NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer by Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yiran Deng, Lan Li, Bingjie Zeng, Haixia Jiang, Liang Shan, Yiwen Huang, Yunhua Xu, Lifang Ma

“…This study seeks to explore the function of the m5C methyltransferase NSUN2 in modulating PD-L1 expression and facilitating immune evasion in NSCLC. …”
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Escherichia coli aggravates inflammatory response in mice oral mucositis through regulating Th17/Treg imbalance by Jia Liu, Jia Liu, Jia Liu, Wenhui Xia, Wenhui Xia, Wenhui Xia, Wenhui Xia, Juehua Cheng, Juehua Cheng, Juehua Cheng, Yanlin Geng, Yanlin Geng, Yanlin Geng, Weiping Li, Weiping Li, Weiping Li, Yuan Fan, Yuan Fan, Yuan Fan

“…Differential gene expression analysis, functional enrichment analysis and immune infiltration analysis were performed using RNA-seq data from oral lichen planus (OLP).ResultsE. coli stimulation aggravated inflammatory responses induced by scratching in lingual mucosa of mice, including increased local and systemic expression of interleukin 6 (IL6), interleukin 17 (IL17), chemokine receptor 6 (CCR6) and chemokine C-C motif ligand 20 (CCL20), increased proportions of Th17 cells and increased Th17/Treg ratio in spleen lymphocytes. …”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimental validation was conducted using quantitative real-time Polymerase Chain Reaction (qRT-PCR), Western blotting, and functional assays in HCC cell lines and xenograft models. …”
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Phyllotaxy and environmental factors influences on leaf trait dimensions in Fraxinus mandshurica: a multidimensional approach within temperate forests by Mingyue Jin, Mingyue Jin, Mingyue Jin, Yunfei Diao, Yunfei Diao, Yunlong Wang, Mingke Zhang, Tianyi Wang, Yajun Ren, Yajun Ren, Yajun Ren, Ming Zhong, Ming Zhong, Ming Zhong, Wanting Cheng, Wanting Cheng, Wanting Cheng, Chengdong Wang, Chengdong Wang, Chengdong Wang, Honghui Teng, Honghui Teng, Honghui Teng

“…No significant variation in the dimensions of economic and stomatal traits was observed across the phyllotaxy gradient; (2) phyllotaxy modulates trait coordination, with decoupled economic and stomatal traits at phyllotaxy 1 but coupled relationships at phyllotaxy 2–6; (3) environmental factors had a greater impact on economic trait dimensions variation, whereas phyllotaxy was more important for stomatal trait dimensions.DiscussionOur study highlights the significance of trait dimensions in understanding plant functional strategies. …”
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IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension by Zongye Cai, Ly Tu, Siyu Tian, Lin Deng, Yahong Fu, Carole Phan, Thierry P. P. van den Bosch, Karin Tran‐Lundmark, Bence M. Nagy, Horst Olschewski, Xiaoxuan Li, Sihao Wang, Danan Wang, Yi Yan, Lijun Fu, Karin A. Boomars, Christophe Guignabert, Daphne Merkus

“…We investigated the functional role and molecular mechanisms of KP activation in PAH. …”
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Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics by Umair Ali Khan Saddozai, Umair Ali Khan Saddozai, Chenxu Liu, Chenxu Liu, Fei Yan, Zhendong Lu, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Usman Akbar, Saadullah Khattak, Haibo Sun, Haibo Sun, Ping Yang

“…Immune infiltration was assessed using the CIBERSORT algorithm.ResultsT cell marker analyses revealed key roles in pathways such as PI3K-Akt signaling and immune modulation. Molecular subtyping identified two clusters with distinct immune microenvironments: Cluster C1 (immunosuppressive phenotype and poorer prognosis) and Cluster C2 (functionally active immune profile associated with better prognosis). …”
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Disability in childhood and the equity of health services: a cross-sectional comparison of mass drug administration strategies for soil-transmitted helminths in southern Malawi by Hannah Kuper, Calum Davey, Judd Walson, Robin L Bailey, Sean Galagan, Khumbo Kalua, James Simwanza, Rachel Pullan, Lazarus Juziwelo, Hugo Legge, Stefan Witek-McManus, Rejoice Msiska, Hastings Mangawah, William Oswald, Joseph Timothy, Emily Pearman, Mariyam Shaikh

“…Community-based ‘door to door’ approaches may provide a more equitable strategy to ensure that children with disabilities are reached, but disability is rarely assessed rigorously in the evaluation of health interventions.Objectives To describe the prevalence and factors associated with disability among children aged 5–17 years and to assess the relative effectiveness of routine school-based deworming (SBD) compared with a novel intervention of community-based deworming (CBD) in treating children with disabilities for soil-transmitted helminths.Setting DeWorm3 Malawi Site (DMS), Mangochi district, Malawi.Participants All 44 574 children aged 5–17 years residing within the DMS.Primary and secondary outcome measures Disability was defined as a functional limitation in one or more domains of the Washington Group/UNICEF Child Functioning Module administered as part of a community-based census. …”
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ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota by Yi-Hsuan Liu, Yueh-Lun Lee, Chia-Li Han, Yu-Chun Lo, Zih-An Liao, Yu-Syuan Shih, Yi-Wen Lin, Syue-Wei Peng, Kang-Yun Lee, Shu-Chuan Ho, Sheng-Ming Wu, Cheng-Wei Lin, Kian Fan Chung, Jer-Hwa Chang, Hsiao-Chi Chuang

“…Methods Six-week-old male Balb/c mice were divided into five groups: control, ITIH4, ovalbumin (OVA), and two OVA + ITIH4 treatment groups at different doses. Lung function and oxygen saturation were measured, and bronchoalveolar lavage fluid (BALF) was analyzed for white blood cell counts and cytokines. …”
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Nature variations of OsNLP4 responsible for nitrogen use efficiency divergence in the two rice subspecies by Jie Wu, Ying Song, Guangyu Wan, Liangqi Sun, Jingxian Wang, Hongkai Wu, Shimei Wang, Chuanzao Mao, Peng Qin, Shigui Li, Chengcai Chu, Chengbin Xiang

“…Heterologous expression in Arabidopsis increases shoot biomass by 23%, demonstrating possible conservation of function in dicots. Mechanistically, the indica allele’s stronger NRE-binding capacity synergistically modulates downstream pathways. …”
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3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…The composition and angiogenic potential of 3D-ASC-derived secretome was assessed by means of protein array and functional tube formation assay, respectively. We analyzed the expression profile of 92 angiogenesis-related genes in 2D versus 3D cultures through a qRT-PCR array, and GO term enrichment analysis followed by network analysis was applied to identify the top hub genes. …”
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miR-144-3p targeting FLRT3 in osteogenic differentiation of mandibular bone marrow mesenchymal stem cells by Jingjun Tian, Chen Lv, Tao Xie, Qi Sun, Changyu Liu, Wen Ma, Chaofeng Liu, Renyi Cheng, Kang Yin, Yanhua Xu

“…Dual-luciferase assays confirmed that FLRT3 is a target gene of miR-144-3p. Functional assays revealed that the miR-144-3p mimic decreased FLRT3 expression, while the inhibitor increased it. …”
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Isolation of a Novel <i>Streptomyces</i> sp. TH05 with Potent Cyanocidal Effects on <i>Microcystis aeruginosa</i> by Xuhan Wang, Siqi Zhu, Shenchen Tao, Shaoyong Zhang, Ruijun Wang, Liqin Zhang

“…In addition, oxidative stress responses, expression of key functional genes in FACHB-905, and variations in microcystin concentrations were comprehensively evaluated. …”
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Eudragit® EPO, modified with 4-phenylboronic acid groups, as a novel polymeric excipient with enhanced mucoadhesive properties by D. S. Gordeeva, S. F. Nasibullin, A. G. Karpov, V. V. Khutoryanskiy, R. I. Moustafine

“…Molecular weight, surface charge, flexibility of the polymer chain and the presence of various functional groups play an important role. Polymers under the trade name Eudragit®, produced by the German concern Evonik Nutrition &amp; Care GmbH, have been used in the pharmaceutical field for several decades to produce controlled-release oral dosage forms. …”
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Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. …”
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Brain Activation During Motor Preparation and Execution in Patients with Mild Cognitive Impairment: An fNIRS Study by Hanfei Li, Chenyu Fan, Ke Chen, Hongyu Xie, Guohui Yang, Haozheng Li, Xiangtong Ji, Yi Wu, Meng Li

“…<b data-eusoft-scrollable-element="1">Methods:</b> We investigated the cortical activation pattern of 57 individuals with mild cognitive impairment (MCI) and 67 healthy controls (HCs) using functional near-infrared spectroscopy (fNIRS) during prepared walking (PW) and single walking (SW) tasks. …”
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Development of an efficient heterologous protein expression platform in Aspergillus niger through genetic modification of a glucoamylase hyperproducing industrial strain by Fufan Gou, Dandan Liu, Chaohui Gong, Kefen Wang, Xingji Wang, Yefu Chen, Qian Liu, Chaoguang Tian

“…Through site-specific integration of target genes into native high-expression loci and strategic modulation of the secretory pathway, we successfully enabled the rapid production of functional enzymes and bioactive proteins from diverse origins. …”
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Serum vitamin D levels in patients with Bell’s palsy: a systematic review and meta-analysis by Elaheh Foroughi, Mehrdad Mozafar, Shayesteh Haghighi, Maryam Moghbel Baerz, Kosar Salehi Torabi, Aref Hafezi Bafti, Fatemeh Asadi, Mani Khorsand Askari, Erfan Shahabinejad

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Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis by Jianyu Yan, Tianyu Wang, Ruizhi Yu, Lijuan Xu, Hongming Shao, Tengfei Li, Zhe Wang, Xudong Cha, Zhenyuan Miao, Chengguo Xing, Ke Xu, Huanhai Liu, Chunlin Zhuang

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m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma by Giedrius Steponaitis, Rugile Dragunaite, Rytis Stakaitis, Amit Sharma, Arimantas Tamasauskas, Daina Skiriute

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Multi-omics analyses reveal fecal microbial community and metabolic alterations in finishing cattle fed probiotics-fermented distiller’s grains diets by Rong Zhang, Shihui Mei, Guangxia He, Miaozhan Wei, Lan Chen, Ze Chen, Min Zhu, Bijun Zhou, Kaigong Wang, Zhentao Cheng, Chunmei Wang, Erpeng Zhu, Chao Chen

“…These findings provide some new insights into clarifying the role and potential mechanisms of FDG diets and also offer a scientific basis for the development of FDG into functional feed resources.…”
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