Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites by Pei Xiao, Ting Song, Xiao Lu Li, Yong Mei Xiao, Rui Xue Wang, Fei Fei Song, Dan Li, Ai Hua Zhang, Ying Wang, Ting Zhang, Ting Zhang

“…BackgroundAlthough dietary fiber is widely recommended for preventing and treating functional constipation (FC), clinical trial evidence remains limited and the efficacy has not been sufficiently tested in children.PurposeThis study aimed to evaluate the effects of dietary fiber on FC symptoms, while identifying modulations in gut microbiota and associated metabolic changes.ResultsBetween January 1, 2024, and June 1, 2024, a total of 60 patients diagnosed with FC were enrolled in the study across three centers; however, 54 children completed the study. …”
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Early Repetitive Transcranial Magnetic Stimulation Exerts Neuroprotective Effects and Improves Motor Functions in Hemiparkinsonian Rats by Tsung-Hsun Hsieh, Xiao-Kuo He, Hui-Hua Liu, Jia-Jin J. Chen, Chih-Wei Peng, Hao-Li Liu, Alexander Rotenberg, Ko-Ting Chen, Ming-Yuan Chang, Yung-Hsiao Chiang, Pi-Kai Chang, Chi-Wei Kuo

“…A hemiparkinsonian rat model, induced by unilateral injection of 6-hydroxydopamine (6-OHDA), was applied to evaluate the therapeutic potential of rTMS in motor functions and neuroprotective effect of dopaminergic neurons. …”
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Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function by Agnieszka Żak-Bochenek, Paulina Żebrowska-Różańska, Joanna Bajzert, Łukasz Łaczmański, Bogumiła Szponar, Natalia Siwińska, Klaudia Gładysz, Katarzyna Sikorska, Anna Chełmońska-Soyta

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Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. …”
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The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia by Sagarika Bhattacharjee, P. T. Sivakumar, Ganesan Venkatasubramanian, Kenichi Oishi, Kyrana Tsapkini, S. H. Annabel Chen, Brenda Rapp, John E. Desmond, T. N. Sathyaprabha, Kaviraja Udupa, Rajan Kashyap

“…Since tDCS current distribution depends on brain structure and function, variant-specific montages are essential. …”
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Associations of functional and biochemical parameters of endothelial dysfunction in postmenopausal women with a different state of carbohydrate metabolism by Lyudmila Aleksandrovna Ruyatkina, Irina Sergeevna Iskhakova, Konstantin Yuryevich Nikolaev, Dmitriy Sergeevich Ruyatkin

“…Consequently, in the literature, there is no information about the function of endothelial vasomotion during occlusion. …”
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Unraveling the Molecular Mechanisms of Blueberry Root Drought Tolerance Through Yeast Functional Screening and Metabolomic Profiling by Xinyu Fan, Beijia Lin, Yahong Yin, Yu Zong, Yongqiang Li, Youyin Zhu, Weidong Guo

“…Overall, the yeast functional screening system used in this study effectively identified genes and metabolites influencing blueberry root drought tolerance, offering new insights into the associated molecular mechanisms.…”
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Global assessment of swallow function (GASF) following VMAT radiotherapy for head and neck squamous cell carcinoma by Kate Toft, Kirsty McLachlan, Mark Winton, Karen Mactier, Nadine Hare, Claire Nugent, Lucie Wincott, Devraj Srinivasan, Joanna Mackenzie, Bill Nailon, David Noble

“…Aim: This study aimed to conduct a global assessment of swallow function (GASF) using a range of swallow outcome tools, in a cohort of patients pre- and post-treatment with image-guided volumetric modulated arc therapy (VMAT) radiotherapy. …”
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Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer by Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou, Xingdang Liu

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Effects of Trimetazidine Combined with Atorvastatin on Cardiac Function in Patients with Stable Angina Pectoris of Coronary Heart Disease by Zhang N, Ren Y, Qin D, Yang X, Chen Z, Zhao L

“…Outcomes included angina characteristics, lipid profile, endothelial function (NO/ET-1), specified inflammatory markers (hs-CRP, TNF-α), cardiac function (LVEF, NT-proBNP), and safety.Results: The observation group had a significantly higher overall response rate (94.0% vs 80.0%, P< 0.05). …”
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Effect of intense endurance training with egg white and wheat germ supplementation on cardiopulmonary function in endurance runners by Abdollah Niloufari, Foad Feizolahi, Fariba Aghaei, Mahsa Mohsenzadeh

“…This study investigated the effects of intense endurance training (HIET) combined with egg white and wheat germ supplementation on immune, respiratory, and cardiopulmonary function in endurance runners. In this quasi-experimental study, 24 male endurance runners from Saqqez City were randomly assigned to either a training + supplement group (n=12) or a training + placebo group (n=12). …”
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Deciphering influence of donor age on adipose-derived stem cells: in vitro paracrine function and angiogenic potential by Chloe Trotzier, Clement Bellanger, Hakima Abdessadeq, Philippe Delannoy, Ali Mojallal, Celine Auxenfans

“…Here we’ve investigated the effect of age on paracrine function, stemness and angiogenic potential of ASC. …”
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The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope by Tetiana Kovalchuk, Oksana Boyarchuk, Nataliya Balatska

“…During the 3-month therapy, the QOL in children showed improvements in physical, emotional, and school functioning (p &lt; 0.05). In parents of children with a history of VVS, there were enhancements in physical, emotional, social, and cognitive functioning, as well as in communication and a reduction in worry levels. …”
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Diversity and functional roles of endophytic and rhizospheric microorganisms in Ophioglossum vulgatum L.: implications for bioactive compound synthesis by Xian-Nv Long, Xian-Nv Long, Xian-Nv Long, Xing-Kai Zhang, Yue Wu, Shu-Shuang Tang, Tai-Xiong Zheng, Di Chen, Guan-Hua Cao, Guan-Hua Cao, Guan-Hua Cao, Xu-Hong Zhou, Sen He, Sen He, Sen He

“…Alpha/beta diversity analyses showed higher microbial richness in rhizosphere soil than in plant tissues. Functional predictions (PICRUSt2/FUNGuild) linked endophytic and rhizospheric bacteria to metabolism, human diseases, and biological systems. …”
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Individual alpha frequency tACS reduces static functional connectivity across the default mode network by Martín Carrasco-Gómez, Martín Carrasco-Gómez, Martín Carrasco-Gómez, Alejandra García-Colomo, Alejandra García-Colomo, Jesús Cabrera-Álvarez, Jesús Cabrera-Álvarez, Alberto del Cerro-León, Alberto del Cerro-León, Carlos J. Gómez-Ariza, Andrés Santos, Andrés Santos, Fernando Maestú, Fernando Maestú, Fernando Maestú

“…IntroductionResearch on the influence of transcranial alternating current stimulation over alpha functional connectivity (FC) is scarce, even when it poses as a potential treatment for various diseases. …”
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Graphene-Based Nanomaterials in Photodynamic Therapy: Synthesis Strategies, Functional Roles, and Clinical Translation for Tumor Treatment by Liang J, Wu Y, Zhang C, Yi R, Zheng J, Zhao R, Shan D, Wang B

“…This review highlights how graphene-based nanomaterials address these challenges through functionalization strategies, including receptor-mediated tumor targeting, size-dependent penetration, optical synergy, and hypoxia modulation. …”
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Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors by Lingli Huang, Lingli Huang, Lingli Huang, Lingli Huang, Xujia Li, Xujia Li, Xujia Li, Xujia Li, Silan Huang, Silan Huang, Silan Huang, Silan Huang, Qi Jiang, Qi Jiang, Qi Jiang, Qi Jiang, Chang Jiang, Chang Jiang, Chang Jiang, Chang Jiang, Wenzhuo He, Wenzhuo He, Wenzhuo He, Wenzhuo He, Yuchen Cai, Yuchen Cai, Yuchen Cai, Yuchen Cai, Guifang Guo, Guifang Guo, Guifang Guo, Guifang Guo

“…Cytoscape, GSCALite, CancerSEA, STRING, HPA, TIGER, TISIDB, and R were used to assess ETV4’s expression and functional impact on basis of the TCGA and GTEx databases. …”
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HES1 revitalizes the functionality of aged adipose-derived stem cells by inhibiting the transcription of STAT1 by Chengcheng Li, Sen Ren, Chengqi Yan, Cheng Wang, Tao Jiang, Yu Kang, Jing Chen, Hewei Xiong, Jiahe Guo, Guoyong Jiang, Shuoyuan Liu, Pengjuan Nie, Zhenbing Chen

“…It has been reported that transcription factors (TFs) play a crucial role in the aging and functionality of stem cells. Nevertheless, there is limited understanding regarding the involvement of TFs in the aging mechanism of ADSCs. …”
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THE INFLUENCE OF A POLYPEPTIDE PREPARATION ON A STRUCTURAL-FUNCTIONAL STATE PERIODONT IN ADJURANT PERIODONITIS (EXPERIMENTAL RESEARCH) by G.M. Silenko, O.B. Belikov, N.I. Belikova, M.V. Khrebor, Y.I. Silenko

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GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy by Xiaoli Yang, Yong Li, Min Min, Nan Jiang, Lijuan Sun, Dandan Zhang, Yuan Cao, Yanhong Zhang, Yufei Wang, Hui Zhong, Xueping Ma, Qi Gao, Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Xufeng Hou, Muyi Liu, Xuemiao Zhang, Congwen Wei

“…Further analysis revealed that the effector function of CD8+T cells in tumors relies on glycolysis regulated by HIF-1α rather than immune checkpoints. …”
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