Expression of carboxylesterase and paraoxonase in the placenta and their association with chlorpyrifos exposure during pregnancy by Piuque M. Rodriguez, Berta Vera, Carolina Burgos, Gustavo Gimenez, Karina S.B. Miglioranza, Cristina L. Ramirez, Andrea Lavalle, Paola M. Ondarza, Natalia L. Guiñazú

“…These findings highlight the need for further investigation into the effects of pesticide exposure during pregnancy and to deepen the knowledge about the function that esterases play in the placenta.…”
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Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis by Zizhen Zhang, Shengde Liu, Ting Xu, Nan Chen, Cheng Liu, Hong Yang, Yuanmeng Shi, Zhiwei Li, Xujiao Feng, Yanhong Yao, Xiaorui Duan, Gehan Xu, Cheng Zhang, Zhenghang Wang, Jian Li, Lin Shen

“…Additionally, we conducted assays for cell migration, invasion, angiogenesis, and ELISA to evaluate VEGFA production, all to confirm the functional role of SLC9A2. Our findings were further validated in human CRC tissue samples and publicly available datasets to assess the clinical relevance of the identified targets. …”
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CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
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Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…Clustering analyses based on the methylation levels of probes and expression levels of the stringently filtered 212- and 37-gene sets further confirmed these two distinct ACP subgroups. Functional enrichment analysis highlighted key roles in synaptic modulation, nervous system development, cell adhesion, as well as pathways linked to RAS signaling, GTPase activity, and membrane potential regulation.ConclusionAlthough clinical characteristics were largely comparable between the clusters, ACP-B patients exhibited shorter median progression-free survival, suggesting a more aggressive phenotype. …”
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A Ralstonia solanacearum effector regulates plant cell death by disrupting the homeostasis of the BPA1-ACD11 complex by Bingbing Xue, Yan Zhou, Yongxiao Xie, Xiaocheng Huang, Jinye Zhang, Yang Zhang, Wenyan Zhong, Jinjia Zhao, Dehong Zheng, Lifang Ruan

“…Our study reveals a novel mechanism by which an effector inhibits ETI and, for the first time, highlights the critical role of protein abundance in its function.IMPORTANCER. solanacearum infects major economic crops, notably tomato, potato, and tobacco, leading to substantial yield reductions and economic losses. …”
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Directional hand movement can be classified from insular cortex SEEG signals using recurrent neural networks and high-gamma band features by Xiecheng Shao, Ryan S. Chung, Jonathon M. Cavaleri, Roberto Martin Del Campo-Vera, Miguel Parra, Shivani Sundaram, Selena Zhang, Ashwitha Surabhi, Ryan J. McGinn, Charles Y. Liu, Spencer S. Kellis, Brian Lee

“…Abstract Motor BCIs, with the help of Artificial Intelligence (AI) and machine learning, have shown promise in decoding neural signals for restoring motor function. Structures beyond motor cortex have provided additional sources for movement signals. …”
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Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma by Xiaoxuan Tang, Shanxing Dang, Jie Qiu, Ruilan Zhou, Jing Ling, Limei Zhang, Xiaopeng Peng, Qingyun Li, Jin Liu, Wei Liao, Qingxiu Mei, Miao Xie, Yehong Sun, Jianmei Huang, Xuelian Du, Wencong Song

“…Additional analyses included functional enrichment, tumor mutational burden, tumor microenvironment (TME) estimates via ESTIMATE, and immune infiltration assessment to clarify CDH18’s potential mechanisms in UCEC. …”
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Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Conclusions Our findings offer a potential therapeutic strategy to maintain a dynamic balance within the TME and improve the immunotherapy efficacy by modulating the relative proportions and functional states of CXCL9 + TAMs and TREM2 + TAMs.…”
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Co-Highly Expressed SLC17A9 and KCNH1 as Potential Prognostic Biomarkers and Therapeutic Targets in Clear Cell Renal Cell Carcinoma by Zongpan Ke, Zhiwang Tang, Deyun Shen, Yixun Liu, Yawei Shu, Xiangyu Mu, Zexuan Li, Ping Xiang, Bing Zhong, Xuechun Hu, Ruoyun Tan, Jun Xiao

“…Leveraging The Cancer Genome Atlas (TCGA) database, we predicted the clinical relevance of these cancer-associated genes and validated their expression profiles through multiple experimental methodologies. Functional assays were conducted to assess the impact of these genes on renal cancer cell lines. …”
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Securing Electric Vehicle Performance: Machine Learning-Driven Fault Detection and Classification by Mahbub Ul Islam Khan, Md. Ilius Hasan Pathan, Mohammad Mominur Rahman, Md. Maidul Islam, Mohammed Arfat Raihan Chowdhury, Md. Shamim Anower, Md. Masud Rana, Md. Shafiul Alam, Mahmudul Hasan, Md. Shohanur Islam Sobuj, Md. Babul Islam, Veerpratap Meena, Francesco Benedetto

“…Electric vehicles (EVs) are commonly recognized as environmentally friendly modes of transportation. They function by converting electrical energy into mechanical energy using different types of motors, which aligns with the sustainable principles embraced by smart cities. …”
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Depth-Guided Monocular Object Pose Estimation for Warehouse Automation by Phan Xuan Tan, Dinh-Cuong Hoang, Anh-Nhat Nguyen, Eiji Kamioka, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Duc-Huy Ngo, Minh-Duc Cao, Thu-Uyen Nguyen, Van-Thiep Nguyen, Duc-Thanh Tran, Van-Hiep Duong, Anh-Truong Mai, Duc-Long Pham, Khanh-Toan Phan, Minh-Quang Do

“…However, RGBD-based methods require specialized depth sensors, which can be costly and may not function reliably in warehouse environments with reflective surfaces, varying lighting conditions, or sensor occlusions. …”
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Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease by Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen

“…Our transcriptomic analysis identified 1249 significantly differentially expressed genes, highlighting a pronounced upregulation of inflammatory genes (SERPINA3, IL6R, IL1RAP, TNFRSF11A) and a concomitant downregulation of genes essential for synaptic support and ion channel function (STMN2, NMNAT2, SCN2A, GRIN1). Kinomic profiling revealed dysregulated kinase activities within DYRK, GSK, and MAPK families, further implicating altered kinase signaling pathways in astrocyte dysfunction. …”
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The interplay between nutrigenomics and low-carbohydrate ketogenic diets in personalized healthcare by Yousef M. Almoghrabi, Yousef M. Almoghrabi, Basmah M. Eldakhakhny, Basmah M. Eldakhakhny, Abdulhadi I. Bima, Abdulhadi I. Bima, Hussein Sakr, Hussein Sakr, Ghada M. A. Ajabnoor, Ghada M. A. Ajabnoor, Hoda M. Gad, Hoda M. Gad, Hoda M. Gad, Fatma Azzahraa H. Mohammad, Salma A. Elsamanoudy, Akram Z. Awan, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy

“…The field of nutrigenomics explores the interaction between diet and gene expression, examining how nutrients function as signaling molecules that influence cellular processes, protein synthesis, and metabolite production. …”
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The protective role of adipogenic lineage precursors in maintaining bone marrow redox homeostasis in a mouse model of prenatal dexamethasone exposure by Jianwen Su, Sushuang Ma, Mankai Yang, Jichang Wu, Yijie Chen, Mingchao Jin, Qin Shi, Xianrong Zhang

“…Collectively, these findings uncover a previously unrecognized function of Adipoq+ cells in regulating redox homeostasis within the bone marrow microenvironment during the early stages of long bone development.…”
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The m6A modification regulates the composition of myofiber types in chicken skeletal muscle by Yanju Shan, Yifan Liu, Ming Zhang, Lichuan Pang, Gaige Ji, Xiaojun Ju, Yunjie Tu, Jingting Shu

“…As a widespread epigenetic RNA modification, N6-methyladenosine (m6A) plays essential regulatory roles in multiple biological processes. However, its function in maintaining and modulating myofiber-type properties remains largely unknown. …”
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Effect of Bifidobacterium longum subsp. infantis YLGB-1496 on common diseases in pediatrics: a randomized, blinded, placebo-controlled trial by Xi Zhang, Ke Chen, Hanglian Lan, Haixia Chen, Hua Chen, Ping Yang, Nianyang He, Weilian Hung, Zaozhong Zeng, Changqi Liu

“…It also decreased the morbidity of URTIs, bronchopneumonia, and eczema, while beneficially modulating gut microbiome composition and immune function without any adverse effects.Clinical trial registrationhttps://www.isrctn.com/ISRCTN12824613, identifier: ISRCTN12824613.…”
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Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency by Mei Qi-Xiang, Fu Yang, Huang Ze-Hua, Yin Nuo-Ming, Wang Rui-Long, Xu Bin-Qiang, Fan Jun-Jie, Huang Chun-Lan, Zeng Yue

“…Pancreatic injury and intestinal barrier function were evaluated in wild-type and intestinal epithelial TLR4 knockout (TLR4ΔIEC) mice. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…SLC7A1 also regulate interactions between tumor cells and macrophages, as well as modulate macrophage function through multiple pathways. …”
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FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma by Xuejuan Gao, Donglan Huang, Ying Liu, Gui Zhang, Xiaofen Zheng, Baiye Guan, Aiwen Chen, Jiayao Wu, Shi-Ming Luo, Zonghua Liu, Luxuan Chen, Xiaohui Liu, Jingjie Jin, Xingfeng Yin, Zhenghua Sun, Yunfang Zhang, Meizhi Lu, Gong Zhang, Wanting Liu, Langxia Liu

“…Furthermore, TOM70 (Translocase of outer mitochondrial membrane 70, also named as TOMM70) has been identified as a functional interacting partner of FAM210B in its modulation on the expression of IFN-α/β, as well as the proliferative and metastatic phenotypes of LUAD cells. …”
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The Impact of a 10-Month Synbiotic Intake on eGFR, Uremic Toxins, Oxidative Stress, and Inflammatory Markers in Non-Dialysis Chronic Kidney Disease Patients: A Prospective, Non-Ran... by Teodor Kuskunov, Eduard Tilkiyan, Irina Zdravkova, Siyana Valova, Krasimir Boyanov, Anelia Bivolarska

“…However, no significant effects were observed on renal function, inflammatory, or oxidative stress markers. …”
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