StimEMG: An Electromyogram Recording System With Real-Time Removal of Time-Varying Electrical Stimulation Artifacts by Jiashun Zhao, Rui Yuan, Henry Shin, Run Ji, Yang Zheng

“…A closed-loop Functional Electrical Stimulation (FES) system that incorporates electromyogram (EMG) signal feedback provides more effective assistance to paralytic patients in maintaining and recovering their motor abilities. …”
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Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…Zheping Chen,1– 3,* Le Zhang,2,3,* Guodong Lu,2,3 Yizheng Zhang,2,3 Dexu Zhao,2,3 Shanshan Zhao,2,3 He Zhang,2,3 Yuelong Jin,4 Xin Zhao,2,3 Yanwu Jin2,3 1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, People’s Republic of China; 3The second Clinical College of Shandong University, Jinan, 250033, People’s Republic of China; 4Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Zhao; Yanwu Jin, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, 250033, People’s Republic of China, Email lujnzx@sohu.com; jinyanwu_aa@163.comBackground: Postoperative sore throat (POST) is a significant adverse effect after endotracheal intubation, especially with double-lumen endotracheal tubes (DLTs). …”
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Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers by Wentong Li, Yiyi Zhang, Chuanhong Li, Mingyang Jiang, Dong Wang, Luomeng Chao, Luomeng Chao, Luomeng Chao, Yuxia Yang

“…Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.ResultsA total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10-3), neuroactive ligand-receptor interaction (p=6.01×10-4), and osteoclast differentiation (NES=2.83). …”
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Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion by Manuel Mataix, Nuria Illera, Inés Hidalgo, Maria del Carmen de Arriba, Elena Martín, Gerónimo Fernández, Carlos González, Fernando Larcher, Victor M. González, Marcela del Rio, Francisco Jiménez, Marta Carretero

“…Non-canonical functions of olfactory receptors, one of the largest families of GPCR receptors not confined to the olfactory system, include an intriguing role on hair physiology. …”
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Influence of high-definition transcranial direct current stimulation to the parietal cortex on postural control: a single-blind randomized crossover study by Fan Yang, Fan Yang, Yang Liu, Yang Liu, Xianglin Lv, Yaqi He, Jinpeng Gao, Pei Zhang, Qing Li, Zhongmei Peng, Jinghua Qian, Jinghua Qian

“…For response strength, when the balance plate moved forward at different magnitude under eyes closed condition, they all decreased significantly after bilateral stimulation (p < 0.05).ConclusionThe parietal lobe participates in the modulation of automatic postural response. The primary function of the right parietal lobe in postural response is to process visual information, while the left is responsible for processing somatosensory information.…”
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Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches by Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan

“…The study included biochemical analysis of liver and kidney function markers, oxidative stress indicators, histological and immunohistochemical examinations, and molecular docking studies. …”
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Targeting FCRLA to induce necrosis in lung adenocarcinoma: a novel strategy for prognosis and therapy via MPT-Driven pathways by Xiaoli Sun, Xiaoli Sun, Xiaoli Sun, Xiaoli Sun, Bowen Cai, Shusen Zhang, Xiaowei Cao, Zhen Wang, Zhigang Cai, Zhigang Cai, Zhigang Cai

“…The JC-1 probe indicated that the mitochondrial membrane potential in the FCRLA-knockdown group was significantly reduced, suggesting impaired mitochondrial function.DiscussionRASGRP2, CD79A, and FCRLA have been identified as being associated with MPTDN in LUAD cells. …”
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Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics by Wei Chen, Wei Chen, Xiaofang Wang, Xiaofang Wang, Guoshun Huang, Guoshun Huang, Qin Sheng, Enchao Zhou, Enchao Zhou

“…We explored their potential physiopathologic function through GSEA.ResultsWe obtained 432 genes related to cellular senescence, 1,208 differentially expressed genes (DEGs) and 840 genes in the key gene module related to LN, which were intersected with each other for CS-DEGs. …”
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Shear Stress Triggers Angiogenesis of Late Endothelial Progenitor Cells via the PTEN/Akt/GTPCH/BH4 Pathway by Shao-Hong Wu, Feng Zhang, Shun Yao, Lu Tang, Hai-Tao Zeng, Ling-Ping Zhu, Zhen Yang

“…Shear stress is an effective modulator of endothelial progenitor cells (EPCs) and has been suggested to play an important role in angiogenesis. …”
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TRAF2 regulates the progression of pulmonary fibrosis through β-catenin-Snail signaling pathway by Zhijie Wan, Jingwen Gu, Wanli Duan, Yuanyuan Chen, Shuya Song, Jingyu Luo, Xide Zhang, Yanyong Yang, Yanyong Yang, Fu Gao, Fu Gao, Ying Xu

“…IntroductionPulmonary fibrosis (PF) is a devastating lung disease characterized by excessive extracellular matrix deposition and impaired pulmonary function, with limited therapeutic options. The pathogenesis of PF involves a complex network of molecular events, including epithelial-mesenchymal transition (EMT), activation of fibroblasts, and dysregulated tissue remodeling. …”
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A novel lncRNA YIL163C enhances genomic stability and antifungal resistance via the DNA damage response in Saccharomyces cerevisiae by Xueting Wang, Xueting Wang, Xuemei Li, Duoyun Li, Yiying Zhang, Bing Bai, Bao Chai, Zewen Wen

“…This study investigates the function of a novel lncRNA, YIL163C, in promoting cell survival and genomic stability under DNA damage conditions.MethodsGenetic suppressor screening was employed to assess the role of YIL163C in rescuing lethality in mec1Δ sml1Δ and rad53Δ sml1Δ exposed to DNA damage. …”
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Carbamazepine-exposed earthworms are characterized by tissue-specific accumulation patterns and transcriptional profiles by Chubin Zhang, Filipe Cabreiro, Leon P. Barron, Stephen R. Stürzenbaum

“…This, in turn, will lead to informed and reliable risk assessments defining the consequences of wastewater and biosolid amendment practices on soil ecology and ecosystem function.…”
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Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway by Ning An, Xiaoru Wang, Jia Qin, Meng Cheng, Mei Bai, Jingcai Cheng, Qiang Xu, Xuefeng Wu

“…The AML12 hepacytes were cultured to investigate the in vitro effects.Results: PEITC treatment markedly attenuated hepatic tissue damage, restored normal liver architecture, and significantly reduced serum levels of transaminases (AST and ALT), while normalizing hepatic metabolic function. These protective effects were mechanistically linked to the suppression of hepatocyte pyroptosis, as PEITC effectively reversed the upregulation of the NLRP3 inflammasome, Caspase-1 cleavage, and Gasdermin D (GSDMD) in triptolide-exposed livers. …”
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Transcription factor XBP1s promotes endometritis-induced epithelial-mesenchymal transition by targeting MAP3K2, a key gene in the MAPK/ERK pathway by Kangkang Gao, Mengqi Si, Xinxi Qin, Beibei Zhang, Zongjie Wang, Pengfei Lin, Huatao Chen, Aihua Wang, Yaping Jin

“…The transcription factor, X-box binding protein 1 splicing variant (XBP1s) is a key regulator of the endoplasmic reticulum stress response (ERS); but the function of XBP1s in the endometritis-induced EMT process remains unclear. …”
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Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT) cells by Piotr Humeniuk, Aidan Barrett, Hannes Axelsson, Carmen Corciulo, Christina Drevinge, Alicia Del Carpio Pons, Davide Angeletti, Julia M. Scheffler, Ulrika Islander

“…Invariant natural killer T (iNKT) cells are fast‐reacting forces and modulators of immune responses that are important to IAV immunity, but it is not known if the presence and function of iNKT cells differ between females and males. …”
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Role of ZBED3 in PALD1/PIP2- dependent calcium homeostasis during oocyte maturation by Danyu Ni, Qijun Xie, Yuting Chen, Yi Wei, Peng Lang, Xiaodan Shi, Ye Yang, Xiufeng Ling, Chun Zhao

“…To investigate the molecular mechanisms underlying the function of ZBED3 during oocyte maturation, we employed miniTurbo biotin ligase-based proximity labeling combined with mass spectrometry to identify protein interactomes in transfected HEK293 cells. …”
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Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130... by Yali Jiang, Feng Ma, Jing Wang, Xiaojing Chen, Lu Xue, Xinping Chen, Jinping Hu

“…Nonetheless, the precise function and mechanism of lncRNA H19 in renal tubulointerstitial fibrosis are not fully comprehended. …”
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Genome-wide CRISPR knockout screen identifies activating transcription factor (ATF1) as an activator of HIV gene expression by Alona Kuzmina, Seraj Wattad, Praveenkumar Murugavelu, Noa Amir, Nili Tickotsky, Liron Levin, Ran Taube

“…Additional gain and loss-of-function experiments show that depletion of ATF1 promotes latency. …”
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Targeting androgen receptor stability and degradation: approaches for developing a therapy for spinal and bulbar muscular atrophy by Riccardo Cristofani, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Marta Cozzi, Paola Pramaggiore, Laura Cornaggia, Ali Mohamed, Elena Casarotto, Maria Brodnanova, Rocio Magdalena, Prashant Koshal, Margherita Piccolella, Valeria Crippa, Mariarita Galbiati, Angelo Poletti, Paola Rusmini

“…Finally, we provide an overview of promising approaches to SBMA intervention involving the modulation of PQC system functions to reduce ARexp accumulation and its toxic effects in affected cells.…”
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Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy by Xue Chen, Ying Wang, Jia-Nan Wang, Yi-Chen Zhang, Ye-Ran Zhang, Ru-Xu Sun, Bing Qin, Yuan-Xin Dai, Hong-Jing Zhu, Jin-Xiang Zhao, Wei-Wei Zhang, Jiang-Dong Ji, Song-Tao Yuan, Qun-Dong Shen, Qing-Huai Liu

“…Collectively, our study demonstrates that FTO is important for EC function and retinal homeostasis in DR, and warrants further investigation as a therapeutic target for DR patients.…”
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