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12601
Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses
Published 2025-02-01“…Mitogen-activated protein kinases (MAPKs) in tomato plants have crucial functions of mediating responses to environmental cues, internal signals, defense mechanisms, cellular processes, and plant development and growth. …”
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12602
Proline as a key player in heat stress tolerance: insights from maize
Published 2024-12-01“…These dual functions contribute significantly to cellular homeostasis under heat stress conditions. …”
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12603
The role of long noncoding RNA SNHG29 in malignant tumors
Published 2025-07-01“…Furthermore, evidence indicates that SNHG29 functions as a competing endogenous RNA (ceRNA), modulating tumor progression via the miRNA‒mRNA axis and signaling pathways such as the ATR‒Chk1, PI3K‒AKT, and Wnt‒β-catenin pathways. …”
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12604
Unravelling the link between circadian clock genes and brain tumors: From pathological disruptions to potential therapeutic interventions
Published 2025-05-01“…The circadian clock is present in nearly all tissues (including glial cells), which play crucial roles in brain functions and development. Circadian clock genes (CCGs) are responsible for regulating numerous cancer-associated biological mechanisms, including the regulation of cell cycle genes, apoptosis, and cell proliferation. …”
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12605
Peptidoglycan-Mediated Bone Marrow Autonomic Neuropathy Impairs Hematopoietic Stem/Progenitor Cells via a NOD1-Dependent Pathway in db/db Mice
Published 2022-01-01“…Inhibition of NOD1 ameliorated PGN-induced bone marrow autonomic neuropathy, which significantly rejuvenated the HSPC pools and functions in vivo. These data reveal for the first time that PGN, as a critical factor on the gut-bone marrow axis, promotes bone marrow denervation and HSPC modulation in the context of diabetes.…”
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12606
Reconfigurable terahertz optoelectronic logic through charge-density-wave phase engineering
Published 2025-05-01“…Conventional approaches face limitations in integrating sensing and computing functions, particularly at terahertz frequencies where traditional semiconductors struggle. …”
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12607
Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells
Published 2024-12-01“…Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class of functionally diverse RNA molecules. Recent studies have revealed that LncRNAs are integral to the crosstalk between CAFs and tumor cells, with the capacity to modify cellular transcriptional activity and secretion profiles, thus facilitating CAFs activation, tumor proliferation, metastasis, drug resistance, and other related functionalities. …”
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12608
Electric polarization catheter for systemic cardiac output
Published 2024-01-01“…The electrical activity plays a vital role in the physiological functions of live organisms, electrical stimulation has been identified as a promising nonpharmacological technique that can modulate the behavior of cellular network, restore and monitoring critical functions and accelerate tissue healing in vitro and in vivo. …”
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12609
Optical Wireless Communications with Metasurfaces: Current Status and Potential for Intelligent Communications
Published 2025-07-01“…Such metasurfaces with sub‐wavelength features also enable other versatile functions like spatial‐ or optical‐angular‐momentum‐mode generation, conversion, and multiplexing, further improving the communication performance and capability of OWCs. …”
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12610
The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis
Published 2014-01-01“…However, further investigations are required to establish the methods of downregulation of the aberrant proinflammatory functions of AMPs without increasing the risk of infections.…”
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12611
Cold Shock Proteins Balance Biofilm-Associated Antibiotic Resistance and Oxidative Vulnerability in Mycobacteria
Published 2025-07-01“…Here, we explored the functions of three Csps (CspA1, CspA2, and CspB) in <i>Mycobacterium smegmatis</i>. …”
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12612
Regulatory mechanisms of m6A RNA methylation in esophageal cancer: a comprehensive review
Published 2025-04-01“…These components identify and bind to specific RNA methylation sites, thereby modulating essential biological functions such as RNA processing, nuclear export, stability, translation and degradation, which significantly influence tumorigenesis, invasion, and metastasis. …”
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12613
An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions
Published 2025-03-01“…Abstract Ribonucleoprotein complexes are dynamic assemblies of RNA with RNA-binding proteins, which modulate the fate of RNA. Inversely, RNA riboregulates the interactions and functions of the associated proteins. …”
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12614
The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms
Published 2025-04-01“…This review broadens that perspective by detailing the signaling mechanisms and primary functions of <i>MYC2</i> transcription factors. It specifically emphasizes their roles in regulating the biosynthesis of secondary metabolites such as alkaloids, terpenes, and flavonoids, and in modulating plant responses to environmental stresses. …”
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12615
Dynamic categorization rules alter representations in human visual cortex
Published 2025-04-01“…Traditionally, sensory regions have been viewed as separate from such context-dependent processing, functioning primarily to process incoming inputs. However, an alternative view suggests sensory regions also integrate inputs with current task goals, facilitating more efficient information relay to higher-level areas. …”
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12616
Transformer-Guided Serial Knowledge Distillation for High-Precision Anomaly Detection
Published 2025-01-01“…This three-stage architecture consists of a fixed pretrained teacher network serving as the upstream feature extractor, a dedicated multi-feature aggregation and filtering module integrated with Vision Transformer components as the intermediate processor, and a trainable student network functioning as the downstream reconstruction module. …”
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12617
Role of neuronal fabp in autophagy and amyloid-β pathology in a Drosophila model of Alzheimer disease
Published 2025-12-01“…Conversely, fabp overexpression had the opposite effect and improved memory. The modulation of Ecdysone-induced protein 75B (Eip75B) levels, the Drosophila homolog of peroxisome proliferator-activated receptor, a lipid-activated nuclear receptor that functions as a transcription factor, affected the expression of autophagy-related genes and the role of fabp in Aβ pathology. …”
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12618
Human response times are governed by dual anticipatory processes with distinct neural signatures
Published 2025-01-01“…These results suggest that human anticipatory behavior emerges from a combination of motor-preparatory and attention-like modulations of neural activity, implemented by anatomically widespread and intermixed, but functionally identifiable, brain networks.…”
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12619
Regulation of non-emotional memory through α1-adrenergic receptors activation: A short review
Published 2025-06-01“…This review summarizes recent advances in understanding the functions of α1-ARs and highlights their contributions to synaptic efficacy, long-term potentiation (LTP), and long-term depression (LTD) in the hippocampus and neocortex. …”
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12620
Dietary peptides in aging: Evidence and prospects
Published 2020-03-01“…With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. …”
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