Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility by Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan

“…The mechanosensory Piezo2 has been implicated in the regulation of intestinal function. However, it remains unclear whether Piezo2 is modulated by the gut microbiota, thus contributing to the development of visceral hypersensitivity and gut dysmotility. …”
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Dietary chlorogenic acid supplementation to alleviate intestinal damage in juvenile American eel (Anguilla rostrata) under histamine stress by Guo-He Cai, Zi-Yan Hu, Yi-Tong Guo, Zhi-Xue Guo, Yun-Zhang Sun, Shao-Wei Zhai

“…These findings suggest that 200 mg/kg CGA can mitigate the negative effects of high histamine in fishmeal on eel growth, intestinal health and Immune function, could be used as an additive in red fishmeal to reduce aquaculture costs.…”
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Status and trends in transcranial magnetic stimulation research: a bibliometric analysis by Qi Deng, Fei Xing, Dan Li, Dan Li, Maomao Huang, Maomao Huang, Zhangyu Xv, Yue Yang, Lei Li, Jiayi Zhu, Rongnan Shi, Guoya Meng, Qin Wang, Jianxiong Wang, Jianxiong Wang, Jianxiong Wang

“…BackgroundTranscranial magnetic stimulation (TMS), as a rapidly advancing non-invasive brain stimulation technique, has demonstrated reliable therapeutic efficacy and significant potential in brain function assessment and research. However, comprehensive bibliometric analyses of the overall TMS field remain limited. …”
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THE "LARGE BARYON PUMP OF THE EARTH" AS A NATURAL IMAGE OF THE "TREE OF LIFE" AND AN OBJECT OF ENVIRONMENTAL LAW, WHICH IS INTEGRATED WITH THE NATURAL ENVIRONMENT OF MAN by Mykhaylo O. Baymuratov, Volodymyr P. Ozhereliev

“…In turn, the need to study the functions of the Earth's natural resources in the environmental discourse and its qualification as an object of law is a natural stage in the development of the system of ecological, noospheric law, and in the future - anthropic law as a metasystem of the natural law of our universe. …”
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Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination by Yanqin Bian, Fang Li, Xinyu A, Zheng Xiang, Nanshan Ma, Jianye Wang, Boran Cao, Pengfei Xin, Xuan Cheng, Chang Liu, Bei Xiang, Jun Shen, Qigui Lu, Lianbo Xiao

“…This study aims to investigate the functional interplay between JBQG and the lncRNA ITSN1-2/NOD2/RIP2 axis in regulating FLS behavior during RA development. …”
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Gamma Transcranial Alternating Current Stimulation Enhances Working Memory Ability in Healthy People: An EEG Microstate Study by Binbin Gao, Jinyan Zhang, Jianxu Zhang, Guangying Pei, Tiantian Liu, Li Wang, Shintaro Funahashi, Jinglong Wu, Zhilin Zhang, Jian Zhang

“…Background:Working memory (WM) is a core cognitive function closely linked to various cognitive processes including language, decision making, and reasoning. …”
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Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.) by Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu

“…At the molecular level, RT-qPCR analysis demonstrated that Zhicaowu significantly suppressed hepatic CYP1a2, CYP2d2, CYP3a1, and CYP2c11 mRNA expression, while Hezi co-treatment restored their expression to normal or elevated levels.ConclusionHezi dose-dependently induced CYP450 enzyme activity, reversing Zhicaowu’s inhibition of CYP1a2/2d2/3a1/2c11 and markedly improving liver function and histopathology. These results elucidate the scientific basis for toxicity reduction in Zhicaowu-Hezi herb pair through metabolic enzyme regulation, supporting its traditional use. …”
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Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis by Xinyi Li, Xinyang Liu, Jianing Zhou, Ping Zhang, Song Chen, Ding Bai

“…More importantly, mechanistic studies demonstrated that miR-140-3p mediated the function of Force-Exos by targeting DNA methyltransferase 1 (DNMT1) to alter the DNA methylation of suppressor of cytokine signaling (SOCS1) and the downstream nuclear factor κB (NF-κB) signaling pathway in PDLCs. …”
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Integrative multi-omics analysis reveals the interaction mechanisms between gut microbiota metabolites and ferroptosis in rheumatoid arthritis by Lifang Liang, Lifang Liang, Lifang Liang, Huaguo Liang, Min He, Min He, Min He, Huiling Zhang, Huiling Zhang, Huiling Zhang, Peifeng Ke, Peifeng Ke, Peifeng Ke

“…Results showed good stability of the complex across indicators such as RMSD, RMSF, SASA, and radius of gyration, suggesting that Diosgenin may intervene in ferroptosis and inflammatory injury in RA by binding to and modulating GPX3 function.ConclusionThis study elucidated the multifaceted mechanisms of GPX3 and MYC in RA pathogenesis and preliminarily validated the potential role of gut metabolites in mediating ferroptosis regulation, offering novel theoretical foundations and potential strategies for diagnostic biomarker screening and targeted therapy in RA.…”
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Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression by Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin, Xiaodong Fu

“…Dual-luciferase reporter assays highlighted cAMP-response element binding protein (CREB)’s essential function in facilitating the FSH-induced upregulation of ALKBH5. …”
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Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis by Yidi Jia, Luoming Zhang, Wei Zhou, Shuhua Chen, He Zhang, Liming Liu, Hui Guo, Zhiyong Wang, Yanfen Cui, Ruifang Niu, Fei Zhang

“…Conclusion This study thus unveils a novel mechanism through which Rack1 executes its oncogenic function. This study also demonstrates that targeting the Rack1-E2F-SOX2 axis may be a potential strategy to inhibit breast cancer development and progression.…”
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A Phase II Study of Denileukin Diftitox in Patients with Advanced Treatment Refractory Breast Cancer by William R. Gwin, Lupe G. Salazar, James Y. Dai, Doreen Higgins, Andrew L. Coveler, Jennifer S. Childs, Rosie Blancas, Yushe Dang, Jessica Reichow, Meredith Slota, Hailing Lu, Mary L. Disis

“…<b>Background/Objectives</b>: Regulatory T cells (Treg) suppress immunity in the tumor microenvironment, are linked to poor prognosis across breast cancer subtypes, and suppress the cytolytic function of cytotoxic CD8+ T cells. Denileukin diftitox, a diphtheria toxin (DT)/IL-2 fusion protein, targets and depletes Tregs. …”
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Enhanced Mitochondrial Dynamics and Reactive Oxygen Species Levels with Reduced Antioxidant Defenses in Human Epicardial Adipose Tissue by Ana Burgeiro, Diana Santos, Ana Catarina R. G. Fonseca, Inês Baldeiras, Ermelindo C. Leal, João Moura, João Costa-Nunes, Patrícia Monteiro Seraphim, Aryane Oliveira, António Canotilho, Gonçalo Coutinho, David Prieto, Pedro Antunes, Manuel Antunes, Eugenia Carvalho

“…<b>Background/Objectives</b>: Epicardial adipose tissue (EAT) is metabolically active and is in dynamic crosstalk with the surrounding cardiomyocytes, modulating their function and metabolism. Oxidative stress is a key contributor to cell death and cardiac remodeling, is a hallmark of diabetes (DM) and cardiovascular disease, such as coronary artery disease (CAD). …”
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Defective Olfactomedin-2 connects adipocyte dysfunction to obesity by Aina Lluch, Jèssica Latorre, Isabel Espadas, Núria Oliveras-Cañellas, José M. Moreno-Navarrete, Estefanía Caballano-Infantes, Gitalee Sarker, Nicolás F. Malvido, Pablo Garrido-Gil, José L. Labandeira-García, Naoki Nakaya, Silvia Mora, Eduardo Chicano, Jaime López-Alcalá, María M. Malagón, Alejandro Martín-Montalvo, Birong Zhang, You Zhou, Ana I. Domingos, Miguel López, Johanna Pörschke, María Gómez-Serrano, Witold Szymanski, Johannes Graumann, Stanislav I. Tomarev, Ismael González-García, José M. Fernández-Real, Francisco J. Ortega

“…Loss and gain of function experiments revealed that OLFM2 modulates key metabolic and structural pathways, including PPAR signaling, citrate cycle, fatty acid degradation, axon guidance and focal adhesion in 3T3 cell lines and primary human adipocytes. …”
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Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling by Mengran Qin, Jiahao Zhu, Lipeng Xing, Yaotian Fan, Junyi Luo, Jiajie Sun, Ting Chen, Yongliang Zhang, Qianyun Xi

“…Significantly, miR-146a-5p serves a crucial function as a microRNA in the communication of the fat-muscle connection. …”
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Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis by Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo

“…Strikingly, targeting of this axis with the AP‐1 inhibitor T‐5224 effectively improves survival and enhances cardiac function in Dox‐induced cardiomyopathy. This study provides mechanistic insights into energy reprogramming that permits myocardial dysfunction, and thus provides a proof of concept for antienergy reprogramming therapy for Dox‐induced cardiomyopathy through directly modulating G6P–AP‐1–Sln axis.…”
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Kidney microbiota dysbiosis contributes to the development of hypertension by Xin-Yu Liu, Jing Li, Yamei Zhang, Luyun Fan, Yanli Xia, Yongyang Wu, Junru Chen, Xinyu Zhao, Qiannan Gao, Bing Xu, Chunlai Nie, Zhengyu Li, Aiping Tong, Wenjie Wang, Jun Cai

“…Renal bacterial taxa and their function are associated with hypertension. Hypertensive hosts showed increased richness in the pathobionts of their kidneys, which were partly derived from the gastrointestinal tract. …”
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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…A trial of Elexacaftor/Tezacaftor/Ivacaftor (ETI) led to significant clinical improvement and enhanced pulmonary function. In vitro testing using patient-derived intestinal organoids was performed in parallel and also demonstrated a significant response to ETI. …”
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Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential by Antonio José Cabrera-Serrano, José Manuel Sánchez-Maldonado, Carmen González-Olmedo, María Carretero-Fernández, Leticia Díaz-Beltrán, Juan Francisco Gutiérrez-Bautista, Francisco José García-Verdejo, Fernando Gálvez-Montosa, José Antonio López-López, Paloma García-Martín, Eva María Pérez, Pedro Sánchez-Rovira, Fernando Jesús Reyes-Zurita, Juan Sainz

“…While autophagy can function as a tumor suppressor in early cancer stages, it often shifts to a pro-tumorigenic role in advanced disease, aiding cancer cell survival under adverse conditions such as hypoxia and nutrient deprivation. …”
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Multi-omics analysis of gestational PM2.5 exposure induces abnormal cardiac metabolism and development in offspring by Li Tian, Qinglin Sun, Jianong Lv, Shiqian Liu, Kexin Zhang, Yang Li, Zhiwei Sun, Lili Cao, Junchao Duan

“…Transcriptomic and proteomic analyses showed that differentially expressed genes and proteins were primarily enriched in pathways related to mitochondrial function, cardiac development, and ATP metabolism. …”
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