Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer by Wei Jin, Yuchang Lu, Jingen Lu, Zhenyi Wang, Yixin Yan, Biao Liang, Shiwei Qian, Jiachun Ni, Yiheng Yang, Shuo Huang, Changpeng Han, Haojie Yang

“…These CAFs were primarily related to seven pathways, including peroxisome function, B cell receptor signal, and cell adhesion molecule. …”
Get full text

Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis by Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen, Ying Zheng, Bo Zheng, Fei Sun

“…Abstract Background Testicular aging has profound effects on spermatogenesis, sperm function, and the spermatogenic microenvironment, contributing to reduced male fertility. …”
Get full text

The feedback driven atomic scale Josephson microscope by Samuel D. Escribano, Víctor Barrena, David Perconte, Jose Antonio Moreno, Marta Fernández Lomana, Miguel Águeda, Edwin Herrera, Beilun Wu, Jose Gabriel Rodrigo, Elsa Prada, Isabel Guillamón, Alfredo Levy Yeyati, Hermann Suderow

“…By tracing the periodic oscillations in the new bistable regime as a function of the position in a Scanning Tunneling Microscope, we obtain atomic scale maps of the critical current in 2H-NbSe2 and find spatial modulations due to a pair density wave. …”
Get full text

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells by Jiayu Yu, Nannan Zhao, Yuying Wang, Nan Ding, Zhenchang Guo, Zichan He, Qingye Zhang, Jingai Zhang, Xiaoqiong Yang, Ming Zhang, Xiaoling Du, Kai Zhang, Lingyi Chen

“…In summary, our study identified 66 MEK substrates supporting the extracellular signal-regulated kinase (ERK)-independent function of MEK and revealed that DCP1A, phosphorylated by MEK, regulates ESC self-renewal and differentiation through modulating P body formation.…”
Get full text

Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis by Jan Zlamal, Vera M. Ripoll, Christine S.M. Lee, Filip Toma, Karina Althaus, Flavianna Rigoni, Andreas Witzemann, Shane Whittaker, David Capraro, Günalp Uzun, Tamam Bakchoul, Vivien M. Chen

“…Most importantly, the specific inhibition of SYK in platelets but not in neutrophils prevented VITT antibody–induced multicellular thrombus formation, without perturbing the platelet function. Our findings indicate that the specific targeting of platelet SYK might be a promising therapeutic approach to prevent thrombotic complications in patients with antibody-mediated immunothrombosis.…”
Get full text

Identification of predictors for bacterial meningitis diagnosis based on transcriptomics and genetic analysis by Hexiang Jiang, Xibing Yu, Jingyan Fan, Houhui Song, Yang Yang

“…NKT cells appeared to play a protective role, with FYN potentially modulating T-cell receptor function in these cells, thereby reducing BM risk. …”
Get full text

The interplay of cellular senescence and reprogramming shapes the biological landscape of aging and cancer revealing novel therapeutic avenues by Fuan Ding, Ying Yu, Jiangqi Zhao, Shibo Wei, Yan Zhang, Jung Ho Han, Zhuo Li, Hong-Bo Jiang, Dongryeol Ryu, Minkyoung Cho, Sung-Jin Bae, Wonyoung Park, Wonyoung Park, Ki-Tae Ha, Ki-Tae Ha, Bo Gao

“…In aging tissues, transient (partial) reprogramming has been shown to erase senescence markers and restore cell function without inducing tumorigenesis, underlining a novel strategy to combat age-related degeneration. …”
Get full text

USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2 by Runjing Li, Feng Gao, Yunan Chen, Jiamin Zhao, Rui Shi, Man Li, Zhenzi Zuo, Pan Chang, Dema De, Lin Chen, Feng Fu, Mingge Ding

“…His-679 in the UCH domain of USP10 exerted deubiquitination to maintain the stability of the Mfn2 by removing the K11/K48 ubiquitin chain and preventing proteasomal pathway degradation, thereby maintaining mitochondrial function and homeostasis. Knockdown or knockout of Mfn2 largely eliminated the cardioprotection of USP10. …”
Get full text

The Gluten-free diet and oncological prevention – the importance of a conscious lifestyle for physically active people – A Literature Review by Julia Wątor, Alicja Podolska, Patrycja Kolano, Jerzy Krzeszowiak, Barbara Chojnacka, Tomasz Pulanecki, Barbara Boba, Sylwia Bryksy, Aleksandra Ożga, Agnieszka Woźniacka

“…Importantly, regular physical activity offers added protection by reducing inflammation and improving immune function. …”
Get full text

DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples by Sara Pischedda, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Sandra Viz-Lasheras, Alba Camino-Mera, Xabier Bello, María José Curras-Tuala, Irene Rivero-Calle, Ana I. Dacosta-Urbieta, Federico Martinón-Torres, Antonio Salas, GENDRES Consortium

“…A weighted correlation network analysis emphasized the pivotal role of a module with RAB11FIP5 as the hub gene, known for its critical function in regulating viral infections. …”
Get full text

Overview of pharmacodynamical research of traditional Chinese medicine on hyperuricemic nephropathy: from the perspective of dual-regulatory effect on the intestines and kidneys by Ting Wang, Ting Wang, Li Li, Li Liu, Ruirong Tan, Qinxuan Wu, Xin Zhu, Hua Hua, Ying Dai, Huan Li, Jiuzhou Mao, Junning Zhao, Junning Zhao, Zhujun Yin, Zhujun Yin

“…Meanwhile, the recent advancements in TCMs for the treatment of HN are summarized and analyzed, with a focus on their modulation of intestinal flora and metabolites, urate-related transporters, immuno-inflammation and barrier function in the intestines. …”
Get full text

Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing by Bicong Gao, Haifeng Ni, Junhong Lai, Ning Gao, Xinxin Luo, Ying Wang, Yani Chen, Jiaying Zhao, Zhou Yu, Jing Zhang, Wenjin Cai, Guoli Yang

“…Based on findings in vivo, we demonstrated that adhesion-mediated differentiation of mitochondrial function modulated macrophage polarization. The finite activation of integrin signaling upregulated transglutaminase 2 (Tgm2) in a trans-manner, augments PGC1α-mediated mitochondrial biogenesis. …”
Get full text

Transcriptomic signatures of neonatal acute respiratory distress syndrome in a prospective cohort of respiratory distress by Chan Liu, Qing Ai, Jingli Yang, Ying Fan, Wen Jia, Leyu Si, Yuting Yao, Feifan Chen, Shiyue Liu, Yu He, Yuan Shi

“…This study characterized whole blood transcriptomic profiles of NARDS in a pilot cohort of 48 neonates with respiratory distress, demonstrating a significant GA-dependent modulation of gene expression. Functional analyses revealed prominent involvement of interferon-related pathways in NARDS, with greater suppression in neonates born before 34 weeks. …”
Get full text

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues by Mojtaba Daneshi, Pawel P. Borowicz, Mara R. Hirchert, Yssi L. Entzie, Jessica G. Syring, Layla E. King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P. Reynolds, Alison K. Ward, Carl R. Dahlen, Matthew S. Crouse, Joel S. Caton

“…IntroductionMaternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate immunity. …”
Get full text

Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma by Yuhuan Wen, Qile Chen, Hao Wang, Shiyun Xie, Honglv Chen, Wenruo Yao, Le Zhang, Weimin Sun, Junjie Wen, Xiaojing Yang, Kian Fan Chung, Qingling Zhang, Ailin Tao, Jie Yan

“…Modulation of the IL-17C/IL-17RE axis represents a novel therapeutic target in neutrophilic asthma.…”
Get full text

Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth by Akram Ghantous, Semira Gonseth Nusslé, Farah J. Nassar, Natalia Spitz, Alexei Novoloaca, Olga Krali, Eric Nickels, Vincent Cahais, Cyrille Cuenin, Ritu Roy, Shaobo Li, Maxime Caron, Dilys Lam, Peter Daniel Fransquet, John Casement, Gordon Strathdee, Mark S. Pearce, Helen M. Hansen, Hwi-Ho Lee, Yong Sun Lee, Adam J. de Smith, Daniel Sinnett, Siri Eldevik Håberg, Jill A. McKay, Jessica Nordlund, Per Magnus, Terence Dwyer, Richard Saffery, Joseph Leo Wiemels, Monica Cheng Munthe-Kaas, Zdenko Herceg

“…Hypermethylation was significantly associated with worse pre-B ALL patient survival and with reduced VTRNA2-1 expression (n=2,294 tissues; 26 types), supporting a functional and translational role for VTRNA2-1 methylation. …”
Get full text

Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity by Duo Gao, Yimin Zhuang, Shuai Liu, Boyan Ma, Yiming Xu, Hongxing Zhang, Yiliyaer Nuermaimaiti, Tianyu Chen, Guobin Hou, Wenli Guo, Jingtao You, Zhiyu Huang, Jianxin Xiao, Wei Wang, Mengmeng Li, Shengli Li, Zhijun Cao

“…Using a multi-omics approach, we performed 16S rRNA gene sequencing to evaluate microbial diversity, conducted metagenomic analysis to identify functional bacteria, and utilized untargeted metabolomics to profile serum metabolites. …”
Get full text

Healing through faith: Meeting a chaplain coupled with biblical readings could produce lymphocyte changes that correlate with brain activity (HEALING study) [version 5; peer review... by András Béres, Csaba Aranyi, Miklós Emri, Éva Perpékné Papp, Edit Hörcsik, Márta Kuti, Ferenc Tomanek, Ferenc Nagy, Dániel Fajtai, Pál Bödecs, Péter Szabó, Eszter Vinczen, Bettina Bakos, Renáta Sillinger, Eszter Gál, Hajnalka Kisdeákné, Ágnes Petőfalviné, Dániel Kovács, Gergely Bíró, Tamás Németh, Judit Fodor, Imre Repa, Erzsébet Papp, Antal Szilágyi, Zoltán Szalai, György Nagyéri, Marianna Kiss-Merki

“…A subgroup of the visited patients was subjected to functional magnetic resonance imaging (fMRI), during which they listened to an audiotape of readings of the same biblical passage (n = 21). …”
Get full text

A non-small cell lung cancer fragile elderly patient treated with immunotherapy and non-ablative radiation therapy: a case report of a winning combination by Jessica Saddi, David Alberto Santos Hernandez, David Alberto Santos Hernandez, David Alberto Santos Hernandez, Giulia Maria Stella, Giulia Maria Stella, Giulia Galli, Giulia Galli, Sabrina Borgetto, Elisabetta Bonzano, Andrea Lancia, Salvatore La Mattina, Sara Colombo, Luigi Squillace, Guido Baietto, Chandra Bortolotto, Chandra Bortolotto, Gioacchino D’Ambrosio, Laura Mantovani, Paolo Pedrazzoli, Paolo Pedrazzoli, Francesco Agustoni, Francesco Agustoni

“…Complete response was observed without severe side effects (his poor respiratory function did not change during both treatments).ConclusionIn this case report we showed that the association of immunotherapy and non-ablative radiation regimens may represent a safe and effective strategy to achieve complete response also in fragile patients, in whom the burden of side effects should be prioritized.…”
Get full text

Ultrasound‐Triggered Nanocomposite “Lever” Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair by Yuting Shen, Shaoyue Li, Xiaodong Hou, Jifeng Yu, Yuli Zhu, Chongke Zhao, Zhiyuan Niu, Xin Guan, Bing Xiong, Sirui Wang, Yifei Yang, Xiao Li, Liping Sun, Shengbo Wu, Bin Huang, Huixiong Xu, Haohao Yin

“…Therefore, there is an urgent need to design a hydrogel dressing with a ‘lever’ function to balance ROS levels in the wound to achieve both antimicrobial and anti‐inflammatory effects on DFUs. …”
Get full text