Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP by Johannes Vogt, Jenq‐Wei Yang, Arian Mobascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, Sergei Kirischuk, Petr Unichenko, Guilherme Horta, Konstantin Radyushkin, Albrecht Stroh, Sebastian Richers, Nassim Sahragard, Ute Distler, Stefan Tenzer, Lianyong Qiao, Klaus Lieb, Oliver Tüscher, Harald Binder, Nerea Ferreiros, Irmgard Tegeder, Andrew J Morris, Sergiu Gropa, Peter Nürnberg, Mohammad R Toliat, Georg Winterer, Heiko J Luhmann, Jisen Huai, Robert Nitsch

“…PRG‐1+/− mice, which are animal correlates of human PRG‐1+/mut carriers, showed an altered cortical network function and stress‐related behavioral changes indicating altered resilience against psychiatric disorders. …”
Get full text

Apoptosis-associated genetic mechanisms in the transition from rheumatoid arthritis to osteoporosis: A bioinformatics and functional analysis approach by Hao-Ju Lo, Chun-Hao Tsai, Tsan-Wen Huang

“…Key genes were pinpointed by intersecting differentially expressed genes from RA and OP datasets with WGCNA module genes. Functional enrichment analysis using the “clusterProfiler” package focused on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. …”
Get full text

High intensity interval training and selenium nanoparticles protect hippocampal neurons and enhance cognitive function in diabetic rats by Kimia Aliakbari, Payam Saidie

“…Cognitive function was assessed using the Morris water maze test. …”
Get full text

CAML-PSPNet: A Medical Image Segmentation Network Based on Coordinate Attention and a Mixed Loss Function by Yuxia Li, Peng Li, Hailing Wang, Xiaomei Gong, Zhijun Fang

“…For this, a new network based on PSPNet, using a coordinate attention mechanism and a mixed loss function for segmentation (CAML-PSPNet), is proposed. …”
Get full text

Turning Waste into Treasure: Functionalized Biomass‐Derived Carbon Dots for Superselective Visualization and Eradication of Gram‐Positive Bacteria by Ke‐Fei Xu, Zihao Wang, Macheng Cui, Yuhan Jiang, Chengcheng Li, Zi‐Xi Wang, Ling‐Yi Li, Chenyang Jia, Lijie Zhang, Fu‐Gen Wu

Get full text

Techno-functional, rheological, and chemical properties of plant-based protein ingredients obtained with dry fractionation and wet extraction by Davide De Angelis, Vittoria Latrofa, Giacomo Squeo, Antonella Pasqualone, Carmine Summo

“…While wet extraction technologies can offer a wide modulation of ingredient functionality, providing a broad spectrum of food applications, dry fractionation seems to guarantee a narrow range of techno-functional properties, although with potentially higher performance in certain areas like solubility and foaming.…”
Get full text

Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells? by Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, Maria Rita Rippo

“…Cellular senescence is also accompanied by a deep reshaping of microRNA expression and by the modulation of mitochondria activity, both master regulators of the SASP. …”
Get full text

Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties by Ke Che, Cong Wang, Hao Chen, Hao Chen, Hao Chen, Hao Chen

“…Future directions emphasize interdisciplinary collaboration to harness PDENs’ potential in combating metabolic disorders, enhancing food functionality, and advancing personalized nutrition strategies.…”
Get full text

Enhancing Mitochondrial Function Through Pharmacological Modification: A Novel Approach to Mitochondrial Transplantation in a Sepsis Model by Bomi Kim, Yun-Seok Kim, Kyuseok Kim

“…Furthermore, formoterol-enhanced mitochondrial transplantation demonstrated a substantial reduction in TNF-α levels in LPS-induced hyperinflammatory THP-1 cells (untreated: 915.91 ± 12.03 vs. formoterol-treated: 529.29 ± 78.23 pg/mL, <i>p</i> < 0.05), suggesting its potential to modulate immune responses. <b>Conclusions:</b> Mitochondrial transplantation using drug-enhancing mitochondrial function might be a promising strategy in sepsis.…”
Get full text

Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. by Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas

“…We showed that the two cell types exhibit distinct patterns of open chromatin and that cell-specific open chromatin can guide the finding of functional variants. We identified an open chromatin region at chromosome 7q22.3 in megakaryocytes but not erythroblasts, which harbors the common non-coding sequence variant rs342293 known to be associated with platelet volume and function. …”
Get full text

Neural Correlates of Flight Acceleration in Pigeons: Gamma-Band Activity and Local Functional Network Dynamics in the AId Region by Suchen Li, Zhuo Tang, Mengmeng Li, Lifang Yang, Zhigang Shang

“…Among various kinematic parameters, flight acceleration provides critical information for the brain to modulate movement intensity, speed, and direction. …”
Get full text

L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction by Seyed Mohammad Amin Kashani, Narges Abdoli, Forouzan Khodaei, Zahra Honarpishefard, Tahereh Golzar, Nazi Dastkhosh, Azad Salimi, Negar Azarpira, Hossein Niknahad, Reza Heidari

“…It was found that ARG treatment significantly improved renal function by modulating mitochondrial function and decreasing oxidative stress markers (P<0.05). …”
Get full text

Altered functional activity and connectivity in Parkinson’s disease with chronic pain: a resting-state fMRI study by Erlei Wang, Nan Zou, Jinru Zhang, Yiqing Bao, Yang Ya, Junkang Shen, Yujing Jia, Chengjie Mao, Guohua Fan

“…This study investigated changes in spontaneous neuronal activity and functional connectivity (FC) associated with chronic pain in PD patients.MethodsThe study included 41 PD patients with chronic pain (PDP), 41 PD patients without pain (nPDP), and 29 healthy controls. …”
Get full text

Molecular insights into the functional role of PbNRT2.4 in potassium homeostasis and nutrient transport in Pyrus ussuriensis by Han Yang, Hao Xu, Yujie Shi, Liyan Chen, Lijuan Zhang, Liping Kan, Yumeng Jin, Xinlan Mei, Yangchun Xu, Nazir Ahmed, Caixia Dong

Get full text

Phenotypic and functional changes of NK cells in patients with myelodysplastic syndrome and acute myeloid leukemia treated with hypomethylating drugs by D. I. Zhigarev, M. V. Khoreva, L. V. Gankovskaya

“…Since the discovery of NK cells in 1973, the mechanisms of their functioning have been studied in details, and there is currently no doubt that they play a special role in the process of recognition and destruction of transformed and malignant cells. …”
Get full text

Effect of nano-hydroxyapatite filling on masticatory function and gingival sulcular fluid inflammatory factor levels in periapical inflammation by Honghui Xie, Aihong Tan, Zhijian Su, Chao Pan, Shuangjiang Li, Haibo Xiao

“…Abstract Objective The purpose of this study is to investigate the influence of nano-hydroxyapatite (nano-HA) filling on the restoration of masticatory function and the modulation of inflammatory factors within gingival sulcular fluid in patients suffering from periapical inflammation. …”
Get full text

Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington's Disease. by Joseph Goodliffe, Anastasia Rubakovic, Wayne Chang, Dhruba Pathak, Jennifer Luebke

“…The findings that Q31 MSNs differed from Q97 and WT neurons with regard to some physiological features and structurally suggest a novel role of the N17 domain in the function of WT Htt. The motor phenotype seen in Q97 mice was less robust than that reported in an earlier study (Gu et al., 2015), and the alterations to MSN physiological properties were largely consistent with changes reported previously in a number of other mouse models of HD. …”
Get full text

Understanding the role of electrostatic force, van der Waals force, and osmotic pressure in retinal function and barrier integrity by Khayry Al-Shami, Jafar Shatnawi, Khaled Qasagsah, Salman Almurabi, Ghayda’ Shatnawi, Tasnim Darawsheh, Shahed Karaja

“…Abstract The retina’s intricate interplay of forces and structures, with a focus on the retinal pigment epithelium (RPE) and photoreceptors, is essential for retinal health and function. Among these forces, electrostatic forces play a crucial role, working alongside van der Waals forces and oncotic pressure to maintain the retina’s attachment to the RPE and ensure the integrity of the blood-retina barrier (BRB). …”
Get full text

Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men by Jéssica Guedes, Indira Pla, Aniel Sanchez, Gyorgy Marko-Varga, Gilberto Barbosa Domont, K Barbara Sahlin, Berk Hazir, Aleksander Giwercman, Fábio César Sousa Nogueira, Johan Malm, Yvonne Lundberg Giwercman

Get full text

Identification of functional SNP associated with sperm quality in porcine ANXA5 that contributes to the growth of immature Sertoli cell by Mingyang Han, Diwen Yao, Yuyang Song, Yuhang Liu, Zhihua Chen, Jialian Li, Fenge Li, Xiuqin Yang, Lihe Dai, Buyue Niu

“…The aim of this study was to explore the effect of ANXA5 in the growth of swine Sertoli cells and identify its functional variations. Firstly, the expression of porcine ANXA5 in different tissues was detected by semi-quantitative RT-PCR and its effect on the proliferation of Sertoli cells was evaluated by CCK8, EdU, flow cytometry analyses and qRT-PCR. …”
Get full text