Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging by Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carmen Solcan, Mitica Ciorpac, Andrei Szilagyi, Daniela-Carmen Ababei, Raluca-Maria Gogu, Bogdan-Ionel Tamba

“…Additionally, the study suggests that chronic, intermittent treatment with Cannabixir® Medium Flos may modulate astrocyte function, reduce neuroinflammation, and potentially influence cell proliferation and neuronal apoptosis in a dose-dependent manner. …”
Get full text

Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets by Tomasz Sirek, Tomasz Sirek, Katarzyna Król-Jatręga, Katarzyna Król-Jatręga, Przemysław Borawski, Nikola Zmarzły, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Piotr Ossowski, Olga Nowotny-Czupryna, Kacper Boroń, Dominika Janiszewska-Bil, Elżbieta Mitka-Krysiak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek

“…The identified miRNAs and mRNAs hold potential as biomarkers for diagnosis and treatment, but further validation in functional studies is required. This study provides a foundation for targeted therapies aimed at modulating this critical pathway to improve breast cancer outcomes.…”
Get full text

Impact of methyl Jasmonate on blueberry ripening fruits: assessment of cell wall thermal stability, nutritional parameters and antioxidant enzymatic activity by Carlos Vasquez-Rojas, Carlos Vasquez-Rojas, Marcelo Muñoz-Vera, Sebastián Flores, Mauricio Betancourt, Mauricio Betancourt, Ricardo I. Castro, Patricio Ramos, Patricio Ramos, Daniel Laporte, Carolina Parra-Palma, Luis Morales-Quintana

“…This work provides a preliminary framework for integrating MeJA into sustainable horticultural practices to meet consumer demand for high-quality functional fruits.…”
Get full text

Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer by Hui Huang, Hui Huang, Ying Yang, Xiaojiao Wang, Xiaojiao Wang, Biao Wen, Biao Wen, Xianglan Yang, Wei Zhong, Wei Zhong, Qiurong Wang, Qiurong Wang, Feng He, Feng He, Jun Li, Jun Li

“…IntroductionDespite the established influence of gut bacteria, the role of the gut virome in modulating colorectal cancer (CRC) patient chemotherapy response remains poorly understood. …”
Get full text

Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation by Changyan Li, Peng Rao, Xiang Liu, Xiang Liu, Lin Yang, Lin Yang, Yongliang Jiang, Yongliang Jiang, Gaosheng Yin, Shuangxiu Li, Shuangxiu Li, Ping Yang, Ping Yang, Lin Sun

“…Triphenyltetrazolium chloride (TTC) staining was used to detect infarct size. The cardiac function was monitored by the Langendorff isolated cardiac perfusion system. …”
Get full text

Application of mesenchymal stem cells in liver fibrosis and regeneration by Zhenyu Liu, Junkai Ren, Cheng Qiu, Ying Wang, Tong Zhang

“…As a promising stem cell type, MSCs offer numerous advantages in liver disease treatment, including low immunogenicity; ease of acquisition; unlimited proliferative ability; pluripotent differentiation potential; immunomodulatory function; and anti-inflammatory, antifibrotic, and antiapoptotic biological characteristics. …”
Get full text

Transcription Factor <i>RhCUC3</i> Regulates Petal Numbers in Rose Flowers by Yan Fang, Zixin Zhao, Yuanji Shen, Zheyuan Ding, Yongyi Cui, Wen Chen

“…These findings suggest that <i>RhCUC3</i> enhances stamen petaloidy and petal number, potentially by modulating the expression of <i>RhAG</i> and <i>RhAGL</i>, providing new insights into the function of NAC transcription factors in plants.…”
Get full text

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy by Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han

“…Abstract Exosomes shape the tumor microenvironment (TME) by modulating tumor‐associated macrophages (TAMs) and promoting ovarian cancer (OC) progression. …”
Get full text

Targeting gut microbiota and metabolism profiles with coated sodium butyrate to ameliorate high-energy and low-protein diet-induced intestinal barrier dysfunction in laying hens by Sasa Miao, Jiankui Li, Ying Chen, Wenyan Zhao, Mengru Xu, Fang Liu, Xiaoting Zou, Xinyang Dong

“…The results revealed that CSB treatment improved the laying rate and mitigated the detrimental effects on intestinal barrier function and the inflammatory response induced by the HELP diet in laying hens (P < 0.05). …”
Get full text

Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis by Yanping Lin, Rong Li, Xin Shen, Mingjin Wu, Jiadai Tang, Jiangyan Guo, Caixin Yin, Tingrong Xia, Dongqi Li, Fengdi Hu, Yedan Liao, Rui Li, Lin Xie

“…ObjectivesCircular RNAs (circRNAs) are a class of non-coding RNAs with diverse pathophysiological functions. However, the functional roles and molecular mechanisms of circRNAs in lung adenocarcinoma (LUAD) remain to be further elucidated.MethodsThe expression levels of Circ_0007552 (Circ_RILPL1), miR-7974, and BRCA1-associated protein 1 (BAP1) mRNA in LUAD tissues and cells were detected by quantitative real-time PCR (qRT-PCR). …”
Get full text

Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis by Martina Lepore Signorile, Elisabetta Di Nicola, Giovanna Forte, Paola Sanese, Candida Fasano, Vittoria Disciglio, Katia De Marco, Marialaura Latrofa, Loris De Cecco, Marica Ficorilli, Marta Lucchetta, Erica Torchia, Chiara Dossena, Giusy Bianco, Vito Spilotro, Claudia Ferroni, Nicoletta Labarile, Raffaele Armentano, Francesco Albano, Anna Mestice, Gianluigi Gigante, Valerio Lantone, Giuliano Lantone, Leonardo Vincenti, Alberto Del Rio, Greta Varchi, Valentina Grossi, Cristiano Simone

“…Here, we performed an extensive in vitro and in vivo molecular and functional characterization, revealing the pivotal role of the lysine methyltransferase SET and MYND Domain Containing 3 (SMYD3) in colorectal cancer stem cell (CRC-SC) biology. …”
Get full text

Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…In terms of fecal metabolomics, both acupuncture techniques are implicated in primary bile acid biosynthesis, dopaminergic synapse function, and sphingolipid signaling pathways. Notably, EA exerts a more significant influence on the steroid hormone biosynthesis pathway, whereas MA impacts the tryptophan metabolic pathway.ConclusionBoth EA and MA demonstrate antihypertensive effects by modulating intestinal microbiota composition and metabolite profiles in SHRs, although the specific microbiota and metabolites affected differ between the two techniques, and EA treatment reversed more fecal and serum metabolites than did MA. …”
Get full text

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…Alternatively, 15-oxo-LXA4, an electrophilic α,β-unsaturated ketone, alkylates nucleophilic amino acids and can modulate redox-sensitive transcriptional regulatory protein and enzyme function. 15-oxo-LXA4 activated nuclear factor (erythroid related factor 2)-like 2-regulated expression of anti-inflammatory and repair genes and inhibited NF-κB-regulated pro-inflammatory mediator expression. …”
Get full text

Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson’s disease by Amos Olalekan Abolaji, Adeola Oluwatosin Adedara, Judith Chizoba Madu, Oluwabunmi Tomilola Owalude, Oludare Michael Ogunyemi, Damilola A. Omoboyowa, Folorunsho Bright Omage, Alexander J. Whitworth, Michael Aschner

“…This was followed by a 21-day treatment of PD flies with similar concentrations of resveratrol in the diet to evaluate cognitive function, oxidative stress, and antioxidant biomarkers, using Levodopa (0.1 mM) as positive control. …”
Get full text

A Transcriptomics Approach to Unveil the Antioxidant Effects of Tryptophan on Oocyte Quality Under Oxidative Stress in Pigs by Zhekun Zhu, Yanlong Li, Xinyin Fan, Shuang Cai, Siyu Li, Yutian Wang, Xinyu Wang, Fengjuan Yang

“…These findings suggest that tryptophan supplementation not only mitigated oxidative stress but also modulated gene expression related to cellular functions and stress response. …”
Get full text

Circulating innate lymphoid cells are dysregulated in patients with prostate cancer by Daniela Claudia Maresca, Evelina La Civita, Benedetta Romano, Maria Rosaria Ambrosio, Fabio Somma, Tania Wyss, Bernardo Rocco, Valentina Rubino, Luigi Cari, Philippe Krebs, Antonio Rodriguez-Calero, Matteo Ferro, Sara Trabanelli, Camilla Jandus, Felice Crocetto, Angela Ianaro, Daniela Terracciano, Giuseppe Ercolano

“…This study investigated the phenotypic and functional profiles of ILC subsets in the peripheral blood mononuclear cells (PBMCs) of patients with PCa stratified by Gleason score. …”
Get full text

Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
Get full text

Dehydroacteoside rejuvenates senescence via TVP23C-CDRT4 regulation by Yoo Jin Lee, Eun Seon Song, Yun Haeng Lee, Kyeong Seon Lee, Byeonghyeon So, Ji Ho Park, Jee Hee Yoon, Duyeol Kim, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Ki Yong Lee, Joon Tae Park

“…Dehydroacteoside restored mitochondrial function, thereby reducing mitochondrial ROS generated by inefficient electron transport. …”
Get full text

Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Abstract Background Higher embryonic mortality, especially in aged breeding hens, is associated with insufficient hepatic functionality in maintaining redox homeostasis. Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
Get full text

EXPLORING DISCOURSE MARKERS IN COMPLAINTS: A COMPARATIVE ANALYSIS OF NATIVE AND NON-NATIVE ITALIAN SPEAKERS by Anna De Marco, Emanuela Paone

“…At the B1-B2 level, a broader range of DMs was observed, fulfilling functions such as mitigating or reinforcing the complaint, modulating certainty, and managing the expressive tone of the interaction. …”
Get full text