Investigating the mutual effects of autophagy and apoptosis in heart tissue of type 2 diabetic rats in interaction with aerobic exercise training and vitamin D3 injection by Hadi Golpasandi, Mohammad Rahman Rahimi, Slahadin Ahmadi

“…The aim of this study was to investigate how aerobic training and vitamin D3 supplementation modulate the cardiac tissue of diabetic rats and highlight potential therapeutic strategies to improve cardiac function in diabetic conditions. …”
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Subpopulations of natural killer-T-like cells before and after surgical treatment of laryngeal cancer by Janusz Klatka, Ewelina Grywalska, Anna Hymos, Ewelina Krasowska, Michał Mielnik, Dorota Siwicka-Gieroba, Justyna Markowicz, Piotr Trojanowski, Witold Olszański, Jacek Roliński

“…Different research projects suggest that the role of T lymphocytes might be significant in tumour development. iNKT cells are a new subpopulation of T cells and show cytotoxic activity against tumours. iNKT cells participate in modulating the function of other cells which have anti-tumour properties and secrete cytokines, which have pro-inflammatory and anti-inflammatory effects. …”
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A Single-Cell Assessment of Intramuscular and Subcutaneous Adipose Tissue in Beef Cattle by Mollie M. Green, Hunter R. Ford, Alexandra P. Tegeler, Oscar J. Benitez, Bradley J. Johnson, Clarissa Strieder-Barboza

“…Accordingly, both bulk RNAseq and snRNAseq analyses identified activated pathways of inflammation and metabolic function in IM. These results demonstrate distinct transcriptional cellular heterogeneity between SAT and IM depots in beef steers, which may underly the mechanisms by which fat deposits in each depot. …”
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Genetic association analysis between LDL-c lowering drugs and portal hypertension using Mendelian randomization analysis by Qing-Ao Xiao, Xiao-Long Li, Lei Qin, Xiao-Lin Zhang

“…The IVs of target genes were subjected to MR analysis with coronary atherosclerosis (CAD) as a positive control, confirming that the IVs can effectively substitute for the biological function of the target gene, thereby further enhancing the reliability of the results. …”
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Reevaluation of the gastrointestinal methanogenic archaeome in multiple sclerosis and its association with treatment by Pei Yee Woh, Yehao Chen, Christina Kumpitsch, Rokhsareh Mohammadzadeh, Laura Schmidt, Christine Moissl-Eichinger

“…These findings highlight potential roles for M. smithii and M. sp900766745 in modulating treatment outcomes, warranting further investigation into their relevance to gut microbiome function and MS management.IMPORTANCEMultiple sclerosis (MS) is a chronic neuroinflammatory disease affecting the central nervous system, with approximately 2.8 million people diagnosed worldwide, mainly young adults aged 20–30 years. …”
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Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis by Rui Chu, Mingming Li, Yeshou Xie, Yinuo Du, Tao Ni

“…ObjectiveInsulin-like growth factor-1 (IGF-1) is thought to play an important role in regulating skeletal muscle mass and function, with its decline potentially linked to age-related frailty and sarcopenia. …”
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Ethnicity-Based Differences in Corneal Asphericity: Intraocular Lens Power Calculation, Image Quality, and Visual Acuity After Cataract Surgery Using Eye Models by Das KK, Suryakumar R, Lu W, Maxwell A

“…Differences in power in model eyes with various ethnic asphericities were assessed using spherical SA60AT, Clareon CNA0T0 (− 0.20 μm SA), and a monofocal aspheric IOL (− 0.28 μm SA). Modulation transfer function (MTF) and VA were calculated at different defocus. …”
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Revealing the therapeutic potential of synthetic cannabinoids: a systematic review of cannabinoid receptor binding dynamics and their implications for cancer therapy by Sahar S. Alghamdi, Hussah N. Albahlal, Danah E. Aloumi, Sarah Bin Saqyah, Arwa Alsubait, Jehan Alamre, Mohammed Alrashed, Nada Alsuhabeny, Afrah E. Mohammed

“…Results Various pharmacological actions of synthetic cannabinoids function as agonists, antagonists, and inverse agonists at the CB1R and CB2R receptors. …”
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Erythrodermic Psoriasis in the Context of Emerging Triggers: Insights into Dupilumab-Associated and COVID-19-Induced Psoriatic Disease by Aya Fadel, Jayakumar Nithura, Zahraa F. Saadoon, Lamia Naseer, Angelo Lopez-Lacayo, Ligia Elena Rojas Solano, Chaveli Palau Morales, Robert J. Hernandez, Hussain Hussain

“…Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, impaired epidermal barrier function, and immune dysregulation. The Th17/IL-23 axis plays a central role in its pathogenesis, promoting the production of key pro-inflammatory cytokines such as IL-17, IL-23, and TNF-α, which sustain chronic inflammation and epidermal remodeling. …”
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Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts by Marcus M. Ilg, Alice R. Lapthorn, Sophie L. Harding, Tariq Minhas, Gouri Koduri, Stephen A. Bustin, Selim Cellek

“…These CAFs remodel the extracellular matrix, creating a microenvironment that supports tumor growth and compromises immune cell function, enabling cancer cells to evade immune detection. …”
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Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing by Lijuan Li, Mi Tao, Xueyun Gao, Quan Cao, Zejing Liao, Feng Chen, Ayinigaer Yusufu, Haihang Nie, Ziyue Zeng, Kai Huang, Xuan Deng, Ping Gao, Xiaoyan Wu

“…In the STZ mouse model, PROM1 correlated with fibrosis and diminished renal function, whereas THY1 exhibited protective effects. …”
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Integrative diagnostic criterion for evaluation of COVID-19 severity and the risk of post-COVID syndrome by I. V. Nesterova, M. G. Atazhakhova, V. A. Matushkina, Yu. V. Teterin, V. N. Gorodin, G. A. Chudilova

“…Pathophysiology of severe COVID-19 is characterized by changes in the number, phenotype, and function of neutrophil granulocytes (NG). Among the effector antiviral mechanisms of NG, the neutrophil extracellular traps (NETs) are among the most important features. …”
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Association of placental mitochondrial DNA mutations on infant negative affectivity: modifying effects of maternal lifetime stress and infant sex by Agathe M. de Pins, Hsiao-Hsien Leon Hsu, Rosalind J. Wright, Kelly J. Brunst

“…Research links prenatal stress exposures with placental mitochondrial DNA (mtDNA) mutational load, suggesting that disrupted mitochondrial placental function may play a role. We conceptualize that placental mitochondrial biomarkers reflect environmentally-induced oxidation that may contribute to mechanisms influencing neurodevelopment. …”
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Comprehensive Advanced Physicochemical Characterization and In Vitro Human Cell Culture Assessment of BMS-202: A Novel Inhibitor of Programmed Cell Death Ligand by Hasham Shafi, Andrea J. Lora, Haley M. Donow, Sally E. Dickinson, Georg T. Wondrak, H.-H. Sherry Chow, Clara Curiel-Lewandrowski, Heidi M. Mansour

“…TEER studies indicated that BMS-202 does not disrupt the HaCaT cell barrier function. <b>Conclusions:</b> The findings from this study establish that BMS-202 has promising physicochemical and in vitro characteristics at therapeutic concentrations for topical applications, providing a foundation for future formulation development focused on skin-related cancers or localized immune modulation.…”
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Application of Network Pharmacology, Molecular Docking, and In Vitro Experimental Evaluation to Decipher the Anti-Inflammatory Mechanisms of <i>Cirsium japonicum</i> by Jiaxue Wang, Hui Tao, Zhenlong Wang, Wei An, Ya Zhao, Bing Han, Jinquan Wang, Xiuzhu Sun, Xiumin Wang

“…The results revealed that 14 active components of <i>C. japonicum</i> targeted 171 anti-inflammatory proteins. GO function enrichment analysis yielded 173 items, while KEGG pathway enrichment analysis identified 48 signaling pathways related to inflammation regulation. …”
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CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability by Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Victor S. Batista

“…In addition, the framework incorporates novel state-of-the-art discriminative models for predicting hERG, NaV1.5 and CaV1.2 channel activity, which can function independently as effective components of virtual screening pipelines.…”
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Endosomal H₂O₂ Molecules Act as Signaling Mediators in Akt/PKB Activation by Sujin Park, Chaewon Kim, Sukyeong Heo, Dongmin Kang

“…In the present study, we investigated the regulatory function of H₂O₂ in early endosomes during signaling throughout receptor-mediated endocytosis. …”
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Nitric Oxide Therapeutics: New Hopes for More Effective Tuberculosis Treatment Combine with Targeted and Controlled Nanotechnology by Jin X, Wang J, Ruan Y, Li J, Kong X, Xia J, Yang J, Zhang Q, Liu J, Pi J

“…Additionally, it plays a role in modulating immune cell function, contributing to their anti-tuberculosis (anti-TB) effects by regulating macrophage activity. …”
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Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas by Yu Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou

“…Surfactant-associated 3 (SFTA3), a long non-coding RNA predominantly expressed in normal lung epithelial cells, plays a crucial role in lung development. Nevertheless, its function in lung adenocarcinoma (LUAD) remains inadequately understood. …”
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Integrated lncRNA and mRNA analysis reveals the immune modulatory mechanisms of antimicrobial peptide BSN-37 in mouse peritoneal macrophages by Huihui Zhang, Yanhe Lv, Jingjing Li, Bingze Jiao, Jiahui Fu, Xujie Zhao, Likun Cheng, Yilin Bai, Lei Wang, Yanwei Li, Bolin Hang, Xiaobing Wei, Mingcheng Liu, Zhanwei Teng, Meinan Chang, Chengshui Liao, Yueyu Bai, Xiaojing Xia, Ke Ding, Jianhe Hu

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