Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis by Yuanpei Zhao, Yijun Li, Qingwen Xu, Lili Ding, Weiming Li, Qinghua Zou, Yichen Hu, Kaiwen Shi, Hongyuan Liu

“…Our findings suggest that these genes may function as critical regulators of lysosomal autophagy in UC.…”
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Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway by Jiawei Zhang, Tingting Liu, Tongqing Xue, Zhongzhi Jia

“…IntroductionIntestinal ischemia reperfusion (I/R) injury is a severe condition characterized by inflammation, oxidative stress, and compromised intestinal barrier function, which can lead to death. This study investigated the effects of paricalcitol, a synthetic vitamin D receptor (VDR) agonist, on intestinal I/R injury, focusing on the activating transcription factor 4 (ATF4)-C/EBP homologous protein (CHOP) signaling pathway and the modulation of endoplasmic reticulum stress (ERS).MethodsThis study consists of both in vivo and in vitro experiments. …”
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Role of Urokinase-Type Plasminogen Activator Receptor in the Regulation of Angiogenic Properties of Sca1+ Vasculogenic Progenitor Cells by К. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuev, N. B. Kulbitsky, E. V. Parfenova

“…The urokinase-type plasminogen activator receptor (uPAR) is known to play an important role in the regulation of endothelial cell function and postnatal angiogenesis. However, uPAR its involvement in the regulation of the properties of vascular progenitor cells remains poorly studied.   …”
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A Bayesian framework to model variance of grain yield response to plant density by Nicolas Giordano, Dustin Hayes, Trevor J. Hefley, Josefina Lacasa, Brian L. Beres, Lucas A. Haag, Romulo P. Lollato

“…Abstract Background The expected grain yield response to plant density in winter wheat (Triticum aestivum L.) follows a diminishing returns function. To our knowledge, all previous studies dealing with plant density have assumed constant variance. …”
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Efficacy and safety of Chinese patent medicines for allergic rhinitis based on 2020 Chinese Pharmacopoeia: a protocol for systematic review and meta-analysis of randomized controll... by Weibo Zhao, Lingyao Kong, Xuehui Wang, Qingyuan Liu, Yaqi Wang, Ji Wang

“…Secondary outcomes include quality of life, relapse rates, nasal function, biomarkers, and adverse events. No languages and publication data limitations. …”
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Studying the effect of double-stranded RNA upon activity of mouse splenocytes using flow cytometry by E. S. Tsyplenkova, E. A. Vyazovaya, E. D. Danilenko

“…The results of the study made it possible to evaluate the effect of dsRNA on the immune cell function, with respect of their interaction, maturation, and migration. …”
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Glymphatic dysfunction in classical trigeminal neuralgia: DTI-ALPS index stratification from healthy controls to post-MVD by Xiaolin Hou, Bo Wu, Ruxiang Xu, Cheng Yin

“…Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index is a non-invasive marker of glymphatic function. Its relevance in classical trigeminal neuralgia (CTN), postoperative glymphatic changes after microvascular decompression (MVD), and associations with clinical and structural measures remain unclear. …”
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Alisol Triterpenoids Exhibit Triple Modulatory Mechanisms on the Cell Membrane to Overcome Cancer Multidrug Resistance by Chen JY, Chang YT, Ho YC, Teng YN

“…They also improved membrane fluidity and inhibited the function of P-glycoprotein (P-gp) efflux transporters in both HepG2/VIN and ABCB1/Flp-InTM-293, leading to increased drug accumulation. …”
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DCP-YOLOv7x: improved pest detection method for low-quality cotton image by Yukun Ma, Yajun Wei, Minsheng Ma, Zhilong Ning, Minghui Qiao, Uchechukwu Awada

“…Meanwhile, the loss function is modified, and NWD (Normalized Wasserstein Distance) is introduced to significantly improve the detection precision and convergence speed of small targets. …”
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Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia by Chenyang Wang, Xiaolu Bu, Mengyao Cao, Yunyu Lian, Haocong Ling, Mo You, Junfei Yi, Xiaoya Gao, Duobin Wu, Yang Li

“…Results Intracerebroventricular administration of miR-199a-3p agomir exacerbated amyloid deposition and impaired cognitive function in AD mice, and promoted microglial polarization toward the M1 phenotype. …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…ETS variant transcription factor 1 (ETV1) plays an important role in multiple malignancies. However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored. …”
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ENPP1 affects insulin action and secretion: evidences from in vitro studies. by Rosa Di Paola, Nunzia Caporarello, Antonella Marucci, Claudia Dimatteo, Claudia Iadicicco, Silvia Del Guerra, Sabrina Prudente, Dora Sudano, Claudia Miele, Cristina Parrino, Salvatore Piro, Francesco Beguinot, Piero Marchetti, Vincenzo Trischitta, Lucia Frittitta

“…The aim of this study was to deeper investigate the mechanisms through which ENPP1, a negative modulator of insulin receptor (IR) activation, plays a role on insulin signaling, insulin secretion and eventually glucose metabolism. …”
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Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders by Madia Lozupone, Ivana Leccisotti, Anita Mollica, Giuseppe Berardino, Maria Claudia Moretti, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vittorio Dibello, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panza

“…However, the role of APOE in central nervous system pathophysiology extended beyond its lipid transport function. In the present review article, we analyzed the links existing between APOE genotypes and the neurobiology of neuropsychiatric symptoms in neurodegenerative and vascular diseases. …”
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Boosting Aeroponic System Development with Plasma and High-Efficiency Tools: AI and IoT—A Review by Waqar Ahmed Qureshi, Jianmin Gao, Osama Elsherbiny, Abdallah Harold Mosha, Mazhar Hussain Tunio, Junaid Ahmed Qureshi

“…Many studies have investigated plasma uses in both soil-based and soilless plant cultures; nevertheless, however, its function in aeroponics remains unexplored. Therefore, the present work aims to thoroughly investigate and review the integration of plasma-activated water (PAW) and plasma-activated mist (PAM) in aeroponics systems to solve important problems. …”
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Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis by Pingping Liu, Zhenghui Xiao, Xiulan Lu, Xinping Zhang, Jiaotian Huang

“…This work aimed to evaluate the regulatory function of Breg cells in sepsis-associated pancreatic injury. …”
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Transceiver Design of a Secure Multiuser FDSS-Based DFT-Spread OFDM System for RIS- and UAV-Assisted THz Communications by Md. Najmul Hossain, Kottakkaran Sooppy Nisar, Tetsuya Shimamura, Md. Rakibul Islam, Sk. Tamanna Kamal, Shaikh Enayet Ullah

“…The simulation results demonstrate the effectiveness of the proposed system in terms of PLS enhancement for color image transmission, with a low image structural similarity index of 0.65%, 1.60%, and 0.70% for users 1, 2, and 3, respectively; an achievable OOB power emission of 337 dB; and estimated peak-to-average power ratios (PAPRs) ranging from 7.10 to 7.85 dB at a complementary cumulative distribution function (CCDF) of <inline-formula> <tex-math notation="LaTeX">$1\times 10^{-4}$ </tex-math></inline-formula> for different ground-transmitting channels. …”
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Astragalus polysaccharide protects against cardiac injury in a tnnt2a mutant zebrafish model of dilated cardiomyopathy by Chang Zhou, Hui Zhao, Longping Peng, Yidan Dong, Qiong Wu, Xu Wang, Yingjia Xu, Youhua Wang

“…Abstract Background Dilated cardiomyopathy (DCM) is a severe and irreversible heart disease characterized by dilated ventricles and decreased myocardial function. DCM has a poor prognosis and a very low survival rate, with a 5-year mortality rate ranging from 15 to 50%, and is an important cause of sudden cardiac death and heart failure. …”
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Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes by Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

“…While similar shifts in Aβ occur across causal genes, their impact on AAO varies in the function of their contribution to APP processing in the brain. …”
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miR-374-5p inhibits osteogenesis by targeting PTEN/PI3K/AKT signaling pathway by Guangning Long, Fen Liu, Hongmeng Cheng, Jun Guo, Pei Wang, Yunfei Luo, Zhihua Li, Fei Tong

“…Markers of osteoblast function, such as Runx2, OSX, and OCN, were examined in osteoblasts from rats by qRT-PCR and Western blot. …”
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Indirect sliding mode adaptive fractional order nonlinear observer based controller with fractional order single-ended primary inductor converter by Sena Alemu Wondimu, Desalegn Tsega Dagne, Kinde Anlay Fante

“…We used the Caputo fractional derivative to develop a mathematical model that solves the average state space equation of the FOSEPIC converter. The Mittag-Leffler function, along with Lyapunov methods, are used to analyze the system’s dynamic stability. …”
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