Carveol, a natural monoterpene from essential oils prevents neuronal impairments associated with murine Parkinson's disease model in rats by Ola A. Habotta, Lashin Saad Ali, Rami B. Kassab, Qinghua Zhang, Maoyong Zheng, Barakat M. Alrashdi, Jehad Zuhair Tayyeb, Motasim Jawi, Mohamed A. Elhefny, Hassan Al Sberi, Dina Abd-Eldaim, Omer Abdelbagi, Maha S. Lokman

“…CR administration improved the motor function and modulated the disrupted neurotransmitters system, as demonstrated by the enhancement of dopamine, serotonin, gamma-aminobutyric acid, and acetylcholinesterase activity. …”
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3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury by Carlos A. Dallera, Fabiola Placeres-Uray, Patrizzia Mastromatteo-Alberga, Maria Dominguez-Torres, Alyssa F. Balleste, Aditi S. Gorthy, Tyler S. Rahimzadeh, Isabelle Aliancin, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari, Irwin C. Jacobs, Elizabeth A. Chlipala, Hannah Benton, Michael A. Zeligs, Coleen M. Atkins

“…BR4044 treatment of TBI animals preserved sensorimotor function and associative fear memory. Cortical contusion size and neuronal loss in the parietal cortex and CA3 region of the hippocampus were also significantly reduced with BR4044 treatment. …”
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Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…While previous studies have demonstrated that microRNA-502-5p (miR-502-5p) can protect chondrocytes through p53/NF-κB pathway modulation, its role in human synovial tissue remains unclear. …”
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Sistem Monitoring Kualitas Air Kolam Budidaya Menggunakan Jaringan Sensor Nirkabel Berbasis Protokol LoRa by Adhitya Bhawiyuga, Widhi Yahya

“…Based on the functional evaluation the proposed system can give the proper response on the changes of the water quality in term of turbidity, acidity level, dissolved oxygen and temperature. …”
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Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action by Chen Z, Zuo Z, Zhang L, Gong M, Ye Y, Jin Y, Zhao X

“…Zheping Chen,1,2,* Zhenxiang Zuo,3,4,* Le Zhang,2,4 Moxuan Gong,2,5 Yuyang Ye,2,4 Yanwu Jin,2,4,6 Xin Zhao2,4 1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 3Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 4The Second Clinical College, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 5Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200041, People’s Republic of China; 6Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, 250100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanwu Jin; Xin Zhao, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, Shandong, 250033, People’s Republic of China, Tel +86-17660085535 ; +86-17660085551, Email jinyanwu_aa@163.com; lujnzx@sohu.comBackground: Postoperative sore throat (POST) represents a common airway complication closely related to endotracheal tube (ETT), exhibiting a higher incidence following tracheal intubation compared to other airway apparatuses. …”
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Cryo-EM reveals a double oligomeric ring scaffold of the CHIKV nsP3 peptide in complex with the NTF2L domain of host G3BP1 by Yuanzhi Liu, Jie Wang, Yinze Han, Xiaoyan Xia, Rui Zeng, Xinyu Fan, Bo Zhang, Kaituo Wang, Jian Lei

“…Overall, our findings present the structural and functional mechanisms on CHIKV nsP3 modulating host G3BP1 and provide a potential antiviral target based on the protein–protein interaction interface.IMPORTANCEChikungunya virus (CHIKV) is an arbovirus responsible for causing fever, headache, and severe joint pain in humans, with widespread outbreaks affecting millions worldwide. …”
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EEG-fMRI neurofeedback versus motor imagery after stroke, a randomized controlled trial by Simon Butet, Mathis Fleury, Quentin Duché, Elise Bannier, Giulia Lioi, Lou Scotto di Covella, Emilie Lévêque-Le Bars, Anatole Lécuyer, Pierre Maurel, Isabelle Bonan

“…Thirty stroke survivors, exhibiting partial upper-limb motor impairment with a Fugl-Meyer Assessment Upper Extremity score (FMA-UE) > 21 and partially functional corticospinal tract (CST) were randomly allocated to the NF and MI groups. …”
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AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury by Xiaoxu Huang, Tongqi Li, Guanran Zhang, Jieqiong Chen, Tong Li, Shiqi Yang, Qiyu Bo, Xiaohuan Zhao, Xiaoling Wan, Xinyue Zhu, Bo Yu, Xiaodong Sun, Junran Sun

“…Fundus photography, electrophysiology and hematoxylin-eosin staining were used to evaluate the morphological and functional RPE damage. Transcriptome sequencing was used to detect the differentially expressed genes between Aβ1-40 group and control group. …”
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CO13 | Genetic background in hypercholesterolemic patients framing cardiovascular risk

“…Many FH subjects (about 60%) did not demonstrate functional mutations in major candidate genes (LDLR, APOB, PCSK9, LDLRAP1). …”
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Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation by Tingyi Luo, Yujing Tang, Wangcheng Xie, Zhilong Ma, Jian Gong, Yonggui Zhang, Tingsong Yang, Xuyang Jia, Jia Zhou, Zhengyu Hu, Lin Han, Qigang Wang, Zhenshun Song

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PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma by Bei J, Sun Z, Fu R, Huang X, Huang J, Luo Y, Li Y, Chen Y, Wei Z

“…Immune infiltration was analyzed via CIBERSORT and ssGSEA, while DNA methylation and somatic mutation analyses were performed using MExpress and “maftools”, respectively, alongside in vitro and in vivo experiments to assess PPIH’s functional roles.Results: Our findings indicated that PPIH is significantly upregulated in various cancer types, correlating with poor patient prognosis, increased somatic mutations, and altered gene methylation patterns. …”
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Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation by Majda Haznadar, Kristopher W. Krausz, Ezra Margono, Christopher M. Diehl, Elise D. Bowman, Soumen Kanti Manna, Ana I. Robles, Bríd M. Ryan, Frank J. Gonzalez, Curtis C. Harris

“…Abstract Vitamin D is an essential micronutrient required for normal physiological function and recognized for its role regulating calcium metabolism. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…Collectively, our data suggest that administering probiotic fermented milk containing specific functional strains such as BX245 could result in a reduction in tumor burden in CRC mice. …”
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Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor by Yuanfeng Gu, Wenjun He, Wenxuan Li, Jingshu Cai, Zhuyun Wang, Kemeng Li, Guangcheng Qin, Xiaojie Gu, Xiaojing Lin, Li Ma, Xiaoqiu Xiao, Yi Hou, Ting Luo

“…In C3H10T1/2-induced adipocytes, ARC upregulated the protein expression of uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and other brown-specific marker genes, promoting mitochondrial function and browning of adipocytes. Mechanistically, our findings suggest that ARC may promote adipocyte browning via the A2AR-cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway. …”
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Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1 by Xueting Ren, Jinpeng Wu, Jing Li, Zhen Zhai, Xiang Li, Feng Guan, Meng Wang, Xiaobin Ma, Zengqi Tan, Huafeng Kang, Shuai Lin

“…While abnormal glycosylation of PD-L1 is known to influence its expression and function, the precise regulatory mechanisms remain unclear. …”
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Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions by Haifeng Zhang, Haifeng Zhang, Xian Zhang, Xian Zhang, Yan Chai, Yuhua Wang, Yuhua Wang, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen

“…By releasing a variety of cytokines and chemokines, astrocytes regulate neuroinflammation, thereby influencing the survival and function of surrounding cells. In recent years, researchers have concentrated their efforts on elucidating the signaling crosstalk between astrocytes and other cells under various conditions, while exploring potential therapeutic interventions targeting these cells. …”
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Heart Rate Variability in Young Adults with Bronchial Asthma with and without Previous COVID-19 Infection: A Cross-sectional Study by Gunaseelan Deivendran, Thamarai Selvi Kanagaraj, Bhavisha Sreenivasan Leelabai, Nalini Jayanthi, Saravanan Ayyavoo

“…Introduction: Heart Rate Variability (HRV) is a validated, non invasive measure of Autonomic Nervous System (ANS) function. Both bronchial asthma and post Coronavirus Disease-2019 (COVID-19) syndrome are independently associated with autonomic dysregulation. …”
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HIF-1 attenuates high-fiber diet-mediated proliferation and stemness of colonic epithelium by Pollyana Ribeiro Castro, Renan Oliveira Corrêa, Monara Kaélle Sérvulo Cruz Angelim, Vinícius de Rezende Rodovalho, Mariane Font Fernandes, Vinícius Dias Nirello, Arilson Bernardo dos Santos Pereira Gomes, Jaqueline de Souza Felipe, Lais Passarielo Pral, Sarah de Oliveira, Patrícia Brito Rodrigues, José Luís Fachi, Guilherme Reis-de-Oliveira, Bradley J. Smith, Victor C. Carregari, Nicolas G. Shealy, Catherine Shelton, Daniel Martins-de-Souza, Pedro M. Moraes–Vieira, Mariana Xavier Byndloss, Patrick Varga-Weisz, Marco Aurélio Ramirez Vinolo

“…Furthermore, we show that HIF-1 stabilization modulates intestinal stem cell (ISC) function through metabolic reprogramming in a microbiota-dependent manner. …”
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Galantamine-Memantine Combination in the Treatment of Parkinson’s Disease Dementia by Emma D. Frost, Swanny X. Shi, Vishnu V. Byroju, Jamir Pitton Rissardo, Jack Donlon, Nicholas Vigilante, Briana P. Murray, Ian M. Walker, Andrew McGarry, Thomas N. Ferraro, Khalid A. Hanafy, Valentina Echeverria, Ludmil Mitrev, Mitchel A. Kling, Balaji Krishnaiah, David B. Lovejoy, Shafiqur Rahman, Trevor W. Stone, Maju Mathew Koola

“…In this review, we summarize the KYNA-centric model for PD pathophysiology and discuss how this treatment combination is promising in improving cognitive function in patients with PDD through its action on KYNA.…”
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Metagenomic and metabolomic analysis of gut microbiome's role in spinal cord injury recovery in rats by Jieqi Zhang, Xihan Ying, Rong Hu, Yi Huang, Ruoqi Wang, Lei Wu, Dexiong Han, Ruijie Ma, Kelin He

“…These findings highlight significant interactions between the gut microbiota and host metabolism after SCI and suggest that microbiome-targeted interventions may hold therapeutic potential for improving recovery by modulating metabolic function and oxidative stress responses. …”
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