Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice by Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun

“…In preclinical trials, apigenin improves the physical function of animals with a premature aging‐like state, alleviating physical frailty and cognitive impairment. …”
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Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study by Ni Shi, Sushma Nepal, Rachel Hoobler, Cristina Menni, Mary C. Playdon, Daniel Spakowicz, Philippa M. Wells, Claire J. Steves, Steven K. Clinton, Fred K. Tabung

“…Dietary patterns that exert metabolic effects on insulin and inflammation may influence chronic disease risk by modulating gut microbial composition and function.…”
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Licorice (Glycyrrhiza glabra) and its derivative (Glycyrrhizic and glycyrrhetinic acid) in finfish aquaculture: A review by Kenneth Prudence Abasubong, Jean-Jacques Y. Adjoumani, Guang-Zhen Jiang, Wen-bin Liu, Xiang-Fei Li, Xiu-Fei Cao, Hesham Eed. Desouky

“…Aquaculture employs a range of feed additives to boost fish growth, immune system function, disease prevention, and antioxidant status. …”
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Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer’s disease patients by Sarah Mustaly-Kalimi, Wacey Gallegos, Daniel Steinbrenner, Smriti Gupta, Aiden J. Houcek, David A. Bennett, Robert A. Marr, Daniel A. Peterson, Israel Sekler, Grace E. Stutzmann

“…We measured an array of mitochondrial functions using fluorescent biosensors and optical imaging in RyR2-expressing HEK cells and neurons derived from AD and nonAD individuals. …”
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TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis by Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan

“…However, their presence and function in the acute phase of TBI remain unclear. …”
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AKR1C3 protects cardiomyocytes against hypoxia-induced cell apoptosis through the Nrf-2/NF-κB pathway by Zhang Wenlu, Tian Wei, Xia Xin, Tian Hua, Sun Ting

“…Imbalances in prostaglandin levels have been linked to coronary events. However, the function and molecular mechanism by which AKR1C3 influences AMI are not yet fully understood. …”
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YOLOv9-GDV: A Power Pylon Detection Model for Remote Sensing Images by Ke Zhang, Ningxuan Zhang, Chaojun Shi, Qiaochu Lu, Xian Zheng, Yujie Cao, Xiaoyun Zhang, Jiyuan Yang

“…Finally, the Variable Minimum Point Distance Intersection over Union (VMPDIoU) loss is proposed to optimize the model’s loss function. This method employs variable input parameters to directly calculate key point distances between predicted and ground-truth boxes, more accurately reflecting positional differences between detection results and reference targets, thus effectively improving the model’s mean Average Precision (mAP). …”
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Cardioprotective effects of liposomal resveratrol in diabetic rats: unveiling antioxidant and anti-inflammatory benefits by Ahmed Z. Alanazi, Mohammed Alqinyah, Abdullah S. Alhamed, Hanan Mohammed, Mohammad Raish, Khaldoon Aljerian, Jawza F. Alsabhan, Khalid Alhazzani

“…LR effectively lowered oxidative stress and enhanced cardiovascular function. It also demonstrated a remarkable ability to suppress NF-kB-mediated inflammation by inhibiting the pro-inflammatory cytokines TNF-α and IL-6. …”
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Experimental and exergy evaluation of a PCM integrated active indirect solar dryer for Turkey berries with economic and environmental assessment by K. Senthil Kumar, R. Vasanthi, Mahdi Sh. Jaafar, Arunkumar Munimathan, Manoj Kumar Shanmugam, Mamdooh Alwetaishi, Asif Afzal, Parvathy Rajendran, It Ee Lee

“…Without TES AMISD used 1384 W of energy but with the implementation of TES it only needed 1268 W to function properly. The information about energy output demonstrates TES produces maximum energy consumption efficiency both with and without Phase Change Material (PCM). …”
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Manganese Intoxication Induced by Total Parenteral Nutrition in the Intensive Care Unit: A Case Report by Victoria Seijas-Martínez-Echevarría, Rita Martínez-Manzanal, Ester Mena-Pérez, Pilar Nuñez-Valentín, Guadalupe Ruiz-Martin

“…It is essential to monitor patients receiving parenteral nutrition (PN) solutions containing Mn, especially in those who have biomarkers of susceptibility, even if they have not yet shown neurological signs, and routinely measure whole-blood Mn concentrations, iron levels, age, and liver function. If Mn intoxication is suspected, a brain MRI examination should be conducted.…”
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Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis by Zhiwu Lin, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Jiudong Jiang, Yang Gao, Rulin Li, Jiangang Fan, Yang Yu, Liang Wu, Yanchun Yang

“…This study aimed to explore CD2AP’s function in LUAD and its potential as a biomarker and therapeutic target through multi-omics analysis. …”
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POTA: A Pipelined Oblivious Transfer Acceleration Architecture for Secure Multi-Party Computation by Li Xiaolin, Yan Wei, Liu Hongwei, Zhang Yong, Hao Qinfen, Liu Yong, Sun Ninghui

“…In the POTA design, we develop efficient subsystems targeting the two most compute-intensive parts: the construction of puncturable pseudoran- dom function (PPRF), and large matrix-vector multiplications under the learning parity with noise (LPN) assumption within the silent OT protocol. …”
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CD73low B-cell phenotypes and distinct cytokine profiles in patients with active anti-Jo-1 antibody positive idiopathic inflammatory myopathies by Ingrid E Lundberg, Vivianne Malmstrom, Caroline Grönwall, Begum Horuluoglu, Charlotte De Vries, Maho Nakazawa, Karin Lodin

“…Patients with active IIM had significantly higher serum levels of B-cell activating factor, inducible protein-10, interleukin-6 and sCD40L which correlated with changes in B-cell populations.Conclusions Since CD73 has an immunoregulatory function by modulating the ATP/adenosine pathway, which is also targeted by methotrexate, the low CD73 B-cell expression in anti-Jo-1 antibody-positive IIM may lead to B-cell hyperactivation. …”
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Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus by Xiuying Li, Chunyan Li, Qingjie Li, Yuzhuo Wang, Modi Yang, Zhongsheng Zhou, Bo Zhang, Hang Li, Yingying Xu, Te Liu

“…This elucidation sheds light on the molecular mechanisms underpinning the role of hypothalamic ERα in modulating the IGF-1 and NKB pathways, contributing to DEHP-induced precocious puberty in females, and underscores the critical regulatory function of IGF-1/NKB crosstalk in this phenomenon. …”
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Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis by Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi

“…Evidence shows that Vitamin D modulates immunologic function and inflammation by affecting various immunological cells. …”
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Immunoadjuvant therapy in the regulation of cell death in sepsis: recent advances and future directions by Md. Monirul Islam, Md. Monirul Islam, Eizo Watanabe, Umme Salma, Masayuki Ozaki, Takayuki Irahara, Subaru Tanabe, Ryusuke Katsuki, Dai Oishi, Naoshi Takeyama

“…Moreover, delayed apoptosis and impaired neutrophil function contribute to nosocomial infections and immune dysfunction in sepsis. …”
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Multi-Algorithm-Integrated Tertiary Lymphoid Structure Gene Signature for Immune Landscape Characterization and Prognosis in Colorectal Cancer Patients by Xianqiang Liu, Dingchang Li, Yue Zhang, Hao Liu, Peng Chen, Yingjie Zhao, Guanchao Sun, Wen Zhao, Guanglong Dong

“…Conclusions: The multi-algorithm-integrated model demonstrated robust performance in predicting patient prognosis and immunotherapy response, offering a novel perspective for assessing immunotherapy efficacy. CCL2 may function as a TLS modulator and holds potential as a therapeutic target in CRC.…”
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CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD by Ying Li, Guangzhi Xiao, Xianghui Fu, Xing Luo, Fengfan Yang, Yadan Li, Zhaohui Zheng

“…This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promotes pulmonary fibrosis in COPD by modulating AMPK/STAT6-dependent M2 macrophage polarization. …”
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Multi-omics analysis of tumor necrosis factor superfamily 4 reveals its prognostic value with T cell exhaustion feature in cancer by Kai Lei, Weiqing Chen, Anqi Wang, Anyu Zeng, Yun Ding, Tianqi Luo, Qi Zhou

“…However, its biological function in pan-cancer remains largely unexplored. …”
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Physiology, pharmacology and prospects for dipeptidilpeptidase-4 inhibitors use by D. V. Kurkin, D. A. Bakulin, E. I. Morkovin, A. V. Strygin, Yu. V. Gorbunova, E. V. Volotova, I. E. Makarenko, V. B. Saparova, R. V. Drai, V. I. Petrov

“…They regulate a postprandial insulin secretion and a β-cell function, modulate a fasting and postprandial glucagon secretion, regulate the eating behavior and have many pleiotropic (immunomodulatory, anti-inflammatory, antifibrotic, etc.) effects. …”
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