Elderly individuals exhibit dysregulated monocyte responses to viral immune complexes compared to adults and children by Léa Domitien Payet, Anthony Coléon, Anne Sophie Bedin, Lucas Auguste, Maël Morvan Duroyon, Caroline Mollevi, Hubert Blain, Franck Mennechet, Éric Jeziorski, Édouard Tuaillon

“…These insights highlight the importance of further research to develop age-specific therapeutic strategies to modulate immune function during viral IC exposure.…”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Conclusion The HSF1‐MYCN axis constitutes a transcription‐dependent regulatory mechanism that may function as both a prognostic indicator and a promising therapeutic target in liver cancer. …”
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CircMYH9/miR-133a-3p/CXCR4 axis: a novel regulatory network in sperm fertilization and embryo development by Qian Sun, Yanyu Li, Wen Yang, Wen Feng, Jiayun Zhou, Yijuan Cao, Bei Zhang, Zuobin Zhu, Conghui Han

“…This study provides valuable insights into the molecular mechanisms governing sperm function and early embryonic development.…”
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A digital intervention to improve mental health and interpersonal resilience for young people who have experienced online sexual abuse: the i-Minds non-randomised feasibility clini... by Sandra Bucci, Filippo Varese, Ethel Quayle, Kim Cartwright, Amanda Larkin, Cindy Chan, Prathiba Chitsabesan, Victoria Green, William Hewins, Matthew Machin, Alice Newton, Erica Niebauer, John Norrie, Gillian Radford, Cathy Richards, Marina Sandys, Victoria Selby, Sara Shafi, Jennifer Ward, Pauline Whelan, Matthias Schwannauer

“…Quantitative and qualitative data showed that the i-Minds app was safe, acceptable and associated with promising signals of efficacy on valuable outcomes post treatment, including technology-assisted-sexual-abuse-related post-traumatic symptoms, resilience, internalising symptoms and reflective functioning. Most participants accessed or completed app modules. …”
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Effects of dietary supplementation with different levels of rose pomace on rumen bacterial diversity and fermentation, and longissimus dorsi fatty acids in Hu sheep by Linjiao He, Linjiao He, Linjiao He, Ruirui Tian, Ruirui Tian, Ruirui Tian, Ziting Wang, Ziting Wang, Ziting Wang, Jinlong Li, Jinlong Li, Jinlong Li, Shan Zhang, Shan Zhang, Shan Zhang, Zhijun Zhang, Zhijun Zhang

“…An RP supplementation level of 2–4% yielded optimal results, providing valuable insights for sheep farmers seeking functional feed additives.…”
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Robust prediction of glioma prognosis by hypoxia-induced ferroptosis genes: VEGFA-XBP1 co-expression for salvage therapy by Zhou Liwei, Lu Hanwen, Zhao Wenpeng, Yu Weijie, Chen Sifang, Zhang Bingchang, Li Zhangyu, Gao Xin, Li Wenhua, Mao Jianyao, Xie Yuanyuan, Tan Guowei, Wang Zhanxiang

“…This study deciphers the functional role of hypoxia-induced ferroptosis in glioma prognosis. …”
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Regulation of seed germination: ROS, epigenetic, and hormonal aspects by Yakong Wang, Xiangyang Sun, Jun Peng, Fuguang Li, Faiza Ali, Zhi Wang

“…We propose that ROS functions as a hub in the complex network regulating seed germination.…”
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Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions by Jinyong He, Cong Du, Cuiping Li, Wei Li, Jinlan Qiu, Mingpeng Ma, Yunhao Chen, Qi Zhang

“…Acute liver failure (ALF) represents a critical clinical syndrome marked by massive hepatocyte death and severe functional deterioration. While metabolic dysregulation is a recognized hallmark, the pathophysiological implications of iron metabolism disturbance in ALF progression remain poorly understood, which may unveil novel therapeutic targets. …”
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Integrative mechanisms of plant salt tolerance: Biological pathways, phytohormonal regulation, and technological innovations by Abdul Waheed, Lu Zhuo, Minghui Wang, Xu Hailiang, Zewen Tong, Cuhan Wang, Aishajiang Aili

“…These adaptive responses are governed by various functional components that interact to modulate plant stress tolerance. …”
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Large Grain 2, an NHL Domain-Containing Protein, Interacts with FUWA and Regulates Plant Architecture and Grain Size Through the Brassinosteroid Signaling Pathway in Rice by Zhengyan Xu, Jierui Zeng, Xiaorong Zhou, Yang Liu, Feifan Chen, Haitang Liu, Xiao Peng, Zhengqi Han, Feihong Hou, Hao Wang, Weilan Chen, Bin Tu, Ting Li, Jiawei Xiong, Zhaohui Zhong, Yuping Wang, Bingtian Ma, Peng Qin, Shigui Li, Hua Yuan

“…Our study provides new insights into the function of NHL domain-containing proteins in plants and introduces a novel BR component for crop improvement. …”
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miRNA Expression: I/R Cardiomyocyte and Sevoflurane by José Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Guillermo Quesada Muñoz, Maria Jose Rodriguez Capitán

“…The miRNA gene expression analysis (NGS) showed significantly increased expression of the hsa-miR-140-5p and hsa-miR-455-5p, both miRNAs associated with cardiac function; the hsa-miR-98-5p and hsa-miR-193a-5p, both related to apoptosis inhibition; and the hsa-let-7d-5p associated with myocardial protection. …”
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A Comparative Analysis of Genetic and Epigenetic Factors in METH Addiction: A Focus on SLC (SLC6A4) and COMT Genes by Haider K. Hussain, Yolanda Loarce Tejada, Anna Barbaro

“…., 5-HTTLPR) were associated with an increased risk of METH addiction (odds ratio (OR) = 2.31, 95% confidence interval (CI): 1.45–3.68; p = 0.001); meanwhile, variations in COMT (Val158Met) were linked to both susceptibility and executive function deficits. Epigenetic modifications—most notably DNA methylation in SLC6A4 and COMT—also emerged as important contributors to addiction pathways, potentially influencing dopamine and serotonin regulation. …”
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GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…NTRK2/cGMP–PKG signaling pathway plays a crucial role in regulating the function and polarization of macrophages, which are key immune cells at the maternal–fetal interface. …”
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Dietary magnesium intake affects the association between dietary vitamin A and depression: a cross-sectional study by Canqun Yan, Conghui Gao, Kebin Zhan, Cheng Li

“…Vitamin A, essential for immune and neurological function, has shown conflicting associations with depression. …”
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Real-Time ConvNext-Based U-Net with Feature Infusion for Egg Microcrack Detection by Chenbo Shi, Yuejia Li, Xin Jiang, Wenxin Sun, Changsheng Zhu, Yuanzheng Mo, Shaojia Yan, Chun Zhang

“…Additionally, a composite loss function is devised to address class imbalance issues. …”
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A Multicenter Retrospective Study Evaluating IL-5-Targeted Biologic Therapies for the Treatment of Asthma and Allergic Bronchopulmonary Aspergillosis in Adults With Cystic Fibrosis... by Sameer Desai, PhD, Sophia Shen, MD, Zosia Gryz, BSc, Elizabeth Tullis, MD, Anne L. Stephenson, MD, PhD, Bradley S. Quon, MD, MSc

“…Interpretation: Our results show that in adults with CF, anti-IL-5 biologic therapies were well tolerated and can improve rate of change in lung function, but there was no impact on SCS use or PEx frequency. …”
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RDRM-YOLO: A High-Accuracy and Lightweight Rice Disease Detection Model for Complex Field Environments Based on Improved YOLOv5 by Pan Li, Jitao Zhou, Huihui Sun, Jian Zeng

“…We propose RDRM-YOLO, an enhanced YOLOv5-based network, integrating four key improvements: (i) a cross-stage partial network fusion module (Hor-BNFA) is integrated within the backbone network’s feature extraction stage to enhance the model’s ability to capture disease-specific features; (ii) a spatial depth conversion convolution (SPDConv) is introduced to expand the receptive field, enhancing the extraction of fine-grained features, particularly from small disease spots; (iii) SPDConv is also integrated into the neck network, where the standard convolution is replaced with a lightweight GsConv to increase the accuracy of disease localization, category prediction, and inference speed; and (iv) the WIoU Loss function is adopted in place of CIoU Loss to accelerate convergence and enhance detection accuracy. …”
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Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system by Martta Peltoniemi, Surachet Imlimthan, Sonja C. Jalonen, Niklas Daniel Åke Persson, Terhi J. Lohela, Tuomas O. Lilius, Mirkka Sarparanta

“…Abstract Background The glymphatic system is a recently discovered brain-wide clearance system that allows the cerebrospinal fluid (CSF) flow to clear metabolic waste, but the tools for the quantitative and non-invasive investigation of its function and activity especially in humans is lacking, hindering studies on glymphatic system physiology and therapeutic potential of glymphatic drug delivery and modulation. …”
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LncRNA ZFAS1 promotes the transformation from prostatitis to prostate cancer via myddosome assembly-mediated activation of NF-κB signaling by Tao Feng, Hao Shen, Shenglan Ye

“…This research aims at investigating the function of ZFAS1 in regulating prostatitis to prostate cancer transformation and the underlying mechanism. …”
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Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling by Tao X, Zhao M, Gao K, Zhang W, Xu D, Li W, Mu F, Lin R, Guo C, Li R, Wang J

“…However, the potential of Wel to improve ischemic stroke (IS) and the underlying mechanisms remain unclear.Methods: The middle cerebral artery occlusion and reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) were established to evaluate the potential neuroprotective of Wel. Neurological function, brain infarct volume, brain swelling, and histopathological staining were analyzed to demonstrate the therapeutic efficacy of Wel. …”
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