Post-translational modification of transcription factors: perspectives in vascular medicine by Elena Astanina, Elisa Setten, Francesco Boccalatte, Federico Bussolino, Valentina Comunanza

“…Metabolite-induced post-translational modifications of transcription factors significantly modulate their functionality, leading to drastic changes in transcriptional outcomes. …”
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The Role of Heat Shock Proteins in Insect Stress Response, Immunity, and Climate Adaptation by Davide Banfi, Tommaso Bianchi, Maristella Mastore, Maurizio Francesco Brivio

“…Heat shock proteins (HSPs) play a key role in enhancing insect resilience to abiotic and biotic stresses by preserving cellular integrity and modulating immune responses. This review summarizes the main functions of HSPs in insects, including protein stabilization, interaction with antioxidant systems, and involvement in the innate immune response. …”
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Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins by Céline N. Weller, Jonathan Hall

“…By bringing a target protein and a ubiquitin E3 ligase into close proximity, ubiquitin monomers can be transferred onto surface lysines of the protein, which is subsequently degraded by the proteasome. The functions of RNA- and DNA-binding proteins have been especially hard to modulate with small molecules. …”
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Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages by Aida Tort-Miró, Aida Tort-Miró, Aida Tort-Miró, Uxía Alonso, Beatriz Martín-Mur, Beatriz Martín-Mur, Jordana Muñoz-Basagoiti, Jordana Muñoz-Basagoiti, Jordana Muñoz-Basagoiti, Yan Zeng, David Marín-Moraleda, David Marín-Moraleda, David Marín-Moraleda, Enrique Ezcurra, Enrique Ezcurra, Enrique Ezcurra, Sergio Montaner-Tarbes, Sergio Montaner-Tarbes, Sergio Montaner-Tarbes, María J. Navas, María J. Navas, María J. Navas, Marta Muñoz, Marta Muñoz, Marta Muñoz, Paula Monleón, Paula Monleón, Paula Monleón, Judith González-Oliver, Judith González-Oliver, Judith González-Oliver, Esmeralda Cano, Esmeralda Cano, Esmeralda Cano, Carles Vilalta, Carles Vilalta, Carles Vilalta, Marc Caballé, Lourdes Criado, Karl Kochanowski, Karl Kochanowski, Karl Kochanowski, Francesc Accensi, Francesc Accensi, Virginia Aragón, Virginia Aragón, Virginia Aragón, Florencia Correa-Fiz, Florencia Correa-Fiz, Florencia Correa-Fiz, Anna Esteve-Codina, Anna Esteve-Codina, Fernando Rodríguez, Fernando Rodríguez, Fernando Rodríguez, Jordi Argilaguet, Jordi Argilaguet, Jordi Argilaguet

“…In particular, the capability of bacterial-based immunostimulants to modulate innate immune cells functionality makes them cost-effective candidates as vaccine adjuvants, antimicrobials, or preventive immunostimulators inducing long-term innate immune memory in livestock. …”
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MDCFVit-YOLO: A model for nighttime infrared small target vehicle and pedestrian detection. by Huiying Zhang, Qinghua Zhang, Yifei Gong, Feifan Yao, Pan Xiao

“…Additionally, three innovative loss functions-focalerDIoU, focalerGIOU and focalerShapeIoU are proposed to reduce losses during the training process. …”
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TUMOR-ASSOCIATED MICROBIOME by Ayşe Caner

“…Specially, microbiome-cancer modulation is driven by a host-microbe interactions such as contact-dependent, contactindependent, and immunological mechanisms, by altering the balance of host cell proliferation and death, and influencing the immune system functions, the metabolism of host-produced factors, and the formation of microbial products. …”
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In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes. by Mohammed Asmal, James B Whitney, Corinne Luedemann, Angela Carville, Robert Steen, Norman L Letvin, Ralf Geiben-Lynn

“…Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins as therapeutic agents for HIV in vivo has not yet been demonstrated. …”
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Pt/IrO x enables selective electrochemical C-H chlorination at high current by Bo Wu, Ruihu Lu, Chao Wu, Tenghui Yuan, Bin Liu, Xi Wang, Chenyi Fang, Ziyu Mi, Surani Bin Dolmanan, Weng Weei Tjiu, Mingsheng Zhang, Bingqing Wang, Zainul Aabdin, Sui Zhang, Yi Hou, Bote Zhao, Shibo Xi, Wan Ru Leow, Ziyun Wang, Yanwei Lum

“…Abstract Employing electrochemistry for the selective functionalization of liquid alkanes allows for sustainable and efficient production of high-value chemicals. …”
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Melanin/PEDOT:PSS organic synaptic transistors: a step towards sustainable neuromorphic applications by Natan L Nozella, Guilherme S Selmi, Nayrim B Guerra, Marcelo R Piton, Carlos F O Graeff, Rafael F de Oliveira

“…Inspired by the functioning of the human brain, organic synaptic transistors represent a promising avenue for developing neuromorphic technologies. …”
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The dual role of PGAM5 in inflammation by Yuxin Qi, Bhavana Rajbanshi, Ruihan Hao, Yifan Dang, Churong Xu, Wei Lu, Liming Dai, Bingjun Zhang, Xiaoling Zhang

“…Notably, PGAM5 has dual effects on controlling inflammation: distinct PGAM5-mediated mitochondrial functions exhibit cellular heterogeneity, leading to its dual functions in inflammation control. …”
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VERIFICATION OF A TRAIN ON RAILWAY TRACK SIMULATION AND OPTIMIZATION SYSTEM by Adam MAŃKA, Piotr KISIELEWSKI, Jarosław KONIECZNY, Krzysztof LABISZ, Janusz ĆWIEK

“…The model implements the module for multiple-criteria optimization with a set of proposed objective functions allowing reductions in train passing time, total costs, energy consumption, and adverse environmental impacts. …”
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Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway by Ziqiang Dong, Zhihui Dong, Lili Xu, Jinfeng Zhang, Lin Li, Rongjuan Wang, Xiaoyan Huang, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou

“…Collectively, our work underscores VTX’s promising role in enhancing motor, cognitive functions, and mitigating depressive symptoms following cerebrovascular accidents, potentially through inflammation regulation. …”
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Copper Increases the Cooperative Gating of Rat P2X2a Receptor Channels by Elias Leiva-Salcedo, Denise Riquelme, Juan Pablo Huidobro-Toro, Claudio Coddou

“…<b>Background/Objectives:</b> P2X receptor channels are widely expressed in the CNS, where they have multiple functions in health and disease. The rat P2X2a (rP2X2a) receptor channel is modulated by copper, an essential trace element that plays important roles in synaptic modulation and neurodegenerative disorders. …”
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Dry Eye Syndrome in the Practice of a Cataract Surgeon: A Clinical Case by N. V. Maychuk, M. G. Petrova, D. A. Yarkin, N. Sh. Sarhadov

“…When conducting a study of the condition of the ocular surface using a slit lamp with a module for diagnosing dry eye syndrome (MediWorks, China), signs of an evaporative form of mild (right eye) and moderate (left eye) degree were revealed: the average tear film rupture time was 9.68 (OD) and 2.83 (OS) seconds, the height of the lacrimal meniscus is 0.22 mm (OD) and 0.17 mm (OS), the thickness of the lipid layer is grade 3 (OD) and grade 2 (OS), the percentage of non-functioning meibomian glands is 35 % (OD) and 44 % (OS). …”
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Cross-feeding-based rational design of a probiotic combination of Bacterides xylanisolvens and Clostridium butyricum therapy for metabolic diseases by Shanshan Qiao, Tao Wang, Jingzu Sun, Junjie Han, Huanqin Dai, Mengxuan Du, Lan Yang, Chun-Jun Guo, Chang Liu, Shuang-Jiang Liu, Hongwei Liu

“…Moreover, the two-strain combinations more effectively restored gut microbial functions by reducing disease-associated pathways and opportunistic pathogen abundance. …”
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Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation by Lucia Landi, Annamaria Lucrezia D’Ortenzio, Sarah Mojela Makau, Rita Milvia De Miccolis Angelini, Gianfranco Romanazzi

“…The expression pattern of 17 candidate effector genes of <i>M. fructicola</i> with functions linked to host invasion and fungal life, and seven peach genes involved in the immune defense system were monitored at 0, 2, 6, 10, and 24 h-post inoculation (hpi). …”
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Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems by Viviana Aya, Daniel Pardo-Rodriguez, Laura Camila Vega, Mónica P. Cala, Juan David Ramírez

“…In athletes, these microbial functions may be further specialized to meet the unique metabolic demands of different sports disciplines. …”
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RsWRKY40 coordinates the cold stress response by integrating RsSPS1-mediated sucrose accumulation and the CBF-dependent pathway in radish (Raphanus sativus L.) by Sen Chen, Liang Xu, Yan Wang, Baozhen Mao, Xiaoli Zhang, Qiyu Song, Feng Cui, Yingbo Ma, Junhui Dong, Kai Wang, Hongyu Bi, Liwang Liu

“…RsWRKY40 functioned in cambium activity and cold tolerance by modulating RsSPS1-mediated sucrose accumulation. …”
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Coordination of innate immune responses by connexins by Qirou Wu, Qirou Wu, Tiejun Zhao, Pinglong Xu, Pinglong Xu

“…Connexins form hemichannels, gap junctions, and connexosomes to mediate signaling molecule transfer, including nucleotide derivatives, ions, antigens, and mitochondria, which occur between adjacent cells or between cells and their microenvironments. By modulating intercellular communication, connexins regulate various immune cell functions and contribute significantly to the coordination of innate immunity. …”
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Regulation of Cell Proliferation and Differentiation by PPARβ/δ by Rolf Müller, Markus Rieck, Sabine Müller-Brüsselbach

“…Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. …”
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