Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury by Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song

“…We showed that prophylactic gavage of F. plautii attenuates myocardial I/R injury as evidenced by improved cardiac function and reduced cardiac injury. We also found that its metabolite DAT recapitulates these cardioprotective effects against myocardial I/R injury. …”
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Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration by Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang

“…Abstract Disruption of low oxygen tension homeostasis during intervertebral disc degeneration inhibits endogenous stem cell viability and function, posing a challenge for endogenous regeneration. …”
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Regulation of Mitochondrial Metabolism by <i>Mfn1</i> Gene Encoding Mitofusin Affects Cellular Proliferation and Histone Modification by Han Xu, Xiaoyu Zhao, Yuan Yun, Yuxin Gao, Chunjie Bo, Lishuang Song, Chunling Bai, Lei Yang, Guangpeng Li, Guanghua Su

“…This study investigated the effect of <i>Mfn1</i> expression on cell proliferation, apoptosis, and mitochondrial function by overexpressing <i>Mfn1</i> (in OE-Mfn1 cells) and silencing <i>Mfn1</i> using short hairpin RNA (shRNA) (in shMfn1 cells). …”
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Large-Scale Apple Orchard Identification from Multi-Temporal Sentinel-2 Imagery by Chunxiao Wu, Yundan Liu, Jianyu Yang, Anjin Dai, Han Zhou, Kaixuan Tang, Yuxuan Zhang, Ruxin Wang, Binchuan Wei, Yifan Wang

“…Finally, to address the issue of the low proportion of apple orchards in remote sensing images, a Convolutional Block Attention Module (CBAM) and Focal Loss function were integrated into the SegNet model, followed by hyperparameter optimization, resulting in AOCF-SegNet. …”
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Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesIL-10 activation by Ding-Jia-Cheng Jia, Qi-Wen Wang, Ying-Ying Hu, Jia-Min He, Qi-Wei Ge, Ya-Dong Qi, Lu-Yi Chen, Ying Zhang, Li-Na Fan, Yi-Feng Lin, Yong Sun, Yao Jiang, Lan Wang, Yan-Fei Fang, Hui-Qin He, Xiong-E Pi, Wei Liu, Shu-Jie Chen, Liang-Jing Wang

“…Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microenvironment and repair barrier function. …”
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Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis by Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group

“…Abstract Background Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). …”
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Cortical Actin Depolymerisation in 3D Cell Culture Enhances Extracellular Vesicle Secretion and Therapeutic Effects by Zhen Yang, Xiaoke Li, Qiyuan Lin, Fanfan Zhou, Kaini Liang, Jiao Jiao Li, Yudi Niu, Qingchen Meng, Tianyuan Zhao, Hao Li, Du Wang, Jianjing Lin, Hui Li, Bin Wang, Wei Liu, Yanan Du, Jianhao Lin, Dan Xing

“…In addition, sEVs derived from 3D cultured MSCs demonstrated enhanced therapeutic function both in vitro and in rat models of osteoarthritis (OA) and wound healing. …”
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Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα by Shogo Sato, Takuya Sakurai, Junetsu Ogasawara, Ken Shirato, Yoshinaga Ishibashi, Shuji Oh-ishi, Kazuhiko Imaizumi, Shukoh Haga, Yoshiaki Hitomi, Tetsuya Izawa, Yoshinobu Ohira, Hideki Ohno, Takako Kizaki

“…It is now evident that many nuclear hormone receptors can modulate target gene expression. REV-ERBα, one of the nuclear hormone receptors with the capacity to alter clock function, is critically involved in lipid metabolism, adipogenesis, and the inflammatory response. …”
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The renin-angiotensin system in healthy human platelets: expressed but inactive by François Panosetti, François M. Cuenot, Damian S. Saint Auguste, Ana C. Martins Cavaco, Allancer D. C. Nunes, Philip H. J. Lu, Céline Magrini, Max Molot, Gabriel Sanglard, Rodi Günçü, Yassine Zouaghi, Charles Béguelin, Augusto Martins Lima, Nikolaos Stergiopulos

“…Our findings suggest that while RAS receptors are expressed in platelets, RAS peptides do not impact platelet function, at least in our experimental setting. COVID-19 coagulopathy may occur independently of the RAS.…”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective processes such as antioxidant and proteostasis control, mitochondrial function, inflammation, and the metabolism of lipids and glucose. …”
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Lycium barbarum and Lactobacillus acidophilus synergistically protect against anti-tuberculosis drug-induced male reproductive injury via gut microbiota-independent pathways in mic... by Xiaoyong Song, Wei Guan, Wei Guan, Zhimin Du, Yi Gong, Dan Wang, Yajun Xiong, Yuting Gao, Xinli Shi

“…Besides, wolfberry restored intestinal barrier function, enhanced the abundance of L. acidophilus in the gut, and modulated key processes involved in spermatid differentiation, sperm development, and the meiotic cell cycle. …”
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Ultrasound-Mediated Non-Specific Splenic Immunopotentiation to Elicit Broad-Spectrum Anti-Neoplastic Effects by Dong W, Wang G, Li S, Wang Q, Li W, Liu H, Liang Y, Zhou Z, He X, Guo W, Yuan J, Chai Y, Geng J, Li Z

“…It fully demonstrated that FUS directly stimulated splenic immune cell proliferation and activation (especially NK and CD8 T cells) rather than CAP excitation to modulate splenic immune function. Particularly, NK cells are much more indispensable and important in responding to FUS stimulation for cancer suppression than CD8 T cells. …”
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LCFANet: A Novel Lightweight Cross-Level Feature Aggregation Network for Small Agricultural Pest Detection by Shijian Huang, Yunong Tian, Yong Tan, Zize Liang

“…Furthermore, we introduce the MPDINIoU loss function, combining InnerIoU and MPDIoU to optimize bounding box regression. …”
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Metabolomic and transcriptomic analyses reveal MYB-Related genes involved in drought resistance in grafted potatoes via the flavonoid pathway by Yinqiao Jian, Chunyan Gao, Yangyang Shang, Junhong Qin, Shaoguang Duan, Chunsong Bian, Guangcun Li

“…The significant role of flavonoids as modulators of drought resistance, supported by comprehensive transcriptomic and metabolomic analyses, underscores the pivotal regulatory function of the MYB-WD40-bHLH transcription factor complex in orchestrating the stress response.…”
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Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/− mice by Mackenzie Smith, Grace E. Dodis, Amanda M. Vanderplow, Sonia Gonzalez, Yewon Rhee, Karie Scrogin, Rocco G. Gogliotti

“…Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MeCP2) gene. …”
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Flexible grasping of robot arm based on improved Informed-RRT star by Xiong YIN, Yan CHEN, Wenhao GUO, Zichen YANG, Hanxin CHEN, An LIAO, Daojin YAO

“…First, the maximum number of iterations and the adaptive function are pre-set to shorten the generation time of the manipulator’s motion trajectory and enhance sampling guidance and quality. …”
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GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer’s disease by Xiaoqin Wang, Shijing Wu, Zhangjing Deng, Mengyu Yan, Dandan Wang, Maojun Yang, Fuxing Zhong, Jiaqi Song, Lihua Chen, Yingxi Chen, Qi Tian, Weihua Yu, Yang Lü

“…Furthermore, it upregulated the expression of brain-derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD95), and synaptophysin (SYP), indicating enhanced neuronal and synaptic function. GPR43 upregulation also modulated the levels of mitochondrial damage-related enzymes, including superoxide dismutase (SOD), malondialdehyde (MDA), and lactate dehydrogenase (LDH) levels, and reduced mitochondrial swelling. …”
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HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation by Shoude Zhang, Yuan Zhao, Zhanwei Dong, Mao Jin, Ying Lu, Mina Xu, Hong Pan, Guojin Zhou, Mang Xiao

“…Blood pressure, inflammation, oxidative stress, vascular remodeling, and VSMC function were assessed. In vitro experiments with A7r5 cells and human aortic smooth muscle cells (HAoSMCs) explored the effects of HIF-1α silencing and YAP1 overexpression. …”
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Uncovering the Multifaceted Role of <i>PA2649</i> (<i>nuoN</i>) in Type III Secretion System and Other Virulence Production in <i>Pseudomonas aeruginosa</i> PAO1 by Lin Chen, Yujie Si, Xue Han, Yue Xiao, Yidan Pan, Kangmin Duan, Songzhe Fu

“…Overexpression of <i>rsmY</i>, <i>rsmZ</i>, <i>gacA</i>, <i>hfq</i>, and <i>exsD</i> partially rescued T3SS function, confirming that <i>PA2649</i> influences T3SS via the Rsm-Exs pathway. …”
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FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK–mTOR Signaling Pathway by Meng Liu, Xuhui Fan, Dongya Chen, Huibin Yao, Zhihui Huang, Heng Li, Qing Zhang, Yuqi Wang, Haihan Song, Yufeng Yan

“…Conclusion: FCGR1A modulates microglial polarization by affecting the AMPK–mTOR signaling pathway in ischemic conditions. …”
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