Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Enteric microbiota plays a crucial role in the health and productivity of poultry, including influences on nutrient absorption, immune function, and pathogen resistance. In this study, we conducted a genome-wide association study (GWAS) to identify host genetic variants associated with selected bacterial genera found in chickens. …”
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The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures by Jan Trieschmann, Daniel Bettin, Moritz Haustein, Annette Köster, Marek Molcanyi, Marcel Halbach, Mira Hanna, Mariam Fouad, Konrad Brockmeier, Jürgen Hescheler, Kurt Pfannkuche, Tobias Hannes

“…While it is well documented how the electrophysiology of neonatal cardiomyocytes is modulated by cardiac fibroblasts of the same developmental stage, it is unknown how adult cardiac fibroblasts (aCFs) affect the function of embryonic stem cell-derived cardiomyocytes (ESC-CMs). …”
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Protective effect of exercise induced metabolite-3 in ischemia-reperfusion injury by Zijie CHENG, Xuejun WANG, Zimu WANG, Juying QIAN

“…Transcriptomic analysis suggested that EIM-3 exerts its protective function potentially by regulating glucose metabolim. …”
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Mineral identification in thin sections using a lightweight and attention mechanism by Xin Zhang, Wei Dang, Jun Liu, Zijuan Yin, Guichao Du, Yawen He, Yankai Xue

“…Additionally, Inner-Intersection Over Union (InnerIOU) is used as the loss function to improve the average quality localization performance of anchor boxes. …”
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MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3 by Feilong Chen, Zhiyu Li, Tutu Wang, Yu Fu, Lei Lyu, Chengyuan Xing, Shunchang Li, Li

“…In this study, liver function was impaired in a T2DM rat model, leading to the aggravation of liver fibrosis. …”
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Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer by Geng Xu, Yaling Jiang, Chen Sun, Bernd W. Brandt, Kamran Nazmi, Luca Morelli, Giulia Lencioni, Elisa Giovannetti, Dongmei Deng

“…While previous studies attributed bacteria-induced resistance to indirect host modulation, recent findings suggest a direct mechanism. …”
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Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüpp... by Hiroaki Sunaga, Hiroki Matsui, Saki Anjo, Mas Risky A. A. Syamsunarno, Norimichi Koitabashi, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi

“…Background Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). …”
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Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion by Fangyan Wang, Xinyu Wang, Chaoyi Wang, Wangxin Yan, Junpeng Xu, Zhengyang Song, Mingli Su, Jingjing Zeng, Qiannian Han, Gaoyi Ruan, Eryao Zhang, Wantie Wang

“…Methods This study examined intestinal barrier function and ferroptosis-related parameters in mice with IIRI following treatment with metformin. …”
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Bioactive camel milk peptides as regulators of insulin receptor signaling: Experimental and computational perspectives by Issoufou Katambe Mohamed, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang, Mouhamed Fall

“…Bioactive peptides have emerged as promising modulators of IR function; however, their mechanisms of action remain largely elusive. …”
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Effects of chemogenetic virus injection and clozapine administration in spinal cord injury by Ji Hyeon Kim, Sae Yeon Hwang, Hye-Lan Lee, Sol Lip Yoon, Yoon Ha, Hye Yeong Lee, Seungjun Ryu

“…The objective was to determine whether the administration of DREADDs and clozapine (0.1 ​mg/kg) could enhance motor function and neuronal recovery, particularly when applied during the acute phase of SCI. …”
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Calcium-iron crosstalk in epileptogenesis: Unraveling mechanisms and therapeutic opportunities by Xuan Li, Ao-Long Tao, Nayiyuan Wu, Xiu Zhang, Fen Xiao, Jing Wang, Zhi-Bin Wang

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Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. …”
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Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma by Hyemin Hwang, Jimin Kim, Tae-Hun Kim, Yeonju Han, Dayoung Choi, Sua Cho, Seunghwan Kim, Sanghee Park, Taehyun Park, Filippo Piccinini, Won Jong Rhee, Jae-Chul Pyun, Misu Lee

“…Among these, miR-6126 was significantly downregulated in Huh7RS cells compared to Huh7S cells. Functional studies using 2-dimensional (D) and 3D cell culture systems revealed that miR-6126 overexpression reduced sorafenib resistance in Huh7RS cells, while its inhibition increased resistance in Huh7 cells. miR-6126 downregulated key proteins involved in cancer stem cell maintenance, such as CD44 and HK2. …”
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Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure by Nyzil Massey, Suraj S. Vasanthi, Claire Holtkamp, Christina Meyer, Nikhil S. Rao, Luis G. Gimenez-Lirola, Chong Wang, Hyunmook Im, Avinash S. Bevoor, Sridhar Kannurpatti, Thimmasettappa Thippeswamy

“…Results SAR treatment attenuated the soman-induced anxiety/fear-like behavioral changes and motor impairment and modulated the severity of spontaneous seizures. Despite improved hippocampal functional connectivity (fMRI), SAR did not mitigate soman-induced cognitive deficits at 5–7 weeks. …”
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Transcriptional and microbial profile of gastric cancer patients infected with Epstein-Barr virus by Klezzer de Oliveira Carneiro, Taíssa Maíra Thomaz Araújo, Ronald Matheus Da Silva Mourão, Samir Mansour Moraes Casseb, Samia Demachki, Fabiano Cordeiro Moreira, Ândrea Kely Campos Ribeiro Dos Santos, Geraldo Ishak, Daniel de Souza Avelar Da Costa, Leandro Magalhães, Amanda Ferreira Vidal, Rommel Mario Rodriguez Burbano, Paulo Pimentel de Assumpção

“…ROC analysis identified genes with high specificity and sensitivity for discriminating EBV+ gastric cancer, including GBP5, CMKLR1, GM2A and CXCL11 that play pivotal roles in immune response, inflammation, and cancer. Functional enrichment pointed to cytokine-cytokine receptor interactions, antigen processing, and Th17 immune response, emphasizing the role of the tumor microenvironment, shaped by inflammation and immunomodulation, in EBV-associated GC. …”
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Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfus... by Zan Liu, Zitong Zhao, Zhenghui Xiao, Ming Li, Xiyang Wang, Yan Huang, Yong Li

“…Among these, miR-378a-3p was identified as a candidate for regulating ferroptosis. To confirm its functional role, we treated II/R mice with BMSC-EVs overexpressing miR-378a-3p and assessed the outcomes. …”
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Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer by Yumin Ke, Meili Liang, Zhimei Zhou, Yajing Xie, Li Huang, Liying Sheng, Yueli Wang, Xinyan Zhou, Zhuna Wu

“…To identify differentially immune-related genes (DIRGs) linked to OCCC. We assessed DIRGs functional enrichment and built a protein-protein interaction (PPI) to explore DIRGs interactions. …”
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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice by Maria Luisa De Paolis, Gilda Loffredo, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Lucy Babicola, Matteo Di Segni, Roberto Coccurello, Stefano Puglisi-Allegra, Emanuele Claudio Latagliata, Marcello D’Amelio

“…Moreover, decreased midbrain volume and functional VTA disconnection are identified as predictors of accelerated progression from Mild Cognitive Impairment to AD-dementia in clinical populations. …”
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A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation by Robyn P. Seipp, Robyn P. Seipp, Guillaume Hoeffel, Alexander R. Moise, Alexander R. Moise, Siri Lok, Siri Lok, Anne-Claire Ripoche, Concepción Marañón, Anne Hosmalin, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies

“…While the canonical Tapasin isoform plays a critical role in stabilizing MHC class I by facilitating optimal peptide loading in the endoplasmic reticulum (ER), the other isoforms function in distinct ways that impact immune regulation. …”
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Didymin Ameliorates Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis by Regulating Gut Microbiota and Amino Acid Metabolism in Mice by Zhongxing Chu, Zuomin Hu, Feiyan Yang, Yaping Zhou, Yiping Tang, Feijun Luo

“…<b>Background:</b> Didymin is a dietary flavonoid derived from citrus fruits and has been shown to have extensive biological functions, especially anti-inflammatory effects, but its mechanism is unclear. …”
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