Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice by Yuming Wu, Yujing Zhang, Yuan Yu, Xin Wang, Zifan Zhen, Yin Yuan, Bing Xie, Mengqi Han, Mengyuan Wang, Xinyu Zhang, Xueqiang Sun, Xiaoyue Wen, Kenji Hashimoto, You Shang, Shiying Yuan, Jiancheng Zhang

“…Our research demonstrates that sepsis could induce the migration of IL-7Rhigh CD8low γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway in male mice. …”
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Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration by Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan

“…Due to miRNA‐1a/15b function on multiple processes modulating adult cardiomyocyte mitosis, its inhibition augmented adult cardiomyocyte cell‐cycle completion and daughter cell formation, and improved contractility in 3D human cardiac organoids, and in a mouse model of ST‐segment elevation myocardial infarction. …”
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Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance by Yanyan Zhang, Jiale Liu, Muzi Li, Yi Dong, Zongyun Li, Dan Yi, Tao Wu, Lei Wang, Di Zhao, Yongqing Hou

“…The impact of ZnO as a feed additive on growth-performance and intestinal function of <i>Enterotoxigenic Escherichia coli</i> (ETEC) K88-infected piglets remains unclear. …”
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ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7 by Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu

“…Overall, ACSS2‐mediated H4K12cr emerges as a pivotal modulator governing intestinal barrier function during IBD progression.…”
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FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice by Alba Irisarri, Ana Corral, Núria Perez-Salvador, Aina Bellver-Sanchis, Marta Ribalta-Vilella, Roger Bentanachs, Marta Alegret, Juan Carlos Laguna, Emma Barroso, Xavier Palomer, Daniel Ortuño-Sahagún, Manuel Vázquez-Carrera, Mercè Pallàs, Laura Herrero, Christian Griñán-Ferré

“…Abstract This study investigated the effects of fat mass and obesity-associated (FTO) inhibition on cognitive function and metabolic parameters of senescence-accelerated mouse prone 8 (SAMP8) mice fed a high-fat diet (HFD). …”
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Induction of SUSD2 by STAT3 Activation Is Associated with Tumor Recurrence in HER2-Positive Breast Cancer by Yisun Jeong, Hyungjoo Kim, Daeun You, Soo Youn Cho, Sun Young Yoon, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim

“…Sushi domain-containing protein 2 (SUSD2), a transmembrane protein containing a sushi motif, has been reported to have tumor-promoting functions in various types of cancer, including breast cancer. …”
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Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation by Hongyu Jiang, Wei Liu, Jiajie Chen, Yue Tian, Zhibo Jia, Yanbin Wu, Yanjun Guan, Leijia Chen, Wenjing Xu, Haoye Meng, Yingjie Xiong, Jianting Ye, Cheng Huang, Ruichao He, Sice Wang, Yufei Ding, Wei Fan, Yunkang Yang, Jiang Peng, Aiyuan Wang

“…The evaluation of their biological function was conducted through live/dead staining, CCK-8 assay, scratch assay, and Transwell assay in a laboratory setting. …”
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Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model by Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla-Varela, Angimar Uriepero-Palma, Fleur S. Peters, Kamira Maharaj, Julio C. Chavez, John Powers, Alyssa Obermayer, Timothy I. Shaw, José R. Conejo-Garcia, Paulo C. Rodriguez, Eva Sahakian, Javier Pinilla-Ibarz, Arnon P. Kater

“…Integrated metabolic and functional analyses revealed impaired, depolarized mitochondria across all T-cell subsets in untreated patients with CLL, leading to further ex vivo and in vivo mouse studies on the underlying signaling alterations. …”
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High-Coverage Profiling of Hydroxyl and Amino Compounds in Sauce-Flavor Baijiu Using Bromine Isotope Labeling and Ultra-High Performance Liquid Chromatography–High-Resolution Mass... by Zixuan Wang, Youlan Sun, Tiantian Chen, Lili Jiang, Yuhao Shang, Xiaolong You, Feng Hu, Di Yu, Xinyu Liu, Bo Wan, Chunxiu Hu, Guowang Xu

“…<b>Methods</b>: The method employs 5-bromonicotinoyl chloride (BrNC) for rapid (30 s) and mild (room temperature) labeling of hydroxyl and amino functional groups, utilizing bromine’s natural isotopic pattern (Δ<i>m</i>/<i>z</i> = 1.998 Da) for efficient screening. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Considering the homeostatic function EVs exert, inherently encompassing subtle biologic modifications, the current study may have lacked sufficient power to demonstrate statistical significance in a sample set with evident donor variation. …”
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Influenza-induced microRNA-155 expression is altered in extracellular vesicles derived from the COPD epithelium by Laura V. Reid, C. Mirella Spalluto, C. Mirella Spalluto, Tom M. A. Wilkinson, Tom M. A. Wilkinson, Karl J. Staples, Karl J. Staples

“…However, further work to fully characterize the function of EV miRNA in response to IAV in both health and COPD is required.…”
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CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice by Yuanyu Shen, Xiaolei Zhang, Siqi Liu, Lijing Xin, Wentao Xuan, Caiyu Zhuang, Yue Chen, Beibei Chen, Xinhui Zheng, Renhua Wu, Yan Lin

“…Conclusions CEST imaging combined with 1H-MRS demonstrated the effectiveness of riluzole in modulating Glu- and GABA-related changes and improving cognitive function in 3xTg AD mice, potentially through regulating key proteins involved in neurotransmitter metabolism. …”
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Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis by Lianjun Yang, Ke You, Kun Wang, Bin Liu, Tao Chen, Zhifei Cui, Dawei Zhang, Zhihai Su, Xiang Liu, Hai Lu

“…Furthermore, treatment with L. reuteri resulted in a marked reduction in serum levels of pro-inflammatory cytokines, including IL-1β, IL-18, IL-17A, and IL-23, indicating its potential to modulate systemic inflammation. Additionally, L. reuteri enhanced intestinal mucosal barrier function, as demonstrated by improved histopathological integrity, reduced intestinal permeability, and restored expression of tight junction proteins ZO-1 and occludin. …”
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FLT3 ligand regulates expansion of regulatory T-cells induced by regulatory dendritic cells isolated from gut-associated lymphoid tissues through the Notch pathway by Na Li, Jingwei Mao, Haiying Tang, Xiaoyan Tan, Jian Bi, Hao Wu, Xiuli Chen, Yingde Wang, Yuanyuan Ji

“…CD103+CD11b+ DC exhibited DCreg-like functionality and was identified as DCreg for subsequent investigation. …”
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Usp18 Mediates D-Dopachrome Tautomerase-Induced Astrocytic Inflammation After Spinal Cord Injury by Zhang X, Hou Y, Cai R, Zhou Y, He B, Cao Z, Li A, Song H, Wang Y, Jiang H, Qi L, Wang Y

“…Administration of D-DT inhibitor 4-CPPC at lesion sites following SCI significantly reduced the protein levels of Usp18 and ameliorated functional deficits of rat hindlimb locomotion.Conclusion: SCI-induced elevation of D-DT at lesion sites activates astrocytic inflammation via upregulating the expression of Usp18. …”
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FABP4 as a therapeutic host target controlling SARS-CoV-2 infection by Hatoon Baazim, Emre Koyuncu, Gürol Tuncman, M Furkan Burak, Lea Merkel, Nadine Bahour, Ezgi Simay Karabulut, Grace Yankun Lee, Alireza Hanifehnezhad, Zehra Firat Karagoz, Katalin Földes, Ilayda Engin, Ayse Gokce Erman, Sidika Oztop, Nazlican Filazi, Buket Gul, Ahmet Ceylan, Ozge Ozgenc Cinar, Fusun Can, Hahn Kim, Ali Al-Hakeem, Hui Li, Fatih Semerci, Xihong Lin, Erkan Yilmaz, Onder Ergonul, Aykut Ozkul, Gökhan S Hotamisligil

“…We demonstrate that loss of FABP4 function, by genetic or pharmacological means, reduces SARS-CoV-2 replication and disrupts the formation of viral replication organelles in adipocytes and airway epithelial cells. …”
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RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation by Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang

“…These findings highlight the possibility of using RONIN as a viable therapeutic target to ameliorate presbycusis by enhancing the TFEB function.…”
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Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy by Bolan Yu, Huanpeng Chen, Yuying Yang, Yuqing Deng, Fengjiao Wei, Qingyu Zhao, Yongqi Liu, Zhonghua Liu, Zhaofeng Huang

“…In addition, we demonstrated that Sirf CAR-T cells could modulate the tumor microenvironment by decreasing myeloid-derived stem cells as well as increasing CD11c+ dendritic cells and M1-type macrophages in tumor tissue.Conclusions In summary, our findings indicate that CD47 blocker SIRPα-Fc enhances the antitumor efficacy of CAR-T cells and propose to block CD47/SIRPα signaling effect on CAR-T cells function, which could provide a new strategy for successful cancer immunotherapy by rationalizing combination of CD47 blocker and CAR-T cell therapy.…”
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Long‐Term Effects of Nusinersen Dosing Frequency on Adult Patients With Spinal Muscular Atrophy: Efficacy of a 6‐Month Dosing Interval by Keita Takahashi, Hitaru Kishida, Misako Kunii, Yosuke Miyaji, Yuichi Higashiyama, Hiroshi Doi, Naohisa Ueda, Hideyuki Takeuchi, Fumiaki Tanaka

“…Methods We assessed 14 adult patients treated with nusinersen every 6 months over a period of up to 39 months using the Hammersmith Function Motor Scale Expanded (HFMSE) and Revised Upper Limb Module (RULM). …”
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Few-shot object detection for pest insects via features aggregation and contrastive learning by Shuqian He, Shuqian He, Biao Jin, Biao Jin, Xuechao Sun, Wenjuan Jiang, Wenjuan Jiang, Jiaxing Gu, Fenglin Gu

“…To manage class imbalance and enhance the focus on challenging samples, focal loss and class weights are integrated into the model’s comprehensive loss function. Experimental validation on the PestDet20 dataset, consisting of diverse tropical pest insects, demonstrates that the proposed method significantly outperforms existing approaches, including YOLO, TFA, VFA, and FSCE. …”
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