Expression and structural analysis of taste receptor genes in Iberian and Duroc pigs by Cristina Óvilo, Rita Benítez, Yolanda Núñez, Ramón Peiró-Pastor, Fabian García, Eduardo De Mercado, Emilio Gómez-Izquierdo, Juan García-Casco, Clemente López-Bote, María Muñoz

“…The objectives of this work were to deepen the understanding of the regulation of the function of taste receptor genes in the circumvallate papillae of obese Iberian pigs in comparison to Duroc pigs, and to characterize their genetic variation and associations with relevant production traits. …”
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Association of Omega-3 Index and Blood Cell Count-Derived Systemic Inflammatory Indexes among Testicular Germ Cell Tumor Survivors by Milica Zeković, Marko Živković, Marija Takić, Sanja Stanković, Nebojša Bojanić, Aleksandar Janičić, Uroš Bumbaširević

“…Background and objectives: Although testicular cancer is considered the paradigm of highly curable malignancy, treatment-induced adverse effects and potential impairment of gonadal function may cause non-negligible long-term health repercussions, including metabolic disturbances and cardiovascular sequelae. …”
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Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and mole... by Gajendra Singh Thakur, Ajay Kumar Gupta, Dipti Pal, Yogesh Vaishnav, Neeraj Kumar, Sivakumar Annadurai, Sanmati Kumar Jain

“…Numerous efforts have been made to inhibit P-gp function with the aim of restoring the effectiveness of chemotherapy due to its broad specificity. …”
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Correlation between Serum Levels of Some Immunological Biomarkers and Severity of Idiopathic Immune Thrombocytopenia by Ola A. Hashim, Rawaa N. Alchalabi, Bassam F. Matti, Yaseen I. Mamoori

“…Dysregulation in the expression or function of these biomarkers contributes significantly to disease pathogenesis and progression. …”
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Lightweight coal miners and manned vehicles detection model based on deep learning and model compression techniques: A case study of coal mines in Guizhou region by Beijing XIE, Heng LI, Zheng LUAN, Zhen LEI, Xiaoxu LI, Zhuo LI

“…Furthermore, the WIOU boundary regression loss function is employed to increase the model's focus on common quality samples, addressing issues such as regression errors caused by imbalanced training samples. …”
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Zearalenone causes ovarian damage and abnormal estradiol secretion in meat rabbits by inducing oxidative stress and inflammatory responses by Fengyang Wu, Fengyang Wu, Fengxia Wang, Zhaohong Tang, Xinyu Yang, Yanhua Liu, Man Zhao, Shudong Liu, Shuaijuan Han, Baojiang Chen

“…Zearalenone (ZEA), a prevalent mycotoxin in animal feeds, is known to disrupt normal ovarian development and function due to its estrogenic activity. This study investigates the toxic effects of ZEA on the ovaries of meat rabbits and explores the underlying mechanisms. …”
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Kangshujiangu granules improve NAFLD via cross-organ autophagy activation shared with osteoporosis by Ningxi Wang, Li Song, Yue Peng, Langqiu Wei, Zhaofan Long, Che Wang, Qiling Liu, Chuandao Shi

“…Bone density, lipid profiles, and liver function were analyzed for NAFLD-OP correlations. In vivo: 60 female SD rats were randomized into control, NAFLD-OP model, low/medium/high-dose KSJG, and Icariin (ICA) groups. …”
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Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study by Min Zhou, Min Zhou, Peng-Fei He, Peng-Fei He, Keren Zhang, Li-Juan Deng, Ning Wang, Gang Wang, Guang-Yao Yang, Shang Ju

“…Mediation analyses investigated the roles of glucolipid metabolism and renal function in the OBS-PAD association. Sensitivity and stratification analyses were conducted to ensure robustness.ResultsThis study included 2,437 eligible adult participants. …”
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Feedback Regulation of sPLA2-COX/5-LOX-Ca2+ in Seminal Plasma and Its Impact on Sperm Quality Parameters by Liu Y, Dai L, Zhang F, Liu Y, Li X, Ma W

“…A heat-stressed weak spermatogenesis model (37– 42°C) was established, and AA/COX were added in vitro to assess their impact on sperm quality.Results: Significant correlations were found between AA pathway markers (PL, sPLA2, AA, COX1/2, PGE1, PGF2α, 5-LOX, LTB4) and sperm parameters (motility, acrosome reaction, mitochondrial function, DNA fragmentation). A predictive model combining PL, AA, and COX1 effectively assessed sperm quality. …”
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Study on the therapeutic effects of Qinghuang ointment in a mouse model of imiquimod-induced psoriasis and its underlying mechanisms by LIU Dan, GONG Canyi, XU Jing, WEN Si, WU Zhaoji, HE Jiao, XIA Bijun

“…[Conclusions] Qinghuang ointment has a good therapeutic effect on psoriasis in mice, and its mechanism may be related to improving skin barrier function, modulating immune responses, and inhibiting Th1/Th17 cell-mediated inflammatory response.…”
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Influence of the metabolic and inflammatory profile in patients with frozen shoulder – systematic review and meta-analysis by Dina Hamed-Hamed, Celia Rodríguez-Pérez, Leo Pruimboom, Santiago Navarro-Ledesma

“…Hypothyroidism was also evaluated, with a total SMD of 0.067, a total variance of 0.0021, and a 95% confidence interval of -0.024 to 0.158, confirming no association between FS and thyroid function. Regarding inflammatory biomarkers, IL-1β was the most predominant, showing significantly higher levels in FS, with an SMD of μ^ = 2.2671 (95% CI: 0.5750 to 3.9591). …”
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Modulatory effects of polyherbal mixture on the immuno-antioxidant capacity and intestinal health of chicks infected with Escherichia coli O78 by Qian Qu, Mengjie Liu, Yifan Hu, Gengxiong Huang, Zhaoying Xuan, Jianchi Lun, Xiaoli Chen, Weijie Lv, Shining Guo

“…These beneficial bacteria were significantly positively correlated with antioxidant capacity and intestinal barrier function, while pathogenic bacteria were significantly positively correlated with proinflammatory cytokines (P < 0.05). …”
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AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis by Wang P, Zheng L, Yang Y, Yue X, Liu J, Fan K, Zhou H, Dong H

“…Then we collected femoral atherosclerosis and normal aortic samples, further conducted single-cell sequencing and spatial transcriptomic methods to confirm the potential function and pathway of AQP1 in endothelial cells. …”
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Mendelian randomization reveals probucol’s preventive role in Behçet’s disease via circulating metabolites by Zhang Hongchen, Zhang Yijia, Xu Yubo, Zhong Jianguang, Sun Mouyuan, Li Jian, Li Jin

“…This disease often disrupts lipid metabolism, adversely affecting vascular endothelial function. Exploring preventive strategies, such as lipid-lowering medications, is crucial. …”
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In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration by Tara Ní Néill, Marcos N. Barcellona, Niamh Wilson, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley

“…Conservative treatments fail to restore disc function, motivating the exploration of nucleic acid therapies, such as the use of microRNAs (miRNAs). miRNAs have the potential to modulate expression of discogenic factors, while silencing the catabolic cascade associated with degeneration. …”
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Effects of Hydrogen Sulfide at Normal Body Temperature and in the Cold on Isolated Tail and Carotid Arteries from Rats and TRPA1 Knockout and Wild-Type Mice by Leonardo Kelava, Eszter Pakai, Kazushi Ogasawara, Kata Fekete, Gabor Pozsgai, Erika Pinter, Andras Garami

“…<b>Conclusions:</b> Our results reveal the function of TRPA1 in the H₂S-induced dilation of carotid arteries in mice. …”
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Moderators and mediators of the relationship between parental depression and children’s emotion dysregulation: a systematic review by Ahmad Sabalbal, Samer El Hayek, Samer El Hayek, Evelyne Baroud, Wael Shamseddeen

“…The biological variables (the child’s genotype and left parietal alpha asymmetry) highlight a biological vulnerability to dysregulation beyond parent–child effects and environmental factors: left parietal alpha asymmetry was a partial mediator, while genotype was a moderator as children carriers of the S/LG genotypes experienced higher levels of dysregulation as a function of exposure to higher levels of prenatal maternal depression. …”
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Pengaruh Pemberian Glutamin pada Kemampuan Fagositosis Makrofag terhadap Pseudomonas Aeruginosa by Daslina , Eryati Darwin, Aziz Djamal

“…Glutamine is an amino acid  in the body that able to modulate the body's immune function. The objective of this study was to determine the potential of glutamine in enhancing the ability of the immune system against infection of P.aeruginosa. …”
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Plant Dominant Low-Protein Diet, Nutritional Status (Phase Angle) and Progression of Renal Failure: Case-Report Study by Danijela Ristic-Medic, Snjezana Petrovic, Biljana Pokimica, Marija Paunovic, Vesna Vucic

“…Methods: A 68-year-old female, obese (BMI 31.9 kg/m²) with CKD grades 3 presented to her primary care physicians in October 2022, changed her diet from an unhealthy Western diet to a personalized PLADO (protein 0.6–0.8 g/kg/day), caloric-restricted diet rich in fiber, according to basal metabolic rate (energy intake 1400 kcal/day) prescribed by a dietitian doctor. Liver and thyroid function and ferritin and potassium levels were within normal limits. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…Finally, we evaluated the magnitude and functional quality of the elicited antigen-specific cellular immune responses in vivo. …”
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