Genome-Wide Association Study of Brown Rice Weight Identifies an RNA-Binding Protein Antagonistically Regulating Grain Weight and Panicle Number by Lin Zhou, Hong Jiang, Long Huang, Ziang Li, Zhonghao Yao, Linhan Li, Kangwei Ji, Yijie Li, Haijuan Tang, Jinping Cheng, Yongmei Bao, Ji Huang, Hongsheng Zhang, Sunlu Chen

“…BRW1.1, one of the four newly identified loci, was found to encode a novel RNA-binding protein. Functional characterization revealed that BRW1.1 acts as a negative regulator of BRW, potentially through modulating mRNA translation processes. …”
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Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

“…The pharmacological mechanisms of CHQF were explored using network pharmacology, transcriptomics, and metabolomics, which enabled the identification of potential therapeutic targets and pathways, as further validated by in vivo and in vitro experiments.Results: CHQF administration significantly improved the survival rates, reduced systemic inflammation, and restored liver function in CLP-induced sepsis mice, while also mitigating liver tissue injury. …”
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Determination of the Roles of <i>H. pylori</i> Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1β, and IL-18 in Ulcer and Gastriti... by Yaren Buyukcolak-Cebeci, Emel Timucin, Sumeyye Akcelik-Deveci, Nesteren Mansur-Ozen, Tuana Aydinlar, Arzu Tiftikci, Sinem Oktem-Okullu

“…The presence of the <i>H. pylori alpA</i> gene is markedly associated with the lack of Gasdermin D activation, indicating a possible suppressive function or immune evasion tactic. These results underscore the critical role of <i>H. pylori</i> virulence determinants in modulating pyroptosis and suggest that understanding this relationship may pave the way for developing targeted therapeutic strategies to mitigate <i>H. pylori</i>-associated pathologies.…”
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A Systematic Review of Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Treatment for Glioblastoma by Edoardo Agosti, Sara Antonietti, Tamara Ius, Marco Maria Fontanella, Marco Zeppieri, Pier Paolo Panciani

“…MSC-EVs, including exosomes, microvesicles, and apoptotic bodies, perform a significant function in cellular communication and have shown promise in mediating anti-tumor effects. …”
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Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study by Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

“…ObjectiveThis study aimed to examine the effect of a clinic-based strengthening exercise (CbSE) and asynchronous video-based strengthening exercise (AVbSE) on pain, range of motion, muscle strength, quality of life, and physical function among patients with knee osteoarthritis. …”
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Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense by Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y

“…Jintao Shi,1,&amp;ast; Yang Xuan,1– 3,&amp;ast; Qinyu Zhang,1,&amp;ast; Jiangtao Chen,1 Weihan Zhu,1 Hao Zhang,2,3 Yue Duan2,3 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 2Department of Urology and Andrology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 3Zhejiang Provincial Key Laboratory of Sexual Function of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, 310005, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yue Duan; Hao Zhang, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, No. 318, Chaowang Road, Hangzhou City, Zhejiang Province, People’s Republic of China, Email dyurology@163.com; htjtcm@163.comBackground: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a chronic inflammatory disorder with complex etiology and limited treatment options, is closely associated with oxidative stress and regulates cell death. …”
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Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro by Aling Shen, Meizhu Wu, Zhi Guo, Farman Ali, Jinkong Wu, Hong Chen, Ying Cheng, Dawei Lian, Jun Peng, Min Yu, Keji Chen

“…Blood pressure, vascular function, pathological morphology, and collagen deposition in Ang II infused mice and cell viability of Ang II stimulated A7R5 cells were assessed. …”
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Transcriptome Analysis Reveals the Molecular Mechanisms for Mycorrhiza-Enhanced Drought Tolerance in Maize by Regulating the Ca²⁺ Signaling Pathway by Qiaoming Zhang, Wenjing Yang, Miaomiao Wang, Junwei Chen, Zhaoran Zhang, Yanan Wei, Qingshan Chang, Minggui Gong

“…A high number of DEGs with this function (including calcineurin B-like protein (CBL), CBL-interacting protein kinase (CIPK), mitogen-activated protein kinase (MAPK), and calcium-dependent protein kinase (CDPK) receptor kinases) were upregulated-DEGs or downregulated-DEGs in <i>F. mosseae</i>-inoculated maizes under drought stress. …”
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Garlic-Derived Exosome-Like Nanovesicles: A Promising Natural Nanotherapy for Periodontitis via PHGDH/PI3K/AKT-Mediated Metabolic and Inflammatory Regulation by Yu C, Liu Y, Yu X, Liu J, Cao P, Liu G, Cai Y, Zhang Y, Luan Q

“…These therapeutic effects were mediated by upregulation of PHGDH, activation of the PI3K/AKT signaling pathway, increased expression of mTOR and Nrf2, and inhibition of NF-κB activity, which together contributed to improved mitochondrial function and metabolic reprogramming under inflammatory conditions.Conclusion: GaELNs demonstrate potent anti-inflammatory, antioxidative, and metabolism-enhancing properties, offering significant therapeutic potential for the treatment of periodontitis by modulating the PHGDH/PI3K/AKT pathway. …”
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Usnic acid and tannic acid as inhibitors of coccidia and Clostridium perfringens: alleviating necrotic enteritis and improving intestinal health in broiler chickens by Huiping Xu, Minghao Yang, Jianyang Fu, Huiyuan Lv, Jiang Guo, Changji Lu, Zengpeng Lv, Yuming Guo

“…Both usnic acid alone and in combination with tannic acid alleviate NE-induced adverse effects in broilers by modulating intestinal immunity, altering the microbial composition, and improving intestinal barrier function. …”
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In Vitro Anthelmintic Activities of Khaya anthotheca and Faidherbia albida Extracts Used in Chad by Traditional Healers for the Treatment of Helminthiasis and In Silico Study of Ph... by Baigomen Christalin, Masoud Besati, Noumedem Anangmo Christelle Nadia, Mahdi Yaghoobi, Yamssi Cédric, Claire Ciancia, Mounvera Abdel Azizi, Gamago Nkadeu Guy-Armand, Vincent Khan Payne, Haibo Hu

“…Docking studies were carried out using the Schrodinger Maestro software’s Glide module. The score function in the software was used to rank and group distinct possible adduct structures generated by molecular docking. …”
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Soil organic carbon mineralization is controlled by the application dose of exogenous organic matter by O. Mendoza, S. De Neve, H. Deroo, H. Li, A. Françoys, A. Françoys, S. Sleutel

“…Therefore, we set up a 90 d incubation experiment with large soil volumes (sandy loam and silt loam) to compare the mineralization of EOM (<span class="inline-formula">¹³</span>C-labelled ryegrass) and SOC as a function of three EOM application doses (0.5, 1.5, and 5 g dry matter kg<span class="inline-formula">⁻¹</span> soil). …”
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Association of 5α-reductase inhibitor prescription with immunotherapy efficacy in metastatic renal cell carcinoma: a multicenter retrospective analysis by Lin Yang, Hai Huang, Qiong Wang, Peng Wu, Ke Chen, Weijia Li, Bisheng Cheng, Jilin Wu, Jianghua Yang, WenTai Shangguan, Wenxue Huang, Cunzhen Ma, Zhuohang Li, Boyuan Sun

“…Recent studies suggest that androgen receptor (AR) signaling plays a role in regulating CD8+ T-cell function, implying that 5α-reductase inhibitors (5-ARIs), which lower androgen activity, could enhance antitumor immunity and improve clinical outcomes in patients receiving immunotherapy. …”
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Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage by Vemula Sravathi, Madhuri Doppalapudi, Ravi Kumar Yadala, Anilkumar Banothu, Vijaya Kumar Anumolu, Hanuman Donga Durga Veera, Bhaskar Debbarma

“…In conclusion, VIS exhibits potent anti-inflammatory and mucosal-protective properties, making it a promising therapeutic candidate for managing UC. Its ability to modulate inflammatory pathways and enhance intestinal barrier function suggests its potential as an alternative treatment for UC.…”
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Effects of antagonistic network-targeted tDCS on brain co-activation patterns depends on the networks’ electric field: a simultaneous tDCS-fMRI study by Hechun Li, Hongru Shi, Sisi Jiang, Changyue Hou, Haonan Pei, Hanxi Wu, María Luisa Bringas Vega, Gang Yao, Dezhong Yao, Cheng Luo

“…Material and method: The current study utilized simultaneous network-targeted transcranial direct current stimulation(tDCS) and functional magnetic resonance imaging (fMRI) to investigate the effects of tDCS targeting antagonistic networks on brain dynamics. …”
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GSTA1/CTNNB1 axis facilitates sorafenib resistance via suppressing ferroptosis in hepatocellular carcinoma by Shiwen Ma, Fei Xie, Xiaohu Wen, Yao Mawulikplimi Adzavon, Ruping Zhao, Jinyi Zhao, Han Li, Yanqi Li, Jingtao Liu, Chen Liu, Yang Yi, Pengxiang Zhao, Boqing Wang, Wei Zhao, Xuemei Ma

“…Mechanistically, GSTA1 enhances the accumulation of lipid peroxides and suppresses ferroptosis by exerting its peroxidase function to regulate the SR. Notably, the upregulation of GSTA1 expression is mediated by the transcription factor CTNNB1 (β-catenin), resulting in the formation of a cytoplasmic complex between GSTA1 and CTNNB1. …”
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Improved effect of antibiotic treatments on the hippocampal spatial memory dysfunction of mice induced by high fluoride exposure: Insight from assembly processes and co-occurrence... by Ning Sun, Jinge Xin, Zhifang Zhao, Yu Chen, Baoxing Gan, Lixiao Duan, Jiuyang Luo, Dandan Wang, Yan Zeng, Kangcheng Pan, Bo Jing, Dong Zeng, Hailin Ma, Hesong Wang, Xueqin Ni

“…Since the absorption of F- enters the body mainly through the gastrointestinal tract, studying the effects of excessive intake of fluoride on brain memory function in various gut microbiome states might have profound implications for the prevention of fluorosis because growing evidence revealed the significance of the “microbiota-gut-brain” axis (MGBA). …”
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The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking by Ren Li, Ren Li, Ren Li, Bingqing Zheng, Bingqing Zheng, Bingqing Zheng, Yuqiong Zhang, Yuqiong Zhang, Yuqiong Zhang, Lu He, Chaomin Ren, Chaomin Ren, Chaomin Ren, Linlin Guan, Linlin Guan, Linlin Guan, Huan Yang, Huan Yang, Huan Yang, Jiayu Tian, Jiayu Tian, Jiayu Tian, Xingyi Chen, Xingyi Chen, Xingyi Chen, Dongxing Shi, Dongxing Shi, Dongxing Shi, Lifang Zhao, Lifang Zhao, Lifang Zhao, Zhihong Zhang, Zhihong Zhang, Zhihong Zhang

“…By integrating information from multiple databases, we identified key target genes linked to these compounds and conducted functional enrichment analyses to elucidate their roles in pathological processes.ResultsOur results demonstrate that these phthalates affect the pathogenesis of asthma and COPD by modulating various target genes, including PTGS2, MMP9, and CASP3, which are involved in essential biological pathways such as apoptosis and immune response. …”
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Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome by Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor, Raúl F. Pérez, Alfonso Peñarroya, Pablo Santamarina-Ojeda, Annalisa Roberti, Jennifer M. Kefauver, Carlota Álvarez-Díaz, Mar Rodríguez-Santamaría, José Luis Trejo, Laureano Tomás-Daza, Llorenç Rovirosa, Biola M. Javierre, Agustín F. Fernández, Mario F. Fraga

“…We also integrated liCHi-C data with RNA sequencing (RNA-seq) data to identify functional implications. Furthermore, we assessed the effect of exposure to environmental enrichment (EE). …”
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Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency by Xiaoxian Zhang, Li Huang, Cheng Li, Jinjuan Yang, Fuyu Duan, Qiang Su, Yuelin Zhang, Meng Kou, Xiaoya Zhou, Liyan Guo, Shaoxiang Chen, Yongxia Niu, Ziyue Li, Sihua Ou, Min Zhang, Kenneth King-Yip Cheng, Jianlong Wu, Xiang Xu, Qizhou Lian

“…Additionally, AAV9-hNdufs6 gene therapy initiated at an early stage increased Ndufs6 expression in cardiac tissue, preserved mitochondrial structure and function, prevented cardiomyocyte fibrosis through modulation of the AMPK/Drp1 signaling pathway. …”
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