Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/β-catenin-ABCG2 signaling pathway in ALDHA1 colorectal cancer stem cells by Binghe Chen, Dezhong Zhang, Jun Kuai, Mingkun Cheng, Xiangjie Fang, Guangyan Li

“…The aim of this study was to investigate the biological function of miR-199a/b on cisplatin resistance in colorectal cancer stem cells and its related mechanisms. …”
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Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease by Chang Dai, Raouf A. Khalil

“…Also, the individual Ca²⁺ handling pathways could be integrated to function in a regenerative, capacitative, cooperative, bidirectional, or reciprocal feed-forward or feed-back manner. …”
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Proteomic Analysis Reveals That Dietary Supplementation with Fish Oil Enhances Lipid Metabolism and Improves Antioxidant Capacity in the Liver of Female <i>Scatophagus argus</i> by Jingwei He, He Ma, Dongneng Jiang, Tuo Wang, Zhiyuan Li, Gang Shi, Yucong Hong, Chunhua Zhu, Guangli Li

“…However, the effects of fish oil on hepatic function at the protein level remain poorly characterized. …”
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Non-technical skills for neurosurgeons: An international survey by S.M. Cavallo, E. Pellencin, G. Carone, N. Castelli, R. Ayadi, A. Moiyadi, L. Padayachy, T.R. Meling, F. Di Meco, A. Perin, F. Olldashi, A. Al Anazi, I. Kanaan, F. Garcia Colmena, P. Ajler, M. Socolovsky, E. Knosp, C. Raftopoulos, J.C. Rodrigues, Jr., Y.P. Enchev, B. Xu, P. Chul-Kee, K. Rotim, J. Posti, B. Meyer, H. Shimamoto, Y. Makhambetov, J. Frosen, S.P. Chandra, P. Cappabianca, G. Piatelli, L. Genitori, A. Germanò, G. Sabatino, C. Bernucci, C. Giussani, A. Olivi, D. Locatelli, R. Stefini, C. Castrioto, A. Mangiola, M.M. Fontanella, L. Tacconi, C. Conti, M. Skrap, N. El Abbadi, M.R. Sharma, M.S. Shamim, S. Sharif, J.P. Farias, I.S. Florian, A.O. Gushcha, L. Rasulic, P. Vulekovic, B.T. Ang, A. Lagares, R. Diez Valle, J. Ensenat, L. Ley Urzaiz, J.A. Barcia Albacar, S.S. Kupanur, L. Regli, I.F. Dunn, D. Adelson, J. Bederson, A.D. Levi, A.Y. Alturky, C. Matula, B. Cortes, W. Xiang, T. Li, N.M.F. El-Ghandour, R. Kanai, R. Patir, B.K. Misra, S. Dwarakanath, F. Servadei, F. Tomasello, C. Casali, G. Unsgard, J.J. Morcos, T. Souhil, I. Khoja, I. Kehayov, M. Vukic, M. Ziebell, H.A. Gulisano, M. Tange, K. Kurozumi, M. Locatelli, D. Garbossa, J.L. Gomez Amador, A.O. Rodriguez, K. Ashkan, M. Lim, M. Maleki, A. Agrawal, A. Naik, D.M. Sciubba, L.J. Kim, R.J. Spinner, P. McDonald, G. Pavesi

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Construction of Multifunctional Photothermal/Photocatalytic Materials Based on the Principle of Three Primary Colors: A Case Study of g‐C3N4/Ag2CrO4 by Haiwen Wang, Ting Wang, Zixian Zhu, Sijie Ren, Yu Huang, Shangshu Qian, Wanqi Tang, Xuepeng Yin, Hao Niu, Xiaomeng Wang, Tianpin Wu, Shanmin Gao

“…ABSTRACT The strategic design and synthesis of photothermal/photocatalytic materials are pivotal to realizing photothermal conversion water evaporation coupled with photocatalytic sewage purification functions. In this work, based on the principle of three primary colors, brick‐red g‐C3N4/Ag2CrO4 composite was loaded onto a green polyurethane (PU) sponge using polyvinyl alcohol (PVA) as the linking agent. …”
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Interactions with and activation of immune cells by CD41a+ extracellular vesicles by Marie Tamagne, Marie Tamagne, Mehdi Khelfa, Mehdi Khelfa, Souganya Many, Deborah Neyrinck-Leglantier, Deborah Neyrinck-Leglantier, Adèle Silane Delorme, Adèle Silane Delorme, Marion Klea Pinheiro, Marion Klea Pinheiro, Muriel Andrieu, Sabine Cleophax, France Pirenne, France Pirenne, Benoît Vingert, Benoît Vingert

“…There may be several reasons for these differences, including the presence of extracellular vesicles (EVs) derived from plasma membrane budding and present in the platelet concentrates. Indeed, EVs can modulate the immune system through interactions with many immune cells, but the underlying mechanisms remain incompletely understood.MethodsWe therefore investigated how interactions with CD41a+ EVs cause immune cells to change phenotype and function. …”
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ABA-activated subclass III SnRK2s control kernel maturation in maize by Yayun Wang, Tiandan Long, Aying Qin, Qiang Liao, Hao Wang, Junjie Zhang, Hanmei Liu, Yinghong Liu, Yufeng Hu, Yubi Huang, Yangping Li

“…Knockout of ZmSnRK2s demonstrated that subclass III ZmSnRK2s are required for kernel maturation in maize, and the loss-of-function of subclass III ZmSnRK2s showed a disruption in kernel dehydration and dormancy. …”
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Hemodynamic homeostasis disequilibrium in critical illness by Jie Wang, Xiaoting Wang, Dawei Liu, Hui Lian, Guangjian Wang, Zewen Tong, Qingyu Deng, Qirui Guo, Qian Zhang, Yangong Chao, Wanhong Yin

“…Such balance is essential for sustaining cellular metabolism and maintaining the function of vital organs throughout embryonic development and the human lifespan. …”
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Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome by Raffaele Caruso, Silvia Rocchiccioli, Anna Maria Gori, Antonella Cecchettini, Betti Giusti, Guido Parodi, Lorena Cozzi, Rossella Marcucci, Marina Parolini, Ilaria Romagnuolo, Lorenzo Citti, Rosanna Abbate, Oberdan Parodi

“…We investigated whether clopidogrel interaction affects platelet function and modulates factors related to inflammation and oxidation in ACS patients differently responding to clopidogrel. …”
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The Impact of Lifestyle on the Course of Hashimoto’s Disease: The Role of Diet, Physical Activity, and Stress - A Literature Review by Alicja Podolska, Agnieszka Woźniacka, Barbara Boba, Barbara Chojnacka, Julia Wątor, Jerzy Krzeszowiak, Aleksandra Ożga, Patrycja Kolano, Sylwia Bryksy, Tomasz Pulanecki

“…Sedentary behavior and chronic stress also impair immune function. On the other hand, anti-inflammatory diets, physical activity, and stress management may support immune balance and complement standard HT treatment. …”
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Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone l... by Jumi Kim, Jumi Kim, Jiseon Ha, Jiseon Ha, Chanho Song, Chanho Song, Muhammad Azhar Sajjad, Muhammad Azhar Sajjad, Fadia Kalsoom, Hyeonjoong Kwon, Hyeonjoong Kwon, Jaewoo Park, Sun Park, Sun Park, Kyongmin Kim, Kyongmin Kim

“…AGK2 suppresses HBV replication through direct antiviral actions, and by epigenetic modulation of cccDNA, indicating that using AGK2 to target SIRT2 and associated epigenetic regulators shows promise as a functional cure for chronic hepatitis B.…”
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Genetic Mapping of a QTL Controlling Fruit Size in Melon (<i>Cucumis melo</i> L.) by Fazle Amin, Nasar Ali Khan, Sikandar Amanullah, Shusen Liu, Zhao Liu, Zhengfeng Song, Shi Liu, Xuezheng Wang, Xufeng Fang, Feishi Luan

“…These results provide a better understanding for further fine mapping and functional gene analysis related to melon fruit size.…”
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The Cecal Distribution of Microalgal Pigments in Rats: Do Carotenoids and Chlorophylls Play a Pharmacobiotic Role? by Tatiele Casagrande do Nascimento, Patrícia Acosta Caetano, Marcylene Vieira da Silveira, Luiz Eduardo Lobo, Uashington Da Silva Riste, Mariany Costa Deprá, Maria Rosa Chitolina Schetinger, Cristiano Ragagnin de Menezes, Roger Wagner, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…These results support the potential application of microalgal pigments as functional food ingredients or supplements with gut health benefits.…”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Alistair Perry, Laura E. Hughes, Natalie E. Adams, Michelle Naessens, Niels A. Kloosterman, Matthew A. Rouse, Alexander G. Murley, Duncan Street, P. Simon Jones, James B. Rowe

“…The consequences of frontotemporal lobar degeneration include changes in prefrontal cortical neurophysiology, with abnormalities of neural dynamics reported in the beta frequency range (14–30 Hz) that correlate with functional severity. We examined beta dynamics in two clinical syndromes associated with frontotemporal lobar degeneration: the behavioral variant of frontotemporal dementia (bvFTD) and progressive supranuclear palsy (PSP). …”
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Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing by Fuling Mao, Zixuan Hu, Ruifeng Shi, Hongbing Zhang, Zihe Zhang, Yongwen Li, Xuanguang Li, Penghu Gao, Jinhui Li, Minghui Liu, Hongyu Liu, Jun Chen

“…Protective microbiota primarily exerted metabolic functions, whereas harmful microbiota were mainly implicated in infection, inflammation and immune modulation. …”
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NUDT21 regulates lysyl oxidase-like 2(LOXL2) to influence ECM protein cross-linking in silica-induced pulmonary fibrosis by Lan Peng, Wenqing Sun, Demin Cheng, Xinying Jia, Wenxiu Lian, Ziwei Li, Haojie Xiong, Ting Wang, Yi Liu, Chunhui Ni

“…LOXL2 is a copper-dependent lysine oxidase whose main function is to catalyze the cross-linking of extracellular matrix components, particularly collagen and elastin. …”
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Three Circulating miRNAs Related to Non-Small-Cell Lung Cancer Progression: An Integrative Analysis of Their Biological Roles by Yanqin Niu, Gaohui Fu, Sijian Xia, Menglong Li, Lin Qiu, Jun Wang, Kang Kang, Deming Gou

“…Additionally, we evaluated the biological functions of these miRNA biomarkers through EdU and wound healing assays in A549 cells. …”
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The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n‐alkane degradation in Pseudomonas aeruginosa SJTD‐1 by Wanli Peng, Xiuli Wang, Qinchen Liu, Zhihong Xiao, Fulin Li, Nannan Ji, Zhuo Chen, Jiaying He, Junhao Wang, Zixin Deng, Shuangjun Lin, Rubing Liang

“…Further bioinformatics analysis of AlkR revealed the widespread VanR–AlkB couples distributed in Pseudomonadaceae with high conservation in the sequences of functional genes and intergenic regions, highlighting a conserved regulatory pattern for n‐alkane utilization across this family. …”
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A Novel Hybrid Peptide VLP-Aβ Exhibits Antioxidant Activity In Vitro and In Vivo via KEAP1-NRF2-ARE Signaling Pathway by Junyong Wang, Wenxiu Zhang, Rijun Zhang, Xuelian Zhao, Jing Zhang, Yichen Zhou, Yucui Tong, Zaheer Abbas, Zhenzhen Li, Haosen Zhang, Di Yang, Sichao Chen, Cong Hu, Dayong Si, Xubiao Wei

“…Further investigation revealed that VA alleviates oxidative stress by modulating the KEAP1-NRF2-ARE signaling pathway. These findings provide insights into the properties of the antioxidant peptide VA, expand the understanding of its molecular mechanisms, and suggest new opportunities for developing VA as a novel functional agent in the agricultural, food, and clinical industries.…”
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Application of indigenous Saccharomycopsis fibuligera for light-flavor Baijiu fermentation: Changes of microbial community and flavor metabolism by Jie Tang, Bin Lin, Yimin Shan, Gang Zhang, Liping Zhu, Wei Jiang, Qun Li, Lei Zhang, Shengzhi Yang, Qiang Yang, Shenxi Chen, Hai Du

“…(the main fungal biomarkers), which was driven by the functional S. fibuligera. Mantel test further highlighted acidity, temperature, and moisture as critical environmental factors influencing the microbial community (P < 0.05, |ρ| > 0.7). …”
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