The protective effect and mechanism of (-)-(S)-B-973B on SH-SY5Y cell injury induced by 1-me-thyl-4-phenyl pyridine by LI Huanhuan, QIAO Zhen, WANG Ji, CAO Xiu, DU Xixun

“…Conclusion This study shows that (-)-(S)-B-973B exerts a protective effect against SH-SY5Y cell injury induced by MPP+, possibly by enhancing mitochondrial function and exerting an anti-oxidative stress effect.…”
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The Impact of a Single Hip Manipulation on Quadriceps Activity and Performance: A Randomized Study by Rafał Studnicki, Monika Sochaj, Karol Skup, Bartłomiej Niespodziński, Piotr Aschenbrenner, Radosław Laskowski, Piotr Łuczkiewicz

“…Restoring proper muscle balance may enhance rehabilitation outcomes, but effective strategies for modulating muscle activity remain unclear. High-velocity low-amplitude hip manipulation has shown potential to influence neuromuscular function, yet its impact on quadriceps activation during knee extension has not been well studied. …”
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Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy by Kangshou Ji, Kangshou Ji, Meizi Han, Mingqian Yang, Qian Xu, Yan Zhang, Yan Zhang

“…ZGCD not only significantly reduces blood pressure, but also enhances cardiac function while producing fewer adverse effects. The therapeutic effects of ZGCD on DCM can likely be ascribed to its capacity to modulate the AGEs-RAGE signaling pathway, as well as its efficacy in enhancing lipid metabolism and mitigating atherosclerosis.Systematic Review Registrationidentifier (INPLASY202430133).…”
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Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn by Ellen Donohoe, Aoife Canning, Eanna Johnston, Seyedmohammad Moosavizadeh, Jiemin Wang, Martin Leahy, Oliver Treacy, Aideen E. Ryan, Thomas Ritter

“…Mice that received subconjunctival, but not topical, administration of sEVTGFβ exhibited regulatory immune cell profiles with reduced pro-inflammatory- macrophages, increased anti-inflammatory macrophages, and restored Treg function and balance of the Treg/Th17 axis. Conclusions Overall, IFNγ and TGFβ licensing strategies were found to yield unique MSC-sEV phenotypes that can modulate inflammation differentially in vitro and in a corneal chemical burn model. …”
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Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies by Jinghuan Gan, Ziming Xu, Chen Wen, Hao Wu, Zhichao Chen, Zhihong Shi, Hao Lu, Yajie Wang, Shuai Liu, Yong Ji

“…Abstract Background Emerging evidence indicates that globus pallidus (GP) function can be modulated by orexin-A in movement disorders, while its role in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) remains unclear. …”
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Toxoplasma gondii ROP18 induces maternal–fetal dysfunction by downregulating CD73 expression on decidual macrophages by Jingjing Guo, Xiaohui Wang, Lei Wei, Shuai Li, Junwei Wang, Yan Zhang, Ruohan Yang, Han Zhang, Aiqun Xu, Yuzhu Jiang, Xuemei Hu

“…It has been demonstrated that Toxoplasma gondii (T. gondii) infection during pregnancy can impair dMφ function, potentially leading to adverse pregnancy outcomes, through downregulation of these inhibitory molecules. …”
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DL-Tryptophan Alleviates Sepsis-Related Acute Liver Injury via AhR Activation by Li B, Wang Q, Hu L, Duan W, Chen Y, Wang Z, Liu C, Liao L

“…Western blotting was utilized to verify AhR expression, and its function was subsequently investigated using the AhR inhibitor CH223191.Results: DL-tryptophan markedly reduced the expression of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) and liver damage markers (AST, ALT) in CLP-induced sepsis. …”
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Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial by Xuanjun Liu, Weixu Mao, Guowei Zhao, Juan Liao, Qigang Li, Gan He

“…The time to first defecation was significantly shorter in the test group (4.5 ± 1.8 vs. 5.9 ± 1.7 days, t = 3.132, p = 0.003).ConclusionPerioperative ONS combined with intestinal microbiota interventions improves postoperative nutritional status, modulates inflammatory dynamics, and accelerates intestinal function recovery. …”
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Breast milk: its components and special effects on newborns and infants by T. Voroncova, T. Konyk, M. Trokhymenko, Y. Mudryk

“…Colostrum, which is rich in immunoglobulins (including IgA), lactoferrin, leukocytes and epidermal growth factor, provides primary immune defence by stimulating tissue regeneration and intestinal barrier function. Transitional milk, which appears on days 4-14, increases the energy value due to increased lactose and fat content, promoting weight gain and microbiota development. …”
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Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Research in context by Alexandra Oliveira Carvas, Andrea Leuthardt, Patricia Kulka, Greta Lommi, Shad Hassan, Bernd Coester, Sofia Lundh, Tune Pers, Anna Secher, Kirsten Raun, Thomas A. Lutz, Christelle Le Foll

“…However, mRNA bulk sequencing points to a role of RAMP1/3 in synaptic function and receptor trafficking. Interpretation: Altogether, these results demonstrate the dependency of cagrilintide on AMY1R and AMY3R to lower body weight. …”
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Unraveling natural carbonate variability in Narragansett Bay, RI using multiple high temporal resolution pH time series by Abigail Baskind, Georgia Ahumada, Kristofer Gomes, Heather Stoffel, Shuai Gu, Andrew J Davies, Andrew J Davies, Hongjie Wang

“…The increase in atmospheric carbon dioxide (CO2) over the last 200 years has largely been mitigated by the ocean’s function as a carbon sink. However, this continuous absorption of CO2 by seawater triggers ocean acidification (OA), a process in which water becomes more acidic and more depleted in carbonate ions that are essential for calcifiers. …”
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NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS by Fan Z, Ge Q, Ni B, Zhang J, Du T, Xu H, Duan Z, Zhang S, Wang C, Xue J, Ling F, Chen Z, Shen B, Wei Z

“…In vivo modeling, WT and NRF2 gene knockout mice received intraperitoneal cyclophosphamide to induce cystitis. Bladder function was assessed via Void Spot Assays, and Urodynamic. …”
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Fermented strawberry pomace enhances carcass characteristics and meat quality by regulating plasma biochemical indices and antioxidant capacity in aged laying hens by Wei Lan, Wei Lan, Wei Lan, Ting Chen, Ting Chen, Binghua Qin, Binghua Qin, Md. Abul Kalam Azad, Md. Abul Kalam Azad, Zhihua Li, Yadong Cui, Yadong Cui, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…Ocular inflammation index and tear film function were evaluated by slim microscopy. Hematoxylin–eosin (HE) staining was used to observe conjunctival and corneal structure. …”
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Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity by Shuntaro Izawa, Debora Fusca, Hong Jiang, Christian Heilinger, A. Christine Hausen, F. Thomas Wunderlich, Lukas Steuernagel, Peter Kloppenburg, Jens C. Brüning

“…Here, we focused on Ox2R expression and function in melanin-concentrating hormone (MCH) neurons, which have opposite roles to orexin neurons in sleep and metabolism regulation. …”
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Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy by Mahrou Vahabi, Geng Xu, Dzjemma Sarkisjan, Btissame El Hassouni, Giulia Mantini, Valentina Donati, Bing Wang, Giulia Lencioni, Richard J. Honeywell, Dongmei Deng, Sabrina Strano, Godefridus J. Peters, Giovanni Blandino, Elisa Giovannetti

“…Conclusion By integrating CRISPR-Cas9 with functional assays and transcriptomics, our study established a framework for decoding resistance mechanisms and highlights potential therapeutic strategies to enhance RX-3117 efficacy in NSCLC. …”
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Genome-Wide Analysis of the <i>CDPK</i> Gene Family in <i>Populus tomentosa</i> and Their Expressions in Response to Arsenic Stress and Arbuscular Mycorrhizal Fungi Colonization by Minggui Gong, Jiajie Su, Shuaihui Wang, Youjia Wang, Weipeng Wang, Xuedong Chen, Qiaoming Zhang

“…However, there is still limited knowledge regarding the genes of the <i>Populus tomentosa CDPK</i> family and their underlying functions in response to arsenic (As) stress and arbuscular mycorrhizal fungi (AMF) colonization. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…In vivo experiments were conducted on a PF mouse model to observe cell morphology, collagen deposition, fibrosis localization, and to evaluate peritoneal functions such as filtration rate, urea nitrogen clearance, peritoneal thickness, and protein leakage. …”
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Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine‐Induced Cachexia by Luis Vincens Gand, Chiara Lanzuolo, Mugeng Li, Valentina Rosti, Natalie Weber, Dongchao Lu, Christian Bär, Thomas Thum, Andreas Pich, Theresia Kraft, Mamta Amrute‐Nayak, Arnab Nayak

“…Knowledge of the underlying cause of muscle mass loss and compromised muscle function is key for developing therapeutic solutions to ameliorate cachectic conditions.…”
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Prepronociceptin-Expressing Neurons in the Bed Nucleus of the Stria Terminalis Signal Escape Behavior by Maria M. Ortiz-Juza, Randall L. Ung, Sophia M. Hegel, Ayden L. Ring, Noah W. Miller, Ruben A. Garcia-Reyes, Hiroshi Nomura, Hiroyuki K. Kato, Nicolas C. Pégard, Jose Rodriguez-Romaguera

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