Whey protein hydrolysate intervention ameliorates memory deficits in APP/PS1 mice: Unveiling gut microbe–short‐chain fatty acid–brain axis by Yongjie Zhou, Hanxiu Meng, Ning Ding, Hui Hong, Yongkang Luo, Chao Wu, Yuqing Tan

“…Although the dietary modulation of the brain–gut axis was explored for AD therapy, the exact mechanism remains unclear. …”
Get full text

Deciphering multi-dimensional interfacial mechanisms via organic cosolvent engineering for sustainable zinc metal batteries by Xiaoyu Yu, Ming Chen, Junhao Wang, Shiqi Li, Haitang Zhang, Qingao Zhao, Haiyan Luo, Yaping Deng, Hanfeng Liang, Jiang Zhou, Fei Wang, Dongliang Chao, Yeguo Zou, Guang Feng, Yu Qiao, Shi-Gang Sun

“…These multidimensional insights bridge the knowledge gap in cosolvent functionality, offering rational principles for tailoring solvation structures and interfacial dynamics in next-generation aqueous batteries.…”
Get full text

Adipocytes reprogram the proteome of breast cancer cells in organotypic three-dimensional cell cultures by Karla Tovar-Hernández, Yarely M. Salinas-Vera, Ángeles Carlos-Reyes, Alejandra P. García-Hernández, Laurence A. Marchat, Gilberto Mandujano-Lázaro, Emmanuel Ríos-Castro, Andrea Velasco-Suárez, Ivonne Mendez-Gómez, Ángeles C. Tecalco-Cruz, Eloisa Ibarra-Sierra, César López-Camarillo

“…Bioinformatic analysis of upregulated proteins indicated that the most enriched GO terms and molecular functions were related to lipids transport, cell differentiation, hypoxia response, and cell junctions. …”
Get full text

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…Objective This literature review aims to provide an updated exploration of the functional aspects of BM niche cells within the hematopoietic microenvironment in the context of age-related hematological malignancies. …”
Get full text

Two rice cultivars recruit different rhizospheric bacteria to promote aboveground regrowth after mechanical defoliation by Changjin Jiang, Fei Wang, Jinling Tian, Wanyuan Zhang, Kabin Xie

“…In field trials, Minghui63 and Nipponbare enriched taxonomically and functionally distinct bacteria in the rhizosphere and root. …”
Get full text

Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury by Yan Fan, Jian Mei, Yuehao Shen, Ying Gao, Lina Zhao, Shuqi Meng, Shuai Zhou, Yu Qian, Ying Zhang, Zhiwei Wang, Yu Song, Jianfeng Liu, Shuaijie Pei, Yan Cui, Hong Yang, Shan-Yu Fung, Keliang Xie

“…Concurrently, the incorporation of two FFD functional groups into a single polypeptide enhances the biological activity of PV-K. …”
Get full text

Macrophage-Specific Progranulin Deficiency Prevents Diet-Induced Obesity through the Inhibition of Hypothalamic and Adipose Tissue Inflammation by Chan Hee Lee, Chae Beom Park, Hyun-Kyong Kim, Won Hee Jang, Se Hee Min, Jae Bum Kim, Min-Seon Kim

Get full text

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease by Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Korey Kam, Áine M. Duffy, John J. LaFrancois, Paige Leary, Elissavet Chartampila, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg, Christos Panagiotis Lisgaras, Christos Panagiotis Lisgaras

“…We further hypothesize that the high activity of cholinergic neurons at early ages ultimately leads to their decline in function later in the disease. We review the effects of a prenatal diet that increases choline, the precursor to acetylcholine and modulator of many other functions. …”
Get full text

Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk compositionResearch in context by Karla Rio-Aige, Marta Selma-Royo, Raúl Cabrera-Rubio, Sonia González, Cecilia Martínez-Costa, Margarida Castell, María J. Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano

Get full text

Cross-frequency neuromodulation: leveraging theta-gamma coupling for cognitive rehabilitation in MCI patients by Xiao Yuan, Xiao Yuan, Zhilan Tu, Renren Li, Renren Li, Chenxi Pan, Chenxi Pan, Jing Ma, Jing Ma, Meng Liu, Dan Yang, Hualan Yang, Fangyun Li, Zhi Bie, Yixuan Ku, Yunxia Li, Yunxia Li

“…Changes in TGC between left frontal theta and occipital gamma oscillations were significantly associated with WM performance, indicating a neurocognitive link.ConclusionThis study highlights rTMS as a non-invasive tool for enhancing WM by modulating TGC and reducing gamma power. These findings suggest a promising strategy for improving cognitive function in MCI, with significant clinical implications for cognitive optimization and therapeutic interventions.…”
Get full text

Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential by Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung

“…YML represents a next-generation Fc platform, offering enhanced pharmacokinetics and improved effector functions, thus providing a powerful strategy for developing biologics with superior serum persistence and therapeutic efficacy.…”
Get full text

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease by Zhen Wei, Xiaodong Pan, Xiaodong Pan, Xiaodong Pan, Xiaodong Pan, Xiaodong Pan, Xiaoli Cui, Jing Zhang, Jing Zhang, Xiaoman Dai, Xiaoman Dai, Xiaoman Dai, Yuqi Zeng, Yuqi Zeng, Xiaochun Chen, Xiaochun Chen, Xiaochun Chen

“…Experimental approaches included quantitative PCR, western blotting, immunofluorescence staining, chromatin immunoprecipitation, and luciferase reporter assays to examine the interaction between PU.1 and TREM2. The phagocytic function of microglial cells was evaluated using Aβ42 and Nile red fluorescent microsphere phagocytosis assays.ResultsTREM2 and PU.1 expression significantly correlated with brain β-amyloid (β) deposition. …”
Get full text

Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease by Wanyue Fu, Zhongshi Huang, Weiqi Li, Lingling Xu, Miaomiao Yang, Yan Ma, Hanghang Liu, Haisheng Qian, Wanni Wang

“…The fabricated CuL NCs function as therapeutic agents with exceptional antioxidant and anti-inflammatory capabilities because of their great stability and capacity to scavenge reactive oxygen species (ROS). …”
Get full text

TD-CFD-DPM Coupled method for multi-objective optimization of collision pollination parameters in hybrid rice seed production by Te Xi, Rongkai Shi, Huaiqu Feng, Bo Chen, Nian Li, Yongwei Wang, Jun Wang

“…This model was then combined with a response surface experimental design to construct an objective function, which was used to visualize the pollen movement trajectory and deposition distribution. …”
Get full text

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy by Wenjie Xi, Weijie Wu, Lili Zhou, Qi Zhang, Shushu Yang, Lihong Huang, Yijun Lu, Jing Wang, Xinjin Chi, Yang Kang

“…On the other hand, the NPs have an immunomodulatory function, which can effectively convert pro-inflammatory macrophage (M1) into anti-inflammatory macrophage (M2), thus reduce the release of inflammatory cytokines and slow down the inflammatory storm of sepsis. …”
Get full text

Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma by Tamas Fulop, Abdullah M Khan, Valentín Ortiz-Maldonado, Marcus Vetter, Rainer Wirth, Fabian Ullrich, Paul J Bröckelmann, Amin T Turki, Elena-Diana Chiru, Bastian von Tresckow, Raul Cordoba, Nina Rosa Neuendorff

“…These treatment modalities re-enable the patient’s own immune system to combat malignant cells and offer the potential for sustained remissions and cure for various diseases.Age profoundly affects the physiological function of the immune system. The process of biological aging is largely driven by inflammatory signaling, which is reciprocally fueled by aging-related alterations of physiology and metabolism. …”
Get full text

Hydroxychloroquine – Beyond Malaria: Its Role in Rheumatology and COVID-19 – A Literature Review by Adam Jan Ząbek, Jakub Paweł Kuźniar, Emilia Gabriela Chrzanowska, Michalina Zagalska, Marta Turek, Tomasz Tamborski, Adam Grzebinoga, Julia Szlążek, Iwona Pudełko, Barbara Roguska

“…Current Knowledge                                                                                                           HCQ modulates immune responses and lysosomal function, making it effective in controlling inflammation. …”
Get full text

Investigating a novel β-glucan source to enhance disease resistance in Pacific white shrimp (Penaeus vannamei) by Tanaporn Uengwetwanit, Umaporn Uawisetwathana, Pacharaporn Angthong, Mongkhol Phanthura, Metavee Phromson, Siriporn Tala, Timpika Thepsuwan, Sage Chaiyapechara, Wai Prathumpai, Wanilada Rungrassamee

“…The feed additive altered the expression of host genes linked to immunity, inflammation, and intestinal barrier function. Moreover, Vibrio spp. and Pseudoalteromonas spp. abundances were significantly modulated (p-value < 0.05) with specific Vibrio clades responding differently depending on the β-glucan concentration. …”
Get full text

Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy by Xinhui Wu, Tianlong Wang, Jinhui Zhao, Lei Zhang, Zhiqing Liu, Yixing Chen, Yiping Luo, Yaqi Liu, Yan Chen, Hui Jiang, Dilixiati Duolikun, Junjian Liu, Wentao Cao, Longpo Zheng

“…The DAT/KS membrane under ultrasound (US) treatment enables the controlled modulation of piezoelectric stimulation and the release of saikosaponin D (SSD), which promotes osteogenic differentiation while simultaneously inhibiting osteoclast differentiation and function, thereby effectively restoring bone homeostasis and enhancing osteoporotic bone repair. …”
Get full text

Natural killer cell therapy in hepatocellular carcinoma: a comprehensive review by Shirin Tavakoli, Maryam Samareh-Salavati, Mahshid Akhavan Rahnama, Shahrokh Abdolahi, Ali Hassanzadeh, Zeinab Ghazvinian, Javad Verdi, Nasim Vousooghi, Saba Manoochehrabadi, Bahram Chahardouli, Maryam Barkhordar, Iman Seyhoun, Mohammad Ahmadvand

“…In addition, advancements in immunotherapy, including adoptive NK cell therapy, and the strategies to boost NK cell function against HCC such as cytokine-based treatments, immune checkpoint inhibitors, vaccine-based approaches, genetic delivery, non-coding RNAs, antibody-based methods, and natural agents have been discussed. …”
Get full text