The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression by Cong He, Baojiang Chen, Hecai Yang, Xiaoqing Zhou

“…The aim of this review is to summarize the most recent advances in research regarding the dual role of microglia in AD concerning both immunomodulation and pathological progression by considering mechanisms of activation of microglia, effects on Aβ clearance, tau pathology, and impacts due to genetic variations on microglial functions. Among these findings are the dual role of microglia, the status of activation for M1 and M2 phenotypes, and the crucial role that genetic variants like TREM2 have in modulating the response of microglia. …”
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Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders by Lee Jun Jie, Sitjar Patrick Henry Sebastian, Ang Eng Tat, Goh Jorming

“…Current scientific endeavours in the field of geroscience have begun to reveal how factors such as exercise could modulate the brain aging process. In this review, we ask how exercise could potentially modulate aging, and by extension, the development of Alzheimer’s Disease (AD). …”
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IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications by Rihan Wu, Rihan Wu, Hao Yang, Hao Yang, Chunlei Liu

“…Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both a viral defense molecule and a regulator of tumor progression. …”
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Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics by Xiaoting Hou, Yu Chen, Noah D. Carrillo, Vincent L. Cryns, Richard A. Anderson, Jichao Sun, Songlin Wang, Mo Chen

“…Abstract The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIPn) signaling is a critical regulator of these processes and other biological activities, though its precise impact on cytoskeletal dynamics has yet to be systematically investigated. …”
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The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis by Andrea Mastrangelo, Tania Colasanti, Cristiana Barbati, Arbi Pecani, Danilo Sabatinelli, Monica Pendolino, Simona Truglia, Laura Massaro, Riccardo Mancini, Francesca Miranda, Francesca Romana Spinelli, Fabrizio Conti, Cristiano Alessandri

“…The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions. The regulation of PTMs is crucial for the activity and survival of the cells. …”
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Reconstruction and Separation Method of Ranging and Communication Phase in Beat-Note for Micro-Radian Phasemeter by Tao Yu, Hongyu Long, Ke Xue, Mingzhong Pan, Zhi Wang, Yunqing Liu

“…The beat-note is processed by complex conjugate rotation, which can effectively eliminate the PRN modulated phase. Simulation and analysis results demonstrate that this method can significantly enhance the purity of the measured phase in the beat-note while maintaining the ranging and communication functions. …”
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Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury by Lingyan Li, Xingjie Wu, Qianqian Guo, Yu'e Wang, Zhiyong He, Guangqiong Zhang, Shaobo Liu, Liping Shu, Babu Gajendran, Ying Chen, Xiangchun Shen, Ling Tao

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Corrosion inhibition of stainless steel 304 in hydrochloric acid solution using clindamycin antibiotic as eco-friendly inhibitor by Mona Abdelfatah, Salah Mohmed Rashwan

“…The adsorption of this drug on SS304 surface follows Langmuir adsorption isotherm. The thermodynamic functions of activation and adsorption processes were calculated and discussed. …”
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The Role of Neurohypophysial Hormones in the Endocrine and Paracrine Control of Gametogenesis in Fish by Maya Zanardini, Hamid R. Habibi

“…However, growing evidence suggests that AVPand OXT also regulate gonadal functions in teleost fish. Their expression in both male and female gonads, the presence of their receptors in ovaries and testes, and their interactions with steroids and other gonadal factors indicate a role in modulating gametogenesis and steroidogenesis via autocrine and paracrine mechanisms. …”
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A brief discussion on the role of calcitonin gene-related peptide in the efficacy of rehabilitation medicine by Guan Zhencheng, Xue Aiguo

“…CGRP regulates various physiological functions, including vasodilation, inflammation modulation, and cardiac protection, and plays a key role in pain transmission. …”
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Organizational provisions of accounting for inventories as component of information and communication system of enterprise by B.L. Kyryluk

“…It is necessary to form the accurate and timely information, therefore, automation of accounting is the necessary task for effective functioning of the company. The implementation of solutions is possible by creating an additional module in the configuration of 1C. …”
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Sex playing with the mind: effects of oestrogen and testosterone on moon and cognition by OSVALDO P. ALMEIDA

“…In summary, gonadal hormones seem to modulate various aspects of mental functioning. If future studies prove this to be true, hormone replacement therapy should have a major impact on the physical and mental health of older people in the years to come.…”
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Multifaceted role of zipper-interacting protein kinase beyond cell death: Implication of ZIPK dysregulation in neuronal and vascular injuries by Fei She, Tao Zhang, Tae Ho Lee

“…ZIPK is involved in many cellular functions, including cell death, smooth muscle contraction, transcriptional regulation, inflammatory signaling and the regulation of angiogenesis. …”
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Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria by Mary Lopez-Perez, Zakaria Seidu, Mads Delbo Larsen, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Gestur Vidarsson, Michael F. Ofori, Lars Hviid

“…IgG glycosylation modulates antibody functionality, with increased affinity to FcγRIIIa for IgG lacking fucose in the Fc region (Fc-afucosylation). …”
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Growth Factors in Inflammatory Bowel Disease by Nicholas Wright

“…Several of these functions are incriminated in the pathogenetic and healing phenomena that accompany inflammatory bowel disease (IBD). …”
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Theory and practice of transcranial extracellular impedance control (tEIC) by Ayumu Matani

“…As the working hypothesis in the present study, neural coupling (NC) is the sum of synaptic coupling (SC) and volume current coupling (VcC), and VcC influences cognitive and behavioral functions. VcC is a remote direct electrical coupling, or electrical crosstalk, across extracellular space between electroencephalogram (EEG) generators, which are spatiotemporally synchronously activated pyramidal neural populations. …”
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The Influences of Symbiotic Host Gut Microbiota During Obesity and Diabetes by Harmit S Ranhotra

“…Altered metabolites availability can modulate host organs/tissues functions which may influence certain disease onset and progression. …”
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MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization. by Johannes Besser, Daniela Malan, Katharina Wystub, Angela Bachmann, Astrid Wietelmann, Philipp Sasse, Bernd K Fleischmann, Thomas Braun, Thomas Boettger

“…The electrical properties of the heart are primarily determined by the activity of ion channels and the activity of these molecules is permanently modulated and adjusted to the physiological needs by adrenergic signaling. miRNAs are known to control the expression of many proteins and to fulfill distinct functions in the mammalian heart, though the in vivo effects of miRNAs on the electrical activity of the heart are poorly characterized. …”
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A Complex Wavelet-Based OTFS Scheme for LEO Satellite Communication by Saifur Rahman Sabuj, Han-Shin Jo

“…This study investigates a wavelet-aided orthogonal time-frequency space (W-OTFS) modulation system operating in low earth orbit (LEO) satellite systems. …”
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Prosodic Effects of Focus and Constituency in Mandarin and in English by Meghan Clayards, Michael Wagner, Wei Zhang

“…The prosody of an utterance encodes multiple types of information simultaneously, including information status of constituents—for example, by modulations in prosodic prominence to encode focus—and information about syntactic constituent structure—by modulations of prosodic phrasing. …”
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