Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas–FasL pathway activation and metabolic reprogramming by Liang Yao, Liang Yao, Liang Yao, Chen Gu, Chen Gu, Chen Gu, Ruipeng Ge, Ruipeng Ge, Ruipeng Ge, Xiaoqian Zhang, Xiaoqian Zhang, Xinqian Meng, Xinqian Meng, Lei Wang, Lei Wang, Lei Wang, Lei Wang, Daiyin Peng, Daiyin Peng, Daiyin Peng, Daiyin Peng, Guozhuan Li, Guozhuan Li

“…IntroductionNot all polysaccharides function as antitumor drugs, nor do they universally possess the same advantages regarding safety and biocompatibility. …”
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HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages by Zhou J, Ding L, Chen J, Chen C, Jiang P, Mei Z, Jiang Q, Hua X

“…Co-immunofluorescence was used to analyze the functional phenotype of macrophages and spatial localization of HMGB1 in prostate of EAP mice. …”
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Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology by Zhanhao Ye, Dongmin Cao, Wenxing Ao, Ting Li, Minghua Xian, Shumei Wang

“…Results: RR showed significant neuroprotective effects, reducing infarct volume, improving neurological scores, and restoring intestinal function compared to the model group. In addition, gut microbiota analysis revealed that RR administration reversed gut microbiota dysbiosis in MCAO/R rats by increasing the abundance of Bifidobacterium and Lactobacillus while decreasing the abundance of Escherichia-Shigella. …”
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NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death by Tian Zhang, Dongsheng Tang, Pengfei Wu, Shaoping Jiang, Yuquan Zhang, Abid Naeem, Yong Li, Chunhui Li, Bo Hu, Shuai Guo, Caixia Sun, Haihua Xiao, Ran Yan, Yuhua Weng, Yuanyu Huang

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Wound Healing Properties of Plant-Based Hydrogel and Oleogel Formulations in a Rat Scald Burn Model by Oana Janina Roșca, Alexandru Nistor, Georgeta Hermina Coneac, Ioana Viorica Olariu, Ana-Maria Cotan, Roxana Racoviceanu, Elena Rodica Heredea, Adelin Ciudoiu, Gabriela Didea, Camelia Mihaela Lupou, Florin Borcan, Teodora Hoinoiu, Cristina Adriana Dehelean, Lavinia Lia Vlaia, Codruța Marinela Șoica

“…There is an increasing demand for novel topical alternatives that can effectively improve wound healing by modulating the inflammatory cascade, accelerating epithelial and dermal regeneration, and restoring barrier function. …”
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Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation by Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Christoph Rummel, Christoph Rummel, Christoph Rummel

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53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway by Yundong Fu, Wei Wu, Maosha Zhang, Zeming Rong, Bao Lin, Xin Zhou, Dingwei Li, Xin Shi, Jing Guo, Shuyun Ma, Qiang Chen

“…The direct interaction between 53BP1 and p53 is dispensable for this process, which is distinct from the established function of 53BP1-USP28-p53 complex. Notably, 53BP1 binds to E2F7 transcription start sites (TSSs) in an H4K20me2-dependent manner, which modulates p53’s binding ability through regulating epigenetic modifications at E2F7 TSS. …”
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Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2‐P62 Axis and Suppressing IRF4 Transcription by Bingxin Guo, Xing Shi, Qiong Jiang, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao, Lingwei Wang, Rongchang Chen, Shanze Chen

“…Prior research indicated immunoproteasome inhibition alleviated various inflammatory diseases by modulating immune cell functions. However, its therapeutic potential in COPD remains largely unexplored. …”
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Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review by Balaji Venkataraman, Aya A. Touny, Shamanth Neralagundi Harihar gowdru, Bhoomendra A. Bhongade, Rajesh B. Patil, Shreesh Ojha, Mauro Pessia, Sandeep B. Subramanya

“…This pathological process induces oxidative stress, inflammation, and cellular damage, which collectively impair intestinal function. Recent studies have explored natural therapeutic approaches, including the use of plants, herbal formulations, and phytochemicals, to mitigate the detrimental effects of intestinal I/R injury. …”
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Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury by Marina García-Bejarano, Marina García-Bejarano, Marina García-Bejarano, Riccardo Aucello, Riccardo Aucello, Federica Zen, Federica Zen, Marwa El Soury, Marwa El Soury, Francesca Cordero, Jesús M. de la Fuente, Isabelle Perroteau, Giulia Ronchi, Giulia Ronchi, Giovanna Gambarotta, Giovanna Gambarotta

“…Further investigations are needed to clarify RGS16 function, which could pave the way for novel therapeutic strategies to enhance nerve regeneration and alleviate neuropathic pain.…”
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Effects of postbiotic products from Saccharomyces cerevisiae fermentation on lactation performance, antioxidant capacity, and blood immunity in transition dairy cows by Dongwen Dai, Fanlin Kong, Haoqi Han, Weina Shi, Han Song, Ilkyu Yoon, Shuo Wang, Xiaojing Liu, Na Lu, Wei Wang, Shengli Li

“…Overall, our results indicate the potential benefits of supplementing SCFP in transition dairy cows by modulating immunity and liver metabolic function and supporting ECM yield. …”
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Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer by Junyue Tao, Junyue Tao, Junyue Tao, Yiding Chen, Yiding Chen, Yiding Chen, Xiaokang Bian, Xiaokang Bian, Xiaokang Bian, Tingting Cai, Tingting Cai, Tingting Cai, Changhao Song, Changhao Song, Changhao Song, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao, Jialing Meng, Jialing Meng, Jialing Meng, Qintao Ge, Qintao Ge, Jun Zhou, Jun Zhou, Jun Zhou

“…BackgroundRecent studies have underscored the potential involvement of cathepsin Z (CTSZ) in modulating the progression of diverse tumor types. Nevertheless, its specific role in prostate cancer (PCa) remains insufficiently understood. …”
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Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands by Twan Otten, Twan Otten, Xun Jiang, Xun Jiang, Manoj Kumar Gupta, Manoj Kumar Gupta, Nadira Vadaq, Maartje Cleophas-Jacobs, Jéssica C. dos Santos, Albert Groenendijk, Albert Groenendijk, Wilhelm Vos, Wilhelm Vos, Louise E. van Eekeren, Marc J. T. Blaauw, Marc J. T. Blaauw, Elise M.G. Meeder, Elise M.G. Meeder, Elise M.G. Meeder, Olivier Richel, Vasiliki Matzaraki, Jan van Lunzen, Jan van Lunzen, Leo A. B. Joosten, Leo A. B. Joosten, Yang Li, Yang Li, Yang Li, Cheng-Jian Xu, Cheng-Jian Xu, Andre van der Ven, Mihai G. Netea, Mihai G. Netea

“…IntroductionDuring the COVID-19 pandemic, major events with immune-modulating effects at population-level included COVID-19 infection, lockdowns, and mass vaccinations campaigns. …”
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ELD1 mediates photoperiodic flowering via OsCCA1 alternative splicing and interacts with phytochrome signaling in rice by Liang Cai, Benyuan Hao, Zhuang Xu, Song Cui, Qianyun Wu, Jiyoung Lee, Haigang Hou, Yuan Hu, Liang Zhu, Jie Wang, Wen Li, Kongyou Chang, Weihao Shao, Shanshan Zhu, Xiangchao Gan, Chao Li, Ling Jiang, Yunlu Tian, Xi Liu, Shijia Liu, Liangming Chen, Haiyang Wang, Shirong Zhou, Jianmin Wan

“…Notably, partial loss of ELD1 function results in early flowering under long-day conditions. …”
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Macrophage-derived IL-15 imprints peritoneal TRM-like CD8 T cells in cirrhosis and spontaneous bacterial peritonitis by Oluwatomi Ibidapo-Obe, Sven Stengel, Mick Frissen, Johanna Reißing, Karsten Große, Michael Rooney, Stefanie Quickert, Trong-Hieu Nguyen, Sabine Baumgart, Hector Leal-Lassalle, Raquel Benedé-Ubieto, Yulia A. Nevzorova, Tony Bruns

“…This study assesses whether peritoneal CD8 T cells from patients with cirrhosis exhibit TRM-like functionalities, focusing on how inflammatory events shape phenotype and function. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…Soluble NKG2D ligands known to regulate the receptor function have been associated to cancer progression. …”
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Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule by Fanfan Wang, Fanfan Wang, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Ling Xin, Yanyan Fang, Yanyan Fang, Yue Sun, Mingyu He, Mingyu He

“…Additionally, FISH, luciferase reporter assays, and rescue experiments were performed to validate the regulatory role of ENST00000619282 and its sponge-like function in RA-FLS. Clinical samples were analyzed to determine the correlation between FTO/YTHDF1/ENST00000619282/Bax/Bcl-2 and immune-inflammatory markers. …”
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Estudio de la variación solar quieta para el observatorio geomagnético de Fúquene by Ladino Parra Rosa Angélica, Figueredo Báez Yaqueline, Valdés Meneses Emna Mireya

“…Later on the correction was applied by flattening and the information was regrouped in three levels of solar activity: hight, medium and low (in function of the number of sunspots); for each one of them the harmonics were averaged per month. …”
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HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread by Omolara O. Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J. Bunders, Marcus Altfeld, Clare Jolly, Jaclyn Mann, Thumbi Ndung’u

“…Virus cell-to-cell spread efficiency was measured through flow cytometry-based detection of p24, while nutrient uptake assays and mitotracker dye detection served as surrogate markers for T-cell metabolism and mitochondrial function. Chimeric subtype C viruses exhibited significantly lower RC compared to subtype B viruses (P = 0.0008). …”
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基于药物基因组学的急性缺血性卒中个体化抗栓治疗进展 Advances in Pharmacogenomics-Based Individualized Antithrombotic Therapy for Acute Ischemic Stroke by 杨佳洁，张亮，黄立安（YANG Jiajie, ZHANG Liang, HUANG Li’an ）

“…Patients carrying loss-of-function alleles such as CYP2C19*2 or CYP2C19*3 demonstrate diminished responses to standard antiplatelet therapy and cannot effectively reduce the risk of stroke recurrence. …”
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