Integrated analysis of microbiome and transcriptome reveals the mechanisms underlying the chlorogenic acid-mediated attenuation of oxidative stress and systemic inflammatory respon... by Zhaoying Hu, Lianchi Wu, Yujie Lv, Chaoyue Ge, Xinyu Luo, Shenao Zhan, Weichen Huang, Xinyu Shen, Dongyou Yu, Bing Liu

“…CGA reduced systemic inflammation by improving intestinal barrier function and modulating inflammation-associated microbiota (Blautia and Megamonas), thus inhibiting endotoxin translocation. …”
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Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1 Min Jia,1 1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. Hematoxylin and eosin (HE) staining and Masson’s trichrome staining were performed to evaluate the cardiac pathological damage. …”
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Effect of oral sodium bicarbonate supplementation on urine TGF-𝜷 in normal serum bicarbonate CKD, a randomized controlled trial by Nipon Ngupis, Bancha Satirapoj, Theerasak Tangwonglert, Ouppatham Supasyndh, Paramat Thimachai, Narongrit Siriwattanasit

“…Longer-term studies and alternative alkali therapies should be explored to determine the optimal strategies for preserving kidney function in this population. Clinical trial registration: TCTR20240817007 (17/08/2024).…”
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YOLO-SRMX: A Lightweight Model for Real-Time Object Detection on Unmanned Aerial Vehicles by Shimin Weng, Han Wang, Jiashu Wang, Changming Xu, Ende Zhang

“…Finally, the Wise-IoU loss function is adopted to replace the traditional bounding box loss. …”
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The effect of a period of resistance training on Thrombosponidine-1 and Follistatin-like-1 in heart tissue of obese male rats by Neda Ghasemi, Mania Roozbayani, Hossein Shirvani

“…In physiological conditions, such as resistance training as one of the effective training methods to improve cardiovascular function, the role of these factors is not properly known. …”
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Enhanced deep learning model for apple detection, localization, and counting in complex orchards for robotic arm-based harvesting by Tantan Jin, Xiongzhe Han, Pingan Wang, Zhao Zhang, Jie Guo, Fan Ding

“…Specifically, an optimized You Only Look Once (YOLO) v8n model was developed by integrating a dilation-wise residual–dilated re-parameterization block module, a generalized feature pyramid network, and the Scylla Intersection-over-Union loss function. …”
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PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection by Yuxiao Zhu, Yangyue Ni, Ran Liu, Min Hou, Bingya Yang, Jingwei Song, Hongzhi Sun, Zhipeng Xu, Minjun Ji

“…In addition, the PPAR-γ agonist can induce Treg cells in vitro directly or by modulating the macrophage’s function indirectly. Furthermore, through interaction with Foxp3 in CD4+ T cells, the PPAR-γ agonist can promote the expression of Foxp3; however, the inhibitor of PPAR-γ weakened the expression of Foxp3 by modifying the coexpression of Foxp3 and PPAR-γ. …”
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<i>DSW-YOLO</i>-Based Green Pepper Detection Method Under Complex Environments by Yukuan Han, Gaifeng Ren, Jiarui Zhang, Yuxin Du, Guoqiang Bao, Lijun Cheng, Hongwen Yan

“…A <i>SimAM</i> parameter-free attention mechanism was added to the last layer of the backbone, boosting P, R, mAP50, and mAP50-95 to 90.6%, 84.0%, 91.8%, and 68.5%, and reducing average detection time to 1.1 ms. The <i>CIOU</i> function was replaced with <i>WIOUv3</i> to accelerate convergence, decrease loss, and significantly enhance detection performance. …”
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Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221 by Somia H. Abd-Allah, Tarek Khamis, Walaa Samy, Amira Ebrahim Alsemeh, Doaa M. Abdullah, Samia Hussein

“…Additionally, the treatment of cirrhotic rats with hUCB-MSCs, exosomes, or the combination of them significantly upregulated mTOR, Beclin, LC3, and Smad7 (P<0.001, for each) and miRNA-23 (P=0.021, P<0.001, P<0.001, respectively).Conclusion: hUCB-MSCs and their derived exosomes ameliorated liver cirrhosis by anti-inflammatory and anti-fibrotic effects besides modulation of autophagy. The exosomes had a better improvement effect either alone or combined with hUCB-MSCs, as proved by improvement in liver function tests, and molecular, histopathological, and immunohistochemical profiles.…”
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AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease by Yangyang Wang, Siyu Li, Xiao Liang, Jianing Fan, Shijie Li, Fanlin Zhou, Xiaoju Li, Mengmeng Lai, Dianmao Feng, Yu Li

“…Conclusions Our findings demonstrate that AP2A1 activates Rab7 to restore autophagic function and mitigate AD progression, providing novel therapeutic perspectives for autophagy-targeted interventions in AD.…”
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A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated... by Xue-Fei Wei, Feng Zhang, Han-Xu Zhu, Zhe-Zhe Tian, Miao-Miao Xu, Yu-Chen Fan, Kai Wang, Kai Wang

“…The TL1A/DR3 signaling axis modulates immune responses and contributes to hepatic inflammation. …”
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Genetic Evidence for Causal Effects of Immune Cell Subtypes on Postherpetic Neuralgia by Chen T, Tang S, Chen R, Ding W, Chen Y, Jian Z, Wu M, Jia M, Zhang X

“…This study reinforces the mechanistic connection between immune cell function and the pathogenesis of PHN, highlighting the necessity for further exploration in this area. …”
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The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians by Menna A. Hassan, Salwa M. Abo El-Khair, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed

“…The Adenosine triphosphate binding cassette transporter genes G5 and G8 (ABCG5, ABCG8) are two half transporters which work together as a heterodimer to regulate cholesterol levels in bile, and any alterations in their function can contribute to gallstone formation. The primary objective of this study was to evaluate the association between three specific polymorphisms—ABCG5 i7892T > C, ABCG5 Q604E, and ABCG8 D19H—and the risk of gallstone disease (GSD) in Egyptian females. …”
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A Nutritional Supplement Containing Curcumin C3 Complex, Glucosamine, and Chondroitin Alleviates Osteoarthritis in Mice and Canines by Enpei Zheng, Ting Cen, Ye Ma, Ziyuan Weng, Chuanheng Jiang, Luxi Hou, Jun Leng, Changmin Hu

“…According to our findings, the administration of C3GC was determined to preserve subchondral microarchitectural structure integrity (<i>p</i> < 0.05) and resulted in better motor function in comparison with GC. In animals taking nutritional supplements, the OARSI scores of joint tissue sections were reduced, with the medial tibial plateau OARSI score being particularly low in the C3GC group (<i>p</i> < 0.0001). …”
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Assessment of binary prediction of fraudulent advertisements in ATS candidate tracking cloud systems by V. V. Ligi-Goryaev, G. A. Mankaeva, T. B. Goldvarg, S. S. Muchkaeva, V. V. Dzhakhnaev

“…Then, after reducing the dimensionality of the data, the data was reloaded, and both the model and vectorizer were retrained before being used for prediction. The tkinter module was used for the graphical interface. The predict() function utilizes the trained model for predictions based on the feature vector.…”
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Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer by Zhihang Jiang, Zhihang Jiang, Xiaoqing Li, Xiaoqing Li, Long Hu, Zheng Jiang

“…PCED1A protein expression was evaluated by immunohistochemistry and Western blotting. The function of PCED1A in CRC was investigated through in vitro experiments.ResultsSuccinylation scores were significantly altered in multiple tumor types. …”
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Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results by Sutema IAMP, Latarissa IR, Widowati IGAR, Sartika CR, Ciptasari NWE, Lestari K

“…The results showed that probiotics, reduced acne lesions, improved skin barrier function, and decreased inflammatory markers. Both oral and topical probiotics showed potential in balancing skin microbiome and reducing acne severity. …”
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Intermittent theta burst stimulation applied during early rehabilitation after stroke: study protocol for a randomised controlled trial by Gereon R Fink, Lukas Hensel, Christian Grefkes, Caroline Tscherpel, Corinna Ringmaier, Daria Kraus, Stefanie Hamacher, Lukas J Volz

“…Introduction Intermittent theta burst stimulation (iTBS) applied to primary motor cortex (M1) has been shown to modulate both the excitability and connectivity of the motor system. …”
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Integrative Analysis of Dog Serum‐Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis by Şükrü Değirmençay, Selçuk Özdemir, Sefa Küçükler, Reyhane Bayat, Muhammed Kadak

“…CircRNAs play a crucial role in regulating inflammatory responses; however, their function in canine parvovirus (CPV) infection remains largely unexplored. …”
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Development of a PPP1R14B-associated immune prognostic model for hepatocellular carcinoma by Ligang Zhao, Xiaoling Jin, Qiushi Yu, Yigang He, Facai Yang, Weihu Ma, Zhengqing Lei, Jiahua Zhou

“…Abstract Background This study sought to comprehensively examine PPP1R14B’s function and its immune-related correlations in hepatocellular carcinoma (HCC). …”
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