Males and females respond differently to treatment during isolated kidney perfusion: combined effects of glucocorticoid and estradiol by Marina Vidal-dos-Santos, Marina Vidal-dos-Santos, Roberto Armstrong-Jr, Roberto Armstrong-Jr, Mayara Munhoz de Assis Ramos, Mayara Munhoz de Assis Ramos, Lucas Ferreira da Anunciação, Fernanda Yamamoto Ricardo-da-Silva, Cristiano de Jesus Correia, Petra J. Ottens, Luiz Felipe Pinho Moreira, Henri G. D. Leuvenink, Ana Cristina Breithaupt-Faloppa

“…No difference was observed in males in regards to treatment.ConclusionThe combined treatment of E2 and MP during isolated kidney perfusion compromised kidney function in females. In males, no detrimental effects were observed. …”
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Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease by Isobel Timothea French, Kuo-Hsuan Chang, Wei-Kuang Liang, Wen-Sheng Chang, Yen-Shi Lo, Yi-Ru Wang, Mei-Ling Cheng, Norden E. Huang, Hsiu-Chuan Wu, Siew-Na Lim, Chiung-Mei Chen, Chi-Hung Juan

“…Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.…”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…Background In the tumor microenvironment (TME), hypoxia stands as a significant factor that modulates immune responses, especially those driven by T cells. …”
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Identification of osteoarthritis-associated chondrocyte subpopulations and key gene-regulating drugs based on multi-omics analysis by Ting Hao, Zhiwei Pei, Sile Hu, Zhenqun Zhao, Wanxiong He, Jing Wang, Liuchang Jiang, jirigala Ariben, Lina Wu, Xiaolong Yang, Leipeng Wang, Yonggang Wu, Xiaofeng Chen, Qiang Li, Haobo Yang, Siqin Li, Xing Wang, Mingqi Sun, Baoxin Zhang

“…Abstract The mechanism by which chondrocytes respond to mechanical stress in joints significantly affects the balance and function of cartilage. This study aims to characterize osteoarthritis-associated chondrocyte subpopulations and key gene targets for regulatory drugs. …”
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Ceria nanoparticles alleviate myocardial ischemia-reperfusion injury by inhibiting cardiomyocyte apoptosis via alleviating ROS mediated excessive mitochondrial fission by Ying Sun, Jiabao Xu, Ling Zou, Yan Tan, Jie Li, Haoran Xin, Yanli Guo, Weikai Kong, Dingyuan Tian, Xinyu Bao, Xiaoqin Wan, Xiaoxu Li, Zhihui Zhang, Xiaochao Yang, Fang Deng

“…The improved mitochondrial dynamics saves the cardiomyocytes from apoptosis and reduces the acute injury of left ventricular wall during the MIRI. The ejection function of the left ventricle for both the short-term and long-term MIRI rats is well preserved. …”
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C1q reprograms innate immune memory by Inge Jonkman, Maaike M. E. Jacobs, Yutaka Negishi, Yutaka Negishi, Julia I. P. van Heck, Vasiliki Matzaraki, Joost H. A. Martens, Marijke Baltissen, Michiel Vermeulen, Zahi A. Fayad, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Luuk B. Hilbrands, Leo A. B. Joosten, Leo A. B. Joosten, Mihai G. Netea, Mihai G. Netea, Musa M. Mhlanga, Musa M. Mhlanga, Nils Rother, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Raphaël Duivenvoorden

“…Innate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli. In addition to its function in host defense, trained immunity contributes to diverse immune-mediated diseases. …”
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GmWRKY33a is a hub gene responsive to brassinosteroid signaling that suppresses nodulation in soybean (Glycine max) by Mingliang Yang, Mingliang Yang, Chengjun Lei, Chengjun Lei, Chao Ma, Chao Ma, Xiuming Hou, Xiuming Hou, Mingming Yao, Mingming Yao, Liang Mi, Liang Mi, Enliang Liu, Linli Xu, Shukun Wang, Shukun Wang, Chunyan Liu, Chunyan Liu, Qingshan Chen, Qingshan Chen, Dawei Xin, Dawei Xin, Chang Xu, Chang Xu, Jinhui Wang, Jinhui Wang

“…Here, the RNA-Seq was used to identify important gene associated with BRs and symbiotic nitrogen fixation, and the function of candidate gene was verified by transgenic hairy roots. …”
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Efficacy of image-guided accurate limbal relaxing incisions for astigmatism correction during cataract surgery by Xiaoxin Hu, Jiao Qi, Kaiwen Cheng, Wenwen He, Yu Du, Keke Zhang, Yi Lu, Xiangjia Zhu

“…Eyes with paired LRIs exhibited better corneal average height of modulation transfer function, a better corneal performance index and a better quality of vision index than those with single LRI (all P ​< ​0.05). …”
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Hydrogen sulfide donor NaHS inhibits formaldehyde-induced epithelial-mesenchymal transition in human lung epithelial cells via activating TGF-β1/Smad2/3 and MAPKs signaling pathway... by Haopei Wang, Miaomiao Jia, Yuxin Chang, Xingwei Ling, Wenyan Qi, Hongtao Chen, Feipeng Chen, Haiyang Bai, Yuhan Jiang, Chengfan Zhou

“…Formaldehyde (FA) long term exposure leads to abnormal pulmonary function and small airway obstruction of the patients. …”
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Reproducibility of in vivo electrophysiological measurements in mice by International Brain Laboratory, Kush Banga, Julius Benson, Jai Bhagat, Dan Biderman, Daniel Birman, Niccolò Bonacchi, Sebastian A Bruijns, Kelly Buchanan, Robert AA Campbell, Matteo Carandini, Gaelle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Berk Gerçek, Fei Hu, Julia Huntenburg, Cole Lincoln Hurwitz, Anup Khanal, Christopher Krasniak, Petrina Lau, Christopher Langfield, Nancy Mackenzie, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, Alejandro Pan-Vazquez, Cyrille Rossant, Noam Roth, Michael Schartner, Karolina Z Socha, Nicholas A Steinmetz, Karel Svoboda, Marsa Taheri, Anne E Urai, Shuqi Wang, Miles Wells, Steven J West, Matthew R Whiteway, Olivier Winter, Ilana B Witten, Yizi Zhang

“…Understanding brain function relies on the collective work of many labs generating reproducible results. …”
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Afucosylated IgG in idiopathic nephrotic syndrome patients with anti-nephrin autoantibodies correlate with disease activity by Sonia Spinelli, Andrea Garbarino, Francesca Lugani, Edoardo La Porta, Noemi Rumeo, Giorgio Piaggio, Alberto Magnasco, Antonella Trivelli, Maria Ludovica Degl’Innocenti, Gino Tripodi, Simona Granata, Francesca Leone, Elena Zocchi, Lorenzo Gallon, Gian Marco Ghiggeri, Enrico Verrina, Gianluigi Zaza, Giovanni Candiano, Maurizio Bruschi

“…Variation in techniques for detecting anti-nephrin Abs and lack of urinary data contribute to uncertainties of results.While reduced IgG fucosylation is known to enhance antibody-dependent cellular cytotoxicity in non-INS autoimmune diseases, its role in modulating anti-nephrin autoantibody function and disease severity in INS remains unexplored. …”
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Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss by Joana Saavedra, Joana Saavedra, Joana Saavedra, Mariana Nascimento, Mariana Nascimento, Mariana Nascimento, António J. Figueira, António J. Figueira, Marina I. Oliveira da Silva, Marina I. Oliveira da Silva, Tiago Gião, Tiago Gião, Tiago Gião, João Oliveira, João Oliveira, João Oliveira, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Cláudio M. Gomes, Cláudio M. Gomes, Isabel Cardoso, Isabel Cardoso, Isabel Cardoso

“…The S100 family is a group of calcium-binding proteins with intra- and extracellular functions, that are important modulators of inflammatory responses. …”
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Microbiomic and Metabolomic Insights into the Mechanisms of Alfalfa Polysaccharides and Seaweed Polysaccharides in Alleviating Diarrhea in Pre-Weaning Holstein Calves by Jianan Zhao, Haoliang Tian, Xiaohui Kong, Danqi Dang, Kaizhen Liu, Chuanyou Su, Hongxia Lian, Tengyun Gao, Tong Fu, Liyang Zhang, Wenqing Li, Wei Zhang

“…Therefore, by supplementing with AP and SP, the diarrhea rate in calves was reduced, and the immune function of Holstein calves was enhanced, while simultaneously promoting a higher relative abundance of beneficial gut bacteria and suppressing the relative abundance of pathogenic bacteria. …”
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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Additionally, the use of compounds that can modulate the function of these molecules could be evaluated for the management of LTx patients.…”
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Investigation of DC-Biased Optical OFDM With Precoding Matrix for Visible Light Communications: Theory, Simulations, and Experiments by Tao Jiang, Ming Tang, Rui Lin, Zhenhua Feng, Xi Chen, Lei Deng, Songnian Fu, Xiang Li, Wu Liu, Deming Liu

“…The simulation results demonstrate the complementary cumulative distribution function of PAPR can be reduced &#x223C;3 dB, while the performance of clipping distortion power and clipping error probability are significantly improved. …”
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Mechanical Design and Motion Analysis of a Hybrid Robot for Equine Rehabilitation by YE Zenglin, DAI Zhonghong, ZHANG Liang'an, WEI Liangguo, CHEN Hua

“…ObjectiveEquine therapy, also referred to as therapeutic riding or equine-assisted therapy, is a clinical methodology that promotes physical, psychological, and social functioning through the integration of horse handling and riding skills. …”
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The critical role of matrix metalloproteinase 9-mediated microglial polarization in perioperative neurocognitive disorders of aged rats by Xi Xin, Xi Xin, Xi Xin, Xi Xin, Xi Xin, Haonan Zhang, Haonan Zhang, Haonan Zhang, Haonan Zhang, Haonan Zhang, Chenyi Yang, Chenyi Yang, Chenyi Yang, Chenyi Yang, Chenyi Yang, Chenyi Yang, Xinyi Wang, Xinyi Wang, Xinyi Wang, Xinyi Wang, Xinyi Wang, Xinyi Wang, Lin Zhang, Lin Zhang, Lin Zhang, Lin Zhang, Lin Zhang, Ji Ma, Ji Ma, Ji Ma, Ji Ma, Ji Ma, Haiyun Wang, Haiyun Wang, Haiyun Wang, Haiyun Wang, Haiyun Wang, Haiyun Wang, Haiyun Wang, Haiyun Wang

“…Administration of SB-3CT effectively reversed these pathological manifestations.ConclusionThe inhibition of MMP9 can enhance neurological function by modulating the polarization of microglia and alleviating neuroinflammation, which is a new approach for perioperative neuroprotection in high-risk PND patients.…”
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Multi-omics insights into antioxidant and immune responses in Penaeus monodon under ammonia-N, low salinity, and combined stress by Yundong Li, Sheng Huang, Song Jiang, Lishi Yang, Jianhua Huang, Qibin Yang, Ziyi Jiang, Jianzhi Shi, Zhenhua Ma, Erchao Li, Falin Zhou

“…A comprehensive analysis further indicated that the combined stressors of ammonia nitrogen and salinity exert a synergistic effect on the immune function and physiological homeostasis of shrimp by modulating antioxidant metabolic pathways and gut microbial communities. …”
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Protective Role of the Podocyte IL-15 / STAT5 Pathway in Focal Segmental Glomerulosclerosis by Aïssata Niasse, Kevin Louis, Olivia Lenoir, Chloé Schwarz, Xiaoli Xu, Aymeric Couturier, Hélène Dobosziewicz, Anthony Corchia, Sandrine Placier, Sophie Vandermeersch, Lothar Hennighausen, Perrine Frère, Pierre Galichon, Brigitte Surin, Souhila Ouchelouche, Liliane Louedec, Tiffany Migeon, Marie-Christine Verpont, Nadir Yousfi, David Buob, Yi-Chun Xu-Dubois, Hélène François, Eric Rondeau, Laurent Mesnard, Juliette Hadchouel, Yosu Luque

“…Introduction: During glomerular diseases, podocyte-specific pathways can modulate the intensity of histological disease and prognosis. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Methods: Three novel transgenic mouse models were engineered to investigate the functional contribution of Gpr45 to body weight and appetite regulation: 1) a global Gpr45 knockout, 2) a conditional floxed Gpr45 allele, and 3) a Gpr45-CreERT2 knock-in. …”
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