CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels

“…These results support the hypothesis that Lp(a) contributes to a pro-oxidative and pro-inflammatory milieu, potentially through modulation of platelet activation and function. These findings highlight the need for further investigation into Lp(a)-mediated platelet activation and suggest MRP-8/14 as a potential biomarker and therapeutic target in patients with elevated Lp(a). …”
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Mature megakaryocytes acquire immune characteristics in a mouse model of aplastic anemia by Ashvind Prabahran, Liangliang Wu, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Hiroki Mizumaki, Valentina Baena, Zulfeqhar Syed, Christian A. Combs, Jichun Chen, Xingmin Feng, Neal S. Young

“…Single-cell RNA sequencing analysis (scRNA-seq) revealed upregulation of immune response pathways and downregulation of pathways related to platelet function and homeostasis in MKs from animals with marrow failure (BMF). …”
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In Vitro CO-Releasing and Antioxidant Properties of Sulfonamide-Based CAI-CORMs in a H₂O₂-Stimulated Human Achilles Tendon-Derived Cell Model by Emanuela Berrino, Paolo Guglielmi, Fabrizio Carta, Simone Carradori, Cristina Campestre, Andrea Angeli, Francesca Arrighi, Virginia Pontecorvi, Paola Chimenti, Daniela Secci, Claudiu T. Supuran, Marialucia Gallorini

“…Tendon disorders are marked by a reduction in mechanical function, accompanied by pain and swelling. At the molecular level, tendinopathy leads to oxidative stress-driven inflammation, increased cell death, disruption of extracellular matrix balance, abnormal growth of capillaries and arteries, and degeneration of collagen formation. …”
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The Role of Glutamine in Muscle Regeneration and Recovery: A Literature Review by Aneta Redner, Julia Głowacz, Michał Popiel, Klaudia Kulig, Maksymilian Wiśniowski, Kamil Dziekoński, Jakub Rybowski, Patrycja Zwierzchlewska, Kacper Buczek, Hubert Gorycki, Dominik Stanibuła

“…It also examines the biological pathways through which glutamine may exert its effects, including modulation of inflammation and enhancement of protein turnover.   …”
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Fu’s subcutaneous needling facilitates muscle repair by regulating mitochondrial homeostasis in rat with chronic peripheral nervous pain by Po-En Chiu, Po-En Chiu, Zhonghua Fu, Zhonghua Fu, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Yi-Ching Tsai, Chia-Yun Tsai, Wei-Jen Hsu, Li-Wei Chou, Li-Wei Chou, Li-Wei Chou, De-Wei Lai, De-Wei Lai

“…These findings provide novel insights into FSN’s potential for counteracting neuropathy-induced muscle damage and improving mitochondrial function, supporting its clinical application. Additionally, FSN’s role in muscle repair suggests a connection between growth factor signaling and nerve regeneration, offering a foundation for future research on muscle-neural recovery mechanisms.…”
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GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau by Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, Sheeny Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic L. Julian, Meixia Pan, Jacob Marsh, Andrea R. Argouarch, Min Wu, Douglas W. Scharre, Erica H. Bell, Lawrence S. Honig, Jean Paul Vonsattel, Geidy E. Serrano, Thomas G. Beach, Celeste M. Karch, Aimee W. Kao, Mark E. Hester, Xianlin Han, Hongjun Fu

“…Blocking GRAMD1B function decreases free cholesterol and lipid droplets. …”
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Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance by Xin Zhang, Huan Liu, Yu Li, Yanlong Wen, Tianxin Xu, Chen Chen, Shuxia Hao, Jielun Hu, Shaoping Nie, Fei Gao, Gengjie Jia

“…By leveraging microbiota disturbance similarities, we (1) classified 32 types of dietary fibers into six functional subgroups, revealing correlations with fiber solubility; (2) established associations among 161 diseases, uncovering shared microbiota disturbance patterns that explain disease co‐occurrence (e.g., type II diabetes and kidney diseases) and distinct microbiota patterns that discern symptomatically similar diseases (e.g., inflammatory bowel disease and irritable bowel syndrome); (3) designed a body‐site‐specific microbiota disturbance scoring scheme, computing a disturbance score (DS) for each disease and highlighting the pronounced capacity of Crohn's disease to disturb gut microbiota (DS = 14.01) in contrast with food allergy's minimal capacity (DS = 0.74); (4) identified 1659 fiber‐disease associations, predicting the potential of dietary fiber to modulate specific microbiota changes associated with diseases of interest; (5) established murine models of inflammatory bowel disease to validate the preventive and therapeutic effects of arabinoxylan that notably perturbed the Bacteroidetes and Firmicutes phyla, as well as the Bacteroidetes and Lactobacillus genera, aligning with our model predictions. …”
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S‐Block Metal Mg‐Mediated Co─N─C as Efficient Oxygen Electrocatalyst for Durable and Temperature‐Adapted Zn–Air Batteries by Henan Wang, Xinxin Niu, Wenxian Liu, Ruilian Yin, Jiale Dai, Wei Guo, Chao Kong, Lu Ma, Xia Ding, Fangfang Wu, Wenhui Shi, Tianqi Deng, Xiehong Cao

“…Employing density functional theory (DFT) calculations, it is revealed that incorporating Mg markedly depresses the d‐band center of Co sites, thereby fine‐tuning the adsorption energy of the oxygen reduction reaction (ORR) intermediate. …”
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Synergistic effects of berberine and curcumin-loaded chitosan nanoparticles in Nile tilapia: mitigating high-carbohydrate diet-induced metabolic dysfunction, hepatic injury, and im... by Ekramy Elmorsy, Ali A. El-Raghi, Ibrahim T. El-Ratel, Mahmoud A. Hassan, Helal F. Hetta, Mohamed E. Mohamed, Kasim S. Abass, Samah F. Ibrahim, Heba Allah M. Elbaghdady

“…The B-CR-CHNPs treatment significantly enhanced growth, feed utilisation, protein efficiency, digestive enzyme activities, blood protein levels, liver function, and lipid metabolism compared to the HCD group (p < 0.05). …”
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Association between magnesium depletion score and Klotho levels among U.S. adults: Findings from NHANES 2007–2016 by Xiaoyi Ma, Yuxin Yang, Kemin Yan, Lei Su, Jin Li, Yingying Gong, Wen He

“…MDS was computed according to specific criteria, encompassing alcohol intake, proton pump inhibitor utilization, diuretic utilization, and renal function. Participants were categorized into groups according to MDS score: none to low (score = 0 or 1), medium (score = 2), and high (score >2). …”
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Herbal medicine (Oryeongsan) for fluid and sodium balance in renal cortex of spontaneously hypertensive rats by You Mee Ahn, Hye Yoom Kim, Dae Gill Kang, Kyung Woo Cho, Ho Sub Lee

“…The purpose of the present study was to identify the actions of ORS on the renal excretory function and blood pressure (BP) and to define the mechanisms involved in association with renin-angiotensin system (RAS) and natriuretic peptide system (NPS) in spontaneously hypertensive rats (SHR), an animal model of human essential hypertension. …”
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Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization by Yixin Zhou, Wenjin Teng, Jianchun Wu, Yingbin Luo, Yuli Wang, Yan Li

“…These findings support Piperlongumine’s potential as a therapeutic agent and offer a foundation for targeting endoplasmic reticulum stress to modulate TAM function in lung cancer treatment.…”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…These results provide comprehensive information on the MsADF gene family in alfalfa and lay a solid foundation for elucidating their biological function.…”
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A refined comparative mouse model of acute and chronic atopic dermatitis by Jinok Kwak, Hyunok Doo, Eun Sol Kim, Gi Beom Keum, Sumin Ryu, Yejin Choi, Juyoun Kang, Haram Kim, Yeongjae Chae, Sheena Kim, Ju-Hoon Lee, Hyeun Bum Kim

“…Such probiotics are often originated from the animals, and these are being developed to modulate the immune system and enhance skin barrier function, offering promising new treatment options for AD. …”
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Utilizing Nanoparticles of Hesperidin Loaded on Layered Double Hydroxide to Reduce Hepatotoxicity Caused by Paracetamol in Rats: Controlling of Biotransformation, Oxidative Stress,... by Deyaa A. Shaban, Ahmed A. G. El-Shahawy, Mohamed I. Zanaty, Zienab E. Eldin, Mohamed Abd-Elbaset, Anwar Shams, Shadi Tamur, Osama M. Ahmed

“…<b>Results</b>: Administering of Hesp and Hesp-NPs to APAP-treated rats significantly reduced oxidant parameter (malondialdehyde) and serum enzymes (ALT, AST, LDH, and ALP) associated with liver function. Antioxidant markers in the liver, such as catalase and glutathione, also increased notably. …”
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ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA by Shuhao Wang, Lu Zhu, Yubing Wang, Yue Han, Qingkun Wang, Wenqing Yang, Lei Zhao, Yu Zhang, Delong Pei, Wankun Huang, Aihua Jin, Zhenhua Lin, Junjie Piao

“…In summary, our study underscores the oncogenic function of ILF3 in CRC and suggests that ILF3 knockdown may serve as a promising therapeutic approach for CRC.…”
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Relapse prevention group therapy via video-conferencing for substance use disorder: protocol for a multicentre randomised controlled trial in Indonesia by Tomohiro Shinozaki, Ryota Sakamoto, Toshihiko Matsumoto, Chika Yamada, Kristiana Siste, Enjeline Hanafi, Youdiil Ophinni, Evania Beatrice, Vania Rafelia, Peter Alison, Albert Limawan

“…Secondary outcomes will include addiction severity, quality of life, motivation to change, psychiatric symptoms, cognitive function, coping, and internalised stigma. Assessments will be performed at baseline (week 0), post-treatment (week 13), and 3 and 12 months post-treatment completion (weeks 24 and 60). …”
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Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventr... by Jie‐Fu Fan, Xing Tan, Wen Wang, Ji‐Kui Li, Yu‐Chen Xiao, Wei‐Zhong Wang, Yang‐Kai Wang

“…Intracisternal drug delivery and adeno‐associated viral vectors microinjection were used in both Wistar‐Kyoto rats and spontaneous hypertensive rats to modulate the function of Ang II, PGE2 receptor 3, and expression of COX2 (cyclooxygenase 2). …”
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Divergent effects of monomethyl branched-chain fatty acids on energy metabolism and insulin signaling in human myotubes by Parmeshwar Bajirao Katare, Ragna H. Tingstad, Sivar T. Beajani, Jørgen Pasjkurov Indseth, Vibeke H. Telle-Hansen, Mari C.W. Myhrstad, Arild C. Rustan, Lars Eide, Oliwia Witczak, Vigdis Aas

“…Branched-chain fatty acids (BCFAs) are predominantly saturated fatty acids with one or more methyl branches on the carbon chain, typically found in dairy products and measured in micromolar concentrations in human plasma. The biological function of BCFAs in humans remains ill-defined, but a relationship between circulating BCFAs and cardiometabolic health has been suggested. …”
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Omega-3 Fatty Acids Regulate Mammary Gland Lipogenesis and Development via Gαs-Mediated cAMP–EPAC Signaling Pathway by Baofeng Li, Senlin Su, Siyu Yuan, Dongpang Chen, Qianzi Zhang, Qihui Li, Xiaoai Lin, Xiaohuan Liang, Wutai Guan, Shihai Zhang

“…Furthermore, the regulatory function of GPR120 under non-inflammatory conditions in in vivo and in vitro models is explored. …”
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