Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation by Shailaja Mahajan-Thakur, Andreas Böhm, Gabriele Jedlitschky, Karsten Schrör, Bernhard H. Rauch

“…Differential expression patterns and intracellular signaling pathways of each receptor enable S1P to exert its widespread functions. Although a vast amount of information is available about the functions of S1P and its receptors in the regulation of physiological and pathophysiological conditions, S1P-mediated mechanisms in the vasculature remain to be elucidated. …”
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The Role of Vitamin D and Vitamin D Receptor in Sepsis by Shenglan Shang, Dongxin Chen, Yuqi Wei, Shuo Zou, Qiuyue Chang, Hong Zhou, Airong Yu

“…Vitamin D (VD) pleiotropic functions were demonstrated in different biological processes, including inflammation and immunity. …”
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Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1 by Xuewei Fan, Xuewei Fan, Nan Zhang, Xichen Zhang, Shudong Li, Jiangming Fu, Min Sun, Xiaoxiao Ma, Muhammad Zahoor Khan, Xin Jiang

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed significant enrichment of these interacting proteins in metabolic pathways and cellular processes related to reproduction, growth, and development.ConclusionThe interaction between GRA23 and PEX3 suggests potential parasite modulation of peroxisomal functions, while its association with TRAP1 indicates possible exploitation of host chaperone mechanisms. …”
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FOXOs and their roles in acute and chronic neurological disorders by Yasin Asadi, Yasin Asadi, Yasin Asadi, Rozenn K. Moundounga, Rozenn K. Moundounga, Rozenn K. Moundounga, Anand Chakroborty, Anand Chakroborty, Anand Chakroborty, Augustina Pokokiri, Augustina Pokokiri, Augustina Pokokiri, Hongmin Wang, Hongmin Wang, Hongmin Wang

“…The forkhead family of transcription factors of class O (FOXOs) consisting of four functionally related proteins, FOXO1, FOXO3, FOXO4, and FOXO6, are mammalian homologs of daf-16 in Caenorhabditis elegans and were previously identified as tumor suppressors, oxidative stress sensors, and cell survival modulators. …”
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The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 by Anne G. Ostermeyer-Fay, Abhay Kanodia, Ranjana Pathak, Maria Jose Hernandez-Corbacho, Aarnoud C. van der Spoel, Yusuf A. Hannun, Daniel Canals

“…The diversity in the ceramide structure, leading to tens of ceramide species and the discrete distribution based on subcellular topology, could explain the wide variety of functions attributed to this bioactive lipid. One of these pools of ceramide resides in the plasma membrane, and several works have suggested that an increase in plasma membrane ceramide (PMCer) in response to stimulation leads to cell death and modulates cell adhesion and migration. …”
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Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease by Benjamin Frederick Theis, Jun Sung Park, Jong Sung Anthony Kim, Sareh Zeydabadinejad, Matam Vijay-Kumar, Beng San Yeoh, Piu Saha

“…The human gut microbiome is intricately linked to systemic and organ-specific immune responses and is highly responsive to dietary modulation. As metagenomic techniques enable in-depth study of an ever-growing number of gut microbial species, it has become increasingly feasible to decipher the specific functions of the gut microbiome and how they may be modulated by diet. …”
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The effect of visfatin on the transcriptomic profile of porcine anterior pituitary cells during periimplantation period by Kamil Dobrzyn, Grzegorz Kopij, Marta Kiezun, Ewa Zaobidna, Marlena Gudelska, Barbara Zarzecka, Katarzyna Kisielewska, Agnieszka Rak, Nina Smolinska, Tadeusz Kaminski

“…The pituitary, an element of the regulatory hypothalamic-pituitary-ovarian axis, is one of the most important endocrine glands regulating reproductive system activity. Undisturbed functioning of pituitary ensures the regular course of pregnancy through, among others, the modulation of steroid hormones production, which is critical in the early stages of gestation. …”
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The unique role of the associative thalamus in cognitive processing by Bin A. Wang, Shumei Li, Michael M. Halassa, Burkhard Pleger

“…Recent research has challenged this perspective by revealing previously unrecognized functions, such as regulating cortical excitability, maintaining the balance between excitation and inhibition, and modulating effective connectivity. …”
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Generalized angular-order parton showers in Herwig 7 by Joon-Bin Lee, M. R. Masouminia, Michael H. Seymour, Un-ki Yang

“…Utilizing these kernels, we derive BSM splitting functions in the quasi-collinear limit, ensuring compatibility with the Standard Model (SM) and supersymmetry (SUSY) splitting functions when analogous parameter conditions are applied. …”
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Biochar Utilization in Antimicrobial, Anticancer, and Biosensing Applications: A Review by Ki Ha Min, Koung Hee Kim, Joo-Hyung Seo, Seung Pil Pack

“…Recent advances in functionalized and composite biochar materials have enabled their use in antibacterial and anticancer treatments, as well as biosensing technologies. …”
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LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity by Patricia Garcia-Rodriguez, Patricia Garcia-Rodriguez, Laura Hidalgo, Miguel Angel Rodriguez-Milla, Beatriz Somovilla-Crespo, Javier Garcia-Castro, Javier Garcia-Castro

“…Here, we investigated the impact of LIN28 upregulation on human T cell functions, focusing on its influence on CAR T cell therapy. …”
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Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells by Hengcheng Zhang, Manuel A. Podestà, Cecilia B. Cavazzoni, Yumeng Wu, Jeong-Mi Lee, Xiaofei Li, Paulo Lisboa Raeder, Pragya Chandrakar, Maya Gempler, Sierra Richardson, Deepjyoti Ghosh, Ismail Sayin, Bruce R. Blazar, Reza Abdi, Astrid Weins, Anita S. Chong, Peter T. Sage

“…Follicular regulatory T (Tfr) cells modulate follicular helper T cell-mediated B cell responses, but the functions of Tfr in controlling alloreactive antibody are unknown. …”
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Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases by Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Juan Turati, Carla Caruso, Teresa N. Scimonelli, Mercedes Lasaga

“…Neuropeptides are small amino acidic molecules with the ability to regulate neuronal activity and thereby affect various functions such as thermoregulation, reproductive behavior, food and water intake, and circadian rhythms. …”
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Evidence for a Griffiths Phase to Cluster Spin Glass Transition in the La2/3Sr1/3(Mn1‐3xAl2xTix)O3 System by Ruie Lu, Yuanchao Ji, Yu Wang, Xiaoqin Ke, Fanghua Tian, Chao Zhou, Yin Zhang, Chang Liu, Sen Yang, Xiaobing Ren, Xiaoping Song

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Regulatory networks of FUR and NtcA are intertwined by transcriptional regulators, two-component systems, serine/threonine kinases, and sigma factors in Anabaena sp. PCC 7120 by J. Guío, M. L. Peleato, M. F. Fillat, E. Sevilla

“…In this work, by combining differential gene expression data and electrophoretic mobility shift assays (EMSAs), we sought to identify novel direct targets of FUR proteins with regulatory functions, namely, transcriptional regulators, two-component systems, sigma factors, and other proteins with regulatory functions such as serine/threonine kinases. …”
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The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases by Shan Guo, Qi Zhang, Yingjie Guo, Xiaoyan Yin, Peng Zhang, Tao Mao, Zibin Tian, Xiaoyu Li

“…CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple organ systems by modulating the recruitment and activation of immune cells, which in turn influences the progression of fibrotic diseases in the liver, intestines, pancreas, heart, lungs, kidneys, and other organs. …”
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Amino Acid Metabolism in Liver Mitochondria: From Homeostasis to Disease by Ranya Erdal, Kıvanç Birsoy, Gokhan Unlu

“…Hepatic mitochondria play critical roles in sustaining systemic nutrient balance, nitrogen detoxification, and cellular bioenergetics. These functions depend on tightly regulated mitochondrial processes, including amino acid catabolism, ammonia clearance via the urea cycle, and transport through specialized solute carriers. …”
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Recent progress on acoustofluidic manipulation of cells and particles by Wang Zeyu, Xia Jianping, Garry Ryan, Weitz David A., Li Xiangming

“…In this review, we present the latest advancements in the development of sophisticated acoustofluidic systems that enhance efficiency and enable precise modulation of performance across spatial and temporal scales, thereby extending their functionality and suitability for practical applications.…”
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Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation by Hye-Min Han, Su-Yeon Kim, Dong-Hwee Kim

“…This review highlights the integration of mechanical modulation into therapeutic approaches, emphasizing its potential to restore cellular functionality, improve health, and extend lifespan. …”
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Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. by Eric L Van Nostrand, Adolfo Sánchez-Blanco, Beijing Wu, Andy Nguyen, Stuart K Kim

“…Using a novel genomics approach, we identified HOX co-factor unc-62 (Homothorax) as a developmental regulator that binds proximal to age-regulated genes and modulates lifespan. Although unc-62 is expressed in diverse tissues, its functions in the intestine play a particularly important role in modulating lifespan, as intestine-specific knockdown of unc-62 by RNAi increases lifespan. …”
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