RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice by Yan Ma, Honggang Chen, Yuxin Jiang, Diya Wang, Michael Aschner, Wenjing Luo, Peng Su

“…GAS administration effectively attenuated Mn-induced disruption of the BBB, enhanced the expression of TJPs, and mitigated Mn-induced cognitive dysfunctions, potentially through the modulation of the RhoA/ROCK2 signaling pathway. This research sought to advance our understanding of the molecular pathways involved in Mn-mediated BBB disruption and to identify novel therapeutic approaches for mitigating the deleterious effects of Mn exposure on cognitive function.…”
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Gut microbiome features in pediatric food allergy: a scoping review by Margherita Farnetano, Laura Carucci, Laura Carucci, Serena Coppola, Serena Coppola, Franca Oglio, Franca Oglio, Antonio Masino, Antonio Masino, Marica Cozzolino, Marica Cozzolino, Rita Nocerino, Rita Nocerino, Rita Nocerino, Roberto Berni Canani, Roberto Berni Canani, Roberto Berni Canani, Roberto Berni Canani

“…Moreover, we provide an overview of the mechanisms of action elicited by these bacterial species in regulating immune tolerance and of the main environmental factors that can modulate the composition and function of the GM in early life. …”
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Efficacy and putative mechanisms of action of nutraceuticals in the management of erectile dysfunction: a narrative review by Lorenzo Romano, Michele Musone, Luigi Napolitano, Lorenzo Spirito, Celeste Manfredi, Davide Arcaniolo, Ferdinando Fusco, Biagio Barone, Antonio Tufano, Pier Paolo Prontera, Ugo Amicuzi, Antonio Cioffi, Ciro Imbimbo, Marco De Sio, Carmine Sciorio, Felice Crocetto

“…These natural products have different mechanisms of action, including modulation of endothelial function, reduction of oxidative stress and balance of sex hormones, thus addressing multiple therapeutical targets for the management of ED. …”
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Prevention of high-fat/high-sugar diet-induced type 2 diabetes mellitus-associated non-alcoholic fatty liver disease in rats with fermented and raw Rosa roxburghii Tratt (Cili) jui... by Jingzhi Zhang, Jingzhi Zhang, Haizhi Li, Huiru Yang, Liying Zhu, Yiqiong Zhang, Changyudong Huang, Shuang Wang, Yunfeng Duan, Zhaohui Jiang, Mi Liu, Mi Liu, Shuyun Zhao, Wei Pan, Wei Pan

“…These two kinds of Cili juices can modulate disorders of glucose and lipid metabolism, have anti-inflammatory effects, and improve sterol metabolism and bile acid homeostasis. …”
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Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment by Mina Mirjalili, Mina Mirjalili, Iryna S. Palamarchuk, Iryna S. Palamarchuk, Heather Brooks, Heather Brooks, Reza Zomorrodi, Reza Zomorrodi, Ashley Melichercik, Wei Wang, Wei Wang, Sean M. Nestor, Sean M. Nestor, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Abhishek Datta, Christopher Bowie, Christopher Bowie, Bernadette Mdawar, Bernadette Mdawar, Kullervo Hynynen, Kullervo Hynynen, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji

“…The prefrontal cortex (PFC) and its connections to the hippocampus support executive functions, including working memory. Transcranial alternating current stimulation (tACS) can modulate these connections by engaging theta-gamma coupling (TGC) and may thereby strengthen working memory. …”
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Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization by Jianshui Mao, Liangliang Chen, Genying Zhuang, Zhiqiang Jin, Shoukun Wu, Mingshuai Ying, Lingchao Sheng, Jianwei Lv, Qiuchen Bi, Jingjia Ye

“…Severe spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. …”
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The effects of small geographical resolution and age on the phyllosphere microbial diversity of Castanopsis eyrei in subtropical forest by Lei Xie, XuXu Bao, Shuifei Chen, Hui Ding, Yanming Fang

“…Overall, these findings highlight the ecological importance of habitat in shaping phyllosphere microbial diversity and underscore the interplay between host function and the maintenance of microbial diversity.IMPORTANCEPlant surfaces host diverse microbial communities that significantly impact host health and overall forest productivity. …”
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Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner by Wen Ge, Xiaohua Zhang, Jie Lin, Yangyang Wang, Xiao Zhang, Yu Duan, Xinchun Dai, Jiye Zhang, Yan Zhang, Mengyuan Jiang, Huanhuan Qiang, Zhijing Zhao, Xuebin Zhang, Dongdong Sun

“…Our findings suggest that the Rnd3/Rock1/Drp1 signaling pathway represents a novel target for mitigating DIC, and modulating Rnd3 expression could be a strategic approach to safeguarding cardiac function in patients undergoing Dox treatment. …”
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The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

“…Furthermore, the catalytic product of SPHK1, sphingosine 1-phosphate (S1P), along with its receptor, sphingosine 1-phosphate receptor 3 (S1PR3), plays a regulatory role in the function of the EGFR. However, the specific effects of the SPHK1/S1P/S1PR3 axis on EGFR in NSCLC, as well as the combined effects of SPHK1/S1P/S1PR3 inhibitors with the EGFR-TKI gefitinib, remain to be elucidated. …”
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HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis by Jie Yu, Bing Guo, Fan Zhang, Miao Liu, Ying Xie, Hui-mei Zou, Yuan-yuan Ruan, Xiao-min An, Pei-lei Chen, Ying-qin Luo, Ming-jun Shi, Li-fen Xu

“…Objective The current study aims to elucidate the critical function of hepatocyte nuclear factor 1-beta (HNF1-β) in lupus nephritis (LN) by investigating its modulation of the Derlin-1/valosin-containing protein (VCP)/VCP-interacting membrane selenoprotein (VIMP) complex, endoplasmic reticulum (ER) stress and podocyte apoptosis.Methods In vitro and in vivo models of LN were established using glomerular podocytes treated with LN serum and MRL/lpr mice, respectively. …”
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Does Fibre-fix provided to people with irritable bowel syndrome who are consuming a low FODMAP diet improve their gut health, gut microbiome, sleep and mental health? A double-blin... by Claus T Christophersen, Amanda Devine, Ran Yan, Johnny Lo, Mandy Murphy, Angela Genoni, Evania Marlow, Ian C Dunican, Lesley Andrew

“…This study will examine the effect of Fibre-fix, a supplement containing a mix of dietary fibres, on the human gut microbiome composition, fermentative capacity, sleep, quality of life (QOL) and mental health of people with IBS who consume a low FODMAP diet (LFD).Methods and analysis A randomised, double-blind, placebo-controlled, study design is proposed to examine whether Fibre-fix added to an existing LFD may help modulate gastrointestinal function, improve markers of sleep, mental health and promote QOL in patients with IBS. …”
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Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia by Noreen Bukhari-Parlakturk, Patrick J. Mulcahey, Michael W. Lutz, Rabia Ghazi, Ziping Huang, Moritz Dannhauer, Pichet Termsarasab, Burton Scott, Zeynep B. Simsek, Skylar Groves, Mikaela Lipp, Michael Fei, Tiffany K. Tran, Eleanor Wood, Lysianne Beynel, Chris Petty, James T. Voyvodic, Lawrence G. Appelbaum, Hussein R. Al-Khalidi, Simon W. Davis, Andrew M. Michael, Angel V. Peterchev, Nicole Calakos

“…PSC-TMS also significantly weakened cortico-basal ganglia, cortico-cerebellum, and intra-cerebellum functional connectivity (FC), and strengthened striatal FC relative to Sham. …”
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Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury by Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang

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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications by Min Li, Lu Ding, Lu Ding, Liyuan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li, Zeyu Wang, Zeyu Wang

“…This condition typically stems from either insufficient insulin secretion or a functional defect in the insulin itself. Clinically, diabetes is primarily classified into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. …”
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Evaluating the potential of graphene oxide to promote skeletal muscle complex regeneration by Yulu Chen, Zeyu Zhu, Yian Shen, Xuling Liu, Yushi He, Chengqi Lyu, Jiayu Lu

“…BackgroundRepair and regeneration of the musculoskeletal system are critical for maintaining mobility, physical function, and overall quality of life. This study aimed to optimize the size and concentration of graphene oxide (GO) to achieve a balance that enhances the proliferation and myogenic differentiation of C2C12 cells and investigate the underlying mechanisms, including the activation of key myogenic genes and signaling pathways. …”
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Apigenin as a therapeutic agent against cigarette smoke-induced cellular dysfunction: A comprehensive study on Beas-2B cells by Nabijan Mohammadtursun, Haibaier Huojiaaihemaiti, Muhammatjan Abduwaki, Alimujiang Paierhati, Jingcheng Dong

“…Conclusion: Our findings demonstrate that Api significantly reduces CSE-induced damage in Beas-2B cells, potentially through the inhibition of PI3K/AKT and MAPK signaling pathways and the regulation of multiple genes and mitochondrial function.…”
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Homotherapy for heteropathy of chronic kidney disease and oligoasthenozoospermia through regulating SIRT1/NF-κB pathway by Shenqi pills by Shuo Huang, Qihan Luo, Xinyue Li, Yiming Liu, Jiale Wei, Sichen Wang, Ping Qiu, Changyu Li, Changyu Li

“…A CKD model was induced in C57BL/6 mice via adenine administration, followed by SQP treatment (0.8 or 1.6 g/kg/day) for 50 days. Renal function, histopathology, and molecular pathways were evaluated. …”
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The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…Conclusions: Exosome-loaded hydrogels show potential for improving the structure and function of intervertebral discs in IDD treatment, potentially slowing degeneration by inhibiting matrix degradation and cellular aging. …”
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Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease by Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo

“…Abstract Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. …”
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Molecular Assessment of Traditional Mongolian Medicine Tongola-5 in Lactulose Induced Diarrhea: An in vivo Study by Ma C, Buren Q, Eerde M, Qing M, Bao X, Zhao L, Cao L, Zhang X, Bai Q, Chen M, Hong M, Bao Y, Lian H

“…Moreover, TLG5 treatment resulted in a significant increase in the levels of SCFAs and bile acids in the cecum.Conclusion: TLG5 exerts therapeutic effects on chronic diarrhea through multiple mechanisms, including modulation of intestinal microbiota diversity, enhancement of intestinal barrier function, and attenuation of inflammatory responses. …”
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