Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel by Geoanna M. Bautista, Yingjie Du, Michael J. Matthews, Allison M. Flores, Nicole R. Kushnir, Nicolle K. Sweeney, Nam Phuong N. Nguyen, Elmira Tokhtaeva, R. S. Solorzano-Vargas, Michael Lewis, Matthias Stelzner, Ximin He, James C. Y. Dunn, Martin G. Martin

“…Here, we investigate the effects of SMC-specific Piezo1 deletion on small bowel function. Piezo1 depletion results in weight loss, delayed GI transit, muscularis thinning, and decreased SMCs. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…Biopsies and patient-derived organoid transcriptomes were then analyzed to evaluate if specific intestinal pathways were differentially modulated in MASH subjects. Functional assays were performed to assess the duodenal epithelial absorptive potential and barrier functionality. …”
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Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway by Yue Dong, Fanyi Meng, Jingyi Wang, Jingge Wei, Kexin Zhang, Siqi Qin, Mengfan Li, Fucheng Wang, Bangmao Wang, Tianyu Liu, Weilong Zhong, Hailong Cao

“…Mechanistically, DVF induced EMT through a functional transmembrane receptor called leucine-rich repeat containing 19 (LRRC19). …”
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GNG7 as a tumor-suppressor gene in lung adenocarcinoma: implications for prognosis and immune-based therapies by Kexin Luo, Kexin Luo, Kexin Luo, Kexin Luo, Meihan Liu, Meihan Liu, Meihan Liu, Meihan Liu, Zhongqin Peng, Zhongqin Peng, Zhongqin Peng, Haiyang Zhao, Haiyang Zhao, Haiyang Zhao, Haiyang Zhao, Guoyi Li, Guoyi Li, Guoyi Li, Guoyi Li, Yuanze Cai, Yumeng Lei, Hongpan Zhang, Hongpan Zhang, Yongsheng Zhao, Yongsheng Zhao

“…Immune cell infiltration and immune-related gene expression were evaluated in association with GNG7 levels. In vitro functional assays, including proliferation, migration, invasion, and apoptosis assays, were performed following GNG7 overexpression. …”
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Genome-wide identification and characterization of soybean GH9 endo-1,4-β-glucanases by Weimin Zhan, Huijuan Huang, Zaipan Cai, Zhenwei Zhao, Xuefu Lin, Yize Peng, Zhicheng Dong, Di Qin, Di Qin, Li Jiang

“…GmGH9As contain typical transmembrane structural domains, while GmGH9Cs uniquely includes the carbohydrate-binding module 49 (CBM49) and signal peptide. Furthermore, we identified 13 distinct types of functional motifs, with light-responsive elements being predominant. …”
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Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…Abstract Background Modulating the gut microbiota with prebiotics is a promising strategy for managing metabolic diseases. …”
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Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study by Alissa Behn, Saskia Brendle, Saskia Brendle, Marianne Ehrnsperger, Marianne Ehrnsperger, Magdalena Zborilova, Thomas M. Grupp, Thomas M. Grupp, Joachim Grifka, Joachim Grifka, Nicole Schäfer, Susanne Grässel, Susanne Grässel

“…Luminex multiplex ELISA were performed with lipoaspirates and cell supernatants alongside functional assays evaluating cell migration, proliferation, metabolic activity, and senescence.ResultsA total of 62 cytokines, chemokines, growth factors, neuropeptides, matrix-degrading enzymes, and complement components were identified in lipoaspirates. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…Moreover, a custom cross-attention module based on a cross-attention mechanism was constructed to effectively fuse the functional information and structural information. …”
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Gut microbiota-driven neuroinflammation in Alzheimer’s disease: from mechanisms to therapeutic opportunities by Wenhui Lei, Wenhui Lei, Yiwen Cheng, Xia Liu, Jie Gao, Zhangcheng Zhu, Wenwen Ding, Wenwen Ding, Xiaocui Xu, Xiaocui Xu, Yating Li, Zongxin Ling, Ruilai Jiang, Xiaoying Chen

“…These findings have opened new therapeutic possibilities, with microbiota-targeted approaches such as probiotics, prebiotics, and fecal microbiota transplantation demonstrating promising neuroprotective effects in preclinical studies by reducing neuroinflammation and preserving cognitive function. However, translating these findings into clinical applications requires further validation through randomized controlled trials. …”
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RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells by Na Yi, Han-rui Wang, Yu-ping Zhu, Tao Xiao, Qin Lin, Huan Liu, Yi-lei Meng, Yi-zhuo Sun, Fang Lin, Sang-yu Hu, Hua-ming Cao, Jun-fang Zhang, Lu-ying Peng, Li Li

“…Suppression of SAMD4A inhibits the proliferation of hESCs, impedes cardiac mesoderm differentiation, and impairs the function of hESC-derived cardiomyocytes. Correspondingly, forced expression of SAMD4A enhances proliferation and promotes cardiomyogenesis. …”
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The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism by Yuhui Tang, Baiwei Zhao, Wanchuan Wang, Haoming Chen, Junsheng Zhang, Yi Xie, Yongming Chen, Feizhi Lin, Yuanfang Li, Xiaohui Zhai, Wen Zhou

“…In vitro and in vivo functional experiments validated the effects of TENM3-AS1 to GC metastasis and the reprogramming of FA metabolism. …”
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MS4A7 based metabolic gene signature as a prognostic predictor in lung adenocarcinoma by Yan Jiang, Zhengyu Shu, Lei Cheng, Lei Cheng, Haowei Wang, Taiping He, Liwen Fu, Chao Zhao, Xuefei Li, Weicheng Zeng, Weicheng Zeng

“…These macrophages exhibited distinct metabolic reprogramming and key immune functions, particularly in crosstalk with T cells and neutrophils.ConclusionThe MS4A7 gene plays a critical role in LUAD prognosis, particularly through its involvement in immune modulation within the TME. …”
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CD98hc, a novel of galectin-8 receptor, binds to galectin-8 in an N-glycosylation-dependent manner by Si Yunlong, Zhu Jiahui, Sayed Hend, Mayo Kevin H., Zhou Yifa, Tai Guihua, Su Jiyong

“…Galectin-8 (Gal-8), classified as a ‘tandem-repeat’ type of galectin, binds to cell surface glycans to modulate various cellular functions, including cell adhesion, migration, apoptosis, pathogen recognition, autophagy, and immunomodulation. …”
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Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes by Minzhen Deng, Minzhen Deng, Minzhen Deng, Yuefang Cai, Yuefang Cai, Yu Wang, Dafeng Hu, Yan Li, Zhenqiu Ning, Chengyi Wang, Sookja Kim Chung, Yan Huang, Yan Huang, Jingbo Sun, Jingbo Sun, Lihua Zhou, Jie Li, Xiao Cheng, Xiao Cheng, Xiao Cheng

“…TMP’s neuroprotective effects were further linked to the upregulation of phosphorylated AKT (p-AKT), indicating that the AKT pathway may function downstream of ET-1. These results highlight TMP’s potential in treating ischemic stroke by modulating the ET-1 and AKT signaling pathways, offering a promising avenue for future stroke therapies.…”
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Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI by Shengnan Li, Zhaoliang Shan, Guochun Zhao, Yuwei Li, Minghui Du, Xiuxiu Ti, Yuxue Gao, Wenting Li, Hui Zuo, Yan Wang, Qing Zhang

“…Mechanistically, we show that dMterf4 RNAi-triggered mitochondrial defect mediates downregulation of lysosomal LManVI through Med8/Tfb4-E(z)/pho axis, causing impairment of lysosomal function. Reciprocally, downregulation of lysosomal LManVI further decreases many mitochondrial genes expression through downregulation of transcriptional coactivator PGC-1, leading to aggravating the dMterf4 RNAi-mediated mitochondrial defect, suggesting that mitochondrial defect can crosstalk with lysosomes to make mitochondrial status worse in a positive feedback way. …”
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The clinical efficacy of intravascular laser irradiation of blood (ILIB): A narrative review of randomized controlled trial by Leonardo Díaz, Alain Chaple Gil, Alfredo Von Marttens, Javier Basualdo, Claudio Sotomayor, Alexis Vera Becerra, Víctor Beltrán, Gilbert Jorquera, Rodrigo Caviedes, Eduardo Fernández

“…Background: Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), proposed to modulate oxidative stress, inflammation, and mitochondrial function. …”
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Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice by Yijie Wu, Yanhui Yang, Caixia Du, Xiaoyue Peng, Wenying Fan, Baocheng Chang, Chunyan Shan

“…We found that BBR treatment increased grip strength and improved muscle function. BBR not only reduced weight gain, excessive lipid accumulation and hyperlipidemia, but also ameliorated obesity-induced skeletal muscle atrophy and apoptosis. …”
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Trans-cinnamaldehyde ameliorates neuroinflammation-mediated synaptic plasticity and memory impairment by blocking TLR4/MyD88/MAPKs pathway in global cerebral ischemia by Xinjuan Liu, Zhiyuan Lu, Gaiying He, Waimao Gao, Kaifan Hu, Jie Pan, Yan Zhao, Xingyu Wang, Guang Yang, Ying Xu

“…Behavioral tests, including the open field test, novel object recognition, and water maze, were conducted to assess cognitive function, while long-term potentiation (LTP) analysis was used to evaluate synaptic plasticity. …”
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Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism by Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu

“…Methods We generated mice with intestinal epithelial cell‐specific Fut2 knockout (Fut2△IEC) and established a chronic‐binge alcohol model. 16S rRNA sequencing and metabolomics analysis were used to reveal differences in the composition and function of faecal bacteria. Results The loss of intestinal epithelial Fut2 exacerbates alcohol‐related hepatic oxidative stress damage, and this effect is dependent on gut bacteria. …”
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Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation by Francisco Conceição, João Meneses, Filipa Lebre, Malin Becker, Nuno Araújo-Gomes, Rianne Vos, Ana R. Ribeiro, Ernesto Alfaro-Moreno, Jeroen Leijten, Liliana Moreira Teixeira

“…Osteoarthritis (OA) is a musculoskeletal degenerative disease characterized by alterations in cartilage and subchondral bone leading to impaired joint function. OA disproportionally affects females more than males, yet the molecular mechanisms underlying these biological sex differences remain elusive. …”
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