Structural characterization and immune-enhancing properties of an acidic heteroglycan from Protaetia brevitarsis seulensis larvae by Ju-Hwi Park, Jong-Jin Park, Jongbeom Chae, Seong Do Lee, Subin Gwon, Hunseong Kim, Ju Hyun Min, Young Hoon Jung, Joon Ha Lee, Wonyoung Lee, Jae Sam Hwang, Ibukunoluwa Fola Olawuyi, Ju-Ock Nam, Dongyup Hahn

“…These findings highlight the potential of H-PBSL as a novel immunomodulatory agent derived from an edible insect, with possible applications in functional foods and nutraceuticals.…”
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STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy by Chunxiao Li, Fei Ma, Ying Zhang, Ting Wang, Hongnan Mo, Ning Zhong, Dongkui Xu, Fangzhou Sun, Yantong Zhou, Jianbin Guo, Zhenguo Zhao, Xiaoqi Yang, Haili Qian

“…STS2-deficient CD8+ TILs maintained a more functional state, exhibiting enhanced effector activity, proliferation, and antitumor efficacy while resisting terminal exhaustion. …”
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ROS-responsive adaptive injectable hydrogel promoting inflammatory mastoid bone repair through efficient sterilization and regulating oxidative stress and macrophage phenotype by Yiwen Chen, Ying Lin, Zeyang Liu, Yuanhui Zhang, Ziwei Hu, Maomao Ai, Yanxiong Shen, Dongling Lian, Chenxinwei Wang, Xiaoping Liu, Qunfeng Liu, Huilong Guo, Feng Yu

“…A major challenge is efficiently eliminating dormant opportunistic infections, controlling inflammation, and repairing defected mastoid portion in the middle ear simultaneously to enhance surgical recovery. Herein, a functional injectable polysaccharide-based hydrogel targeting low-cost and easy clinical translation was developed to address bone abnormalities caused by inflammation in the middle ear through introducing a reactive oxygen species (ROS)-sensitive dynamic cross-linked network and catechol groups, which granted it with superb tissue adaptability. …”
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A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp by Li Zhao, Shi-Yu Zhou, Yu Fu, Jin-Long Shen, Bin-Cheng Yin, Di You, Bang-Ce Ye

“…ABSTRACT Gene expression and proper downstream cellular functions upon facing environmental shifts depend on the combined and cooperative regulation of genetic networks. …”
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Targeting mesothelin-CD24 axis repolarizes tumor-associated macrophages to potentiate PD-1 blockade therapy in high-grade serous ovarian cancer by Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Haiou Liu, Chenyang Wang, Kankan Cao, Yujing Zhong, Xueling Wang, Xuyao Xu

“…This study explored how mesothelin (MSLN), a tumor-associated antigen, modulates the expression of CD24, an emerging target for immune modulation, and its role in promoting immune evasion in HGSOC. …”
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N6‐Methyladenosine modification mediated by METTL3 promotes DNA‐PKcs expression to induce anlotinib resistance in osteosarcoma by Yining Zhang, Guohong Shen, Dan Zhang, Tingting Meng, Zhaorui Lv, Lei Chen, Jianmin Li, Ka Li

“…Previous studies have explored the pivotal function of the DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) with regard to osteosarcoma chemoresistance. …”
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Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis by Alzbeta Chabronova, Marie Walters, Sara Regårdh, Stine Jacobsen, Louise Bundgaard, James R. Anderson, Mandy J. Peffers

“…SnoRNAs are short non-coding RNAs that guide post-transcriptional modifications (PTMs) of ribosomal RNA (rRNA) nucleotides, which impact ribosome function and thus cellular protein expression programs. …”
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MAPK, PI3K/Akt Pathways, and GSK-3β Activity in Severe Acute Heart Failure in Intensive Care Patients: An Updated Review by Massimo Meco, Enrico Giustiniano, Fulvio Nisi, Pierluigi Zulli, Emiliano Agosteo

“…Recent studies underscore its dual function as both a negative regulator of pathological hypertrophy and a modulator of cell survival, making it a compelling therapeutic candidate in acute cardiac settings. …”
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Biosynthetic potential of Inonotus obliquus in symbiosis with bacterial cellulose: Optimisation and prospects by Parshenkov Mikhail Alekseevich, Skovorodko Polina Petrovna, Petrusevich Danila Alexandrovich, Makaeva Shagun Narimanovna, Osipova Svetlana Guramovna, Ibragimova Gumru, Istyagina Alexandra Olegovna, Balaeva Kristina Anatolievna

“…These metabolites exhibit potent antioxidant, anti-inflammatory and immunomodulatory properties, underscoring I obliquus as a valuable resource for advanced biopharmaceuticals and functional therapeutics. Yet, achieving consistent and high-yield biosynthesis of these compounds remains challenging. …”
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Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis by Jingxin Ma, Sailing Lin, Chuimian Zeng, Wenhao Wu, Qi Zhang, Guli Zhu, Qi Zhang, Qiongfang Fang, Lijun Fan, Shunichi Takeda, Xiaoyu Li, Xiaoyu Li, Xiushen Li, Yu Zhou, Xueqing Wu

“…SIRT3, an NAD + -dependent deacetylase, is upregulated in GCTs and implicated in tumorigenesis, yet its functional role and underlying mechanisms remain poorly understood. …”
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Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.) by Prashanth Babu, Manjunath Prasad, R. Nirmalaruban, Sudhir Kumar, Rajbir Yadav, Manjeet Kumar, Kiran B. Gaikwad, Naresh Kumar Bainsla, S. Bhaskar Reddy, Nasreen Saifi, Amit Kumar Mazumder, Meda Alekya, Gaurav Kaushik, Palaparthi Dharamteja, Meghashri S. Patil, Shiv Kumar Singh, Dunna Vijay, Ranjeet Ranjan Kumar

“…Notably, eight novel Si-responsive QTLs were detected under Si+-three associated with leaf rust resistance (qLr7AS.1_Si+, qLr6DS.1_Si+, and qLr7BL.1_Si+). Functional annotation of candidate genes revealed the involvement of key pathways, including cation transport, isomerase and, ethylene-responsive transcription factors reflecting Si’s multifaceted role in enhancing mineral uptake, stress tolerance, and overall plant growth. …”
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Irritable Bowel Syndrome with Diarrhea (IBS-D): Effects of <i>Clostridium butyricum</i> CBM588 Probiotic on Gastrointestinal Symptoms, Quality of Life, and Gut Microbiota in a Pros... by Francesco Di Pierro, Fabrizio Ficuccilli, Laura Tessieri, Francesca Menasci, Chiara Pasquale, Amjad Khan, Fazle Rabbani, Nazia Mumtaz Memon, Massimiliano Cazzaniga, Alexander Bertuccioli, Mariarosaria Matera, Ilaria Cavecchia, Martino Recchia, Chiara Maria Palazzi, Maria Laura Tanda, Nicola Zerbinati

“…Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder characterized by altered motility, abdominal pain, and dysbiosis—particularly reduced biodiversity and a lower abundance of butyrate-producing bacteria. …”
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Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue by Carol Costa Encarnação, Carolinne Souza Amorim, Victor Aguiar Franco, Luiz Gabriel Xavier Botelho, Ronan Christian Machado dos Santos, Isadora Ramos-Andrade, Luiz Guilherme Kraemer-Aguiar, Christina Barja-Fidalgo, João Alfredo Moraes, Mariana Renovato-Martins

“…In this study, we investigated the effects of leptin within extracellular vesicles (EVs) secreted by obese adipose tissue on the functional properties and metabolism of MDA-MB-231 breast cancer cells, a model for triple-negative breast cancer (TNBC).MethodMDA-MB-231 cells were treated with EVs derived from the subcutaneous adipose tissue of eutrophic (EUT EVs) and obese (OB EVs) individuals.ResultsOur findings revealed that OB EVs induced significant phosphorylation of STAT3, a key signaling molecule in cancer progression, and promoted increased cell migration, dependent on fatty acid oxidation (FAO). …”
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Aquificae overcomes competition by archaeal thermophiles, and crowding by bacterial mesophiles, to dominate the boiling vent-water of a Trans-Himalayan sulfur-borax spring. by Nibendu Mondal, Subhajit Dutta, Sumit Chatterjee, Jagannath Sarkar, Mahamadul Mondal, Chayan Roy, Ranadhir Chakraborty, Wriddhiman Ghosh

“…In terms of sequence similarity, a majority of those genes were attributable to phylogenetic relatives of mesophilic bacteria, while functionally they rendered functions such as encoding heat shock proteins, molecular chaperones, and chaperonin complexes; proteins controlling/modulating/inhibiting DNA gyrase; universal stress proteins; methionine sulfoxide reductases; fatty acid desaturases; different toxin-antitoxin systems; enzymes protecting against oxidative damage; proteins conferring flagellar structure/function, chemotaxis, cell adhesion/aggregation, biofilm formation, and quorum sensing. …”
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A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance by Ping Li, Ping Li, Xin Yin, Xinzhu Wen, Xuyu Li, Yuqing Wang, Hongyan Zhan, Hanqing Che, Chunsuo Yao, Qi Hou, Ziqian Zhang, Ruifang Zheng, Mingbao Lin

“…IntroductionDysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. Poorly functioning regulatory T cells (Tregs) lead to extreme situations where self-tolerance is robustly disrupted. …”
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E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer by Ligang Chen, Mingyi Wang, Yunge Gao, Yanhong Lv, Lianghao Zhai, Jian Dong, Yan Chen, Xia Li, Xin Guo, Biliang Chen, Yi Ru, Xiaohui Lv

“…The function of FBXW11 in PARPi therapy is still ambiguous. …”
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A Multi-Head Attention-Based Lightweight Generative Adversarial Network for Thyroid Ultrasound Video Super-Resolution by Yuchen Ning, Xianshuang Meng, Lingxiao Zhou, Jun Liu, Shijie Qiu, Jingfang Wu, Xi Wei, Jun Ying, Siwei Zhu, Yantian Zhang

“…This innovative method encompasses a lightweight optical flow extraction network for swift analysis, a recurrent fusion reconstruction module based on multi-head mechanism, and a hybrid loss function designed to expedite network convergence. …”
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Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut mic... by Hao Wu, Yao-lei Li, Yu Wang, Yu-ge Wang, Jia-hui Hong, Mi-mi Pang, Pan-miao Liu, Jian-jun Yang

“…The results demonstrated that AB4 significantly reduces intestinal oxidative stress and inflammation in UC mice, while also protecting intestinal barrier function. Furthermore, AB4 helps restore intestinal microbial balance primarily by modulating the abundance of Lactobacillus, which enhances the metabolism of short-chain fatty acids and upregulates the production of butyric acid (BA). …”
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Exploring Salvia miltiorrhiza&amp;rsquo;s Therapeutic Effects on Adenomyosis by Inhibiting TNF-&amp;alpha;/HIF-1&amp;alpha;/IL-17-Driven Inflammatory Cascade: Mechanistic Insights... by Yang Q, Hong J, Zheng X, Liu X, Lin H, Chen L, Zhong F, Zhang Q, Jiang J, Sun P

“…Functional analyses of core target genes were performed using GO and KEGG, followed by molecular docking, transcriptomics validation, and molecular dynamics simulations. …”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Genetic TMEM88 loss of function models show impaired differentiation of endodermal and mesodermal derivatives in vitro and dysregulated arterial blood pressure in vivo. …”
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