CmHRE2L-CmACS6 transcriptional cascade negatively regulates waterlogging tolerance in Chrysanthemum by Yajun Yan, Wanwan Zhang, You Wang, Yue Wang, Chuanwei Li, Nan Zhao, Lijie Zhou, Jiangshuo Su, Likai Wang, Jiafu Jiang, Sumei Chen, Fadi Chen

“…However, the complex molecular mechanisms underlying ethylene biosynthesis and its functional significance in chrysanthemums under waterlogging conditions have remained unclear. …”
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In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model by Nupur Sharma, Sadam H. Bhat, Shweta Chaudhary, Babu Mathew, Sushmita Pandey, Sanju Yadav, Manisha Yadav, Vasundhra Bindal, Gaurav Tripathi, Neha Sharma, Vipul Sharma, Abhishak Gupta, Ranjan Nanda, Anupama Kumari, Shvetank Sharma, Jaswinder Singh Maras

“…Results: Liver histology showed increased steatosis (28 %) and fibrosis (15 %) in ALD rats, both reduced with abstinence (<20 %, <12 %, p < 0.05). Liver function and lipid profiles improved, while alcohol-metabolizing and inflammatory markers were decreased (>1.5-fold, p < 0.05) following abstinence. …”
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Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice by I. Gálvez, M.C. Navarro, S. Torres-Piles, L. Martín-Cordero, M.D. Hinchado, E. Ortega

“…Introduction: The complex physiological and psychological responses to regular exercise are yet to be fully elucidated. Exercise strongly modulates the immune system, inducing a plethora of dynamic responses involving the innate immune cell function and inflammatory processes that contribute to both potential health benefits and harmful side effects. …”
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Celecoxib enhances the therapeutic efficacy of epirubicin for Novikoff hepatoma in rats by Tian‐Huei Chu, Hoi‐Hung Chan, Tsung‐Hui Hu, E‐Ming Wang, Yi‐Ling Ma, Shih‐Chung Huang, Jian‐Ching Wu, Yi‐Chen Chang, Wen‐Tsan Weng, Zhi‐Hong Wen, Deng‐Chyang Wu, Yi‐Ming Arthur Chen, Ming‐Hong Tai

“…Besides, celecoxib potentiated the antineoplastic function of epirubicin in inhibiting the invasiveness and anchorage‐independent growth of HCC cells. …”
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Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development by Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee

“…Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. …”
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Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice by Abigail O’Niel, Christopher J. Parkins, Alexandra Pederson, Elizabeth Saltonstall, Emily Bunnell, Ria Aggarwal, Phoebe Sandholm, Kat Kessler, Henry F. Harrison, Jessica L. Smith, Alec J. Hirsch, Jacob Raber, Jacob Raber, Jacob Raber, Jacob Raber

“…NL-G-F/E4 mice were more susceptible to KUNV induced cognitive injury and prolonged viral load in the cortex.DiscussionThese results support an important apoE isoform-dependent role in modulating phenotypes in the NL-G-F AD mouse model following WNV exposure.…”
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Investigating cardiovascular diseases related to endocrine therapy in hormone receptor-positive early breast cancer: insights from a nationwide real-world study by Cheng Zeng, Hong Li, Wenna Wang, Lixi Li, Binliang Liu, Bo Lan, Qing Li, Wenjing Yang, Jiani Wang, Fei Ma

“…Nonsteroidal aromatase inhibitors (NSAI) ± ovarian function suppression (OFS) led to the largest increase in abnormal total cholesterol (10.26 to 17.32%), while selective estrogen receptor modulators (SERM) ± OFS caused the greatest rises in triglycerides (16.07 to 25.86%), LDL-C (12.11 to 23.34%), and HDL-C (10.86 to 17.23%). …”
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Gut microbiota-mediated betaine regulates skeletal muscle fiber type transition by affecting m6A RNA methylation and Myh7 expression by Chao Yan, Yilong Yao, Zhaobo Zhang, Fanqinyu Li, Danyang Fan, Wen Liu, Xinhao Fan, Lingna Xu, Yanwen Liu, Shilong Wang, Mengling Hu, Yalan Yang, Zhonglin Tang

“…Skeletal muscle fiber composition is essential for maintaining muscle function and overall health. Growing evidence underscores the pivotal role of the gut-muscle axis in mediating the influence of gut microbiota on skeletal muscle development. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…This study aims to investigate the role of TLR3 in LUAD by examining its expression levels, prognostic significance, and impact on immune signaling pathways.MethodsWe analyzed the impact of TLR3 expression on the prognosis of lung adenocarcinoma patients using data from the Cancer Genome Atlas (TCGA) database and four additional cohorts (GSE72094, GSE30219, GSE50081 and GSE31210). Functional enrichment analyses were performed to compare molecular features between low and high TLR3 expression groups using gene set variation analysis (GSVA). …”
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Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis by Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie, Tiao Lin

“…Additionally, in vivo animal models were utilized to assess the functional role of CD155 in a biological context. RNA-seq and co-immunoprecipitation methods were used to search for downstream target molecules and signaling pathways of CD155. …”
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The impact of corneal epithelial remodeling on visual quality after SMILE and FS-LASIK for high myopia by Yunjing Ma, Qi Li, Qian Guo, Yue Huang, Ruibo Yang, Hui Liu, Chen Zhang, Shaozhen Zhao

“…The objective optical quality includes the modulation transfer function cut off frequency (MTF cut off), Strehl ratio, objective scatter index (OSI), and mean OSI obtained using the Optical Quality Analysis System-II. …”
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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

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CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism by Mian Liu, Yi Gong, Hong Cai, Rui Hua, Hong Li, Zhe Wang, Yao Zhou, Yanlin Ma, Song Quan

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Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability by Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin

“…<b>Conclusions</b>: Gps significantly ameliorate hyperglycemia and hyperlipidemia through a multifaceted mechanism involving gut microbiota modulation, the restoration of intestinal barrier function, and the regulation of microbial metabolites such as SCFAs and BAs. …”
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CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance by Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang

“…Abstract The chemokine CXCL6 is identified as a pivotal regulator of biological processes across multiple malignancies. However, its function in cholangiocarcinoma (CCA) is underexplored. …”
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CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype by Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane‐Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean‐Marie Launay, Jerome Piquereau, Mariana G Tarragó, Marcel Bonay, Anne Forand, Sophie Moog, France Piétri‐Rouxel, Elise Brisebard, Claudia C S Chini, Sonu Kashyap, Matthew J Fogarty, Gary C Sieck, Mathias Mericskay, Eduardo N Chini, Ana Maria Gomez, José‐Manuel Cancela, Sabine de la Porte

“…Here, we identified that deletion in mdx mice of CD38, a NAD+ glycohydrolase‐producing modulators of Ca2+ signaling, led to a fully restored heart function and structure, with skeletal muscle performance improvements, associated with a reduction in inflammation and senescence markers. …”
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Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure by Michael B. Keller, MD, Allison Y. Lin, Moon Kyoo Jang, PhD, Hyesik Kong, PhD, Ananth Charya, MD, Gerald J. Berry, MD, Charles C. Marboe, MD, Ileana L. Ponor, MD, MBA, Shambhu Aryal, MD, Jonathan B. Orens, MD, Pali D. Shah, MD, Steven D. Nathan, MD, Xin Tian, PhD, Sean Agbor-Enoh, MD, PhD

“…In multivariable Cox regression analysis adjusting for patient and transplant risk factors, mean dd-cfDNA levels after AR/OP were independently associated with an increased risk of CLAD/death (adjusted hazard ratio, 2.84; 95% confidence interval, 1.67-4.83; P < 0.001) and remained consistent when accounting for changes in pulmonary function after AR/OP events (hazard ratio, 2.62; 95% confidence interval, 1.53-4.47; P < 0.001). …”
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LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke by Yan Wang, Yan Zhang, Chang Liu, Xiaoyu Zhang, Bo Wang, Yue Kong, Hailin Zhang, Yanfei Tian, Yupeng Zhao, Zhenghui Wu, Huaxing Zhang, Xiaona Du, Huiran Zhang

“…However, its impact on BBB function is currently unclear.Methods A transient middle cerebral artery occlusion model was established to investigate the impact of LRRC8A on BBB integrity. …”
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The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes by Yinjie Gao, Xiaosen Ma, Huiping Wang, Yunying Cui, Yushi Zhang, Min Nie, Anli Tong

“…Previous studies have investigated the transcriptional modulations of aldosterone overproduction of aldosterone-producing adenomas (APAs). …”
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SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer by Junchen Pan, Haixi Liang, Lin Zhou, Wenhua Lu, Bitao Huo, Bitao Huo, Rui Liu, Peng Huang, Peng Huang

“…While most research in this area has focused on the impact of cholesterol on immune functions, the influence of SQLE-mediated squalene metabolism within the tumor immune microenvironment (TIME) remains unexplored.MethodsWe established an immune-competent mouse model (C57BL/6) bearing mouse pancreatic cancer xenografts (KPC cells) with or without stable SQLE-knockdown (SQLE-KD) to evaluate the impact of SQLE-mediated metabolism on pancreatic cancer growth and immune functions. …”
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