In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…MicroRNAs (miRNAs), a class of endogenous non-coding RNAs with post-transcriptional regulatory properties, are known to play a major role in retinal function, both in physiological and pathological conditions. …”
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Phenylhydrazine-induced haemolysis disturbed iron pool homeostasis and activated expression pattern of FPN1 in the intestine of grass carp (Ctenopharyngodon idella) by Xiaoman Huang, Hong Chen, Chenming Tu, Linpeng Zhang, Lihan Liu, Li Lin, Zhendong Qin, Fanbin Zhan

“…As the only molecule that can transport iron to the cell exterior, the ferroportin 1 (FPN1) plays a key role in regulating the homeostasis of the iron ion. However, the function of FPN1 in teleost is remains unclear. In this study, the fpn1 gene was cloned from grass carp and its characteristics were studied. …”
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Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability by María C. M. Aboy-Pardal, Marta C. Guadamillas, Carlos R. Guerrero, Mauro Català-Montoro, Mónica Toledano-Donado, Sara Terrés-Domínguez, Dácil M. Pavón, Víctor Jiménez-Jiménez, Daniel Jimenez-Carretero, Moreno Zamai, Cintia Folgueira, Ana Cerezo, Fidel-Nicolás Lolo, Rubén Nogueiras, Guadalupe Sabio, Miguel Sánchez-Álvarez, Asier Echarri, Ricardo Garcia, Miguel A. Del Pozo

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Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies by Nahida Aktary, Yerim Jeong, Seungji Oh, Yeju Shin, Yoonsoo Sung, Muntajin Rahman, Livia Ramos Santiago, Jinwon Choi, Han Gyeul Song, Fahrul Nurkolis, Rosy Iara Maciel Azambuja Ribeiro, Moon Nyeo Park, Bonglee Kim

“…Additionally, they strengthen synaptic plasticity and stabilize mitochondrial function, offering a holistic approach to disease control. …”
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Effects of Licorice Stem and Leaf Forage on Growth and Physiology of Hotan Sheep by Peng Yin, Weiqing Kong, Linyuan Cheng, Nana Shi, Shonghan Wang, Fei Guo, Haitao Shen, Hua Yao, Hongbin Li

“…On day 80, blood samples were collected via venipuncture for biochemical and immune function analysis, followed by slaughter to obtain meat samples for quality assessment. …”
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Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…ONT long-read RNA-seq discovered that FRA modulated the expression of transcripts related to ferroptosis and lysosomes. …”
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DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi by Minerva Arce-Fonseca, Ana C. Carbajal-Hernández, Mónica Lozano-Camacho, Silvia del C. Carrillo-Sánchez, Francisco-Javier Roldán, Alberto Aranda-Fraustro, José Luis Rosales-Encina, Olivia Rodríguez-Morales

“…Echocardiograms showed that the pBCSSP4 plasmid immunotherapy preserved cardiac structure and function to a greater extent and prevented cardiomegaly. …”
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Identification and analysis of drought-responsive F-box genes in upland rice and involvement of OsFBX148 in ABA response and ROS accumulation by Yifan Wang, Fang Chen, Yuyang Chen, Kaiwen Ren, Dan Zhao, Kun Li, Haipeng Li, Xiaobin Wan, Mu Peng, Zhixin Xiang, Qiaoyu Tang, Zhi Hou, Qing Fang, Yifeng Zhou, Yanke Lu

“…F-box proteins typically function as part of the SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complexes to precisely regulate gene expression and protein level, playing essential roles in the modulation of abiotic stress responses. …”
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Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation by Varun Malik, Adrian D. Elliott, Gijo Thomas, Bradley Pitman, John L. Fitzgerald, Glenn D. Young, Leonard F. Arnolda, Dennis H. Lau, Prashanthan Sanders

“…Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m2; LA size 37 ± 2 mL/m2; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre‐ versus post‐PVI. …”
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1,25-dihydroxyvitamin D3 improves non-alcoholic steatohepatitis phenotype in a diet-induced rat model by Mei Liu, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Liu Lan, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Lin-Hu Quan, Hong-Mei Han

“…We studied the potential protective effects of 1,25-dihydroxyvitamin D3 (1,25 VD3) supplementation on liver damage induced by a choline-deficient (CD) diet in rats, where impaired liver function leads to decreased 25-hydroxyvitamin D3 levels, the precursor for the active 1,25 VD3. …”
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Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1 by Jae-Yeop Jeong, Youngho Son, Youngha Kim, Nami Lee, Yujin Kim, Yu Jung Heo, Sung-E. Choi, Jaemyung Choi, Seung Jin Han, Jayoung Jeon, Hae Jin Kim, Kwan-Woo Lee

“…Additionally, C57BL/6J mice were administered intraperitoneal injections of DEX, with or without DFO, every other day for 12 days. Muscle function was assessed by grip strength, and muscle mass and fiber size were measured histologically.ResultsDEX significantly induced muscle atrophy in C2C12 myotubes, elevating intracellular iron and upregulating atrogin-1 and MuRF1 via increased nuclear translocation of FOXO3a and expression of KLF15. …”
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LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis by Yujie Zhou, Zhen Zhao, Cheng Jiang, Chuansheng Nie, Dongdong Xiao, Zhipeng Wu, Hao Yu, Jianglin Zheng, Xuan Wang, Xiaobing Jiang

“…Methods We conducted gain‐ and loss‐of‐function studies to assess the impact of LINC01088 on GBM tumourigenesis and ferroptosis both in vitro and in vivo. …”
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Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway by Xuecheng Yu, Xin Wang, Fan Xu, Xinyi Zhang, Muyi Wang, Ruikai Zhou, Zhengyi Sun, Xiaohui Pan, Lin Feng, Wanchao Zhang, Yong Sun, Wenting Zhang, Dong Zhou, Yuqing Jiang

“…Notwithstanding, the biological function and underlying mechanisms of miR-615-3p in OS development still unclear. …”
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Super‐Enhancer‐Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T‐ALL Cell Growth and Survival by Juanjuan Yu, Zimu Zhang, Yanling Chen, Jianwei Wang, Gen Li, Yanfang Tao, Yongping Zhang, Yang Yang, Chenyue Zhang, Tiandan Li, Jia Cheng, Tongtign Ji, Zhongling Wei, Wenjuan Wang, Fang Fang, Wei Jiang, Peipei Chu, Hongli Yin, Di Wu, Xiaolu Li, Xiaodong Wang, Jun‐Jie Fan, Shaoyan Hu, Zhen‐Hong Zhu, Shuiyan Wu, Jun Lu, Jian Pan

“…Identifying SE‐driven oncogenes in tumors and understanding their functional mechanisms is of significant importance. …”
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Dietary Administration of Postbiotics from <i>Vibrio proteolyticus</i> DCF12.2 Enhanced Intestinal Integrity, Microbiota, and Immune Response in Juvenile Gilthead Seabream (<i>Spar... by Olivia Pérez-Gómez, Sonia Rohra-Benítez, Marta Domínguez-Maqueda, Isabel M. Cerezo, Alba Galafat, Eduardo Martínez-Manzanares, Juan Miguel Mancera, Francisco Javier Alarcón-López, Jorge García-Márquez, Miguel Ángel Moriñigo, Salvador Arijo

“…These findings demonstrate that dietary fortification with <i>V. proteolyticus</i>-derived postbiotics supports mucosal health as well as modulates the intestinal microbiota and immune responses in gilthead seabream juveniles, offering a promising strategy for functional aquafeed development in sustainable aquaculture.…”
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GPCRs identified on mitochondrial membranes: New therapeutic targets for diseases by Yanxin Pan, Ning Ji, Lu Jiang, Yu Zhou, Xiaodong Feng, Jing Li, Xin Zeng, Jiongke Wang, Ying-Qiang Shen, Qianming Chen

“…However, emerging evidence suggests that GPCRs are also localized on mitochondria, where they play critical roles in modulating mitochondrial functions. These mitochondrial GPCRs (mGPCRs) can influence processes such as mitochondrial respiration, apoptosis, and reactive oxygen species (ROS) production. …”
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circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b by Ruobai Liu, Ruobai Liu, Yilan Song, Yilan Song, Zhiguang Wang, Zhiguang Wang, Longzhu Dai, Longzhu Dai, Qiaoyun Bai, Qiaoyun Bai, Yan Li, Yan Li, Hongmei Piao, Hongmei Piao, Chongyang Wang, Chongyang Wang, Guanghai Yan, Guanghai Yan

“…Furthermore, bioinformatics analysis revealed that circ-0001454 harbors binding sites for miR-770-5p, acting as a sponge to adsorb miR-770-5p and function as a competing endogenous RNA (ceRNA), thereby negatively regulating the expression of miR-770-5p. …”
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Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation by Lian Zeng, Pengchao Hu, Xuan Wang, Xudong Ding, Qingsong Wang, Li Luo, Yu Zhang, Mingyue Li, Yilin Zhao, Shiyong Li, Ailin Luo

“…This study investigates the impact of SIRT3 on ferroptosis modulation in PND and its underlying mechanism. Methods A murine model of PND was established using tibial fracture surgery under isoflurane anesthesia to assess SIRT3 expression and cognitive function. …”
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Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence by Qinfeng Zhou, Kaixuan Wang, Cong Wang, Xiaoxian Sun, Lining Wang, Jie Sun, Yalan Pan, Muzhe Li, Zitong Zhao, Shijie Zhou, Qing Wang, Yafeng Zhang, Yong Ma, Yang Guo

“…Macrophage-conditioned medium’s effects on BMSC osteogenesis and mitochondrial function were assessed through alkaline phosphatase, Alizarin Red S staining, reactive oxygen species and JC-1 mitochondrial membrane potential (ΔΨm) assays.Results In vivo experiments demonstrated that WSTLZTD effectively ameliorated macrophage senescence and osteoporosis in naturally aged mice. …”
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M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation by Juan Ji, Shaoying Yang, Yongxin Xu, Qian He, Qian Liang, Guijuan Feng, Yunfei Xia, Mei Yang, Yuting Huang, Junling Yang, Chen Dong, Rui Zhao, Yunan Wang, Genkai Guo, Xiaoqi Sha, Jing Li, Yuehua Guo, Zhifeng Gu

“…The abnormal phenotype and function of macrophages participate in the development of SLE. …”
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