miR-98-5p Alleviated Epithelial-to-Mesenchymal Transition and Renal Fibrosis via Targeting Hmga2 in Diabetic Nephropathy by Yingchun Zhu, Jiang Xu, Wenxing Liang, Ji Li, Linhong Feng, PengXi Zheng, Tingting Ji, Shoujun Bai

“…Epithelial-to-mesenchymal transition (EMT) can play a significant role in tubulointerstitial fibrosis, and it is a hallmark of diabetic nephropathy progression. Nevertheless, the function of miR-98-5p in the modulation of EMT and renal fibrosis during DN remains barely investigated. …”
Get full text

Mobile health-based remote interaction management intervention for patients with low anterior resection syndrome: study protocol for a randomised controlled trial by Ting Wang, Peng Zhou, Min Fu, Shihui Yu, Shaohua Hu, Hongye He, Xueying Pang, Danqiao Yin, Degang Zhu

“…The primary outcome will be global QoL; the secondary outcomes will include bowel function, social support, self-management measured at the baseline, 3 months and 6 months for three times and patients’ thinkings at the end of the intervention (at 3 months).Ethics and dissemination Ethics approval was granted by the Clinical Medical Research Ethics Committee of the First Affiliated Hospital of Anhui Medical University (PJ2022-07-53).Trial registration number Chinese Clinical Trial Registry (ChiCTR2200061317).…”
Get full text

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC by Xin Yue, Zhen Xiang, Yang Yi, Xuecen Wang, Weilin Zhou, Weijian Wu, Wenjing Qin, Yuxuan Zhao, Xianzhang Bu, Zhenwei Peng

“…The TRIM14/USP14 complex facilitates the excision of pronounced K48-linked polyubiquitination at lysine residues 48 or 118 on GPX4, thereby preserving GPX4’s structural integrity and antioxidative function to counteract ferroptosis. Intriguingly, TRIM14-mediated GPX4 stabilization is further amplified in radioresistant HCC, and subsequent radiation enables USP14-dependent blockade of GPX4 degradation. …”
Get full text

Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomize... by Jeremy J. Walsh, Amedeo D’Angiulli, Jameason D. Cameron, Ronald J. Sigal, Glen P. Kenny, Martin Holcik, Steve Doucette, Angela S. Alberga, Denis Prud’homme, Stasia Hadjiyannakis, Katie Gunnell, Gary S. Goldfield

“…Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. …”
Get full text

Comprehensive analysis of potential biomarkers for the diagnosis and prognosis of Cervical squamous cell carcinoma - based on GEO and TCGA databases by Yufen Chen, Qinghua Deng, Tengyue Fu, Yuxiang Huang, Houlin Li, Jingmu Xie, Feng Liao, Feimiao Zeng, Xinyi Fang, Ruiman Li, Zhuming Chen

“…Prognostic models were constructed and validated, with additional analyses exploring immune cell infiltration and gene function via GSEA and clinical correlation. Finally, key genes were validated via qRT-PCR in CESC tissues.ResultsA total of 112 differentially expressed genes (DEGs) were identified through differential analysis of the GEO and TCGA datasets. …”
Get full text

Immunomodulatory effects of Eimeria maxima surface antigen (EmSAG) as an IFN-γ inhibitory molecule on peripheral blood mononuclear cells (PBMCs) and T cell subsets in chickens by Xianglin Pu, Yiyuan Zhang, Xinmei Huang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song

“…These findings highlight the role of EmSAG as an inhibitor of IFN-γ, facilitating immune evasion by attenuating the Th1 immune response and modulating Treg cell function. This study provides critical insights into the immune evasion mechanisms utilised by chicken coccidia.…”
Get full text

Thirteen-Year Sequelae of Marburg Virus Disease Survival: Persistent Cardiometabolic, Immunometabolic, and Haematological Alterations in the Absence of Psychological Morbidity by Jennifer Serwanga, Raymond Ernest Kaweesa, Joseph Katende Ssebwana, Goeffrey Odoch, Raymond Reuel Wayesu, Anne Daphine Ntabadde, Deborah Mukisa, Peter Ejou, FiloStudy Team, Julius Julian Lutwama, Pontiano Kaleebu

“…Laboratory analyses covered electrolytes, inflammatory markers, renal and liver function tests, haematology, and urinalysis. Standardised psychological assessments measured anxiety, depression, perceived stigma, and social support. …”
Get full text

Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents by Huangshu Ye, Yue Zhang, Li Hu, Yuxin Feng, Tianfan Zhu, Qi Meng, Xiaoxuan Sun, Miaojia Zhang, Zhengsheng Mao, Feng Chen, Yanfang Yu, Qiang Wang, Jie Wang

“…Additionally, Huaier activated the Nrf2 (nuclear factor erythroid 2‐related factor 2) signaling pathway, enhancing mitochondrial function and alleviating oxidative stress. The multifunctional roles of Huaier contributed to its inhibited effect on PASMCs proliferation and thus improved vascular remodeling. …”
Get full text

Antidepressant effects and mechanisms of Wuhua herbal tea in a rat model of chronic unpredictable mild stress by Zhiwei Qi, Lingling Qin, Ming Gao, Ruifeng Yang, Congyi Liu, Ning Wang, Wenjing Li, Yongxin Huang, Lili Wu, Tonghua Liu

“…It also restores BDNF-CREB pathway function, reducing depressive symptoms.…”
Get full text

In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy by Mansi Dahalia, Mansi Dahalia, Haya Majid, Mohd Junaid Khan, Akshat Rathi, Mohd Ashif Khan, Imran Ahmd Khan, Mohammed Samim, Sayeed Ur Rehman, Md Salik Noorani, Divya Vohora, Nidhi

“…In vivo, Compound C demonstrated anticonvulsant (p < 0.05), neuroprotective (5 mg/kg, p < 0.05, 10 mg/kg, p < 0.01, 20 mg/kg p < 0.0001), antidepressant (p < 0.05), and anti-inflammatory (p < 0.05) effects in PTZ-induced seizure models, improving motor function (p < 0.001), cognitive performance (p < 0.01), and reducing neuroinflammatory/metabolic markers (p < 0.05), while modulating STAT3 (p < 0.001), BAX (p < 0.001), Bcl2 (p < 0.05), and Klotho (p < 0.05) gene expression.ConclusionThe therapeutic potential of 1,8-bis(phenylsulfonyl)-1,8-dihydropyrrolo [2,3-b] indole in epilepsy via Klotho modulation was observed. …”
Get full text

Involvement of mediodorsal thalamus and its related neural circuit in pain regulation in mice by Chu-han Liu, Hui-jie Feng, Fei Peng, Shan Wang, Liu-jie Zhao, Hui Zhu, Xue-ying Dou, Ting Yuan, Chuang Li, Nan Zhou, Wen-xin Zhang, Xuan-ren Wang, Yu-lin Dong

“…While anatomical studies have confirm reciprocal projections between the MD and anterior cingulate cortex (ACC), the functional contribution of ACC-MD neural circuitry to nociceptive regulation has not yet been systematically investigated. …”
Get full text

Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells by Daniela Scribano, Claudia Tito, Astri D. Tagueha, Martina Pasqua, Luciana De Angelis, Francesco Fazi, Dolores Limongi, Marta De Angelis, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi

“…Abstract Background The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. …”
Get full text

Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells by Giacomo Fais, Agnieszka Sidorowicz, Giovanni Perra, Debora Dessì, Francesco Loy, Nicola Lai, Paolo Follesa, Roberto Orrù, Giacomo Cao, Alessandro Concas

“…The impact of the synthesis environment and the nanomaterials’ characteristics on cytotoxicity was evaluated by examining reactive species production and their effects on mitochondrial bioenergetic functions. Cytotoxicity assays on PC12 cells, a cell line originated from a rat pheochromocytoma, an adrenal medulla tumor, demonstrated that Ag/Ag₂O NPs synthesized with apolar (Ag/Ag₂O NPs A) and polar (Ag/Ag₂O NPs P) extracts exhibited significant cytotoxic effects, primarily driven by Ag⁺ ion release and the disruption of mitochondrial function. …”
Get full text

A designed predictive modelling strategy based on data decomposition and machine learning to forecast solar radiation by Mumtaz Ali, Ramendra Prasad, Salman Alamery, Aitazaz Ahsan Farooque

“…In the first stage of model design, the RLMD, a frequency resolution method, is applied to decompose the original SR time series into amplitude modulation subseries (AMs), frequency modulation subseries (FMs), and the low-frequency product functions (PFs) to reveal the internal structure of the model construction data to incrementally optimize the RLD-RF model where only PFs were used. …”
Get full text

SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…This approach combined high‐throughput sequencing technologies, such as Deep‐DIA and LC‐MS, with functional validation techniques, including CRISPR/Cas9 gene editing, xenograft models, and molecular pathway analyses. …”
Get full text

HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

“…Transcriptomic analysis revealed that the total loss of HSPA2 affected the expression of genes related to keratinocyte differentiation and interleukin- and interferon-mediated signaling. The functional analysis confirmed bidirectional changes associated with the loss of HSPA2. …”
Get full text

Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice by Liying Shan, Xiaoxia Liao, Xiaoli Yang, Endong Zhu, Hairui Yuan, Jie Zhou, Xiaoxia Li, Baoli Wang

“…In this study, we identified the up-regulation of NKD2 during osteoblast and adipocyte differentiation. Functional experiments revealed that NKD2 stimulated osteoblast differentiation and suppressed adipocyte formation. …”
Get full text

Impact of Fluxapyroxad and Mefentrifluconazole on Microbial Succession and Metabolic Regulation in Rice Under Field Conditions by Changpeng Zhang, Nan Fang, Chizhou Liang, Xiangyun Wang, Yanjie Li, Hongmei He, Xueping Zhao, Yuqin Luo, Jinhua Jiang

“…., <i>Sphingomonas</i>) contrasted with suppression of nitrogen-fixing <i>Bradyrhizobium</i>, indicating functional trade-offs. Metabolomic profiling identified 3512 metabolites, with 332 and 173 differentially expressed metabolites at 7 d (S) and 21 d (T), dominated by lipids, benzenoids, and phenylpropanoids. …”
Get full text

Phytochemical Profiling of Processed Açaí Pulp (<i>Euterpe oleracea</i>) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats by Jefferson Romáryo Duarte da Luz, Eder Alves Barbosa, Rubiamara Mauricio de Sousa, Maria Lúcia de Azevedo Oliveira, Marcela Fabiani Silva Dias, Ingrid Reale Alves, Gisele Custódio de Souza, Elenilze Figueiredo Batista Ferreira, Carla Guzmán-Pincheira, Maria das Graças Almeida, Gabriel Araujo-Silva

“…These findings suggest that Amazonian açaí pulp (APEA) retains potent antioxidant activity after industrial processing, with protective effects against oxidative damage in cardiomyocytes and hepatic tissue, highlighting its potential as a functional food ingredient with cardioprotective and hepatoprotective properties.…”
Get full text

Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway and gut m... by Lei Li, Lei Li, Lei Li, Jun Ma, Jun Ma, Zeshi Li, Zeshi Li, Juelin Chen, Jiawei Zhou, Yawei Wang, Yankun Pei, Yitong Gong, Jianyao You, Yangyang Cao, Man Wang, Jikuai Chen, Wenjun Chang, Weiyi Ma, Hanyu Zhu, Chuhan Xiang, Shuogui Xu, Qing Song, Qing Song

“…These findings suggest that HXZQD maintains intestinal homeostasis during EHS by preserving barrier function and modulating gut microbiota, offering a promising preventive approach for EHS management.…”
Get full text