Allosteric coupling activation mechanism in histidine kinases by Juan Cruz Almada, Ana Bortolotti, Lucía Porrini, Daniela Albanesi, Virginia Miguel, Larisa Cybulski

“…Abstract Histidine kinases (HKs) are crucial regulators of cellular functions, mediating the phosphorylation of specific proteins to modulate their activity and localization. …”
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A Dual‐Modal Memory Organic Electrochemical Transistor Implementation for Reservoir Computing by Yuyang Yin, Shaocong Wang, Ruihong Weng, Na Xiao, Jianni Deng, Qian Wang, Zhongrui Wang, Paddy Kwok Leung Chan

“…Herein, PEDOT:Tos/PTHF‐based organic electrochemical transistors (OECTs) with dual‐modal memory functions—both short‐term and long‐term—are demonstrated. …”
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Innovative hydrogels in cutaneous wound healing: current status and future perspectives by Prasad Sawadkar, Prasad Sawadkar, Ferdinand Lali, Ferdinand Lali, Elena Garcia-Gareta, Elena Garcia-Gareta, Elena Garcia-Gareta, Elena Garcia-Gareta, Beatriz Gil Garrido, Abdullah Chaudhry, Priya Matharu, Christos Kyriakidis, Karin Greco, Karin Greco

“…Furthermore, it highlights the emerging potential of functionalized injectable hydrogels, particularly those engineered for controlled drug release, enhanced bioactivity, and patient-specific therapeutic applications. …”
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The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes by Tan Huang, Sharida Fakurazi, Pike-See Cheah, Pike-See Cheah, Pike-See Cheah, King-Hwa Ling, King-Hwa Ling, King-Hwa Ling

“…Lithium treatment, which restored nucleus REST in trisomic astrocytes, significantly suppressed the expression of these inflammatory mediators and reactive astrocyte markers.DiscussionThese findings suggest that REST is pivotal in modulating astrocyte functionality and reactivity in DS. …”
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Advances in CO2 capture and separation materials: Emerging trends, challenges, and prospects for sustainable applications by Hailing Ma, Hongxin Fu, Yao Tong, Ahmad Umar, Yew Mun Hung, Xin Wang

“…Advances in material design, such as pore modulation, surface functionalization, and the introduction of defect sites, have led to significant improvements in CO2 adsorption capacity, selectivity, and regeneration efficiency, while addressing challenges such as high energy consumption, moisture sensitivity, and production cost. …”
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Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis by Zhongxia Li, Liying Chen, Fan Fei, Wenqi Wang, Lin Yang, Yu Wang, Heming Cheng, Yingwei Xu, Cenglin Xu, Shuang Wang, Yan Gu, Feng Han, Zhong Chen, Yi Wang

“…EE‐enhanced adult‐born dentate granule cells (abDGCs) are functionally activated during seizure events. Importantly, the selective activation of abDGCs mimics the anti‐seizure effects observed with EE, while their inhibition negates these effects. …”
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GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment by Rong Gao, Yongfeng Zhang, Bo Deng, Jiawei Zhang, Zhuowen Liang, Zhao Wei, Feng Xu, Tan Ding

“…In vitro, the functionalized microspheres not only enhanced vanillin release efficiency but also effectively suppressed inflammatory responses and oxidative stress in nucleus pulposus (NP) cells. …”
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Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. by Sarah A Stanley, Amy K Barczak, Melanie R Silvis, Samantha S Luo, Kimberly Sogi, Martha Vokes, Mark-Anthony Bray, Anne E Carpenter, Christopher B Moore, Noman Siddiqi, Eric J Rubin, Deborah T Hung

“…To add to our understanding of the molecular processes involved in intracellular infection, we performed a chemical screen using a high-content microscopic assay to identify small molecules that restrict mycobacterial growth in macrophages by targeting host functions and pathways. The identified host-targeted inhibitors restrict bacterial growth exclusively in the context of macrophage infection and predominantly fall into five categories: G-protein coupled receptor modulators, ion channel inhibitors, membrane transport proteins, anti-inflammatories, and kinase modulators. …”
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Upregulation of an IAA-Glucosyltransferase <i>OsIAGLU</i> in Rice (<i>Oryza sativa</i> L.) Impairs Root Gravitropism by Disrupting Starch Granule Homeostasis by Guo Chen, Xiaoyu Fu, Xinya Ruan, Xiaolu Yu, Dianyun Hou, Huawei Xu

“…This study clearly demonstrates that auxin not only functions in regulating agronomic traits but also plays an essential role in gravity perception by modulating starch granule accumulation in rice root tips.…”
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Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72. by Abhijit Sarkar, Barbara Reinhold-Hurek

“…<h4>Conclusion/significance</h4>Our data suggest that life under conditions of nitrogen fixation is an important part of the lifestyle of strain BH72 in roots, as a wide range of genes far beyond the nif regulon is modulated. Moreover, the NifA regulon in strain BH72 appears to encompass a wider range of cellular functions beyond the regulation of nif genes.…”
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Exogenous attention and its relationship with working memory contents: beyond spatial selection by Águeda Fuentes-Guerra Toral, Fabiano Botta, Juan Lupiáñez, Carlos González-García, Elisa Martín-Arévalo

“…To successfully perform everyday activities, cognitive functions such as working memory (WM) and selective attention are necessary. …”
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Range Space and Similarity Transformation Using Symbolic Mathematics in Python by Chainarong Wisassakwichai, Prasert Phaochoo

“…The effectiveness of these classes has been validated through numerical results, which, when compared to MATLAB functions (null(), pinv(), sym(), and jordan()), demonstrate that the exact symbolic solutions from both classes significantly improve numerical precision for selected application examples from numerical algorithms, power systems and linear algebra. …”
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JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases by Yimeng Dai, Chunguo Cui, Dan Jiao, Xuewei Zhu

“…This study reviews the intricate relationship between ferroptosis and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation of the JAK/STAT pathway is implicated in promoting or inhibiting ferroptosis, depending on the context. …”
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A novel numerical implementation for solving time fractional telegraph differential equations having multiple space and time delays via Delannoy polynomial by Ömür Kıvanç Kürkçü

“…This method enables easy and fast approximationtool consisting of the matrix expansions of the functions using only the Delannoypolynomial. Thus, the solutions are obtained directly from a unique matrix system. …”
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The Role of Bioactive Small Molecules in COPD Pathogenesis by Sha Liao, Yahong Chen

“…These mechanisms relate to the regulation of redox balance, the inhibition of the release of inflammatory mediators, and the modulation of cellular functions. Therefore, the present article aims to explore and elucidate the distinct roles played by different categories of biologically active small molecules in contributing to the pathogenesis of COPD.…”
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Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins by A. V. Voronkov, O. Yu. Gamzeleva

“…The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological  functions is shown. …”
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Herbal Support for the Nervous System: The Impact of Adaptogens in Humans and Dogs by Jagoda Kępińska-Pacelik, Wioletta Biel

“…Modern research confirms that plant substances can modulate neurotransmitters, reduce oxidative stress and support cognitive functions. …”
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A Holography-Based Modal Wavefront Sensor for the Precise Positioning of a Light Emitter Using a High-Resolution Computer-Generated Hologram by Florian Loosen, Johannes Stehr, Lucas Alber, Irina Harder, Norbert Lindlein

“…Instead of Zernike polynomials, more complex phase functions, which are related to certain dislocations of the light source are used as detector modes. …”
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Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury by Brecht Attema, Folkert Kuipers

“…Secondary bile acids (BAs) are microbiome-derived metabolites increasingly recognized for their important signaling functions in host (patho)physiology. In this issue of EMBO Molecular Medicine, Jalil et al (Jalil et al, 2025) report that increased production of secondary BAs upon administration of the human bacterium Clostridium scindens (C. scindens) improves colonic health in mice with chemically-induced colitis via activation of the membrane bound BA receptor TGR5. …”
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Regulation of normal human polyrnorphonuclear leucocytes by carnitine by Andrea Fattorossi, Roberto Biselli, Anna Casciaro, Sonia Tzantzoglou, Claudio de Simone

“…Data shows that carnitine exerts considerable effects on all PMN functions investigated. Although the ultimate effect was often donor dependent, TNFα production was exceptional in that carnitine was able to consistently reduce TNFα production in Staphylococcus aureus stimulated PMN in a clear dose-dependent fashion. …”
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