Secondary metabolites as biostimulants in salt stressed plants: mechanisms of oxidative defense and signal transduction by Muhammad Ikram, Burhan Khalid, Maria Batool, Maaz Ullah, Jiang Zitong, Abdul Rauf, Muhammad Junaid Rao, Haseeb Ur Rehman, Jie Kuai, Zhenghua Xu, Jie Zhao, Jing Wang, Guangsheng Zhou, Bo Wang

“…To counteract these detrimental effects, plants have evolved sophisticated defense mechanisms, one of which involves the production of secondary metabolites (SMs). These SMs function as biostimulants that bolster antioxidative defenses and modulate signal transduction pathways, thus enhancing the plant's tolerance to salt stress. …”
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Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury by Jiangpeng Pan, Juntao Wang, Wei Wang, Ziyang Liu, Shuai Huo, Lei Yan, Wei Jiang, Fengmin Shao, Yue Gu

“…This dual-enzyme mimicry effectively alleviates mitochondrial oxidative damage, restores mitochondrial function, and inhibits apoptosis. Compared to RuCDzyme alone, TPP@RuCDzyme demonstrated significantly enhanced efficacy in alleviating glycerol-induced AKI by inhibiting oxidative stress. …”
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DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46 by Maria Sabina Cerullo, Caterina Canevari, Antonella Marte, Alexandre Bacq, Antonio De Fusco, Marina Maletic, Stéphanie Baulac, Fabio Benfenati

“…DEP-domain containing-5 (DEPDC5) is part of the GATOR1 complex that inhibits the mechanistic target of rapamycin complex-1 (mTORC1). Loss-of-function mutations in human DEPDC5 are the most common cause of lesional or non-lesional focal epilepsies associated with mTOR hyperactivation. …”
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Peptide‐Drug Conjugate for Therapeutic Reprogramming of Tumor‐Associated Macrophages in Breast Cancer by Anni Lepland, Elisa Peranzoni, Uku Haljasorg, Eliana K. Asciutto, Maria Crespí‐Amer, Lorenzo Modesti, Kalle Kilk, Manuel Lombardia, Gerardo Acosta, Miriam Royo, Pärt Peterson, Ilaria Marigo, Tambet Teesalu, Pablo Scodeller

“…MACTIDE‐V is proposed as a promising peptide‐drug conjugate for modulating macrophage function in breast cancer immunotherapy.…”
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YOLOv8-Scm: an improved model for citrus fruit sunburn identification and classification in complex natural scenes by Guoxun Cong, Guoxun Cong, Xinghong Chen, Xinghong Chen, Zongyu Bing, Zongyu Bing, Wenhuan Liu, Wenhuan Liu, Xiangling Chen, Qun Wu, Zheng Guo, Zheng Guo, Yongqiang Zheng, Yongqiang Zheng

“…Three key enhancements are introduced: (1) DSConv module replaces the standard convolution for a more efficient and lightweight design, (2) Global Attention Mechanism (GAM) improves feature extraction for multi-scale and occluded targets, and (3) EIoU loss function enhances detection precision and generalization. …”
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Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice by Henry A. Paz, Henry A. Paz, C. G. Shashank, C. G. Shashank, Lasya Buddha, Tian Lam, Taylor Zhang, Ying Zhong, James D. Sikes, Craig Porter, Reid D. Landes, Roy Morello, Umesh D. Wankhade, Umesh D. Wankhade

“…Proteomic analysis of iWAT identified 38 differentially expressed proteins, with enrichment of pathways related to mitochondrial function and mTOR signaling.DiscussionShort-term cold exposure induced lasting histological and proteomic changes in iWAT and BAT without sustained effects on energy metabolism, likely due to reversion to RT and limited sample size.ConclusionBrief temperature manipulation around pregnancy can durably alter maternal adipose tissue architecture and molecular signatures, underscoring ambient temperature as an important modulator of maternal metabolic adaptation.…”
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Urinary exosomal lnc-TAF12–2:1 promotes bladder cancer progression through the miR-7847–3p/ASB12 regulatory axis by Song Chen, Jie Cheng, Shuangtai Liu, Danni Shan, Ting Wang, Xinghuan Wang

“…In this study, we identified exosomal lnc-TAF12–2:1 as a novel biomarker in BCa diagnosis and aimed to investigate the underlying biological function. Dual luciferase reporter assay, RNA immunoprecipitation (RIP), RNA pulldown assays, and xenograft mouse model were used to verify the competitive endogenous RNA mechanism of lnc-TAF12–2:1. …”
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Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes by Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren

“…Overall, skatole maintains immune microenvironment homeostasis by modulating macrophage polarization in joints and preserves cartilage function by balancing chondrocyte anabolism and catabolism, effectively alleviating OA. …”
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OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression by Jinglian Chen, Chengqing Huang, Jiale Mei, Qiuhua Lin, Wenbo Chen, Jiali Tang, Xinjie Wei, Caixia Mo, Yueyan Zhang, Qi Zeng, Xianwei Mo, Weizhong Tang, Tao Luo

“…This investigation concentrates on the deubiquitinase OTUD4, scrutinizing its functional and molecular implications in ferroptosis within tumor cells. …”
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HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer’s disease by Xiaoqin Zhang, Yiping Zhang, Ting Zhang, Jing Wang, Chang Liu, Qing Shang, Xiaojie Wei, Huaqiang Zhu, Haowei Shen, Binggui Sun

“…AAVs were injected to specifically modulate the expression of HCN2 in dorsal CA1 (dCA1) PNs. …”
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Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation by Yu Feng, Qian Zhao, Yifan Zhao, Chen Ma, Meiling Tian, Xiaosong Hu, Fang Chen, Daotong Li

“…Fecal microbiota transplantation was conducted by administering microbiota from donor group to recipient group via oral gavage to investigate the role of intestinal microbiota in immune modulation. Results BL ameliorated the severity of C. rodentium-induced colitis, and this effect was linked to improved gut homeostasis and enhanced mucosal barrier function. …”
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Effects of dietary supplementation with bile acids on growth performance, antioxidant capacity, lipid metabolism, and cecal microbiota of Danzhou chickens by Xilong Yu, Ting Cao, Euphrème Ipemba, Ghislain Boungou Bakala, Lessebe Gambou Dieu Leveut, Weiqi Peng, Fengjie Ji, Hanfeng Li, Liangmei Xu, Hongzhi Wu

“…In conclusion, the results suggest that dietary supplementation with 400 mg/kg of bile acids enhances antioxidant capacity and immune function in Danzhou chickens, potentially improving serum and hepatic lipid metabolism by modulating the cecal microbiota, thereby promoting growth performance.…”
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The autonomic response following taVNS predicts changes in level of consciousness in DoC patients by Yan Li, Francesco Riganello, Jing Yu, Martina Vatrano, Mingquan Shen, Lijuan Cheng, Xiaohua Hu, Chengcheng Ni, Feiyang Wang, Bo Zheng, ChengCheng Zhang, Chaoyi Xie, Meiqi Li, Wangshan Huang, Fangfang Shou, Nantu Hu, Steven Laureys, Haibo Di

“…Subsequent investigations utilized Support Vector Machine (SVM) modeling, enhanced by a Radial Basis Function (RBF) kernel, to explore potential predictors of patient outcomes. …”
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Advances in stem cell-based therapeutics for acute high-altitude illness: research progress and prospects by Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Dan Chen, Dan Chen, Dan Chen, Cheng-Wei Yang, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Hao Yao

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Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation by Dong Zheng, Bingxin Zhang, Quanqiang Wang, Sisi Zheng, Yibo Xia, Ziwei Zheng, Zhili Lin, Shuxia Zhu, Xinyi Zhang, Luning Cui, Hansen Ying, Tianyu Zhang, Shujuan Zhou, Zixing Chen, Enqing Lan, Yu Zhang, Xuanru Lin, Jingjing Chen, Honglan Qian, Xudong Hu, Yan Zhuang, Zuoting Xie, Xiangjing Zhou, Zhouxiang Jin, Songfu Jiang, Yongyong Ma

“…Tumor-derived exosomes (TDEs) play key roles in modulating the tumor microenvironment, angiogenesis and immune system. …”
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Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR P... by Lipeng Wu, Long Lin, Meng Yu, Huajian Li, Yuanye Dang, Huosheng Liang, Guangyang Chen, Halimulati Muhetaer, Guodong Zheng, Jingjing Li, Xuejing Jia, Bo Wu, Chuwen Li

“…RNA sequencing and functional enrichment analyses were conducted to explore differentially expressed genes (DEGs) and potentially related pathways. …”
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Effects of Dietary Inclusion of <i>Saccharina latissima</i> and <i>Ulva lactuca</i> on Growth Performance and Gut Health in Growing Rabbits by Sabela Al-Soufi, Ana Paula Losada, Marta López-Alonso, Alejandra Cardelle-Cobas, Azucena Mora, Alexandre Lamas, Rosario Panadero, Marta Miranda, Antonio Muíños, Eugenio Cegarra, Javier García

“…<i>S. latissima</i> had a positive effect in reducing coccidia counts (<i>p</i> = 0.10) and improving mucosal morphology (<i>p</i> < 0.001), which can possibly be attributed to modulation of the microbiota and improved mucosal functionality. …”
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Synergistic protective effects of TCM formula NRICM102 and N-acetylcysteine against hepatorenal injury in a mouse model of bongkrekic acid poisoning by Yuh-Chiang Shen, Yuh-Chiang Shen, Yea-Hwey Wang, Kuo-Tong Liou, Kuo-Tong Liou, Kuo-Tong Liou, Wen-Chi Wei, Jing-Jy Cheng, Hui-Kang Liu, Nai-Kuei Huang, I-Wen Lo, Cher-Chia Chang, Cher-Chia Chang, Wen-Fei Chiou, Keng-Chang Tsai, Keng-Chang Tsai, Chun-Tang Chiou, Chia-Ching Liaw, Chia-Ching Liaw, Chia-Ching Liaw, Chia-Ching Liaw, Yi-Chang Su

“…RNA-seq analyses suggested that the NRICM102-NAC combination synergistically modulated critical pathways, including mitochondrial function, cytochrome P450 enzyme activity, oxidative stress, immune responses, and cell death regulation. …”
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Discovery of differentially expressed lncRNAs in porcine ovaries with smaller and bigger litter size by Saixing Duan, Falei Li, Libing Meng, Shimei Cheng, Huangqi Shi, Yingjie Qu, Chaoyue He, Shengyu Gao, Jian Li, Shiduo Sun, Yong Liu, Gaoxiao Xu, Gaoxiao Xu

“…However, these molecular regulation mechanisms affecting sow litter size are still unclear.MethodsRegarding the non-coding molecular regulatory mechanisms in ovarian function with smaller and larger litter size (SLS and LLS), we investigated the expression profile of lncRNA in pig SLS and LLS samples. …”
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Interferon-stimulated circHOMER1 attenuates antiviral innate immunity by Ao Zhang, Ranran Yao, Shijin Geng, Haiying Wang, Rong-Chun Tang, Hengxiang Yu, Rui Xu, Hong-Yan Chen, Yunxuan Zhou, Lan Zhang, Jun Zhang

“…Its functions in the immune system are not discovered. …”
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