The role of T-helper and T regulatory cells in driving neutrophilic and eosinophilic inflammation in bronchiectasis by Evangelia Fouka, Evangelia Fouka, Evangelia Fouka, Anders Lindén, Anders Lindén, Anders Lindén, Apostolos Bossios, Apostolos Bossios, Apostolos Bossios

“…T regulatory (Treg) cells have been shown to play a protective role against excessive chronic inflammation by modulating the function of several types of effector cells, including the Th17 subset. …”
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DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure by Wenwu Tang, Wenwu Tang, Zhixin Wang, Xinzhu Yuan, Liping Chen, Haiyang Guo, Zhirui Qi, Ying Zhang, Xisheng Xie

“…In addition, we further explored potential mechanism and function of hub genes in HF of patients with MHD through GSEA, immune cell infiltration analysis, drug analysis and establishment of molecular regulatory network.ResultsTotally 23 candidate genes were screened out by overlapping 673 differentially expressed genes (DEGs) and 147 key module genes, of which four hub genes (DEPDC1B, CDCA2, APOBEC3B and TYMS) were obtained by two machine learning algorithms. …”
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Exploring the therapeutic potential of propolis in managing diabetes: A preclinical study by Hannah Shi Tiang, Lingling Qin, Tonghua Liu, Xiaotong Yang, Zhiwei Qi, Huizhao Qin, Huelee Yong, Xuesheng Ma, Lili Wu

“…The HDP group exhibited a significant reduction in FBG levels, body weight, connecting peptide levels, homeostatic model assessment of β-cell function scores, and homeostasis model assessment of insulin resistance scores (all P < .05). …”
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Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework by Guirui Zhang, Guirui Zhang, Shupeng Huang, Mingzhen Wei, Yongmo Wu, Zhengyi Xie, Jin Wang, Jin Wang, Jin Wang

“…Therapeutic strategies are evolving from empirical seizure control to mechanism-targeted interventions: antisense oligonucleotides (ASOs) restore SCN1A transcript integrity by blocking pathogenic exon inclusion; adeno-associated virus (AAV9)-mediated activation of GABAergic neuron-specific SCN1A promoters and CRISPR/dCas9-driven endogenous Nav1.1 upregulation have both been shown to improve inhibitory synaptic function and elevate seizure thresholds in preclinical models. …”
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Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages by Yichen Wang, Hongfan Ding, Ruiqi Bai, Qiang Li, Boyuan Ren, Pianpian Lin, Chengfei Li, Minliang Chen, Xiao Xu

“…The co-culture experiments showed that IL-33 enhanced keratinocyte function through activation of the Wnt/β-catenin signaling pathway. …”
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MΦ macrophage – N0 neutrophil dialogue in the presence of TNF-α affects the endothelium by Sergiu-Marian VATAMANU, Monica ȚUCUREANU, Andreea MIHĂILĂ, Elena BUTOI, Anca FARKAS

“…This pro-inflammatory cytokine orchestrates a complex interplay between these immune cells, leading to the activation and recruitment of additional leukocytes, and the modulation of endothelial cell function, which collectively drive plaque formation and progression. …”
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C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis by Ningning Zhang, Qing Shao, Xinni Xiang, Chun Yan, Dan Tao, Qian Li, Huan Rong, Yi Zhao, Tingxiu Xiang, Xiaohua Zeng

“…However, up to now, the biological function of C1QL1 and its molecular mechanism in BrCa remains unknown. …”
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Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis by Jie Zhang, Shuangshuang Wang, Ting Zhang, Minghui Zi, Shuxiang Wang, Qiao Zhang

“…Moreover, EGCG significantly improved aging-related markers induced by a HFD, including the level of senescence-associated β-Galactosidase (SA β-Gal) and expression of p53, p16, and p21 (p < 0.05), while ameliorating liver function in zebrafish. Conclusions These results suggest that EGCG may attenuate MASLD in larval and adult zebrafish induced by 15 consecutive days HFD, which is potentially mediated by modulating the Nrf2/NF-κB/NLRP3 signaling pathway which relieve pyroptosis.…”
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MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study by Shengbo Yang, Litao Zhang, Mingli Hu, Weina He

“…Mediation analysis revealed that Simpson diversity partially mediated the relationship between MIND score and liver health indicators, suggesting a role for gut microbial diversity in modulating hepatic outcomes.ConclusionGreater adherence to the MIND diet was associated with indicators of better liver function, lower systemic inflammation, and improved metabolic health, and a more favorable gut microbiota composition in adults with MASLD.…”
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A meta-analysis of changes in cholinesterase activity among experimental animals infected with Toxoplasma gondii by F. K. Mohammad, S. H. Eassa, R. H. Abdullah

“…Reduced liver ChE activity could be a biomarker of liver injury along with other liver function tests in experimental animals infected with T. gondii. …”

De la neuroplasticidad a las propuestas aplicadas: estimulación temprana y su implementación en Costa Rica / From Neuroplasticity to Applied Proposals: Early Stimulation and Its Im... by Johanna Sibaja-Molina, Tracy Sánchez-Pacheco, Mijail Rojas-Carvajal, Jaime Fornaguera-Trías

“…., developmental psychology, neuroscience) describes not only how environment can modulate brain development and function, but also the plastic mechanisms involved. …”
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Genetic association of lipids and lipid-lowering drug target genes with breast cancer by Tianhua Wang, Yan Yao, Xinhai Gao, Hao Luan, Xue Wang, Lijuan Liu, Changgang Sun

“…We found that HMGCR inhibitors are associated with a reduced risk of breast cancer, and part of their action may be through pathways other than lipid-lowering, including modulation of immune function and reduction of inflammation represented by C-reactive protein levels.…”
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Association Between Thymosin &amp;beta;4 and&amp;nbsp;Coronary Arterial Lesions in Children with Kawasaki Disease by Wu J, Yang P, Zhang J, Chen Z, Wei Y, Su Y, Yi Q

“…Thymosin β 4 (Tβ 4) has been reported to play a role in cardiovascular protection and repair by modulating inflammation, angiogenesis, and endothelial function. …”
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Anthraquinones from Rheum officinale Ameliorate Renal Fibrosis in Acute Kidney Injury and Chronic Kidney Disease by Feng HY, Wang YQ, Yang J, Miao H, Zhao YY, Li X

“…This review discusses the renoprotective effects of R. officinale, including improvements in renal function, reduction of podocyte damage, and inhibition of renal fibrosis. …”
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Analysis of the Integrated Signal Design for Near-Space Communication, Navigation, and TT&C Based on K/Ka Frequency Bands by Lvyang Ye, Shaojun Cao, Zhifei Gu, Deng Pan, Binhu Chen, Xuqian Wu, Kun Shen, Yangdong Yan

“…In addition, factors such as the plasma sheath and multipath also affect the signal propagation. In terms of modulation technology, the constant envelope signal shows an advantage in spectral efficiency; the new integrated signal obtained by integrating communication, navigation, and TT&C signals into a single K/Ka frequency point has excellent characteristics in the simulation of power spectral density (PSD) and autocorrelation function (ACF), verifying the feasibility of the scheme. …”
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Seasonal Self-Purification Process of Nutrients Entering Coastal Water from Land-Based Sources in Tieshan Bay, China: Insights from Incubation Experiments by Fang Xu, Peng Zhang, Yingxian He, Huizi Long, Jibiao Zhang, Dongliang Lu, Chaoxing Ren

“…Nutrients function as essential biological substrates for coastal phytoplankton growth and serve as pivotal indicators in marine environmental monitoring. …”
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Gene and hormones involved in stress density and immunity response of G6 transgenic mutiara catfish (Clarias gariepinus) by Yuniar Mulyani, Ibnu Dwi Buwono, Roffi Grandiosa, Fittrie Meyllianawaty Pratiwy, Epro Barades

“…After 60 days of high-density treatment, NTG fish had higher white blood cell counts (means 46.20 ± 1.00 × 103 cells/mm3) and COR levels (means 69 ± 1.94 ng/mL) than TG fish (means 36.70 ± 1.01 × 103 cells/mm3 and 38.65 ± 1.43 ng/mL), suggesting that NTG fish are more easily stressed. The function of CgGH in TG fish at the ideal stocking density (60 fish/400 L) can shield the kidneys from glomerular necrosis or renal tubular hypertrophy, as demonstrated in NTG fish, according to kidney histology. …”
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Transcript profiling of plastid ferrochelatase two mutants reveals that chloroplast singlet oxygen signals lead to global changes in RNA profiles and are mediated by Plant U-Box 4 by Snigdha Rai, Matthew D. Lemke, Anika M. Arias, María F. Gómez Méndez, Katayoon Dehesh, Jesse D. Woodson

“…The accumulation of 1O2 in fc2 plants broadly repressed genes involved in chloroplast function and photosynthesis, while inducing genes and transcription factors involved in abiotic and biotic stress, the biosynthesis of jasmonic acid (JA) and salicylic acid (SA), microautophagy, and senescence. …”
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Effect of GLP-1 Receptor Agonists (Liraglutide) on Glycemic Parameters and Circulating miRNA Expression in Type 2 Diabetes Mellitus by Aqeel Meer AL-ZAMILY

“…Background: Circulating miRNA modulates a variety of cellular activities including the pathogenesis of many diseases. …”
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Truncated WT1 Protein Isoform Expression Is Increased in MCF-7 Cells with Long-Term Estrogen Depletion by Saavedra-Alonso Santiago, Zapata-Benavides Pablo, Mendoza-Gamboa Edgar, Chavez-Escamilla Ana Karina, Arellano-Rodríguez Mariela, Rodriguez-Padilla Cristina

“…These results support the theory about the relationship of the 36-38 kDa isoform of WT1 and the absence of ER function in advanced breast cancer.…”
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