Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury by Xin Xu, Xinxin Yang, Meng Wang, Jingrong Zhu, Jing Li, Caiyue Chen, Jiameng Liu, Jiahuan Zheng, Bei Fan, Fengzhong Wang, Jing Sun

“…These results point to BRLPP’s potential as a bioactive component in functional foods for the prevention and treatment of ALD by indicating that it has noteworthy hepatoprotective and antioxidant qualities.…”
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Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells by Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim

“…Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) in various immune cell types. …”
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The effects of SGLT2i on cardiac metabolism in patients with HFpEF: Fact or fiction? by Francesca Cinti, Renzo Laborante, Luigi Cappannoli, Cassandra Morciano, Shawn Gugliandolo, Alfredo Pontecorvi, Francesco Burzotta, Maria Donniacuo, Donato Cappetta, Giuseppe Patti, Andrea Giaccari, Domenico D’Amario

“…We will focus on the key metabolic processes possibly modulated by SGLT2i, including myocardial glucose utilization, fatty acid oxidation, and mitochondrial function, and explore their effects on heart failure pathophysiology. …”
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Automatic diagnosis of agromyzid leafminer damage levels using leaf images captured by AR glasses by Zhongru Ye, Yongjian Liu, Fuyu Ye, Hang Li, Ju Luo, Jianyang Guo, Zelin Feng, Chen Hong, Lingyi Li, Shuhua Liu, Baojun Yang, Wanxue Liu, Qing Yao

“…The integration of an edge-aware module and a Canny loss function into the DeepLabv3+ model enhanced the DeepLab-Leafminer model’s capability to accurately segment the edges of leafminer-damaged regions, which often exhibit irregular shapes. …”
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Endoplasmic reticulum adenylate transporter activity affects amino acid metabolism under photorespiratory conditions by Jieni Li, Yuxin Song, Xin Luan, Yajun Gou, Tao Xie, Yu Hong, Na Liu, Yao Su, Xueli Fu, Tianxiu Zhong, Shu Chen, Yuexiong Zhang, Gang Qin, Xiang-Qian Zhang

“…The involvement of the endoplasmic reticulum (ER)-localized adenylate transporter1 (ER-ANT1) in photorespiratory metabolism has been established, yet its precise physiological function remains uncertain. Rice er-ant1 mutant plants grown in ambient air exhibited stunted growth and substantial alterations in amino acid metabolites, but recovery in a high CO2 condition (1.5%). …”
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Impact of apolipoprotein B-associated cholesterol deficiency genotype on milk composition, somatic cell count, and parity effects in Lithuanian Holstein cows by Ramutė Mišeikienė, Nijolė Pečiulaitienė, Lina Kajokienė, Renata Bižienė, Kristina Morkūnienė, Vilius Marma, Saulius Tušas, Paulius Matusevičius, Ewa Wójcik, Alina Janocha, Anna Milczarek, Laimutis Kučinskas

“…Background and Aim: Cholesterol deficiency (CD) in Holstein cattle, caused by a loss-of-function mutation in the apolipoprotein B (APOB) gene, is a heritable autosomal recessive condition with known implications for fat metabolism and cholesterol transport. …”
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PTSD Coach as an early mobile intervention to improve cancer-related anxiety and psychosocial oncology uptake in patients newly diagnosed with head and neck cancer: pilot randomize... by Laurence Ducharme, Chris Lo, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Michael Antoni, Eric Kuhn, Jason E. Owen, Daren Heyland, Robert Platt, Fabienne Fuehrmann, Nader Sadeghi, Zeev Rosberger, Saul Frenkiel, Khalil Sultanem, George Shenouda, Fabio Cury, Melissa Henry

“…When compared to UC, there was a signal for the PTSD Coach group to report lower 3-month cancer-related anxiety (PCL-S; eta squared = 0.013), lower anxiety and depression (HADS; eta squared = 0.015), anxiety (HADS-A; eta squared = 0.028), and higher functional wellbeing (FACT-FW; eta squared = 0.09), based on effect sizes calculated across all three groups. …”
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Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastián‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin‐Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

“…Endothelial‐specific AnxA8 silencing in vivo was performed in ApoE−/− mice. The functional role of AnxA8 was analysed in cultured murine cells. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…The success of each VOC, as well as the virus fitness, were enabled by altered intrinsic functional properties and, reasonably, to virus antigenicity changes, conferring the ability to evade a primed immune response. …”
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Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis by Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig, Guido Kroemer

“…In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with reduced responses to chemotherapy or chemoradiotherapy. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…<h4>Summary</h4>In this report we introduce a weak-model approach for examination of the intrinsic time-varying properties of the hemoglobin signal, with the aim of advancing the application of functional near infrared spectroscopy (fNIRS) for the detection of breast cancer, among other potential uses. …”
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Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis by Tingting Liu, Chao Jin, Jing Sun, Lina Zhu, Chun Wang, Feng Xiao, Xiaochang Liu, Liying Lv, Xiaoke Yang, Wenjing Zhou, Chao Tan, Xianli Wang, Wei Wei, Xiangxiang Pan

“…Flow cytometry analysis was used to characterize the differentiation and function of dendritic cells (DCs)/T cells. Co-immunoprecipitation was used to explore the specific molecular mechanism. …”
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Bikaverin as a molecular weapon: enhancing Fusarium oxysporum pathogenicity in bananas via rhizosphere microbiome manipulation by Honglin Lu, Suxia Guo, Yongbao Yang, Zhihao Zhao, Qingbiao Xie, Qiong Wu, Changjun Sun, Hongli Luo, Bang An, Qiannan Wang

“…Conclusions Bikaverin plays an indirect yet important role in the pathogenicity of Foc TR4 by manipulating the rhizosphere microbiome. This ecological function underscores its potential as a target for sustainable disease management strategies. …”
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High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine by Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L. Luo, Brendan T. Jones, Nadiia Fomina, Frieder Fuchs, Jörg B. Hans, Jessica Eisfeld, Ana Ong, Sören Gatermann, Jason W. Bennett, Patrick Mc Gann

“…Notably, post-invasion ST-773 and ST-1047 P. aeruginosa had a signature of host adaptation with multiple loss-of-function mutations in the quorum-sensing regulator LasR, known to modulate immune responses and provide survival advantages in animal models of infection. …”
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Prion protein regulates invasiveness in glioblastoma stem cells by Mariana B. Prado, Bárbara P. Coelho, Rebeca P. Iglesia, Rodrigo N. Alves, Jacqueline M. Boccacino, Camila F. L. Fernandes, Maria Isabel Melo-Escobar, Shamini Ayyadhury, Mario C. Cruz, Tiago G. Santos, Flávio H. Beraldo, Jue Fan, Frederico M. Ferreira, Helder I. Nakaya, Marco A. M. Prado, Vania F. Prado, Martin L. Duennwald, Marilene H. Lopes

“…Methods To address this goal, we employed CRISPR-Cas9 technology to generate PrPC knockout (KO) glioblastoma cell lines, enabling detailed loss-of-function studies. Bulk RNA sequencing followed by differentially expressed gene and pathway enrichment analyses between U87 or U251 PrPC-wild-type (WT) cells and PrPC-knockout (KO) cells were used to identify pathways regulated by PrPC. …”
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Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan

“…In order to maximize the therapeutic effectiveness of such neutralizing antibodies, Fc engineering to modulate effector functions and to extend half-life is desirable. …”
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NDP52 deficiency accelerates chondrocyte degeneration through promoting pathogenic mitochondrial ROS via reverse electron transport by Yutao Zhu, Yaohan Xu, Dinqi Xie, Nengfeng Yu, Jiaxin Chen, Jiechao Xia, Zixuan Mei, Yang Jin, Chuan Hu, Pan Tang, Sicheng Jiang, Chao Jiang, Honghai Song, Zhijun Hu

“…However, its autonomous function apart from autophagy remained largely unexplored. …”
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Biomarkers of GH deficiency identified in untreated and GH-treated Pit-1 mutant mice by Sarmed Al-Samerria, Huiting Xu, M. Elena Diaz-Rubio, Joseph Phelan, Chi Su, Keer Ma, Anna Newen, Kiana Li, Sayaka Yamada, Ariel L. Negron, Fredric Wondisford, Sally Radovick

“…Male mice exhibited imbalances in taurine and hypotaurine metabolism, while female mice showed disruptions in tyrosine metabolism and mitochondrial function, highlighting sex-dependent metabolic responses to GHD and GH therapy.ConclusionThe Pit-1^K216E mouse model offers a robust platform for exploring GHD’s molecular mechanisms. …”
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LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock by Marie Crandall, Lisa Jones, Faheem W Guirgis, Lauren Page Black, Martin Daniel Rosenthal, Morgan Henson, Jason Ferreira, Christiaan Leeuwenburgh, Colleen Kalynych, Lyle L Moldawer, Taylor Miller, Srinivasa T Reddy, Samuel S Wu, Frederick A Moore

“…Secondary endpoints include change in cholesterol level from enrolment to 7 days, change in Sequential Organ Failure Assessment score over the first 48 hours and 7 days, in-hospital and 28-day mortality, lipid oxidation status, inflammatory biomarkers, and high-density lipoprotein function.Ethics and dissemination Investigators are trained and follow good clinical practices, and each phase of the study was reviewed and approved by the institutional review boards of each institution. …”
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Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease by Shengxiang Liang, Huanhuan Liu, Xiuxiu Wang, Huawei Lin, Ling Zheng, Yusi Zhang, Lixin Peng, Saie Huang, Lidian Chen

“…Conclusions: Swimming training can rescue the function of the glymphatic system, increase the CSF-ISF exchange, promote the polarization distribution of AQP4, and reduce the deposition of Aβ in the hippocampus, thereby improving the learning and memory ability of APP/PS1 mice.…”
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