Corticosteroid Regulation of Synaptic Plasticity in the Hippocampus by Nicola Maggio, Menahem Segal

“…Stress, via release of steroid hormones, has been shown to affect several cellular functions in the brain, including synaptic receptors and ion channels. …”
Get full text

Condition of neuro-hormonal systems in traumatic brain injury and influence of Carbacetam by S. V. Ziablitsev, O. O. Starodubska

“…However, influence on functioning of neuro-hormonal systems in TBI isn't studied. …”
Get full text

Harnessing the Therapeutic Potential of Th17 Cells by Jonas Bystrom, Taher E. Taher, M. Sherwan Muhyaddin, Felix I. Clanchy, Pamela Mangat, Ali S. Jawad, Richard O. Williams, Rizgar A. Mageed

“…Moreover, since RORγt is a nuclear receptor, it is likely to be a potential future drug target for modulating Th17 functions. This review explores pathways through which Th17 subsets are induced, the molecular basis of their plasticity, and potential therapeutic strategies for their modulation in diseases.…”
Get full text

MECHANISM OF THE CONDITIONS FOR INNOVATIVE ACTIVITIES FAVORED by G. Matveev

“…It was characterized by the implementation of one of the functions of the mechanism - diagnosis. As a result of a comparison of actual and normative values of the thresholds in terms of establishing a mechanism of diagnosing module for innovation, the organization draws conclusions about the weakest aspects of the creation of conditions for innovation on the basis of the economic security of the organization's performance, followed by recommendations for the improvement of conditions for the implementation of its innovation organization.…”
Get full text

KRIT1 regulates the homeostasis of intracellular reactive oxygen species. by Luca Goitre, Fiorella Balzac, Simona Degani, Paolo Degan, Saverio Marchi, Paolo Pinton, Saverio Francesco Retta

“…Comprehensive analysis of the KRIT1 gene in CCM patients has suggested that KRIT1 functions need to be severely impaired for pathogenesis. …”
Get full text

Monophasic and biphasic neurodynamics of bi-S-type locally active memristor by Xinyi Wang, Yujiao Dong, Guangyi Wang, Guangyi Wang, Ziyu Zhou, Yidan Mao, Peipei Jin, Yan Liang

“…A second-order neuronal circuit is constructed to emulate periodic spiking and excitability, while a third-order circuit extends functionality to chaotic oscillations and bursting behaviors. …”
Get full text

Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024 by --- Various Authors

“…Kotrashetti (Nerul, Maharashtra, India) ABS 52. PERCEIVED FAMILY FUNCTION, PERCEIVED SOCIAL SUPPORT AND DEPRESSION OF NEW PARENTS UNDER COVID-19 PANDEMIC: A DYADIC ANALYSIS • T. …”
Get full text

Immunomodulatory effects of 4-hydroxynonenal by Melina Ioannidis, Johanna Tjepkema, Michael R.P. Uitbeijerse, Geert van den Bogaart

“…This review explores how 4-HNE influences molecular mechanisms involved in inflammation and immune cell functions. 4-HNE modulates inflammation through the interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement of activated B cells (NF-κB), nuclear factor erythroid 2-related factor (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, and stimulator of interferon genes (STING), thereby affecting immune responses and modulating cytokine production and inflammasome activation. …”
Get full text

Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping by Nunziata Maio, Umberto Terranova, Yan Li, J. Martin Bollinger Jr., Carsten Krebs, Tracey A. Rouault

“…These findings uncover a redox-regulated role for Fe-S clusters in SARS-CoV-2 RNA processing and suggest that the viral core enzymatic functions may be modulated by the redox state of their Fe-S cofactors.…”
Get full text

Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS‐Triggered Cross‐Linker Release by Wen Zhou, Yuwan Chen, Wenxin Fu, Xinwei Li, Yufei Xia, Qun Zhao, Baofeng Zhao, Yukui Zhang, Kaiguang Yang, Lihua Zhang

“…Abstract The study of in situ conformations and interactions of mitochondrial proteins plays a crucial role in understanding their biological functions. Current chemical cross‐linking mass spectrometry (CX‐MS) has difficulty in achieving in‐depth analysis of mitochondrial proteins for cells without genetic modification. …”
Get full text

LncRNAs, nuclear architecture and the immune response by Christy Montano, Cristina Flores-Arenas, Susan Carpenter

“…In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.…”
Get full text

The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Hong-Liang Zhang, Jiang Wu, Jie Zhu

“…Apolipoprotein E (apoE) is a 34.2 kDa glycoprotein characterized by its wide tissue distribution and multiple functions. The nonlipid-related properties of apoE include modulating inflammation and oxidation, suppressing T cell proliferation, regulating macrophage functions, and facilitating lipid antigen presentation by CD1 molecules to natural killer T (NKT) cells, and so forth. …”
Get full text

HIL Automatic Test System Design for the Host Software of LKJ-15C System by HE Xiezhen, ZHOU Zhifei, JIANG Jian

“…The automatic test system is composed of PXI host module, signal conditioning module, Ethernet switch, power module and computer operation module. …”
Get full text

Recent advances in regulatory immune cells: exploring the world beyond Tregs by Peng Shi, Yi Yu, Hongwei Xie, Xiaofang Yin, Xue Chen, Yongfei Zhao, Hai Zhao

“…Regulatory immune cells are pivotal in maintaining immune homeostasis and modulating immune responses to prevent pathologies. …”
Get full text

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiological and behavioral processes and impacting oxidative stress, immune functionality, and tumorigenesis. PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. …”
Get full text

Cancer-associated fibroblasts, tumor and radiotherapy: interactions in the tumor micro-environment by Kris T. P. M. Raaijmakers, Gosse J. Adema, Johan Bussink, Marleen Ansems

“…Consequently, CAFs play a significant role in tumor cell survival, relapse and potentially malignant transformation of surviving cancer cells following therapy. Modulating CAF functioning in the TME therefore is a critical area of research. …”
Get full text

MRCPs-and-ERS/D-Oscillations-Driven Deep Learning Models for Decoding Unimanual and Bimanual Movements by Jiarong Wang, Luzheng Bi, Aberham Genetu Feleke, Weijie Fei

“…Motor brain-computer interface (BCI) can intend to restore or compensate for central nervous system functionality. In the motor-BCI, motor execution (ME), which relies on patients’ residual or intact movement functions, is a more intuitive and natural paradigm. …”
Get full text

Title not available by Ongeri, Sandrine, Crousse, Benoît

“…This account summarizes our work on the synthesis of fluorinated peptidomimetics integrating the N-CF2R triazole functions. Emphasis is placed on the development of fluorinated foldamers possessing preferential conformations. …”
Get full text

Exosomes as Regulators of Macrophages in Cardiovascular Diseases by Marina Soriano-Cruz, Wendy Guadalupe Vázquez-González, Paula Molina-Vargas, Alejandro Faustino-Trejo, Adriana Karina Chávez-Rueda, María Victoria Legorreta-Haquet, Sergio Roberto Aguilar-Ruíz, Luis Chávez-Sánchez

“…Exosomes are small vesicles released by many different types of cells, such as macrophages, dendritic cells, platelets and other immunoregulatory cells, that facilitate communication with other cells, modulating the biological functions of recipient cells. …”
Get full text

Emerging Insights into Sall4’s Role in Cardiac Regenerative Medicine by Jianchang Yang

“…Recent research highlights Sall4’s emerging roles in modulating cardiac progenitors and cellular reprogramming, linking its functions to early heart development and regenerative medicine. …”
Get full text