Reconstitution of T cell‐mediated immunity by umbilical cord‐derived mesenchymal stem cells in ulcerative colitis by Xiaoying Luo, Jieping Deng, Xiaoke Jiang, Jun Mi, Yangqiu Bai, Huimin Zhang, Yalong Li, Min Liu, Conghui Cai, Pengju Li, Huanrong Huang, Yueping Xu, Yiwen Qin, Yang Mi, Hui Ding, Zhiyu Yang, Yue Wu, Zhenjuan Li, Ling Lan, Lida Zhang, Li Wang, Guobing Chen, Han Yue, Oscar Junhong Luo, Bingyong Zhang

“…Dextran sulphate sodium (DSS)‐induced colitis mouse models with or without UMSC injection were used to delineate colon inflammation and T cell function. Results In the clinical trial, the clinical response/remission rates were 80.8/46.2% and 75.0/37.5% after 2 and 6 months of therapy, respectively. …”
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Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses in Pseudomonas aeruginosa infections by Yinglin Wu, Yinglin Wu, Yinglin Wu, Shan Huang, Shan Huang, Shan Huang, Kai Zhang, Yangcheng Shen, Yangcheng Shen, Yangcheng Shen, Shebin Zhang, Shebin Zhang, Shebin Zhang, Haining Xia, Haining Xia, Haining Xia, Jieying Pu, Jieying Pu, Jieying Pu, Cong Shen, Cong Shen, Cong Shen, Cha Chen, Cha Chen, Cha Chen, Jianming Zeng, Jianming Zeng, Jianming Zeng

“…The objective of this study was to elucidate the regulatory mechanisms and pathogenic effects of the T6SS during P. aeruginosa infection, utilizing transcriptome sequencing and functional assays. We found that T6SS expression is elevated in P. aeruginosa isolated from chronically infected patients. …”
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Ice-nucleating particle concentration impacts cloud properties over Dronning Maud Land, East Antarctica, in COSMO-CLM² by F. Sauerland, N. Souverijns, A. Possner, H. Wex, P. Van Overmeiren, A. Mangold, K. Van Weverberg, K. Van Weverberg, N. van Lipzig

“…<p>Ice-nucleating particles (INPs) have an important function in the freezing of clouds but are rare in East Antarctica. …”
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Responses of field-grown maize to different soil types, water regimes, and contrasting vapor pressure deficit by T. H. Nguyen, T. Gaiser, J. Vanderborght, A. Schnepf, F. Bauer, A. Klotzsche, L. Lärm, H. Hüging, F. Ewert, F. Ewert

“…Future improvements in soil–crop models in simulating gas exchange and crop growth should further emphasize the role of soil textures on stomatal function, dynamic root growth, and plant hydraulic system together with aboveground leaf area adjustments.…”
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Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease by Abhishek Shastry, Mia S. Wilkinson, Dalia M. Miller, Michelle Kuriakose, Jennifer L.M.H. Veeneman, Matthew Ryan Smith, Charles C.T. Hindmarch, Kimberly J. Dunham-Snary

“…The results reported here support the hypothesis that mtDNA influences cardiometabolic disease-susceptibility by modulating mitochondrial function and metabolic pathways.…”
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HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development by Lu Chen, Wenxuan Li, Wenjing Zai, Xiangyi Zheng, Xianlong Meng, Qunyan Yao, Wei Li, Ying Liang, Mu Ye, Kaicheng Zhou, Mengxing Liu, Zhicong Yang, Zhanrui Mao, Hongyan Wei, Shuai Yang, Guoming Shi, Zhenghong Yuan, Wenqiang Yu

“…However, whether HBV integrated sequences determine genotype pathogenicity and how to block their function during HCC progression remains unclear. Methods An in vitro HBV-infected PHH model and liver cancer cell lines were established to confirm the pathogenic potential of HBV-SITEs. …”
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The effect of age and sex on brain metabolites: from childhood to adulthood by María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes

“…This cross-sectional study set out to examine the relationship between levels of neurometabolites and age and sex —key modulators of brain function and structure—, continuously from childhood to early adulthood, in areas relevant to the study of psychiatric disorders.Magnetic resonance spectroscopy (¹H MRS) data was acquired in the dorsomedial prefrontal region (dmPF) and the medial temporal lobe (mTL) in 128 healthy individuals aged 7 to 34 years, 68.5 % females (ndmPF = 124; nmTL = 75). …”
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Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling by Lian Wang, Ning Luo, Jihui Zhu, Zubaidan Sulaiman, Wenhan Yang, Ke Hu, Guihai Ai, Weihong Yang, Xiaowen Shao, Shengkai Jin, Xue Zhang, Yantao Fan, Dan Deng, Zhongping Cheng, Zhengliang Gao

“…To elucidate these, we utilized RNA sequencing to investigate the cellular composition and function. Insights from transcriptome analyses suggested that OC cells from malignant ascites persisted in a quiescent state of low metabolic activity and after metastases to the peritoneum, arrested OC cells were reactivated and induced back to the cell cycle, suggesting that the peritoneum served as a favor tumor microenvironment. …”
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Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation by Ilaria Gisone, Monica Boffito, Elisa Persiani, Roberta Pappalardo, Elisa Ceccherini, Andrea Alliaud, Manuela Cabiati, Rossella Laurano, Letizia Guiducci, Chiara Caselli, Rosetta Ragusa, Claudio Cassino, Chiara Ippolito, Silvia Del Ry, Susanna Sartori, Antonella Cecchettini, Antonella Cecchettini, Salvador Fernández-Arroyo, Gianluca Ciardelli, Federico Vozzi

“…Omics analyses were carried out to compare terms of biological processes, cellular components, and molecular functions between the 3D model here presented and a classical 2D monoculture of hiPSC-CMs.ResultsGelMA was successfully synthesized with two different DoMs (i.e., 30%–40% and 96%–97%) and used to prepare hydrogels at 5%, 7.5% and 10% w/v concentrations. …”
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Addressing Disparities in access to expert physical therapy care and diagnosis for lumbar radiculopathy by Manum Tahir, Hammad Haider

“…According to American Physical Therapy Association (APTA), patients with inadequate insurance coverage are less likely to pursue physical therapy, leading to prolonged pain and increased healthcare costs due to complications.6 In addition to the direct expenditures of medical care, lumbar radiculopathy pain comes with indirect costs for absences from work, disability benefits, and decreased productivity.8 When conservative treatment options fail, elective surgery should be considered for individuals who have functional limitations or chronic pain that does not respond to conservative therapy. …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…LUAD cell lines genetically engineered to overexpress or to silence IL‐11 or its receptor (IL‐11RA) were used for in vitro functional analysis and for in vivo experiments. Additionally, we used three different in vivo models: patient‐derived xenografts (PDXs), tobacco‐exposed mice and genetically engineered mouse models. …”
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MiR-221, miR-320a, miR133a, and miR-133b as potential biomarkers in leiomyosarcoma by Mst Nasrin Akhtar, Mst Nasrin Akhtar, Annabell Walter, Annabell Walter, Kathrin Katenkamp, Kathrin Katenkamp, Yuan Chen, Yuan Chen, Thomas Lehmann, Thomas Lehmann, Wolfram Weschenfelder, Wolfram Weschenfelder, Christian Spiegel, Christian Spiegel, Matthias Vogt, Gunther O. Hofmann, Gunther O. Hofmann, Andreas Hochhaus, Andreas Hochhaus, Nikolaus Gaßler, Nikolaus Gaßler, Joachim H. Clement, Joachim H. Clement, Karin G. Schrenk, Karin G. Schrenk

“…No standardized biomarkers are available to assess early diagnosis or monitoring during the clinical course. MicroRNAs (miRNAs) function in modulating a multitude of targets and are involved in tumorigenesis, cancer progression, and metastasis. …”
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceResearch in context by Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia F. Thomaidou, Stephane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Ines Alvelos, Eugenia Martin Vazquez, Lorella Marselli, Kara Orr, Jamie L. Felton, Jing Liu, John S. Kaddis, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio L. Eizirik, Carmella Evans-Molina

“…Transcriptional phenotyping of pancreatic islets, pancreatic lymph nodes, and spleen highlighted a role for TYK2 inhibition in modulating signalling pathways associated with inflammation, translational control, stress signalling, secretory function, immunity, and diabetes. …”
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The gut dysbiosis and plasma lipid metabolisms signatures in children with active tuberculosis by Baixu Sun, Xiaoran Yu, Hui Qi, Fang Xu, Weiwei Jiao, Min Fang, Li Duan, Xi Zeng, Xuemei Yang, Xingyun Wang, Yu Zhu, Kaixia Mi, Adong Shen, Lin Sun

“…Evidences suggest that metabolites may function as a bridge between gut microbiome and TB progression in children. …”
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AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis by Wuping Tan, Yijun Wang, Siyi Cheng, Zhihao Liu, Mengjie Xie, Lingpeng Song, Qinfang Qiu, Xiaofei Wang, Zeyan Li, Tianyuan Liu, Fuding Guo, Jun Wang, Xiaoya Zhou

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Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges by Qianrong Li, Qianrong Li, Qianrong Li, Chunzhen Ren, Chunzhen Ren, Chunzhen Ren, Bing Jiang, Bing Jiang, Bing Jiang, Xuehan Wang, Xuehan Wang, Xuehan Wang, Chunling Wang, Chunling Wang, Chunling Wang, Xiaodong Zhi, Xiaodong Zhi, Xiaodong Zhi, Xiaodong Zhi, Linchan Li, Linchan Li, Linchan Li, Linchan Li, Xiaoying Guo, Xiaoying Guo, Xiaoying Guo, Xinke Zhao, Xinke Zhao, Xinke Zhao, Xinke Zhao, Yingdong Li, Yingdong Li, Yingdong Li

“…Myocardial fibrosis (MF) involves the activation and excessive proliferation of cardiac fibroblasts (CFs) in the extracellular matrix, leading to increased collagen expression that impairs cardiac function. Currently, there are no effective pharmacological treatments for MF. …”
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Random Finite Element Analysis and Random Factor response Mechanism for Geocell-reinforced Soil Retaining Walls by ZHANG Bingbing, SONG Fei

“…Secondly, a multi-language collaborative automated analysis platform is constructed at the computational implementation level: the random field parameter generation module is developed based on Matlab and the parameter distribution is visualized. …”
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N4BP3 Activates TLR4-NF-&amp;kappa;B Pathway in Inflammatory Bowel Disease by Promoting K48-Linked I&amp;kappa;B&amp;alpha; Ubiquitination by Jiang W, Yin J, Han M, He W, Zhao Y, Hu J, Wang M, Wang S, Xu J, Deng C, Li J, Gong X, Shen Y

“…Studies have demonstrated its essential function in axonal and dendritic branching, promoting hepatocellular carcinoma and breast cancer. …”
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Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement by Liyuan Chen, Danqing He, Zixin Li, Shengjie Cui, Min Yu, Zimo Zhao, Yuetong Chen, Jiayi Song, Nan Jiang, Huajie Yu, Yan Liu

“…Collagen remodeling plays a crucial role during this process, allowing for the necessary changes in the PDL’s structure and function. Endo180, an urokinase plasminogen activator receptor-associated protein, is a transmembrane receptor regulated collagen remodeling. …”
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STRONG II trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma – a single-arm multicentre phase II study by Derk Jan de Groot, Luisa Vonghia, Bas Groot Koerkamp, Lydi M J W van Driel, Alejandra Méndez Romero, Anne Demols, Erik van Werkhoven, Dirk De Ruysscher, Christelle Bouchart, Marjolein Y V Homs, Joris I Erdmann, Martijn Intven, Ferry Eskens, Harm Westdorp, Timon Vandamme, Suus Y van Loosbroek, Maaike T W Milder, Rianne D W Vaes, Wilhelm den Toom, François Willemssen, Yvette Seppenwoolde, Nadia Haj Mohammad, Joep de Bruijne, Eva Versteijne, Anna M Bruynzeel, Freek Brandts, Pètra M Braam, Eric T T L Tjwa, Akos Gulyban, Jeroen Buijsen, Judith de Vos-Geelen, Maxime Dewulf, Ines Joye, Margriet Dieters, Fred J F Ubbels, Frederik J H Hoogwater, Ben Heijmen

“…Secondary endpoints include toxicity, biliary stent-related events, progression-free survival, OS and QoL using the EuroQoL five-dimensional, five-level (EQ-5D-5L) questionnaire, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core 30 (QLQ-C30) and the EORTC Biliary Module (QLQ-BIL21). In addition, we will explore the predictive value of the peripheral immunological status (immune-related proteins and serum functional immunological status assay) and its dynamics in determining survival outcomes. …”
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