonik Lee, Hunter Richman, Yan Yu

“…Abstract Receptor crosstalk, the interaction between different receptors to modulate signaling, is crucial for fine-tuning the inflammatory responses of innate immune cells. …”
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Real-Time Location Monitoring and Routine Reminders Based on Internet of Things Integrated with Mobile for Dementia Disorder by Dwi Rangga Okta Zuhdiyanto, Yuli Asriningtias

“…The system development includes prototype creation that consisting of a mobile application and IoT tools such as the ESP32 WROOM microcontroller, Ublox Neo6M V2 GPS module, and SIM800L V2 GSM module. Functionality testing and impact evaluation were conducted to assess its effectiveness in improving the quality of life for dementia sufferers and facilitating monitoring for caregivers. …”
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