Dysregulated macrophage immunity in Helicobacter pylori infection: unveiling mechanistic insights and therapeutic implications by Miao Xiang, Miao Xiang, Panpan Li, Panpan Li, Xiaofei Yue, Linlin Liu, Linlin Liu, Linjing Wang, Nengjin Sun, Nengjin Sun, Kaile Wang, Kaile Wang, Yuying Zhang, Hongyan Wang, Hongyan Wang

“…This review provides a comprehensive analysis of how H. pylori infection modulates macrophage functions, including impairing pathogen recognition and phagocytosis, disrupting phagosome maturation and reducing immune clearance capacity. …”
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Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond by Masumi Eto

“…Under physiological conditions, PHI-1 selectively regulates PP1 activity to maintain cellular homeostasis, whereas its pathological upregulation promotes oncogenic pathways, stabilizes tumor-promoting proteins, and modulates immune responses. This article explores PHI-1’s emerging role as a pan-cancer biomarker in parallel with emphasizing its physiological functions in signaling networks, smooth muscle contraction, cytoskeletal dynamics, and selective proteostasis. …”
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How Life Experience Shapes Cognitive Control Strategies: The Case of Air Traffic Control Training. by Sandra Arbula, Mariagrazia Capizzi, Nicoletta Lombardo, Antonino Vallesi

“…In particular, specific life experiences, like a highly demanding training for future Air Traffic Controllers (ATCs), could modulate cognitive control functions. A group of ATC trainees and a matched group of university students were tested longitudinally on task-switching and Stroop paradigms that allowed us to measure indices of cognitive control. …”
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Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases by Yeseong Choi, Won-Suk Chung

“…One of their key homeostatic functions is phagocytic capacity in pruning synapses and removing cellular debris/protein aggregates, a process vital for synaptic plasticity and brain maintenance. …”
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Calmodulin: The switch button of calcium signaling by Chiu-Fen Yang, Wen-Chin Tsai

“…Apart from calcium binding, posttranslational modifications (PTMs) also contribute to the modulations of CaM functions by affecting its protein-protein interaction networks and hence drawing out the various downstream signaling cascades. …”
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Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis by Huanyu Jiang, Yantao Zhang, Piyao Ji, Jianghua Ming, Yaming Li, Yan Zhou

“…Results The results indicated that SP-D significantly decreased senescence and enhanced mitochondrial functions in senescent chondrocytes. The RNA-sequencing analysis revealed that the SIRT3/SOD2 pathway predominantly modulated the effect of SP-D on alleviating senescence. …”
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Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms by Sarng S. Pyurveev, Andrei A. Lebedev, Eugeny R. Bychkov, Petr D. Shabanov

“…Kisspeptin-10, a neuropeptide primarily linked to reproductive functions, has emerged as a potential modulator of reward-related behaviors and decision-making. …”
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Estimating the potential risks of developing clusters in medical industry using various ranking criteria by Y. G. Gertsik

“…Objective: to develop methodology for risk assessment of functioning of the medical industry companies as cluster members.Methods: methods of financial management of enterprises in the field of risk management were used.Results: by the example of the selected industry, the interaction of high-tech enterprises in a cluster and risks arising therein are shown. …”
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Diurnal nectar secretion dynamics in Roscoea cautleoides (Zingiberaceae) reveal the role of non-sugar chemicals in plant–pollinator interaction by Wen-Jing Wang, Ya-Ting Lin, Hong-Fan Chen, Mei-Yuan Huang, Zong-Xin Ren, Jian-Li Zhao

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Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease by Menglu Liu, Xueyan Zhao, Hanjia Gao

“…The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article.…”
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Designing and Creating an Automatic Hydroponic Plant Watering Control System Using a TDS Sensor Based on an ATMEGA328 Microcontroller by Feriandanu Hakim, I Wayan Supardi, Ni Nyoman Ratini

“…The microcontroller contained in the Arduino Uno module functions as a design regulator. This research aims to assist in providing nutrition automatically so that it can help human work. …”
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Algorithm for forming a geo-map of citizen appeals using artificial intelligence by Mallaev Oybek, Gazatov Jamoliddin, Aliyev Jaloliddin

“…The proposed geo-map module offers essential functions such as automatic detection and analysis of appeals, identification and marking of problem locations on the map, prioritization of urgent issues, prediction and prevention of appeal surges, automation of state services, and rapid response facilitation. …”
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Design of Covert Communication Waveform Based on Phase Randomization by Wenjie Zhou, Zhenyong Wang, Jun Shi, Qing Guo

“…A mathematical model of the NRPCS waveform is formulated, and detailed analyses of the system’s time-domain basis functions, correlation properties, and power spectral characteristics are conducted to substantiate its noise-like behavior. …”
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THE RENIN-ANGIOTENSIN SYSTEM AND ITS INVOLVEMENT IN PAIN CONTROL. A NEW INSIGHT INTO AN OLD SYSTEM by Daniela Pechlivanova, Dimo Angelov, Elena Dzhambazova

“…Accumulating data however enlarged scientific knowledge on the role of RAS in control of brain functions and modulation of pain susceptibility. Scientific evidence indicates a differential involvement of angiotensin receptors in the modulation of pain transmission and suppression. …”
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Unveiling the anti-aging of radix saposhnikoviae: A metabolomic study in Drosophila. by Liwei Jia, Xianglin An, Yan Liu, Xin Meng

“…Aging is characterized by a progressive decline in physiological functions and an increased susceptibility to age-related diseases, yet effective interventions remain limited. …”
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Mechanistic insights into vascular biology via methyltransferase-like 3-driven N6-adenosine methylation of RNA by Deshuang Zhang, Deshuang Zhang, Zhixian Gou, Yi Qu, Xiaojuan Su

“…Recent advancements in the mechanistic comprehension of vascular biology have concentrated on METTL3-mediated N6-methyladenosine modification of RNA, which modulates a spectrum of RNA functionalities with precision. …”
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New insights into the dule roles CDK12 in human cancers: Mechanisms and interventions for cancer therapy by Wei Dai, Dong Xie, Hao Huang, Jingxuan Li, Caiyao Guo, Fuqiang Cao, Luo Yang, Chengyong Zhong, Shenglan Liu

“…However, CDK12 may also exert tumor-suppressive functions in a context-dependent manner. Therefore, caution is warranted when targeting CDK12 in future clinical trials. …”
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HD-tDCS improves conflict processing and general behavioral stability by Ronghan Liu, Miao Wang, Qiang Liu, Xiujuan Jing, Qiang Hao, Hang Yu, Yifeng Wang

“…This study demonstrates a significant enhancement of tDCS on EC, elucidating the dual mechanisms of tDCS in modulating the baseline state and EC, providing valuable insights into the mechanisms of tDCS intervention on cognitive functions.…”
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The mechanisms of treatment resistance in psychiatry in the aspects of pharmacodynamics of psychotropic drugs by V. L. Kozlovskii

“…The difficulties in management and prevention of resistance relate to the lack of understanding of neurochemical changes occurring in the neuronal networks during development of the higher mental functions. Within the concept of the species-preserving behavior development neurochemically associated with the activity of monoaminergic systems in determined pathways and local neuronal networks with the co-transimitterts’ modulation of functions, pharmacodynamics of psychotropic drugs are discussed. …”
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Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health by Eugenio Caradonna, Federico Abate, Elisabetta Schiano, Francesca Paparella, Fulvio Ferrara, Emilio Vanoli, Rossana Difruscolo, Vito Maria Goffredo, Bruno Amato, Carlo Setacci, Francesco Setacci, Ettore Novellino

“…The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism that plays a crucial role in regulating health by producing biologically active molecules that can enter systemic circulation. …”
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